Suchergebnisse - "HISTONE deacetylase"

AR-A014418-based dual Glycogen Synthase Kinase 3β/Histone Deacetylase inhibitors as potential therapeutics for Alzheimer's disease.

Autoren: Santini A Tassinari E Altomare A et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Oct 15; Vol. 296, pp. 117838. Date of Electronic Publication: 2025 Jun 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemistry , Histone Deacetylase Inhibitors*/chemical synthesis , Alzheimer Disease*/drug therapy , Alzheimer Disease*/metabolism , Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors , Glycogen Synthase Kinase 3 beta*/metabolism , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/chemical synthesis, Humans ; Structure-Activity Relationship ; Dose-Response Relationship, Drug ; Molecular Structure ; Cell Line, Tumor ; Histone Deacetylase 2/antagonists & inhibitors ; Histone Deacetylase 2/metabolism ; tau Proteins/metabolism ; Histone Deacetylase 6/antagonists & inhibitors ; Histone Deacetylase 6/metabolism ; Thiazoles ; Urea/analogs & derivatives

Histone Deacetylase 2 in Alzheimer's Disease: A Comprehensive Molecular Blueprint for Therapeutic Targeting.

Autoren: Asadi K K R Satarker S et al.

Quelle: Molecular neurobiology [Mol Neurobiol] 2025 Dec; Vol. 62 (12), pp. 16489-16511. Date of Electronic Publication: 2025 Aug 08.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH-Schlagworte: Alzheimer Disease*/drug therapy , Alzheimer Disease*/enzymology , Alzheimer Disease*/pathology , Histone Deacetylase 2*/metabolism , Histone Deacetylase 2*/antagonists & inhibitors , Molecular Targeted Therapy*, Humans ; Animals ; Histone Deacetylase Inhibitors/therapeutic use ; Histone Deacetylase Inhibitors/pharmacology ; Amyloid beta-Peptides/metabolism ; Brain/pathology ; Oxidative Stress

Design and Synthesis of Novel N -(1 H -pyrazol-3-yl)pyrimidin-4-amine Aurora/HDAC Dual Inhibitors for Colorectal Cancer Treatment.

Autoren: Cui H Huang X Li R et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Nov 27; Vol. 68 (22), pp. 23941-23961. Date of Electronic Publication: 2025 Nov 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemical synthesis , Histone Deacetylase Inhibitors*/chemistry , Histone Deacetylase Inhibitors*/therapeutic use , Histone Deacetylase Inhibitors*/pharmacokinetics , Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/pathology , Drug Design* , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use , Aurora Kinase A*/antagonists & inhibitors , Aurora Kinase A*/metabolism , Pyrimidines*/pharmacology , Pyrimidines*/chemical synthesis , Pyrimidines*/chemistry , Pyrimidines*/therapeutic use , Pyrazoles*/pharmacology , Pyrazoles*/chemical synthesis , Pyrazoles*/chemistry , Pyrazoles*/therapeutic use , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry, Humans ; Animals ; Apoptosis/drug effects ; Mice ; Cell Proliferation/drug effects ; Structure-Activity Relationship ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Mice, Nude ; HCT116 Cells ; Drug Screening Assays, Antitumor ; Histone Deacetylase 1/antagonists & inhibitors ; Histone Deacetylase 1/metabolism

Discovery of Pyrazole-Based Positron Emission Tomography Agent that Maps Histone Deacetylase 6 (HDAC6) in the Nonhuman Primate Brain.

Autoren: Yamasaki T Ohyabu N Wakabayashi T et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Nov 13; Vol. 68 (21), pp. 23375-23388. Date of Electronic Publication: 2025 Oct 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Histone Deacetylase 6*/metabolism , Histone Deacetylase 6*/antagonists & inhibitors , Positron-Emission Tomography*/methods , Pyrazoles*/chemistry , Pyrazoles*/chemical synthesis , Pyrazoles*/metabolism , Pyrazoles*/pharmacokinetics , Pyrazoles*/pharmacology , Brain*/diagnostic imaging , Brain*/metabolism , Radiopharmaceuticals*/chemistry , Radiopharmaceuticals*/chemical synthesis , Radiopharmaceuticals*/pharmacokinetics, Animals ; Fluorine Radioisotopes/chemistry ; Mice ; Mice, Knockout ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/chemistry ; Male ; Humans ; Drug Discovery

New Vanillyl-capped HDAC inhibitors exhibit anti-tumor efficacy in neuroblastoma and glioblastoma cells.

Autoren: Cursaro I Frattaruolo L Scalvini L et al.

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Nov; Vol. 166, pp. 109085. Date of Electronic Publication: 2025 Oct 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemistry , Histone Deacetylase Inhibitors*/chemical synthesis , Glioblastoma*/drug therapy , Glioblastoma*/pathology , Glioblastoma*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Neuroblastoma*/drug therapy , Neuroblastoma*/pathology , Neuroblastoma*/metabolism , Hydroxamic Acids*/pharmacology , Hydroxamic Acids*/chemistry , Hydroxamic Acids*/chemical synthesis, Humans ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Cell Proliferation/drug effects ; Molecular Structure ; Dose-Response Relationship, Drug ; Histone Deacetylase 6/antagonists & inhibitors ; Histone Deacetylase 6/metabolism ; Apoptosis/drug effects ; Cell Line, Tumor ; Molecular Docking Simulation ; Histone Deacetylases/metabolism ; Cell Survival/drug effects

The Allosteric Regulator Inositol Phosphate Dramatically Affects the Efficacy and Selectivity of Inhibitors for Different HDAC Complexes.

Autoren: Pytel WA Patel U Smalley JP et al.

Quelle: Journal of the American Chemical Society [J Am Chem Soc] 2025 Oct 08; Vol. 147 (40), pp. 36044-36052. Date of Electronic Publication: 2025 Sep 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

MeSH-Schlagworte: Inositol Phosphates*/chemistry , Inositol Phosphates*/metabolism , Inositol Phosphates*/pharmacology , Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemistry , Histone Deacetylases*/metabolism, Allosteric Regulation/drug effects ; Humans ; Histone Deacetylase 1/antagonists & inhibitors ; Histone Deacetylase 1/metabolism ; Molecular Structure ; Structure-Activity Relationship

HDAC inhibition protects RPE cells from oxidative stress via enhanced mitochondrial fusion, cytoskeletal repair, and Nrf-2 activation.

Autoren: Lugassy Y Berent E Tarony L et al.

Quelle: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 01; Vol. 240, pp. 59-70. Date of Electronic Publication: 2025 Aug 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH-Schlagworte: Oxidative Stress*/drug effects , Histone Deacetylase Inhibitors*/pharmacology , Retinal Pigment Epithelium*/drug effects , Retinal Pigment Epithelium*/metabolism , Retinal Pigment Epithelium*/pathology , Retinal Pigment Epithelium*/cytology , Mitochondrial Dynamics*/drug effects , NF-E2-Related Factor 2*/metabolism , NF-E2-Related Factor 2*/genetics , Macular Degeneration*/drug therapy , Macular Degeneration*/pathology , Macular Degeneration*/metabolism , Macular Degeneration*/genetics, Humans ; Hydroxamic Acids/pharmacology ; Vorinostat/pharmacology ; Rotenone/pharmacology ; Rotenone/toxicity ; Reactive Oxygen Species/metabolism ; Cytoskeleton/drug effects ; Cytoskeleton/metabolism ; Mitochondria/drug effects ; Mitochondria/metabolism ; Histone Deacetylase 6/antagonists & inhibitors ; Histone Deacetylase 6/genetics ; Kelch-Like ECH-Associated Protein 1/genetics ; Kelch-Like ECH-Associated Protein 1/metabolism ; Cell Line ; Cell Survival/drug effects ; Heme Oxygenase-1/genetics ; Heme Oxygenase-1/metabolism

Design, synthesis, and biological evaluation of estratriene-based hydroxamic acid derivatives as histone deacetylase inhibitors.

Autoren: Chen H Li Y Liang Z et al.

Quelle: The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2026 Jan; Vol. 255, pp. 106867. Date of Electronic Publication: 2025 Sep 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Country of Publication: England NLM ID: 9015483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1220 (Electronic) Linking ISSN: 09600760 NLM ISO Abbreviation: J Steroid Biochem Mol Biol Subsets: MEDLINE

MeSH-Schlagworte: Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemical synthesis , Histone Deacetylase Inhibitors*/chemistry , Hydroxamic Acids*/pharmacology , Hydroxamic Acids*/chemistry , Hydroxamic Acids*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry, Humans ; Molecular Docking Simulation ; Drug Design ; Structure-Activity Relationship ; Apoptosis/drug effects ; HeLa Cells ; Cell Proliferation/drug effects ; Histone Deacetylase 2/antagonists & inhibitors ; Histone Deacetylase 2/metabolism ; Histone Deacetylase 2/chemistry ; Histone Deacetylase 6/antagonists & inhibitors ; Histone Deacetylase 6/metabolism ; Histone Deacetylase 6/chemistry ; Cell Line, Tumor

Pharmacological manipulation of liver fibrosis progression using novel HDAC6 inhibitors.

Autoren: Borrello MT Ruzic D Paish H et al.

Quelle: The FEBS journal [FEBS J] 2025 Jul; Vol. 292 (13), pp. 3397-3411. Date of Electronic Publication: 2025 Mar 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-4658 (Electronic) Linking ISSN: 1742464X NLM ISO Abbreviation: FEBS J Subsets: MEDLINE

MeSH-Schlagworte: Histone Deacetylase 6*/antagonists & inhibitors , Histone Deacetylase 6*/metabolism , Histone Deacetylase 6*/genetics , Histone Deacetylase 6*/chemistry , Liver Cirrhosis*/drug therapy , Liver Cirrhosis*/pathology , Liver Cirrhosis*/metabolism , Liver Cirrhosis*/genetics , Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemistry , Histone Deacetylase Inhibitors*/chemical synthesis, Humans ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Molecular Docking Simulation ; Acetylation/drug effects ; Signal Transduction/drug effects ; Liver/drug effects ; Liver/pathology ; Liver/metabolism ; Disease Progression ; Tubulin/metabolism ; Transforming Growth Factor beta1/metabolism ; Transforming Growth Factor beta1/genetics ; Hydroxamic Acids/pharmacology ; Hydroxamic Acids/chemistry ; Animals ; Histone Deacetylase 1/antagonists & inhibitors ; Histone Deacetylase 1/genetics ; Histone Deacetylase 1/metabolism

Mutations on the surface of HDAC1 reveal molecular determinants of specific complex assembly and their requirement for gene regulation.

Autoren: Alshehri A Baker IM English DM et al.

Quelle: Nucleic acids research [Nucleic Acids Res] 2025 Sep 05; Vol. 53 (17).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

MeSH-Schlagworte: Histone Deacetylase 1*/genetics , Histone Deacetylase 1*/chemistry , Histone Deacetylase 1*/metabolism , Gene Expression Regulation*, Animals ; Mice ; Repressor Proteins/metabolism ; Repressor Proteins/chemistry ; Repressor Proteins/genetics ; Sin3 Histone Deacetylase and Corepressor Complex/metabolism ; Histone Deacetylase 2/metabolism ; Histone Deacetylase 2/genetics ; Histone Deacetylase 2/chemistry ; Mutation ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Histone Deacetylases/chemistry ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/metabolism ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/chemistry ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/genetics ; Acetylation ; Protein Binding ; Trans-Activators ; Co-Repressor Proteins/metabolism ; Histones/metabolism ; Humans ; Mouse Embryonic Stem Cells/metabolism ; Models, Molecular

The HDAC inhibitor romidepsin renders liver cancer vulnerable to RTK targeting and immunologically active.

Autoren: Sequera C Grattarola M Cannet F et al.

Quelle: Nature communications [Nat Commun] 2025 Aug 25; Vol. 16 (1), pp. 7919. Date of Electronic Publication: 2025 Aug 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Depsipeptides*/pharmacology , Depsipeptides*/therapeutic use , Liver Neoplasms*/drug therapy , Liver Neoplasms*/immunology , Liver Neoplasms*/genetics , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/immunology , Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/metabolism , Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/therapeutic use, Humans ; Animals ; Mice ; Cell Line, Tumor ; Pyridines/pharmacology ; Pyridines/therapeutic use ; Anilides/pharmacology ; Anilides/therapeutic use ; Histone Deacetylase 1/metabolism ; Histone Deacetylase 1/genetics ; Histone Deacetylase 1/antagonists & inhibitors ; Histone Deacetylase 2/metabolism ; Histone Deacetylase 2/genetics ; Histone Deacetylase 2/antagonists & inhibitors ; Signal Transduction/drug effects ; Epigenesis, Genetic/drug effects ; Male ; Female ; Protein Kinase Inhibitors/pharmacology ; Xenograft Model Antitumor Assays

Design and evaluation of highly selective histone deacetylase 6 inhibitors derived from the natural product tryptoline.

Autoren: Ali KH Sharma C Oh YJ et al.

Quelle: Molecular pharmacology [Mol Pharmacol] 2025 Aug; Vol. 107 (8), pp. 100062. Date of Electronic Publication: 2025 Jul 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemistry , Histone Deacetylase Inhibitors*/chemical synthesis , Histone Deacetylase 6*/antagonists & inhibitors , Histone Deacetylase 6*/metabolism , Histone Deacetylase 6*/chemistry , Drug Design* , Carbolines*/chemistry , Carbolines*/pharmacology , Biological Products*/pharmacology , Biological Products*/chemistry, Humans ; Molecular Docking Simulation/methods ; Cell Line, Tumor ; Structure-Activity Relationship ; Histone Deacetylase 1/metabolism ; Acetylation/drug effects

Design, Synthesis, and Biological Evaluation of Quinoline-Based Hydroxamic Acid Derivatives as Dual DNMT and HDAC Inhibitors with Potent Anti-Breast Cancer Activity.

Autoren: Lin H Zheng W Yuan Z et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Sep 25; Vol. 68 (18), pp. 19022-19040. Date of Electronic Publication: 2025 Aug 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemical synthesis , Histone Deacetylase Inhibitors*/chemistry , Histone Deacetylase Inhibitors*/therapeutic use , Quinolines*/chemistry , Quinolines*/pharmacology , Quinolines*/chemical synthesis , Quinolines*/therapeutic use , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Drug Design* , Hydroxamic Acids*/pharmacology , Hydroxamic Acids*/chemistry , Hydroxamic Acids*/chemical synthesis , Hydroxamic Acids*/therapeutic use , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use , DNA (Cytosine-5-)-Methyltransferases*/antagonists & inhibitors , DNA (Cytosine-5-)-Methyltransferases*/metabolism, Humans ; Animals ; Female ; Mice ; DNA (Cytosine-5-)-Methyltransferase 1/antagonists & inhibitors ; Cell Line, Tumor ; Structure-Activity Relationship ; Cell Proliferation/drug effects ; Xenograft Model Antitumor Assays ; Histone Deacetylase 1/antagonists & inhibitors ; Histone Deacetylase 1/metabolism ; Mice, Nude

The regulatory mechanisms and treatment of HDAC6 in immune dysregulation diseases.

Autoren: Liang Y Wang Y Xing J et al.

Quelle: Frontiers in immunology [Front Immunol] 2025 Sep 22; Vol. 16, pp. 1653588. Date of Electronic Publication: 2025 Sep 22 (Print Publication: 2025).

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH-Schlagworte: Histone Deacetylase 6*/metabolism , Histone Deacetylase 6*/immunology , Immune System Diseases*/drug therapy , Immune System Diseases*/metabolism , Immune System Diseases*/immunology, Humans ; Animals ; Histone Deacetylase Inhibitors/therapeutic use ; Histone Deacetylase Inhibitors/pharmacology

Monothiooxalamide-Benzothiazole Hybrids: Predictive Docking on HDAC6, Synthesis, Molecular Structure, and Antiproliferative Activity on Breast Cancer Cells.

Autoren: Macías-Hernández CE Balbuena-Rebolledo I García-Báez EV et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Sep 05; Vol. 26 (17). Date of Electronic Publication: 2025 Sep 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Benzothiazoles*/chemistry , Benzothiazoles*/pharmacology , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Histone Deacetylase 6*/metabolism , Histone Deacetylase 6*/chemistry , Histone Deacetylase 6*/antagonists & inhibitors, Humans ; Molecular Docking Simulation ; Cell Proliferation/drug effects ; Female ; Apoptosis/drug effects ; MCF-7 Cells ; Cell Line, Tumor ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/chemistry ; Histone Deacetylase Inhibitors/chemical synthesis ; Animals ; Molecular Structure ; Mice

Histone deacetylase 6: A new player in oxidative stress‑associated disorders and cancers (Review).

Autoren: Qu F Zhao Q Jin Y

Quelle: International journal of molecular medicine [Int J Mol Med] 2025 Sep; Vol. 56 (3). Date of Electronic Publication: 2025 Jul 11.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9810955 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-244X (Electronic) Linking ISSN: 11073756 NLM ISO Abbreviation: Int J Mol Med Subsets: MEDLINE

MeSH-Schlagworte: Oxidative Stress* , Histone Deacetylase 6*/metabolism , Histone Deacetylase 6*/antagonists & inhibitors , Histone Deacetylase 6*/genetics , Neoplasms*/metabolism , Neoplasms*/drug therapy , Neoplasms*/pathology , Neoplasms*/enzymology , Neurodegenerative Diseases*/metabolism, Humans ; Animals ; Histone Deacetylase Inhibitors/therapeutic use ; Histone Deacetylase Inhibitors/pharmacology

The deacetylases HDAC1/HDAC2 control JAK2 ^V617F -STAT signaling through the ubiquitin ligase SIAH2.

Autoren: Mustafa AM Petrosino G Fischer MA et al.

Quelle: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2025 Aug 29; Vol. 10 (1), pp. 275. Date of Electronic Publication: 2025 Aug 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE

MeSH-Schlagworte: Histone Deacetylase 2*/genetics , Histone Deacetylase 2*/metabolism , Histone Deacetylase 1*/genetics , Histone Deacetylase 1*/metabolism , Ubiquitin-Protein Ligases*/genetics , Ubiquitin-Protein Ligases*/metabolism , Janus Kinase 2*/genetics , Janus Kinase 2*/metabolism , Myeloproliferative Disorders*/genetics , Myeloproliferative Disorders*/drug therapy , Myeloproliferative Disorders*/pathology , Myeloproliferative Disorders*/enzymology, Humans ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Animals ; Mice ; Histone Deacetylase Inhibitors/pharmacology

Development and Characterization of the First Selective Class IIb Histone Deacetylase Degraders.

Autoren: Zhai S Honin I Schäker-Hübner L et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Jul 10; Vol. 68 (13), pp. 13793-13821. Date of Electronic Publication: 2025 Jun 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemistry , Histone Deacetylase Inhibitors*/chemical synthesis , Histone Deacetylases*/metabolism, Humans ; Cell Line, Tumor ; Histone Deacetylase 6/antagonists & inhibitors ; Histone Deacetylase 6/metabolism ; Proteolysis/drug effects ; Structure-Activity Relationship ; Thalidomide/analogs & derivatives ; Thalidomide/pharmacology ; Thalidomide/chemistry

Design and synthesis of novel Hydroxamate and non-Hydroxamate HDAC inhibitors based on Chromone and Quinazolone scaffolds.

Autoren: Ashraf R Adel M Serya RAT et al.

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Jul 01; Vol. 161, pp. 108514. Date of Electronic Publication: 2025 Apr 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemical synthesis , Histone Deacetylase Inhibitors*/chemistry , Drug Design* , Hydroxamic Acids*/pharmacology , Hydroxamic Acids*/chemistry , Hydroxamic Acids*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Chromones*/chemistry , Chromones*/pharmacology , Quinazolinones*/chemistry , Quinazolinones*/pharmacology , Quinazolinones*/chemical synthesis, Humans ; Structure-Activity Relationship ; Cell Proliferation/drug effects ; Molecular Structure ; Molecular Docking Simulation ; Drug Screening Assays, Antitumor ; Dose-Response Relationship, Drug ; Histone Deacetylases/metabolism ; Cell Line, Tumor ; Apoptosis/drug effects ; Histone Deacetylase 6/antagonists & inhibitors ; Histone Deacetylase 6/metabolism

Uncovering a Mutation-Independent Therapeutic Strategy against Inherited Retinal Diseases: Development of Class I HDAC/LSD1 Hybrid Inhibitors.

Autoren: Carullo G Piano I Salamone G et al.

Quelle: ACS chemical neuroscience [ACS Chem Neurosci] 2025 Sep 03; Vol. 16 (17), pp. 3364-3384. Date of Electronic Publication: 2025 Aug 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

MeSH-Schlagworte: Histone Demethylases*/antagonists & inhibitors , Histone Demethylases*/metabolism , Histone Demethylases*/genetics , Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemistry , Histone Deacetylase Inhibitors*/therapeutic use , Retinitis Pigmentosa*/drug therapy , Retinitis Pigmentosa*/genetics , Retinitis Pigmentosa*/metabolism, Animals ; Mice ; Humans ; Mutation ; Disease Models, Animal ; Histone Deacetylase 1/antagonists & inhibitors ; Histone Deacetylases/metabolism