Search Results - "HERPES simplex virus"

Computational modelling of a multiepitope vaccine targeting glycoprotein-D for herpes simplex virus 2 (HSV-2): an immunoinformatic analysis.

Authors: Khan MS Shakya M Verma CK

Source: Molecular diversity [Mol Divers] 2025 Dec; Vol. 29 (6), pp. 6401-6423. Date of Electronic Publication: 2025 Mar 09.

Publication Type: Journal Article

Journal Info: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

MeSH Terms: Herpesvirus 2, Human*/immunology , Viral Envelope Proteins*/immunology , Viral Envelope Proteins*/chemistry , Viral Envelope Proteins*/genetics , Epitopes, T-Lymphocyte*/immunology , Epitopes, T-Lymphocyte*/chemistry , Herpes Simplex Virus Vaccines*/immunology, Humans ; Molecular Docking Simulation ; Epitopes, B-Lymphocyte/immunology ; Epitopes, B-Lymphocyte/chemistry ; Computational Biology/methods ; Epitopes/immunology

Safety and immunogenicity of investigational herpes simplex virus-2 vaccines in adults with recurrent genital infection.

Authors: Laing KJ Sholukh AM MacPhee KJ et al.

Source: Vaccine [Vaccine] 2025 Oct 24; Vol. 65, pp. 127821. Date of Electronic Publication: 2025 Oct 06.

Publication Type: Journal Article; Randomized Controlled Trial

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE

MeSH Terms: Herpes Genitalis*/prevention & control , Herpes Genitalis*/immunology , Herpesvirus 2, Human*/immunology , Herpes Simplex Virus Vaccines*/immunology , Herpes Simplex Virus Vaccines*/adverse effects , Herpes Simplex Virus Vaccines*/administration & dosage , Immunogenicity, Vaccine*, Humans ; Female ; Adult ; Male ; Antibodies, Viral/blood ; Antibodies, Neutralizing/blood ; Middle Aged ; Young Adult ; CD4-Positive T-Lymphocytes/immunology ; Adjuvants, Immunologic/administration & dosage ; Double-Blind Method ; Adolescent

Herpes simplex virus 1 fusion glycoprotein B H516P prefusion mutation had no effect on vaccine immunogenicity.

Authors: Hu J Cao H Luan N et al.

Source: Vaccine [Vaccine] 2025 May 31; Vol. 57, pp. 127241. Date of Electronic Publication: 2025 May 11.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE

MeSH Terms: Viral Envelope Proteins*/immunology , Viral Envelope Proteins*/genetics , Immunogenicity, Vaccine* , Herpesvirus 1, Human*/immunology , Herpesvirus 1, Human*/genetics , Herpes Simplex*/prevention & control , Herpes Simplex*/immunology , Herpes Simplex Virus Vaccines*/immunology , Herpes Simplex Virus Vaccines*/genetics , Herpes Simplex Virus Vaccines*/administration & dosage, Animals ; Mice, Inbred BALB C ; Mice ; Female ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; Mutation ; Vaccines, Subunit/immunology ; Vaccines, Subunit/administration & dosage ; Vaccines, Subunit/genetics ; Adjuvants, Immunologic/administration & dosage ; Adjuvants, Vaccine/administration & dosage

Seroconversion Is Misleading as a Test for HSV-2 Infection in Prophylactic Genital Herpes Vaccine Trials: Results of Vaccine Studies in Guinea Pigs.

Authors: Bromberg V Hook LM Lubinski JM et al.

Source: Viruses [Viruses] 2025 May 29; Vol. 17 (6). Date of Electronic Publication: 2025 May 29.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

MeSH Terms: Herpesvirus 2, Human*/immunology , Herpesvirus 2, Human*/genetics , Herpes Genitalis*/prevention & control , Herpes Genitalis*/diagnosis , Herpes Genitalis*/immunology , Herpes Genitalis*/virology , Seroconversion* , Antibodies, Viral*/blood , Herpes Simplex Virus Vaccines*/immunology , Herpes Simplex Virus Vaccines*/administration & dosage, Animals ; Guinea Pigs ; Female ; Disease Models, Animal ; Vagina/virology

A tissue-targeted prime/pull/keep therapeutic herpes simplex virus vaccine protects against recurrent ocular herpes infection and disease in HLA-A*0201 transgenic rabbits.

Authors: Chentoufi AA Prakash S Vahed H et al.

Source: Journal of virology [J Virol] 2025 May 20; Vol. 99 (5), pp. e0013525. Date of Electronic Publication: 2025 Apr 10.

Publication Type: Journal Article

Journal Info: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE

MeSH Terms: Keratitis, Herpetic*/prevention & control , Keratitis, Herpetic*/immunology , Keratitis, Herpetic*/virology , Herpesvirus 1, Human*/immunology , Herpes Simplex Virus Vaccines*/immunology , Herpes Simplex Virus Vaccines*/administration & dosage , HLA-A2 Antigen*/genetics , HLA-A2 Antigen*/immunology, Animals ; Rabbits ; CD8-Positive T-Lymphocytes/immunology ; Epitopes, T-Lymphocyte/immunology ; Animals, Genetically Modified ; CD4-Positive T-Lymphocytes/immunology ; Disease Models, Animal ; Humans

Computational design and evaluation of multiepitope vaccines against herpes simplex virus type 1.

Authors: Zhao Z Wang W Pang J et al.

Source: Frontiers in immunology [Front Immunol] 2025 Jun 04; Vol. 16, pp. 1581571. Date of Electronic Publication: 2025 Jun 04 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Herpesvirus 1, Human*/immunology , Epitopes, T-Lymphocyte*/immunology , Epitopes, T-Lymphocyte*/chemistry , Herpes Simplex*/immunology , Herpes Simplex*/prevention & control , Herpes Simplex*/virology , Herpes Simplex Virus Vaccines*/immunology , Epitopes, B-Lymphocyte*/immunology , Epitopes, B-Lymphocyte*/chemistry, Humans ; Computational Biology/methods ; Molecular Docking Simulation

Reverse vaccinology-based design of multivalent multiepitope mRNA vaccines targeting key viral proteins of Herpes Simplex Virus type-2.

Authors: Suneesh NS Dhotre K Mahajan P et al.

Source: Frontiers in immunology [Front Immunol] 2025 May 20; Vol. 16, pp. 1586271. Date of Electronic Publication: 2025 May 20 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Herpesvirus 2, Human*/immunology , Herpesvirus 2, Human*/genetics , Viral Proteins*/immunology , Viral Proteins*/genetics , mRNA Vaccines*/immunology , Herpes Genitalis*/immunology , Herpes Genitalis*/prevention & control , Herpes Genitalis*/virology , Herpes Simplex Virus Vaccines*/immunology, Humans ; Vaccinology/methods ; Epitopes, T-Lymphocyte/immunology ; Molecular Docking Simulation ; Vaccines, Synthetic/immunology ; RNA, Messenger/immunology ; RNA, Messenger/genetics ; Epitopes/immunology

Next-generation sequencing and immuno-informatics for designing a multi-epitope vaccine against HSV-1-induced uveitis.

Authors: Cao H Cao Z Han Y et al.

Source: Frontiers in immunology [Front Immunol] 2025 Jan 31; Vol. 16, pp. 1461725. Date of Electronic Publication: 2025 Jan 31 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Epitopes*/genetics , Epitopes*/immunology , High-Throughput Nucleotide Sequencing*/methods , Immunoinformatics*/methods , Uveitis*/immunology , Uveitis*/prevention & control , Uveitis*/virology , Herpesvirus 1, Human*/genetics , Herpesvirus 1, Human*/immunology , Herpes Simplex Virus Vaccines*/genetics , Herpes Simplex Virus Vaccines*/immunology , Immunogenicity, Vaccine*/genetics , Immunogenicity, Vaccine*/immunology, Computer Simulation ; Humans ; Molecular Docking Simulation ; Lymphocytes/immunology ; Lymphocytes/virology ; Glycoproteins/genetics ; Adaptive Immunity/genetics ; Adaptive Immunity/immunology ; Immunity, Innate/genetics ; Immunity, Innate/immunology

Analysis of the Interaction Between the Attenuated HSV-1 Strain M6 and Macrophages Indicates Its Potential as an Effective Vaccine Immunogen.

Authors: Zhang Z Ren X Zhang Y et al.

Source: Viruses [Viruses] 2025 Mar 10; Vol. 17 (3). Date of Electronic Publication: 2025 Mar 10.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

MeSH Terms: Macrophages*/virology , Macrophages*/immunology , Herpesvirus 1, Human*/immunology , Herpesvirus 1, Human*/genetics , Herpes Simplex*/immunology , Herpes Simplex*/prevention & control , Herpes Simplex*/virology , Herpes Simplex Virus Vaccines*/immunology, Animals ; Mice ; Vaccines, Attenuated/immunology ; Cytokines/immunology ; Cytokines/metabolism ; Female ; Receptors, Tumor Necrosis Factor, Member 14/metabolism ; Mice, Inbred BALB C ; Antibodies, Viral/blood ; Viral Envelope Proteins/immunology ; Viral Envelope Proteins/metabolism ; Viral Envelope Proteins/genetics

Toward the Eradication of Herpes Simplex Virus: Vaccination and Beyond.

Authors: Chang JY Balch C Oh HS

Source: Viruses [Viruses] 2024 Sep 17; Vol. 16 (9). Date of Electronic Publication: 2024 Sep 17.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

MeSH Terms: Herpes Simplex*/prevention & control , Herpes Simplex*/immunology , Herpes Simplex*/virology , Herpes Simplex Virus Vaccines*/immunology , Herpes Simplex Virus Vaccines*/administration & dosage , Herpes Simplex Virus Vaccines*/genetics , Vaccination* , Simplexvirus*/genetics , Simplexvirus*/immunology, Humans ; Animals ; Vaccines, Subunit/immunology ; Vaccines, DNA/immunology ; Vaccines, Attenuated/immunology ; Disease Eradication

Vaccine value profile for herpes simplex virus.

Authors: Johnston C Scheele S Bachmann L et al.

Source: Vaccine [Vaccine] 2024 Jul 25; Vol. 42 (19 Suppl 1), pp. S82-S100. Date of Electronic Publication: 2024 May 24.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE

MeSH Terms: Herpesvirus 2, Human*/immunology , Herpes Simplex Virus Vaccines*/immunology , Herpes Simplex Virus Vaccines*/administration & dosage , Herpes Genitalis*/prevention & control , Herpes Genitalis*/immunology , Herpes Simplex*/prevention & control , Herpes Simplex*/immunology, Humans ; Herpesvirus 1, Human/immunology ; Vaccination

Neuronal expression of herpes simplex virus-1 VP16 protein induces pseudorabies virus escape from silencing and reactivation.

Authors: Hsu Z-S Engel EA Enquist LW et al.

Source: Journal of virology [J Virol] 2024 Jul 23; Vol. 98 (7), pp. e0056124. Date of Electronic Publication: 2024 Jun 13.

Publication Type: Journal Article

Journal Info: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE

MeSH Terms: Herpesvirus 1, Suid*/genetics , Herpesvirus 1, Suid*/physiology , Virus Activation* , Neurons*/virology , Neurons*/metabolism , Herpes Simplex Virus Protein Vmw65*/metabolism , Herpes Simplex Virus Protein Vmw65*/genetics , Herpesvirus 1, Human*/physiology , Herpesvirus 1, Human*/genetics , Virus Latency*, Animals ; Gene Silencing ; Rats ; Axons/virology ; Axons/metabolism ; Dependovirus/genetics ; Dependovirus/physiology ; Pseudorabies/virology ; Pseudorabies/metabolism ; Cells, Cultured ; Herpes Simplex/virology ; Herpes Simplex/metabolism

Quercetin inhibits herpes simplex virus 1 replication in corneal epithelium and suppresses keratitis progression.

Authors: Yu Y Liu S Liu Q et al.

Source: Virologica Sinica [Virol Sin] 2025 Aug; Vol. 40 (4), pp. 647-657. Date of Electronic Publication: 2025 Jul 15.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier B.V. on behalf of KeAi Communications Co. Ltd Country of Publication: Netherlands NLM ID: 101514185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1995-820X (Electronic) Linking ISSN: 1995820X NLM ISO Abbreviation: Virol Sin Subsets: MEDLINE

MeSH Terms: Quercetin*/pharmacology , Herpesvirus 1, Human*/drug effects , Herpesvirus 1, Human*/physiology , Virus Replication*/drug effects , Keratitis*/drug therapy , Keratitis*/pathology , Keratitis*/virology , Epithelium, Corneal*/drug effects , Epithelium, Corneal*/pathology , Epithelium, Corneal*/virology, Chlorocebus aethiops ; Humans ; Animals ; Cell Line ; Disease Progression ; Female ; Mice ; Mice, Inbred BALB C ; Molecular Docking Simulation ; Nectins/chemistry ; Nectins/genetics ; Nectins/metabolism ; Binding Sites ; Protein Structure, Tertiary ; Virus Attachment/drug effects ; Herpes Simplex Virus Protein Vmw65/chemistry ; Herpes Simplex Virus Protein Vmw65/genetics ; Herpes Simplex Virus Protein Vmw65/metabolism ; Gene Expression Regulation, Viral/drug effects ; NF-E2-Related Factor 2/chemistry ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology

A modular toolbox for the optogenetic deactivation of transcription.

Authors: Muench P Fiumara M Southern N et al.

Source: Nucleic acids research [Nucleic Acids Res] 2025 Jan 24; Vol. 53 (3).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

MeSH Terms: Optogenetics*/methods , Transcriptional Activation*/radiation effects , Transcription, Genetic*/radiation effects, Humans ; Promoter Regions, Genetic ; Light ; HEK293 Cells ; CRISPR-Cas Systems ; Animals ; Herpes Simplex Virus Protein Vmw65/genetics ; Herpes Simplex Virus Protein Vmw65/metabolism ; Gene Expression Regulation ; Trans-Activators/genetics ; Trans-Activators/metabolism

Slug, a Stress-Induced Transcription Factor, Stimulates Herpes Simplex Virus 1 Replication and Transactivates a cis -Regulatory Module within the VP16 Promoter.

Authors: Santos VC Ostler JB Harrison KS et al.

Source: Journal of virology [J Virol] 2023 Apr 27; Vol. 97 (4), pp. e0007323. Date of Electronic Publication: 2023 Apr 06.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE

MeSH Terms: Herpesvirus 1, Human*/physiology , Virus Replication*/genetics , Promoter Regions, Genetic* , Herpes Simplex Virus Protein Vmw65*/genetics , Herpes Simplex Virus Protein Vmw65*/metabolism, Animals ; Mice ; Gene Expression Regulation, Viral ; Herpesviridae Infections/virology ; Mice, Inbred C57BL ; Receptors, Glucocorticoid/genetics ; Receptors, Glucocorticoid/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Female ; NIH 3T3 Cells ; Virus Latency/genetics ; Mutation ; RNA, Small Interfering/metabolism

Interest and Expectations for a Herpes Vaccine Among People Diagnosed with Genital HSV 1-2 Infection: Results from an Italian Survey.

Authors: Lisac L Raccagni AR Lolatto R et al.

Source: Viruses [Viruses] 2024 Nov 18; Vol. 16 (11). Date of Electronic Publication: 2024 Nov 18.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

MeSH Terms: Herpes Genitalis*/prevention & control , Herpes Genitalis*/epidemiology , Herpesvirus 1, Human*/immunology, Humans ; Italy/epidemiology ; Female ; Adult ; Male ; Middle Aged ; Retrospective Studies ; Surveys and Questionnaires ; Young Adult ; Herpesvirus 2, Human/immunology ; Aged ; Herpes Simplex Virus Vaccines/immunology ; Herpes Simplex Virus Vaccines/administration & dosage ; Adolescent ; Vaccination ; Quality of Life ; Herpesvirus Vaccines/immunology

An Adenovirus-Based Recombinant Herpes Simplex Virus 2 (HSV-2) Therapeutic Vaccine Is Highly Protective against Acute and Recurrent HSV-2 Disease in a Guinea Pig Model.

Authors: Wan M Yang X Sun J et al.

Source: Viruses [Viruses] 2023 Jan 13; Vol. 15 (1). Date of Electronic Publication: 2023 Jan 13.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

MeSH Terms: Adenovirus Vaccines* , Herpes Genitalis*/prevention & control , Adenoviridae Infections* , Herpes Simplex Virus Vaccines*, Guinea Pigs ; Animals ; Herpesvirus 2, Human/genetics ; Adenoviridae/genetics ; Viral Envelope Proteins/genetics ; Vaccines, Synthetic/genetics ; Antibodies, Viral

Failure of Herpes Simplex Virus Glycoprotein D Antibodies to Elicit Antibody-Dependent Cell-Mediated Cytotoxicity: Implications for Future Vaccines.

Authors: Mahant AM Guerguis S Blevins TP et al.

Source: The Journal of infectious diseases [J Infect Dis] 2022 Nov 01; Vol. 226 (9), pp. 1489-1498.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE

MeSH Terms: Herpes Simplex* , Viral Vaccines* , Herpes Simplex Virus Vaccines*, Female ; Mice ; Animals ; Complement C1q ; Antibodies, Viral ; Herpesvirus 2, Human ; Antibodies, Neutralizing ; Antibody-Dependent Cell Cytotoxicity ; Glycoproteins ; Viral Envelope Proteins

Prevalence of herpes simplex virus 1 and 2 in culture-negative suppurative keratitis using polymerase chain reaction – A pilot study.

Authors: Rajasekaran, Nancy Magdalene Krishna, Thuhin S Amritanand, Anika et al.

Source: Indian Journal of Ophthalmology. Dec2025, Vol. 73 Issue 12, p1851-1854. 4p.

Subject Terms: *HERPES simplex virus, *POLYMERASE chain reaction, *CORNEAL opacity, *KERATITIS, *VIRUS diseases, *HUMAN herpesvirus 2

Geographic Terms: INDIA

One-step naked-eye fluorescence detection of viruses using quantum dot-magnetic beads coupled with CRISPR/Cas12a.

Authors: Ma, Ai-Xin Zhang, Qing Zhang, Ming-Yu et al.

Source: Chemical Communications. 11/18/2025, Vol. 61 Issue 89, p17432-17435. 4p.

Subject Terms: *QUANTUM dots, *HERPES simplex virus, *OPTICAL signal detection, *MAGNETIC nanoparticles, *FLUORIMETRY, *CRISPRS, *VIRUS identification