Suchergebnisse - "Glycogen Synthase Kinase 3"

GSK3β guides chromosomal repair pathway selection to support BRCA1-independent PARP inhibitor sensitivity.

Autoren: Leung JW Gius D

Quelle: The Journal of clinical investigation [J Clin Invest] 2025 Nov 17; Vol. 135 (22). Date of Electronic Publication: 2025 Nov 17 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

MeSH-Schlagworte: BRCA1 Protein*/metabolism , BRCA1 Protein*/genetics , Poly(ADP-ribose) Polymerase Inhibitors*/pharmacology , DNA End-Joining Repair* , Glycogen Synthase Kinase 3*/metabolism , Glycogen Synthase Kinase 3*/genetics , DNA Repair*, Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Tumor Suppressor p53-Binding Protein 1/metabolism ; Phosphorylation ; DNA Breaks, Double-Stranded ; Animals

Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation.

Autoren: Ríos I Herrero C Torres-Torresano M et al.

Quelle: ELife [Elife] 2025 May 14; Vol. 14. Date of Electronic Publication: 2025 May 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

MeSH-Schlagworte: Macrophages, Alveolar*/metabolism , Granulocyte-Macrophage Colony-Stimulating Factor*/metabolism , Glycogen Synthase Kinase 3*/metabolism , Glycogen Synthase Kinase 3*/genetics , Glycogen Synthase Kinase 3*/antagonists & inhibitors , Cellular Reprogramming*, Humans ; MafB Transcription Factor/metabolism ; COVID-19/pathology ; Glycogen Synthase Kinase 3 beta/metabolism ; Glycogen Synthase Kinase 3 beta/genetics ; SARS-CoV-2 ; Macrophage Colony-Stimulating Factor/metabolism

Protective effects of lithium against testicular ischemia-reperfusion injury: Involvement of the Akt/GSK-3β pathway.

Autoren: Ghasemi M Basiri A Mohammad Jafari R et al.

Quelle: Journal of pediatric urology [J Pediatr Urol] 2025 Jun; Vol. 21 (3), pp. 558-566. Date of Electronic Publication: 2025 Jan 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 101233150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4898 (Electronic) Linking ISSN: 14775131 NLM ISO Abbreviation: J Pediatr Urol Subsets: MEDLINE

MeSH-Schlagworte: Reperfusion Injury*/prevention & control , Reperfusion Injury*/metabolism , Spermatic Cord Torsion*/complications , Testis*/blood supply , Testis*/pathology , Proto-Oncogene Proteins c-akt*/metabolism , Lithium Chloride*/pharmacology , Lithium Chloride*/therapeutic use , Glycogen Synthase Kinase 3*/metabolism, Male ; Animals ; Rats ; Glycogen Synthase Kinase 3 beta ; Disease Models, Animal ; Rats, Sprague-Dawley ; Oxidative Stress/drug effects ; Signal Transduction/drug effects ; Random Allocation

Identification of AS1842856 as a novel small-molecule GSK3α/β inhibitor against Tauopathy by accelerating GSK3α/β exocytosis.

Autoren: He DL Zhang XY Su JY et al.

Quelle: Aging cell [Aging Cell] 2025 Jan; Vol. 24 (1), pp. e14336. Date of Electronic Publication: 2024 Sep 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE

MeSH-Schlagworte: Tauopathies*/drug therapy , Tauopathies*/metabolism , Exocytosis*/drug effects , Glycogen Synthase Kinase 3*/metabolism , Glycogen Synthase Kinase 3*/antagonists & inhibitors, Animals ; Mice ; Humans ; Glycogen Synthase Kinase 3 beta/metabolism ; Glycogen Synthase Kinase 3 beta/antagonists & inhibitors ; Mice, Transgenic ; tau Proteins/metabolism ; Phosphorylation/drug effects

Glycogen synthase kinase 3 (GSK3) inhibition: a potential therapeutic strategy for Alzheimer's disease.

Autoren: Karati D Meur S Roy S et al.

Quelle: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 Mar; Vol. 398 (3), pp. 2319-2342. Date of Electronic Publication: 2024 Oct 21.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Alzheimer Disease*/drug therapy , Alzheimer Disease*/enzymology , Glycogen Synthase Kinase 3*/antagonists & inhibitors , Glycogen Synthase Kinase 3*/metabolism , Protein Kinase Inhibitors*/therapeutic use , Protein Kinase Inhibitors*/pharmacology , Neuroprotective Agents*/therapeutic use , Neuroprotective Agents*/pharmacology, Humans ; Animals ; Glycogen Synthase Kinase 3 beta/antagonists & inhibitors

Androgens Regulate Tau Phosphorylation Through Phosphatidylinositol 3-Kinase-Protein Kinase B-Glycogen Synthase Kinase 3β Signaling.

Autoren: Yao M Rosario ER Soper JC et al.

Quelle: Neuroscience [Neuroscience] 2025 Mar 05; Vol. 568, pp. 503-518. Date of Electronic Publication: 2022 Jun 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE

MeSH-Schlagworte: tau Proteins*/metabolism , Signal Transduction*/drug effects , Signal Transduction*/physiology , Proto-Oncogene Proteins c-akt*/metabolism , Testosterone*/pharmacology , Testosterone*/metabolism , Androgens*/pharmacology , Androgens*/metabolism , Glycogen Synthase Kinase 3*/metabolism , Phosphatidylinositol 3-Kinase*/metabolism, Animals ; Phosphorylation/drug effects ; Glycogen Synthase Kinase 3 beta ; Mice, Transgenic ; Male ; Neurons/metabolism ; Neurons/drug effects ; Dihydrotestosterone/pharmacology ; Mice ; Cells, Cultured ; Receptors, Androgen/metabolism ; Receptors, Androgen/genetics ; Rats ; PC12 Cells ; Alzheimer Disease/metabolism

Animal models of haploinsufficiency revealed the isoform-specific role of GSK-3 in HFD-induced obesity and glucose intolerance.

Autoren: Gupte M Umbarkar P Lemon J et al.

Quelle: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2024 Dec 01; Vol. 327 (6), pp. C1349-C1358. Date of Electronic Publication: 2024 Sep 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1563 (Electronic) Linking ISSN: 03636143 NLM ISO Abbreviation: Am J Physiol Cell Physiol Subsets: MEDLINE

MeSH-Schlagworte: Obesity*/genetics , Obesity*/metabolism , Obesity*/enzymology , Haploinsufficiency* , Diet, High-Fat*/adverse effects , Glucose Intolerance*/genetics , Glucose Intolerance*/metabolism , Glycogen Synthase Kinase 3*/genetics , Glycogen Synthase Kinase 3*/metabolism , Glycogen Synthase Kinase 3*/antagonists & inhibitors, Animals ; Mice ; Disease Models, Animal ; Glycogen Synthase Kinase 3 beta/metabolism ; Glycogen Synthase Kinase 3 beta/genetics ; Glycogen Synthase Kinase 3 beta/antagonists & inhibitors ; Mice, Knockout ; Male ; Mice, Inbred C57BL ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/enzymology

[Electroacupuncture reduces neuronal apoptosis in rats with spinal cord injury by regulating GSK-3β expression and its phosphorylation].

Transliterierter Titel: 督脉电针通过调控糖原合酶激酶3β及其磷酸化水平减少脊髓损伤大鼠神经细胞凋亡.

Autoren: Gao XM Li ZG Yao HJ et al.

Quelle: Zhen ci yan jiu = Acupuncture research [Zhen Ci Yan Jiu] 2024 Nov 25; Vol. 49 (11), pp. 1146-1152.

Publikationsart: English Abstract; Journal Article

Info zur Zeitschrift: Publisher: Institute Of Acupuncture And Moxibustion Country of Publication: China NLM ID: 8507710 Publication Model: Print Cited Medium: Print ISSN: 1000-0607 (Print) Linking ISSN: 10000607 NLM ISO Abbreviation: Zhen Ci Yan Jiu Subsets: MEDLINE

MeSH-Schlagworte: Electroacupuncture* , Spinal Cord Injuries*/therapy , Spinal Cord Injuries*/metabolism , Spinal Cord Injuries*/genetics , Glycogen Synthase Kinase 3 beta*/metabolism , Glycogen Synthase Kinase 3 beta*/genetics , Rats, Sprague-Dawley* , Apoptosis* , Neurons*/metabolism, Animals ; Rats ; Male ; Phosphorylation ; Humans ; Acupuncture Points ; Spinal Cord/metabolism ; Glycogen Synthase Kinase 3/metabolism ; Glycogen Synthase Kinase 3/genetics

Design, synthesis and biological evaluation of thieno[3,2-c]pyrazol-urea derivatives as potent glycogen synthase kinase 3β inhibitors based on the DFG-out conformation.

Autoren: Yan N Liu HY Kong TT et al.

Quelle: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Nov 01; Vol. 112, pp. 129932. Date of Electronic Publication: 2024 Aug 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

MeSH-Schlagworte: Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Pyrazoles*/chemical synthesis , Drug Design* , Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors , Glycogen Synthase Kinase 3 beta*/metabolism , Urea*/pharmacology , Urea*/analogs & derivatives , Urea*/chemistry , Urea*/chemical synthesis , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry, Humans ; Structure-Activity Relationship ; Molecular Structure ; Glycogen Synthase Kinase 3/antagonists & inhibitors ; Glycogen Synthase Kinase 3/metabolism ; Dose-Response Relationship, Drug

Natural compound screening predicts novel GSK-3 isoform-specific inhibitors.

Autoren: Ahmad F Gupta A Marzook H et al.

Quelle: Biochimie [Biochimie] 2024 Oct; Vol. 225, pp. 68-80. Date of Electronic Publication: 2024 May 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 1264604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1638-6183 (Electronic) Linking ISSN: 03009084 NLM ISO Abbreviation: Biochimie Subsets: MEDLINE

MeSH-Schlagworte: Molecular Docking Simulation* , Depsides*/pharmacology , Depsides*/chemistry , Cinnamates*/pharmacology , Cinnamates*/chemistry , Rosmarinic Acid* , Glycogen Synthase Kinase 3*/antagonists & inhibitors , Glycogen Synthase Kinase 3*/metabolism, Humans ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry ; Glycogen Synthase Kinase 3 beta/antagonists & inhibitors ; Glycogen Synthase Kinase 3 beta/metabolism ; Biological Products/pharmacology ; Biological Products/chemistry ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/metabolism

Myeloid GSK3α Deficiency Reduces Lesional Inflammation and Neovascularization during Atherosclerotic Progression.

Autoren: Patel S Shah N D'Mello B et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2024 Oct 10; Vol. 25 (20). Date of Electronic Publication: 2024 Oct 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Atherosclerosis*/pathology , Atherosclerosis*/metabolism , Atherosclerosis*/genetics , Atherosclerosis*/etiology , Inflammation*/pathology , Inflammation*/metabolism , Glycogen Synthase Kinase 3*/metabolism , Glycogen Synthase Kinase 3*/genetics , Neovascularization, Pathologic*/metabolism , Receptors, LDL*/deficiency , Receptors, LDL*/genetics , Receptors, LDL*/metabolism , Mice, Knockout*, Animals ; Mice ; Female ; Disease Progression ; Plaque, Atherosclerotic/pathology ; Plaque, Atherosclerotic/metabolism ; Glycogen Synthase Kinase 3 beta/metabolism ; C-Reactive Protein/metabolism ; Diet, High-Fat/adverse effects ; Myeloid Cells/metabolism ; Myeloid Cells/pathology ; Disease Models, Animal

Anti-Cancer Effect of Sulforaphane in Human Pancreatic Cancer Cells Mia PaCa-2.

Autoren: Park MJ Kim YH

Quelle: Cancer reports (Hoboken, N.J.) [Cancer Rep (Hoboken)] 2024 Dec; Vol. 7 (12), pp. e70074.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101747728 Publication Model: Print Cited Medium: Internet ISSN: 2573-8348 (Electronic) Linking ISSN: 25738348 NLM ISO Abbreviation: Cancer Rep (Hoboken) Subsets: MEDLINE

MeSH-Schlagworte: Isothiocyanates*/pharmacology , Isothiocyanates*/therapeutic use , Sulfoxides*/pharmacology , Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/genetics , Apoptosis*/drug effects , Glycogen Synthase Kinase 3 beta*/metabolism , beta Catenin*/metabolism , beta Catenin*/genetics, Humans ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Phosphorylation/drug effects ; Anticarcinogenic Agents/pharmacology ; Anticarcinogenic Agents/therapeutic use ; Signal Transduction/drug effects ; Glycogen Synthase Kinase 3/metabolism

Pharmacological regeneration of sensory hair cells restores afferent innervation and vestibular function.

Autoren: Lahlou H Zhu H Zhou W et al.

Quelle: The Journal of clinical investigation [J Clin Invest] 2024 Sep 24; Vol. 134 (22). Date of Electronic Publication: 2024 Sep 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

MeSH-Schlagworte: Glycogen Synthase Kinase 3 beta*/metabolism , Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors , Glycogen Synthase Kinase 3 beta*/genetics, Animals ; Mice ; Histone Deacetylase Inhibitors/pharmacology ; Hair Cells, Vestibular/metabolism ; Glycogen Synthase Kinase 3/metabolism ; Glycogen Synthase Kinase 3/antagonists & inhibitors ; Regeneration/drug effects ; Cell Differentiation/drug effects ; Hair Cells, Auditory/metabolism ; Hair Cells, Auditory/drug effects ; Cell Proliferation/drug effects ; Vestibule, Labyrinth/metabolism ; Mice, Inbred C57BL

Structure-activity relationship of dual inhibitors containing maleimide and imidazole motifs against glutaminyl cyclase and glycogen synthase kinase-3β.

Autoren: Wei D Cai J Qin F et al.

Quelle: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Sep 15; Vol. 110, pp. 129851. Date of Electronic Publication: 2024 Jun 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

MeSH-Schlagworte: Aminoacyltransferases*/antagonists & inhibitors , Aminoacyltransferases*/metabolism , Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors , Glycogen Synthase Kinase 3 beta*/metabolism , Imidazoles*/chemistry , Imidazoles*/pharmacology , Imidazoles*/chemical synthesis , Maleimides*/chemistry , Maleimides*/pharmacology , Maleimides*/chemical synthesis, Humans ; Alzheimer Disease/drug therapy ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/chemical synthesis ; Glycogen Synthase Kinase 3/antagonists & inhibitors ; Glycogen Synthase Kinase 3/metabolism ; Molecular Structure ; Structure-Activity Relationship

Design, synthesis, and biological evaluation of kenpaullone derivatives as potential dual inhibitors of cholinesterases and glycogen synthase kinase-3β.

Autoren: Raghuvanshi R Wakudkar SC Manda S et al.

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109232. Date of Electronic Publication: 2025 Nov 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Cholinesterase Inhibitors*/chemical synthesis , Cholinesterase Inhibitors*/pharmacology , Cholinesterase Inhibitors*/chemistry , Drug Design* , Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors , Glycogen Synthase Kinase 3 beta*/metabolism , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Glycogen Synthase Kinase 3*/antagonists & inhibitors , Glycogen Synthase Kinase 3*/metabolism, Humans ; Structure-Activity Relationship ; Molecular Docking Simulation ; Acetylcholinesterase/metabolism ; Molecular Structure ; Dose-Response Relationship, Drug ; Butyrylcholinesterase/metabolism ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Alzheimer Disease/drug therapy

Identification of glycogen synthase kinase 3alpha/beta as a host factor required for HBV transcription using high-throughput screening.

Autoren: Nishitsuji H Naito Y Murakami Y et al.

Quelle: Hepatology (Baltimore, Md.) [Hepatology] 2025 Dec 01; Vol. 82 (6), pp. 1551-1564. Date of Electronic Publication: 2025 Jan 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE

MeSH-Schlagworte: Hepatitis B virus*/physiology , Hepatitis B virus*/genetics , Hepatitis B virus*/drug effects , Glycogen Synthase Kinase 3*/antagonists & inhibitors , Glycogen Synthase Kinase 3*/metabolism , Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors , Glycogen Synthase Kinase 3 beta*/metabolism , Hepatitis B*/drug therapy , Hepatitis B*/virology, Humans ; Hepatocytes/virology ; High-Throughput Screening Assays ; Virus Replication/drug effects ; Antiviral Agents/pharmacology ; Hep G2 Cells ; Symporters/metabolism ; Transcription, Genetic

Glycogen synthase kinase 3 promotes the proliferation of porcine epidemic diarrhoea virus by phosphorylating the nucleocapsid protein.

Autoren: Jia X Chen J Li C et al.

Quelle: Virulence [Virulence] 2025 Dec; Vol. 16 (1), pp. 2506504. Date of Electronic Publication: 2025 May 22.

Publikationsart: Journal Article; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE

MeSH-Schlagworte: Porcine epidemic diarrhea virus*/genetics , Porcine epidemic diarrhea virus*/physiology , Porcine epidemic diarrhea virus*/growth & development , Nucleocapsid Proteins*/metabolism , Nucleocapsid Proteins*/genetics , Glycogen Synthase Kinase 3*/metabolism , Glycogen Synthase Kinase 3*/genetics , Virus Replication* , Coronavirus Nucleocapsid Proteins*/metabolism , Coronavirus Nucleocapsid Proteins*/genetics, Animals ; Phosphorylation ; Swine ; Swine Diseases/virology ; Amino Acid Motifs ; Coronavirus Infections/virology ; Coronavirus Infections/veterinary ; Mutation

A non-hormonal reversible contraceptive targeting GSK3α, a protein kinase, essential for epididymal sperm maturation.

Autoren: Kabi M Khamamkar A Kyei-Baffour K et al.

Quelle: Andrology [Andrology] 2025 Nov; Vol. 13 (8), pp. 2273-2281. Date of Electronic Publication: 2025 Jan 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101585129 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-2927 (Electronic) Linking ISSN: 20472919 NLM ISO Abbreviation: Andrology Subsets: MEDLINE

MeSH-Schlagworte: Epididymis*/drug effects , Epididymis*/enzymology , Glycogen Synthase Kinase 3*/antagonists & inhibitors , Glycogen Synthase Kinase 3*/metabolism , Glycogen Synthase Kinase 3*/genetics , Sperm Maturation*/drug effects , Contraceptive Agents, Male*/pharmacology , Spermatozoa*/drug effects, Animals ; Male ; Mice ; Sperm Motility/drug effects ; Mice, Knockout ; Fertility/drug effects

Targeting of the PI3 K/AKT/GSK3β Pathway in Parkinson's Disease: A Therapeutic Blueprint.

Autoren: AlRuwaili R Al-Kuraishy HM Al-Gareeb AI et al.

Quelle: Molecular neurobiology [Mol Neurobiol] 2025 Nov; Vol. 62 (11), pp. 15108-15131. Date of Electronic Publication: 2025 Jun 05.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH-Schlagworte: Parkinson Disease*/drug therapy , Parkinson Disease*/metabolism , Glycogen Synthase Kinase 3 beta*/metabolism , Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors , Proto-Oncogene Proteins c-akt*/metabolism , Signal Transduction*/drug effects , Signal Transduction*/physiology , Phosphatidylinositol 3-Kinases*/metabolism , Phosphatidylinositol 3-Kinase*/metabolism , Molecular Targeted Therapy*, Humans ; Animals ; Oxidative Stress ; Dopaminergic Neurons/metabolism

GSK3-Driven Modulation of Inflammation and Tissue Integrity in the Animal Model.

Autoren: Kühl F Brand K Lichtinghagen R et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 29; Vol. 25 (15). Date of Electronic Publication: 2024 Jul 29.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Inflammation*/metabolism , Inflammation*/pathology , Glycogen Synthase Kinase 3*/metabolism , Glycogen Synthase Kinase 3*/genetics , Disease Models, Animal*, Animals ; Humans ; Glycogen Synthase Kinase 3 beta/metabolism