Suchergebnisse - "HEPATOTOXICOLOGY"

AMELIORATIVE EFFECT OF COENZYME Q 10 ON TITANIUM DIOXIDE NANOPARTICLES INDUCED HEPATOTOXICITY IN RATS.

Autoren: ABDALLAH, GHADA M. TAHA, MOKHTAR HASSANEIN, KHALED M. A.

Quelle: Assiut Veterinary Medical Journal. Oct2025, Vol. 71 Issue 187, p148-160. 13p.

Schlagworte: Titanium dioxide nanoparticles, Hepatotoxicology, Liver function tests, Rats, Anti-inflammatory agents, Ubiquinones, Antioxidants, Histopathology

Assessment of Nanosilymarin's Therapeutic Efficacy in Mitigating CCl4- Induced Hepatotoxicity in Rats.

Alternate Title: تقييم الفعالية العلاجية للنانو سليمارين في تخفيف السمية الكبدية المستحثة بـ CCl4 في الجرذان.

Autoren: Jasim, Nisreen Yasir Ghadhban, Rashad Fadhil

Quelle: Basrah Journal of Veterinary Research. 2025 Supplement, Vol. 24, p32-44. 13p.

Schlagworte: Hepatotoxicology, Carbon tetrachloride, Treatment effectiveness, Animal disease models, Liver function tests, Liver injuries, Antioxidants

Modulation of Energy Drink-Induced Hepato-renal and Testicular Toxicity by Pomegranate Peel Extract: Insights from Histopathological and Immunohistochemical Analyses.

Autoren: Gaballa, Mohamed M. S. Ahmed, Osama Elsharkawey, Sally et al.

Quelle: Pakistan Veterinary Journal. 2025, Vol. 45 Issue 2, p703-712. 10p.

Schlagworte: Energy drinks, Hepatotoxicology, Reproductive toxicology, Oxidative stress, Histopathology, Pathological physiology, Immunohistochemistry, Plant extracts

THE ANTITOXIC EFFECT OF THE ROSUVASTATIN IN THE CYCLOPHOSPHAMIDE-INDUCED LIVER TOXICITY IN MALE RATS.

Alternate Title: التأثير المضاد للروزوفاستاتين في سمية الكبد المحدثة بالسايكلوفوسفاميد في ذكور الجرذان

Autoren: ATTARBASHEE, RANA KHAIRI¹ drranakhaire@uomosul.edu.iq

Quelle: Assiut Veterinary Medical Journal. Apr2025, Vol. 71 Issue 185, p187-203. 17p.

Schlagworte: Hepatotoxicology, Liver cells, Portal vein, Immunohistochemistry, Cyclophosphamide

Hepatobiliary Adverse Events Linked to Immune Checkpoint Inhibitors: A Real‐World Pharmacovigilance Analysis Using FAERS Data.

Autoren: Chen, Yuzhu Zeng, Yixin Zhang, Kaisheng et al.

Quelle: Thoracic Cancer. Nov2025, Vol. 16 Issue 22, p1-14. 14p.

Schlagwörter: *HEPATOTOXICOLOGY, *BILIOUS diseases & biliousness, *RISK assessment, *PHARMACOLOGY, *ADENOCARCINOMA, *DRUG side effects, *RESEARCH funding, *PATIENT safety, *PROGRAMMED death-ligand 1, *LOGISTIC regression analysis, *SEX distribution, *MULTIPLE regression analysis, *HOSPITAL care, *CHOLANGIOCARCINOMA, *AGE distribution, *CHRONIC active hepatitis, *DESCRIPTIVE statistics, *IMMUNE checkpoint inhibitors, *LIVER diseases, *ODDS ratio, *NIVOLUMAB, *CONFIDENCE intervals, *DATA analysis software, *LUNG cancer, *LIVER failure, *DISEASE incidence, *TIME, *CHEMICAL inhibitors, RISK factors

Firma/Körperschaft: UNITED States. Food & Drug Administration

A multi-dimensional computational framework of drug-induced hepatotoxicity: integrating molecular structure features with disease pathogenesis Open Access.

Autoren: Zhong, Huayu Wang, Juanji Liu, Xiaoxiao et al.

Quelle: Briefings in Bioinformatics. Sep2025, Vol. 26 Issue 5, p1-13. 13p.

Schlagwörter: *MATHEMATICAL models, *RISK assessment, HEPATOTOXICOLOGY, MOLECULAR structure, PATHOGENESIS, DISEASE risk factors, INTRAHEPATIC bile ducts, COMPUTATIONAL biology

Based on "chemical composition-blood migration component-liver metabolism" to study the hepatotoxicity of Sophorae Tonkinensis Radix et Rhizoma.

Autoren: Liu, Chang He, Qian-Qian Yin, Zhi-Gang et al.

Quelle: Traditional Medicine Research. Dec2025, Vol. 10 Issue 12, p1-13. 13p.

Schlagwörter: *POISONS, *HEPATOTOXICOLOGY, *MULTIVARIATE analysis, *NF-kappa B, *CELLULAR signal transduction

The deglycosylated metabolite of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D- glucoside contributes to immune-mediated hepatotoxicity induced by Polygonum multiflorum.

Autoren: Li, Ying Hu, Yuwei Meng, Xiaoli et al.

Quelle: Archives of Toxicology. Dec2025, Vol. 99 Issue 12, p4987-5003. 17p.

Schlagwörter: *HEPATOTOXICOLOGY, *IMMUNE response, *LIVER injuries, *METABOLITES, *JAPANESE knotweed, *T cells, *PROTEINS, *RESVERATROL

A Case of Evolving Hepatotoxicity Following Systemic Drug Reaction to Isoniazid–Rifapentine (3HP).

Autoren: Vizgan, Niels Martinez-Kratz, Jesse LaBudde, Chris et al.

Quelle: Case Reports in Hepatology. 11/24/2025, Vol. 2025, p1-5. 5p.

Schlagwörter: *HEPATOTOXICOLOGY, *ISONIAZID, *SUDDEN onset of disease, *DRUG side effects, *LIVER injuries, *RIFAMPIN, *LATENT tuberculosis

Exploring the role of hepatic lipid droplets in mouse liver toxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin: sequestration, biochemical alterations and gene regulation.

Autoren: Hammoudeh, Nour Soukkarieh, Chadi Hanano, Abdulsamie

Quelle: Scientific Reports. 11/19/2025, Vol. 15 Issue 1, p1-17. 17p.

Schlagwörter: *DIOXINS, *HEPATOTOXICOLOGY, *HEPATOMEGALY, *GENETIC regulation, *POLLUTANTS, *POISONS, *ORGANELLES

Unraveling the Role of CYP2E1 in Antitubercular Drug–Induced Hepatotoxicity: From Molecular Mechanisms to Clinical Implications.

Autoren: Bishnu, Debasree Santra, Suman Purkait, Swagata et al.

Quelle: International Journal of Hepatology. 11/20/2025, Vol. 2025, p1-15. 15p.

Schlagwörter: *CYTOCHROME P-450 CYP2E1, *HEPATOTOXICOLOGY, *ISONIAZID, *GENETIC polymorphisms, *DRUG metabolism, *REACTIVE oxygen species, *ANTITUBERCULAR agents, *THERAPEUTICS

Identifying high-risk drugs and demographic patterns in drug-induced liver injury from FAERS and CVARD analyses.

Autoren: He, Yun Chen, Xiao-Dong Wu, Shi-Nan et al.

Quelle: Scientific Reports. 11/18/2025, Vol. 15 Issue 1, p1-14. 14p.

Schlagwörter: *HEPATOTOXICOLOGY, *DRUG side effects, *DRUG monitoring, *DISEASE risk factors, *ADVERSE health care events, *DEMOGRAPHIC characteristics

Loss of Dioxin Response Element-Mediated Induction of PKM2 Reprograms Hepatic Metabolism in Response to TCDD.

Autoren: Orlowska, Karina Nault, Rance Zacharewski, Tim

Quelle: International Journal of Molecular Sciences. Nov2025, Vol. 26 Issue 22, p10853. 16p.

Schlagwörter: *PYRUVATE kinase, *HEPATOTOXICOLOGY, *DIOXINS, *METABOLOMICS, *ARYL hydrocarbon receptors, *GENE expression, *DRUG metabolism

M3Hep: a multimodal hepatotoxicity prediction model combining mitochondrial toxicity and masking strategy.

Autoren: Liu, Yang Xie, Yu Wang, Xiao et al.

Quelle: Toxicology Mechanisms & Methods. Nov2025, p1-19. 19p. 13 Illustrations.

Schlagwörter: *HEPATOTOXICOLOGY, *PREDICTION models, *MEDICATION safety, *MITOCHONDRIAL pathology, *INFERENTIAL statistics, *MACHINE learning

Green-Synthesized Silver Nanoparticles from Garlic Peel Target NF-κB and Redox Imbalance: A Novel Therapeutic Strategy Against Pyrogallol-Induced Hepatotoxicity in Rats.

Autoren: Althumairy, Duaa A.¹ (AUTHOR)

Quelle: Nanomaterials (2079-4991). Nov2025, Vol. 15 Issue 21, p1610. 23p.

Schlagwörter: *NF-kappa B, *HEPATOTOXICOLOGY, *GARLIC, *OXIDATIVE stress, *SILVER nanoparticles, *ANTIOXIDANTS, *NANOMEDICINE

Interventional Radiotherapy (Brachytherapy) Combined with Systemic Treatment—The Influence of RAS Gene Mutations and Combined Therapy on the Results and Toxicity of Colorectal Cancer Liver Metastases.

Autoren: Cisek, Paweł Kozłowska, Aleksandra Grzybowska-Szatkowska, Ludmiła

Quelle: Cancers. Nov2025, Vol. 17 Issue 21, p3530. 20p.

Schlagwörter: *HEMORRHAGE risk factors, *HEPATOTOXICOLOGY, *LIVER tumors, *RISK assessment, *VASCULAR endothelial growth factors, *COMPUTED tomography, *KRUSKAL-Wallis Test, *COLORECTAL cancer, *RADIOISOTOPE brachytherapy, *TREATMENT effectiveness, *RETROSPECTIVE studies, *MAGNETIC resonance imaging, *REVERSE transcriptase polymerase chain reaction, *MANN Whitney U Test, *METASTASIS, *CANCER chemotherapy, *SURGICAL complications, *GENES, *KAPLAN-Meier estimator, *LOG-rank test, *COMBINED modality therapy, *MEDICAL records, *ACQUISITION of data, *RADIATION doses, *GENETIC mutation, *PROGRESSION-free survival, *DATA analysis software, *OVERALL survival, *EPIDERMAL growth factor receptors, *EVALUATION, *DISEASE risk factors, RISK factors

Idiosyncratic Drug-Induced Liver Injury and Trastuzumab Deruxtecan in Breast Cancer: A Case Report.

Autoren: Lisanti, Camilla Della Rossa, Serena Zottarelli, Emma et al.

Quelle: Current Oncology. Nov2025, Vol. 32 Issue 11, p606. 13p.

Schlagwörter: *BREAST cancer, *HEPATOTOXICOLOGY, *HER2 positive breast cancer, *ANTIBODY-drug conjugates, *ADVERSE health care events, *LIVER function tests

Are New Approach Methodologies (NAMs) the Holy Grail of toxicology? Free.

Autoren: Jaeschke, Hartmut Ramachandran, Anup

Quelle: Toxicological Sciences. Nov2025, Vol. 208 Issue 1, p1-8. 8p.

Schlagwörter: *TOXICOLOGY, *HEPATOTOXICOLOGY, *MICROPHYSIOLOGICAL systems, *ORGANOIDS, *COMPUTER simulation, *ANIMAL experimentation

Taletrectinib Adipate.

Quelle: American Journal of Health-System Pharmacy. Nov2025, Vol. 82 Issue 21, pe861-e864. 4p.

Schlagwörter: *HEPATOTOXICOLOGY, *DRUG side effects, *ANTINEOPLASTIC agents, *ORAL drug administration, *METASTASIS, *PHARMACY information services, *LUNG cancer, *DISEASE progression, *ADULTS

Recurrent fexuprazan‐induced liver injury following unintentional re‐exposure.

Autoren: Seong, Sook Jin Kweon, O Seong Yoon, Young‐Ran et al.

Quelle: British Journal of Clinical Pharmacology. Nov2025, Vol. 91 Issue 11, p3266-3271. 6p.

Schlagwörter: *LIVER injuries, *HEPATOTOXICOLOGY, *WOUNDS & injuries, *PHARMACOGENOMICS, *GASTROESOPHAGEAL reflux