Výsledky vyhľadávania - "HYPOGLYCEMIC agents"

Cost-effectiveness of insulin icodec for the treatment of type 2 diabetes in Canada.

Autori: Garcia DA Mau G Singh S a ďalší

Zdroj: Journal of medical economics [J Med Econ] 2025 Dec; Vol. 28 (1), pp. 1476-1499. Date of Electronic Publication: 2025 Sep 04.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9892255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-837X (Electronic) Linking ISSN: 13696998 NLM ISO Abbreviation: J Med Econ Subsets: MEDLINE

Výrazy zo slovníka MeSH: Diabetes Mellitus, Type 2*/drug therapy , Hypoglycemic Agents*/economics , Hypoglycemic Agents*/therapeutic use , Hypoglycemic Agents*/administration & dosage , Insulin, Long-Acting*/economics , Insulin, Long-Acting*/therapeutic use , Insulin, Long-Acting*/administration & dosage , Insulin*/economics , Insulin*/therapeutic use , Insulin*/administration & dosage, Humans ; Cost-Benefit Analysis ; Canada ; Female ; Quality-Adjusted Life Years ; Male ; Middle Aged ; Insulin Detemir/economics ; Insulin Detemir/therapeutic use ; Insulin Detemir/administration & dosage ; Insulin Glargine/economics ; Insulin Glargine/therapeutic use ; Insulin Glargine/administration & dosage ; Aged ; Adult

Hypoglycemic and Analgesic Effects of Benzyloxyphenylpropanoic Derivatives of Isobornylamine as FFAR-1 Agonists.

Autori: Elkina MA Khvostov MV Kuranov SO a ďalší

Zdroj: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2025 Nov; Vol. 358 (11), pp. e70152.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/chemical synthesis , Receptors, G-Protein-Coupled*/agonists , Analgesics*/pharmacology , Analgesics*/chemistry , Analgesics*/chemical synthesis , Pain*/drug therapy , Pain*/chemically induced , Phenylpropionates*/pharmacology , Phenylpropionates*/chemistry , Phenylpropionates*/chemical synthesis, Animals ; Mice ; Mice, Inbred C57BL ; Male ; Structure-Activity Relationship ; Dose-Response Relationship, Drug ; Blood Glucose/drug effects ; Molecular Structure ; Diabetes Mellitus, Type 2/drug therapy ; Insulin Resistance ; Disease Models, Animal

Novel Insights into the Causal Relationship between Antidiabetic Drugs and Adverse Perinatal Outcomes: A Mendelian Randomization Study.

Autori: Su C He X Chang X a ďalší

Zdroj: Diabetes & metabolism journal [Diabetes Metab J] 2025 Nov; Vol. 49 (6), pp. 1242-1251. Date of Electronic Publication: 2025 Jun 02.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Korean Diabetes Association Country of Publication: Korea (South) NLM ID: 101556588 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2233-6087 (Electronic) Linking ISSN: 22336079 NLM ISO Abbreviation: Diabetes Metab J Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hypoglycemic Agents*/adverse effects , Hypoglycemic Agents*/therapeutic use , Pregnancy in Diabetics*/drug therapy , Diabetes Mellitus, Type 2*/drug therapy, Humans ; Pregnancy ; Mendelian Randomization Analysis ; Female ; Infant, Newborn ; Pregnancy Outcome/epidemiology ; Polymorphism, Single Nucleotide ; Premature Birth/epidemiology

Impact of transitioning from conventional blood glucose monitoring to continuous glucose monitoring on glycemic control and self-management in adults with type 2 diabetes on oral glucose-lowering medications.

Autori: Al Hayek A Klonoff DC Al Zahrani WM a ďalší

Zdroj: Diabetes research and clinical practice [Diabetes Res Clin Pract] 2025 Nov; Vol. 229, pp. 112458. Date of Electronic Publication: 2025 Sep 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8508335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8227 (Electronic) Linking ISSN: 01688227 NLM ISO Abbreviation: Diabetes Res Clin Pract Subsets: MEDLINE

Výrazy zo slovníka MeSH: Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/blood , Blood Glucose Self-Monitoring*/methods , Self-Management*/methods , Hypoglycemic Agents*/therapeutic use , Hypoglycemic Agents*/administration & dosage , Glycemic Control*/methods , Blood Glucose*/analysis, Humans ; Female ; Male ; Middle Aged ; Aged ; Prospective Studies ; Administration, Oral ; Glycated Hemoglobin/analysis ; Adult ; Continuous Glucose Monitoring

Meta-analysis of the effects of semaglutide on body mass index (BMI) and blood lipid levels in polycystic ovary syndrome patients.

Autori: Chen W Xu D Shao X a ďalší

Zdroj: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2025 Dec 31; Vol. 41 (1), pp. 2553052. Date of Electronic Publication: 2025 Sep 17.

Spôsob vydávania: Journal Article; Meta-Analysis

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8807913 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-0766 (Electronic) Linking ISSN: 09513590 NLM ISO Abbreviation: Gynecol Endocrinol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Polycystic Ovary Syndrome*/drug therapy , Polycystic Ovary Syndrome*/blood , Polycystic Ovary Syndrome*/complications , Glucagon-Like Peptides*/therapeutic use , Glucagon-Like Peptides*/pharmacology , Body Mass Index* , Lipids*/blood , Hypoglycemic Agents*/therapeutic use , Hypoglycemic Agents*/pharmacology, Humans ; Female ; Adult ; Glucagon-Like Peptide 1

The bitterness, biosynthesis, chemical transformation, and antidiabetic activity of cucurbitane-type triterpenoids from bitter gourd (Momordica charantia L.).

Autori: Liu L Lin Z Cai X a ďalší

Zdroj: Food chemistry [Food Chem] 2025 Dec 30; Vol. 497, pp. 147081. Date of Electronic Publication: 2025 Nov 11.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Momordica charantia*/chemistry , Momordica charantia*/metabolism , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/metabolism , Hypoglycemic Agents*/pharmacology , Triterpenes*/chemistry , Triterpenes*/metabolism , Triterpenes*/pharmacology , Plant Extracts*/chemistry , Plant Extracts*/metabolism , Plant Extracts*/pharmacology, Humans ; Taste ; Animals ; Molecular Structure ; Glycosides

Citric acid-crosslinked carboxymethyl cellulose hydrogel microneedles enable gentle loading and rapid transdermal delivery of insulin.

Autori: Zhang M Wang Y

Zdroj: International journal of pharmaceutics [Int J Pharm] 2025 Dec 25; Vol. 686, pp. 126350. Date of Electronic Publication: 2025 Nov 02.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE

Výrazy zo slovníka MeSH: Carboxymethylcellulose Sodium*/chemistry , Carboxymethylcellulose Sodium*/administration & dosage , Insulin*/administration & dosage , Insulin*/pharmacokinetics , Insulin*/chemistry , Citric Acid*/chemistry , Citric Acid*/administration & dosage , Hydrogels*/chemistry , Hydrogels*/administration & dosage , Hypoglycemic Agents*/administration & dosage , Hypoglycemic Agents*/pharmacokinetics , Hypoglycemic Agents*/chemistry , Drug Delivery Systems*/methods, Animals ; Administration, Cutaneous ; Needles ; Swine ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/blood ; Male ; Rats ; Rats, Sprague-Dawley ; Skin/metabolism ; Blood Glucose/drug effects ; Microinjections ; Cross-Linking Reagents/chemistry ; Drug Liberation ; Skin Absorption

Capryol® 90 is an efficacious intestinal absorption enhancer for insulin in vivo when combined other excipients.

Autori: McCartney F Caisse P Dumont C a ďalší

Zdroj: International journal of pharmaceutics [Int J Pharm] 2025 Dec 25; Vol. 686, pp. 126315. Date of Electronic Publication: 2025 Oct 27.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE

Výrazy zo slovníka MeSH: Excipients*/chemistry , Excipients*/administration & dosage , Intestinal Absorption*/drug effects , Insulin*/administration & dosage , Insulin*/pharmacokinetics , Insulin*/chemistry , Decanoic Acids*/chemistry , Decanoic Acids*/administration & dosage , Hypoglycemic Agents*/administration & dosage , Hypoglycemic Agents*/pharmacokinetics , Hypoglycemic Agents*/chemistry, Animals ; Male ; Rats ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/drug effects ; Rats, Sprague-Dawley ; Permeability ; Castor Oil/chemistry ; Polyethylene Glycols/chemistry ; Solubility ; Rats, Wistar

Cichoriin, a coumarin glycoside with antidiabetic effect and cardioprotective activity against H 2 O 2 induced oxidative stress in H9c2 cells: in-vitro and in-silico study.

Autori: Sishu NK Selvaraj CI

Zdroj: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 16; Vol. 241, pp. 671-688. Date of Electronic Publication: 2025 Oct 08.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Oxidative Stress*/drug effects , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemistry , Cardiotonic Agents*/pharmacology , Cardiotonic Agents*/chemistry , Coumarins*/pharmacology , Coumarins*/chemistry , Flavonoids*/pharmacology , Flavonoids*/chemistry, Hydrogen Peroxide/toxicity ; Hydrogen Peroxide/pharmacology ; Animals ; Mice ; Rats ; Lipid Peroxidation/drug effects ; 3T3-L1 Cells ; Molecular Docking Simulation ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Cell Survival/drug effects ; Cell Line ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Lipase/antagonists & inhibitors ; Glucose/metabolism

Supercritical fluid extraction and micro-encapsulation of Saussurea costus roots for next gen functional foods: antioxidant potential, surface morphology and anti-diabetic potential.

Autori: Mushtaq M Amin QA Wani TA a ďalší

Zdroj: Food chemistry [Food Chem] 2025 Dec 15; Vol. 495 (Pt 1), pp. 146290. Date of Electronic Publication: 2025 Sep 07.

Spôsob vydávania: Journal Article; Evaluation Study

Informácie o časopise: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Plant Extracts*/isolation & purification , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Antioxidants*/isolation & purification , Antioxidants*/chemistry , Antioxidants*/pharmacology , Hypoglycemic Agents*/isolation & purification , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/pharmacology , Functional Food*/analysis , Saussurea*/chemistry , Plant Roots*/chemistry , Chromatography, Supercritical Fluid*/methods, Humans ; Hep G2 Cells ; alpha-Amylases/antagonists & inhibitors ; alpha-Amylases/metabolism ; Drug Compounding/methods

Hypoglycemic potential of American ginseng saponins: inhibition of α-amylase and improvement of insulin resistance.

Autori: Liang L Guo Y Yao X a ďalší

Zdroj: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2025 Dec 15; Vol. 1267, pp. 124813. Date of Electronic Publication: 2025 Oct 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-376X (Electronic) Linking ISSN: 15700232 NLM ISO Abbreviation: J Chromatogr B Analyt Technol Biomed Life Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Insulin Resistance* , Panax*/chemistry , alpha-Amylases*/antagonists & inhibitors , alpha-Amylases*/metabolism , Saponins*/pharmacology , Saponins*/chemistry , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemistry, Humans ; Hep G2 Cells ; Molecular Docking Simulation ; Chromatography, High Pressure Liquid ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Ginsenosides/pharmacology ; Ginsenosides/chemistry

Unraveling the safety profile of GLP-1 receptor agonists: Mechanistic insights with a focus on semaglutide.

Autori: He X Zhao Z Sun Y a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118163. Date of Electronic Publication: 2025 Sep 10.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glucagon-Like Peptides*/adverse effects , Glucagon-Like Peptides*/pharmacology , Glucagon-Like Peptides*/therapeutic use , Glucagon-Like Peptides*/chemistry , Glucagon-Like Peptide-1 Receptor Agonists* , Diabetes Mellitus, Type 2*/drug therapy , Hypoglycemic Agents*/adverse effects , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/therapeutic use, Humans ; Animals ; Glucagon-Like Peptide-1 Receptor/metabolism ; Glucagon-Like Peptide 1

Screening of key dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from casein hydrolysates based on peptidomics, chemometrics, recombination, and omission experiments.

Autori: Wang S Zhou M Qian J a ďalší

Zdroj: Food chemistry [Food Chem] 2025 Dec 15; Vol. 495 (Pt 3), pp. 146639. Date of Electronic Publication: 2025 Oct 03.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Dipeptidyl-Peptidase IV Inhibitors*/chemistry , Dipeptidyl-Peptidase IV Inhibitors*/administration & dosage , Caseins*/chemistry , Peptides*/chemistry , Peptides*/administration & dosage , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/administration & dosage, Dipeptidyl Peptidase 4/chemistry ; Dipeptidyl Peptidase 4/metabolism ; Animals ; Male ; Humans ; Amino Acid Sequence ; Rats ; Mice

Synthesis of diarylpentane derivatives as novel α-glucosidase inhibitors: Their inhibitory mechanism and hypoglycemic effects.

Autori: Liao XM Li XY Wang Y a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118161. Date of Electronic Publication: 2025 Sep 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glycoside Hydrolase Inhibitors*/chemical synthesis , Glycoside Hydrolase Inhibitors*/pharmacology , Glycoside Hydrolase Inhibitors*/chemistry , Glycoside Hydrolase Inhibitors*/therapeutic use , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemical synthesis , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/therapeutic use , alpha-Glucosidases*/metabolism, Animals ; Mice ; Structure-Activity Relationship ; Molecular Docking Simulation ; Molecular Structure ; Dose-Response Relationship, Drug ; Male ; Humans ; Diabetes Mellitus, Experimental/drug therapy

Modulating glucose homeostasis via expression of PPAR-γ TF: Pharmacological insights into quinolone-based hydrazones.

Autori: Pravin NJ Kavalapure RS Gharge S a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118168. Date of Electronic Publication: 2025 Sep 12.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: PPAR gamma*/metabolism , PPAR gamma*/genetics , Homeostasis*/drug effects , Quinolones*/chemistry , Quinolones*/pharmacology , Quinolones*/chemical synthesis , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Experimental*/metabolism , Diabetes Mellitus, Experimental*/chemically induced , Hydrazones*/pharmacology , Hydrazones*/chemistry , Hydrazones*/chemical synthesis , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/chemical synthesis , Glucose*/metabolism, Animals ; Humans ; Rats ; Structure-Activity Relationship ; Molecular Structure ; Male ; Molecular Docking Simulation ; Hep G2 Cells ; Dose-Response Relationship, Drug ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism

Decades old glitazones still find niche in drug discoveries as PPAR-γ agonists: medicinal chemistry perspective, structure-activity relationships and therapeutic implications.

Autori: Archana P Durai Ananda Kumar T Vijaya Ganesh N a ďalší

Zdroj: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Dec 15; Vol. 131, pp. 118393. Date of Electronic Publication: 2025 Sep 15.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: PPAR gamma*/agonists , PPAR gamma*/metabolism , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/metabolism , Thiazolidinediones*/chemistry , Thiazolidinediones*/pharmacology , Thiazolidinediones*/therapeutic use , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/therapeutic use , Drug Discovery*, Humans ; Structure-Activity Relationship ; Molecular Structure ; Animals ; Chemistry, Pharmaceutical ; PPAR-gamma Agonists

Balancing oral sequential absorption barriers of semaglutide-loaded nanoparticles by optimization of surface glycocholic acid density.

Autori: Zeng H Li Y Liu B a ďalší

Zdroj: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Dec 10; Vol. 388 (Pt 1), pp. 114316. Date of Electronic Publication: 2025 Oct 11.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

Výrazy zo slovníka MeSH: Nanoparticles*/chemistry , Nanoparticles*/administration & dosage , Glycocholic Acid*/chemistry , Glycocholic Acid*/administration & dosage , Glycocholic Acid*/pharmacokinetics , Glucagon-Like Peptides*/administration & dosage , Glucagon-Like Peptides*/pharmacokinetics , Glucagon-Like Peptides*/chemistry , Glucagon-Like Peptides*/therapeutic use , Hypoglycemic Agents*/administration & dosage , Hypoglycemic Agents*/pharmacokinetics , Hypoglycemic Agents*/therapeutic use , Hypoglycemic Agents*/chemistry , Drug Carriers*/chemistry, Animals ; Humans ; Caco-2 Cells ; Administration, Oral ; Male ; Rats, Sprague-Dawley ; Biological Availability ; Surface Properties ; Rats ; Hydrophobic and Hydrophilic Interactions ; Diabetes Mellitus, Experimental/drug therapy ; Glucagon-Like Peptide 1

A study on the mechanism of action of Syringin in the treatment of type 2 diabetes by integrating metabolomics, network pharmacology, molecular docking technology and experimental validation.

Autori: Wan C Sun S Du Y a ďalší

Zdroj: International immunopharmacology [Int Immunopharmacol] 2025 Dec 10; Vol. 167, pp. 115716. Date of Electronic Publication: 2025 Oct 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glucosides*/therapeutic use , Glucosides*/pharmacology , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/metabolism , Phenylpropionates*/therapeutic use , Phenylpropionates*/pharmacology , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Experimental*/metabolism , Hypoglycemic Agents*/therapeutic use , Hypoglycemic Agents*/pharmacology, Animals ; Molecular Docking Simulation ; Network Pharmacology ; Male ; Mice ; Metabolomics ; Humans ; Diet, High-Fat ; Mice, Inbred C57BL ; Blood Glucose/drug effects ; Streptozocin

Acute Kidney Injury After Accelerated Dosing of Tirzepatide in a Patient with Multiple Comorbidities: A Case Report.

Autori: Almansour AH; Department of Family and Community Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Zdroj: The American journal of case reports [Am J Case Rep] 2025 Dec 06; Vol. 26, pp. e950781. Date of Electronic Publication: 2025 Dec 06.

Spôsob vydávania: Journal Article; Case Reports

Informácie o časopise: Publisher: International Scientific Information, Inc Country of Publication: United States NLM ID: 101489566 Publication Model: Electronic Cited Medium: Internet ISSN: 1941-5923 (Electronic) Linking ISSN: 19415923 NLM ISO Abbreviation: Am J Case Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Acute Kidney Injury*/chemically induced , Hypoglycemic Agents*/adverse effects , Hypoglycemic Agents*/administration & dosage , Obesity, Morbid*/drug therapy , Obesity, Morbid*/complications, Humans ; Male ; Aged ; Polypharmacy ; Tirzepatide

Novel computational modeling of trimodal chromatographic retention using Box-Cox and multivariate analysis.

Autori: Komsta Ł Vlatković V Lazović S a ďalší

Zdroj: Journal of chromatography. A [J Chromatogr A] 2025 Dec 06; Vol. 1764, pp. 466505. Date of Electronic Publication: 2025 Oct 31.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3778 (Electronic) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/analysis , Hypoglycemic Agents*/isolation & purification , Chromatography, Reverse-Phase*/methods , Models, Chemical*, Multivariate Analysis ; Principal Component Analysis ; Computer Simulation ; Chromatography, Ion Exchange/methods