Suchergebnisse - "Glutamic Acid/metabolism"

PSMA Theranostics in Prostate Cancer and Beyond: Current and Future Perspectives.

Autoren: Sandhu, Kieran Chen, David Hennes, David et al.

Quelle: Cancers. Nov2025, Vol. 17 Issue 22, p3717. 16p.

Schlagwörter: *GLUTAMIC acid metabolism, *FOLIC acid metabolism, *DRUG resistance in cancer cells, *GLIOMAS, *PREDICTION models, *CELL proliferation, *MICRORNA, *RADIOMICS, *ANTINEOPLASTIC agents, *PROSTATE tumors, *NANOMEDICINE, *CELLULAR signal transduction, *TUMOR markers, *POSITRON emission tomography computed tomography, *GENE expression, *PROSTATE-specific membrane antigen, *CELL death, *NEUROENDOCRINE tumors, *RENAL cell carcinoma, *PATHOLOGIC neovascularization, *DISEASE progression, *EXOSOMES, *PHENOTYPES

Integrating multi-omics and machine learning strategies to explore the "gene-protein-metabolite" network in ischemic heart failure with Qi deficiency and blood stasis syndrome.

Autoren: Wei, Jingjing Wang, Aolong Yu, Peng et al.

Quelle: Chinese Medicine. 7/16/2025, Vol. 20 Issue 1, p1-18. 18p.

Schlagwörter: *RNA metabolism, *GLUTAMIC acid metabolism, *CHINESE medicine, *COMPUTER-assisted molecular modeling, *MYOCARDIAL ischemia, *RESEARCH funding, *BLOOD coagulation disorders, *GLYCOLYSIS, *PHOSPHORYLATION, *ARACHIDONIC acid, *RECEIVER operating characteristic curves, *MULTIOMICS, *NEUTROPHILS, *CARNITINE, *HEART failure, *REVERSE transcriptase polymerase chain reaction, *BLOOD platelet activation, *CELLULAR signal transduction, *DESCRIPTIVE statistics, *GENE expression, *ENERGY metabolism, *MESSENGER RNA, *BLOOD circulation, *PROTEOMICS, *GENETIC disorders, *MACHINE learning, *BLOOD diseases, *METABOLOMICS, *INFLAMMATION, *EXTRACELLULAR space, *CITRATES, *FATTY acids, *MOLECULAR biology, *DATA analysis software, *BIOMARKERS, *DISEASE progression, *ALGORITHMS, *PREDICTIVE validity, *SENSITIVITY & specificity (Statistics), *EVALUATION

Unmasking the relationship between CGRP and glutamate: from peripheral excitation to central sensitization in migraine.

Autoren: Martami, Fahimeh Holton, Kathleen F.

Quelle: Journal of Headache & Pain. 5/6/2025, Vol. 26 Issue 1, p1-19. 19p.

Schlagwörter: *GLUTAMIC acid metabolism, *DRUG metabolism, *RISK assessment, *NEUROPHYSIOLOGY, *NEUROPEPTIDES, *PAIN management, *PAIN catastrophizing, *MIGRAINE, *NEUROTRANSMITTERS, *DISEASE risk factors

Optogenetic inhibition of ventrolateral orbitofrontal cortex astrocytes facilitates ventrolateral periaqueductal gray glutamatergic activity to reduce hypersensitivity in infraorbital nerve injury rat model.

Autoren: Islam, Jaisan Rahman, Md Taufiqur Ali, Muhammad et al.

Quelle: Journal of Headache & Pain. 2/24/2025, Vol. 26 Issue 1, p1-18. 18p.

Schlagwörter: *GLUTAMIC acid metabolism, *OPTOGENETICS, *PAIN measurement, *TRIGEMINAL neuralgia, *RESEARCH funding, *PREFRONTAL cortex, *NEUROGLIA, *TRIGEMINAL nerve, *HYPERALGESIA, *CHRONIC diseases, *RATS, *BRAIN stem, *ANIMAL experimentation, *INFLAMMATION, *ELECTROPHYSIOLOGY, *BIOMARKERS

Mechanisms underlying CSD initiation implicated by genetic mouse models of migraine.

Autoren: Pietrobon, Daniela Brennan, K.C.

Quelle: Journal of Headache & Pain. 1/27/2025, Vol. 26 Issue 1, p1-17. 17p.

Schlagwörter: *CALCIUM metabolism, *GLUTAMIC acid metabolism, *SODIUM metabolism, *BIOLOGICAL models, *ION pumps, *PROTEIN kinases, *EVOKED potentials (Electrophysiology), *NEUROGLIA, *CASEINS, *NEURAL transmission, *CEREBRAL cortex, *MICE, *ADENOSINE triphosphatase, *DISEASE susceptibility, *GENETIC mutation, *MIGRAINE, *CELL receptors

Metabolic Pathways Associated With Obesity and Hypertension in Black Caregivers of Persons Living With Dementia.

Autoren: Brewster, Glenna S. Houser, Madelyn C. Yang, Irene et al.

Quelle: Nursing Research. Jan/Feb2025, Vol. 74 Issue 1, p37-46. 10p.

Schlagwörter: *GLUTAMIC acid metabolism, *PREVENTION of obesity, *STATISTICAL power analysis, *AFRICAN Americans, *RESEARCH funding, *HYPERTENSION, *HUMAN beings, *LOGISTIC regression analysis, *FISHER exact test, *UNSATURATED fatty acids, *DESCRIPTIVE statistics, *MANN Whitney U Test, *CAREGIVERS, *METABOLITES, *LONGITUDINAL method, *METABOLISM, *DATA analysis software, *BUTYRIC acid, *DEMENTIA patients

Geografische Kategorien: GEORGIA

Targeting Neuroplasticity in Substance Use Disorders: Implications for Therapeutics.

Autoren: Wolf, Marina E.¹ (AUTHOR) wolfmar@ohsu.edu

Quelle: Annual Review of Pharmacology & Toxicology. Jan2025, Vol. 65, p259-280. 19p.

Schlagwörter: *SUBSTANCE abuse treatment, *GLUTAMIC acid metabolism, *COCAINE, *PROMPTS (Psychology), *NEUROPLASTICITY, *BASAL ganglia, *SELF medication, *BEHAVIOR, *CELL receptors

Glutamine: A misunderstood amino acid with therapeutic potential.

Autoren: McMullen, Michael K¹ (AUTHOR) dr.michael.mcmullen@hotmail.se

Quelle: Nutrition & Health. Dec2025, Vol. 31 Issue 4, p1325-1329. 5p.

Schlagwörter: Intestinal mucosa physiology, Glutamine metabolism, Aspartic acid metabolism, Glutamic acid metabolism, Nitrogen metabolism, Wounds & injuries, Malnutrition, Glutamine, Burns & scalds, Blood chemical analysis, Intestinal barrier function, Cell proliferation, Bacterial physiology, Systemic inflammatory response syndrome, Nutritional requirements, Oral drug administration, Chronic diseases, Sepsis, Inflammation, Physical activity, Dietary supplements, Gastrointestinal diseases

Glutamatergic neurotransmission in schizophrenia: A systematic review and quantitative synthesis of proton magnetic resonance spectroscopy studies across schizophrenia spectrum disorders.

Autoren: Lopes, Jamie J Carruthers, Sean P Meyer, Denny et al.

Quelle: Australian & New Zealand Journal of Psychiatry. Nov2024, Vol. 58 Issue 11, p930-951. 22p.

Schlagwörter: *GLUTAMIC acid metabolism, *GLUTAMINE, *BRAIN, *PREFRONTAL cortex, *EXCITATORY amino acid agents, *NEURAL transmission, *SCHIZOPHRENIA, *BASAL ganglia, *AFFECTIVE disorders, *SYSTEMATIC reviews, *METABOLITES, *MEDLINE, *PSYCHOSES, *ONLINE information services, *PROTON magnetic resonance spectroscopy

Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer's disease neuropathology.

Autoren: Arnsten, Amy F. T. Perone, Isabella Wang, Min et al.

Quelle: Frontiers in Aging Neuroscience; 2025, p1-17, 17p

Schlagwörter: CALCIUM metabolism, GLUTAMIC acid metabolism, TAU proteins, ALZHEIMER'S disease, PHOSPHORYLATION, AUTOPHAGY, PREFRONTAL cortex, CALCIUM-binding proteins, ENZYME inhibitors, CELLULAR signal transduction, NEURODEGENERATION, NEUROINFLAMMATION, GENE expression, AGING, MEMORY, APOLIPOPROTEINS, COGNITION disorders, INFLAMMATION, CYTOKINES, GENETIC mutation, SIGNAL peptides, COGNITION, GENOTYPES

Metformin improves age-related visual cortex dysfunction in mice by reducing noise correlation in the primary visual cortex.

Autoren: Liu, Xiaoming Zhou, Yifeng Liu, Jiachen et al.

Quelle: Frontiers in Aging Neuroscience; 2025, p1-15, 15p

Schlagwörter: GLUTAMIC acid metabolism, NEURAL physiology, METFORMIN, NOISE, RESEARCH funding, RECEIVER operating characteristic curves, OCCIPITAL lobe, DECARBOXYLATION, IN vivo studies, DESCRIPTIVE statistics, MANN Whitney U Test, CONVOLUTIONAL neural networks, MICE, GENE expression, AGING, ANIMAL experimentation, WESTERN immunoblotting, ANALYSIS of variance, NERVOUS system, VISUAL acuity, VISUAL perception, AUDITORY perception, DATA analysis software, ELECTROPHYSIOLOGY, NONPARAMETRIC statistics, SENSITIVITY & specificity (Statistics), PHARMACODYNAMICS

Geografische Kategorien: CHINA

Neurocognition and NMDAR co-agonists pathways in individuals with treatment resistant first-episode psychosis: a 3-year follow-up longitudinal study

Autoren: Camporesi, Sara Xin, Lijing Golay, Philippe et al.

Quelle: Mol Psychiatry
Molecular psychiatry, vol. 29, no. 11, pp. 3669-3679
Camporesi, Sara; Xin, Lijing; Golay, Philippe; Eap, Chin Bin; Cleusix, Martine; Cuenod, Michel; Fournier, Margot; Hashimoto, Kenji; Jenni, Raoul; Ramain, Julie; Restellini, Romeo; Solida, Alessandra; Conus, Philippe; Do, Kim Q; Khadimallah, Ines (2024). Neurocognition and NMDAR co-agonists pathways in individuals with treatment resistant first-episode psychosis: a 3-year follow-up longitudinal study. (In Press). Molecular psychiatry Springer Nature 10.1038/s41380-024-02631-4 <http://dx.doi.org/10.1038/s41380-024-02631-4>
Camporesi, Sara; Xin, Lijing; Golay, Philippe; Eap, Chin Bin; Cleusix, Martine; Cuenod, Michel; Fournier, Margot; Hashimoto, Kenji; Jenni, Raoul; Ramain, Julie; Restellini, Romeo; Solida, Alessandra; Conus, Philippe; Do, Kim Q; Khadimallah, Ines (2024). Neurocognition and NMDAR co-agonists pathways in individuals with treatment resistant first-episode psychosis: a 3-year follow-up longitudinal study. Molecular psychiatry, 29(11), pp. 3669-3679. Springer Nature 10.1038/s41380-024-02631-4 <http://dx.doi.org/10.1038/s41380-024-02631-4>

Schlagwörter: Male, Adult, Adolescent, Psychotic Disorders / metabolism, Glutamic Acid, 610 Medicine & health, Schizophrenia, Treatment-Resistant / metabolism, Glutamic Acid / metabolism, Neuropsychological Tests, Humans, Female, Longitudinal Studies, Psychotic Disorders/drug therapy, Psychotic Disorders/metabolism, Receptors, N-Methyl-D-Aspartate/metabolism, Young Adult, Follow-Up Studies, Cognitive Dysfunction/drug therapy, Cognitive Dysfunction/metabolism, Antipsychotic Agents/therapeutic use, Antipsychotic Agents/pharmacology, Case-Control Studies, Cognition/physiology, Cognition/drug effects, Schizophrenia, Treatment-Resistant/drug therapy, Schizophrenia, Treatment-Resistant/metabolism, Glutamic Acid/metabolism, Schizophrenia/drug therapy, Schizophrenia/metabolism, Brain/metabolism, Receptors, N-Methyl-D-Aspartate, Receptors, N-Methyl-D-Aspartate / metabolism, Article, Cognition, Psychotic Disorders / drug therapy, Cognitive Dysfunction, Cognition / physiology, Cognitive Dysfunction / drug therapy, Schizophrenia / metabolism, Antipsychotic Agents / pharmacology, Schizophrenia, Treatment-Resistant / drug therapy, Schizophrenia / drug therapy, Brain, Cognitive Dysfunction / metabolism, Psychotic Disorders, Cognition / drug effects, 616.89, Schizophrenia, Brain / metabolism, Antipsychotic Agents / therapeutic use, Schizophrenia, Treatment-Resistant, Antipsychotic Agents

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38849515
https://archive-ouverte.unige.ch/unige:184121
https://doi.org/10.1038/s41380-024-02631-4
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_23EAC9CDB4DD2
https://serval.unil.ch/notice/serval:BIB_23EAC9CDB4DD
https://serval.unil.ch/resource/serval:BIB_23EAC9CDB4DD.P001/REF.pdf
https://boris.unibe.ch/197694/

Reproducibility of the Determination of 13C‐Labeling of Glutamate and Glutamine in the Human Brain Using selPOCE‐MRS at 7 T Upon [U‐13C]–Labeled Glucose Infusion

Autoren: Narjes Ahmadian Sarah M. Jacobs Mark Gosselink et al.

Weitere Verfasser: Narjes Ahmadian Sarah M. Jacobs Mark Gosselink et al.

Quelle: NMR Biomed

Schlagwörter: Male, Adult, Carbon Isotopes, Magnetic Resonance Spectroscopy, Glutamine, Glutamic Acid, Reproducibility of Results, Brain, Glutamine/metabolism, Glucose/administration & dosage, Glucose, Glutamic Acid/metabolism, Isotope Labeling, Journal Article, Brain/metabolism, Humans, Female, Magnetic Resonance Spectroscopy/methods, Research Article

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/40204526
https://dspace.library.uu.nl/handle/1874/461098

Prenatal opioid exposure alters pain perception and increases long-term health risks in infants with neonatal opioid withdrawal syndrome.

Autoren: Radhakrishna, Uppala Radhakrishnan, Rupa Uppala, Lavanya V. et al.

Quelle: Frontiers in Pain Research; 2025, p1-18, 18p

Schlagwörter: SUICIDE risk factors, GLUTAMIC acid metabolism, DRUG addiction complications, PROTEIN metabolism, RISK assessment, DRUG overdose, PRENATAL exposure delayed effects, CHRONIC pain, NEONATAL abstinence syndrome, AUTOPHAGY, MORPHINE, RECEIVER operating characteristic curves, EPIGENOMICS, CHILD health services, PREGNANT women, TRANSCRIPTION factors, OPIOID abuse, OXIDATIVE stress, CELLULAR signal transduction, INSULIN, DESCRIPTIVE statistics, NEURAL transmission, DNA methylation, BLOOD sugar, ESTROGEN receptors, BIOINFORMATICS, OPIOID analgesics, AGING, CIRCADIAN rhythms, PAIN management, GENE expression profiling, SUBSTANCE abuse in pregnancy, TELOMERES, INFLAMMATION, CYTOKINES, DATA analysis software, ONTOLOGIES (Information retrieval), ION channels, PHENOTYPES, CELL receptors, DISEASE risk factors, DISEASE complications, PREGNANCY

Pyroglutamate acidosis 2023. A review of 100 cases.

Autoren: Stewart, Gordon W.¹ g.stewart@ucl.ac.uk

Quelle: Clinical Medicine. Mar2024, Vol. 24 Issue 2, p1-6. 6p.

Schlagwörter: *GLUTAMIC acid metabolism, *IATROGENIC diseases, *DRUG overdose, *METABOLIC disorders, *CHRONIC pain, *RARE diseases, *VANCOMYCIN, *HYPOKALEMIA, *ACID-base equilibrium, *ACIDOSIS, *ACETAMINOPHEN, *OXACILLIN, *GABA, *PREGNANCY

Shengmaisan combined with Liuwei Dihuang Decoction alleviated CIH-induced glutamate excitotoxicity by IGF1/IGFR signaling pathway.

Autoren: Chen, Xue Fan, Xintong Liu, Qingqing et al.

Quelle: Fitoterapia. Dec2025, Vol. 187, pN.PAG-N.PAG. 1p.

Schlagwörter: *GLUTAMIC acid metabolism, *COMBINATION drug therapy, *SMALL interfering RNA, *HETEROCYCLIC compounds, *NEUROPROTECTIVE agents, *MITOCHONDRIA, *BENZYLIDENE compounds, *PROTEIN kinases, *CELLULAR signal transduction, *PLANT extracts, *MICE, *SLEEP apnea syndromes, *COGNITION disorders, *ANIMAL experimentation, *SOMATOMEDIN, *PHOSPHOTRANSFERASES, *MITOCHONDRIAL pathology, *HYPOXEMIA, CONNECTIVE tissue tumors

Is System x c − a Suitable Target for Tumour Detection and Response Assessment with Imaging?

Autoren: Sharkey, Amy R. Witney, Timothy H. Cook, Gary J. R.

Quelle: Cancers. Dec2023, Vol. 15 Issue 23, p5573. 15p.

Schlagwörter: *CYSTEINE metabolism, *GLUTAMIC acid metabolism, *TUMOR treatment, *BIOLOGICAL models, *RADIOISOTOPES, *POSITRON emission tomography computed tomography, *TREATMENT effectiveness, *MOLECULAR biology, *TUMORS, *TUMOR markers, *CELL lines, *PREDICTION models, *MOLECULAR structure, *CARRIER proteins, *DRUG resistance in cancer cells, *EVALUATION

Glutamate-Sensing Genes Are Conserved among Populations Compared to Glutamate Metabolism Genes.

Autoren: Goto, Kosuke Masuzawa, Yoko Kohmura, Masanori et al.

Quelle: Annals of Nutrition & Metabolism. 2023, Vol. 79 Issue 6, p502-510. 9p.

Schlagwörter: *GLUTAMIC acid metabolism, *NUCLEOTIDE analysis, *GLUTAMIC acid, *FLAVORING essences, *AFRICANS, *HISPANIC Americans, *SINGLE nucleotide polymorphisms, *GENETIC variation, *ALLELES, *SURVEYS, *GENES, *GENOMICS, *RESEARCH funding, *TASTE, *EAST Asians, *ASHKENAZIM

The Glutamate/GABA‐Glutamine Cycle: Insights, Updates, and Advances

Autoren: Jens V. Andersen

Quelle: J Neurochem
Andersen, J V 2025, ' The Glutamate/GABA-Glutamine Cycle : Insights, Updates, and Advances ', Journal of Neurochemistry, vol. 169, no. 3, e70029 . https://doi.org/10.1111/jnc.70029

Schlagwörter: Neurons, Glutamine, Neurons/metabolism, Glutamic Acid, Brain, Review, Astrocytes/metabolism, Glutamine/metabolism, Glutamic Acid/metabolism, Astrocytes, Brain/metabolism, Humans, Animals, gamma-Aminobutyric Acid/metabolism, gamma-Aminobutyric Acid

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/40066661
https://curis.ku.dk/ws/files/433330347/Journal_of_Neurochemistry_2025_Andersen_The_Glutamate_GABA_Glutamine_Cycle_Insights_Updates_and_Advances.pdf

Exogenous Substrates Prevent the Decline in the Cellular ATP Content of Primary Rat Astrocytes During Glucose Deprivation

Autoren: Antonia Regina Harders Paul Spellerberg Ralf Dringen

Quelle: Neurochem Res

Schlagwörter: 0301 basic medicine, Original Paper, 0303 health sciences, Proline, Fatty Acids, Glutamic Acid, Rats, Fatty acids, Mitochondria, Fatty Acids/metabolism [MeSH], Rats [MeSH], Adenosine Triphosphate/metabolism [MeSH], Astrocytes/metabolism [MeSH], Animals [MeSH], Glutamic Acid/metabolism [MeSH], Nucleosides, Cells, Cultured [MeSH], Proline [MeSH], Amino acids, Glucose/metabolism [MeSH], Metabolism, ATP, Amino Acids/metabolism [MeSH], 03 medical and health sciences, Glucose, Adenosine Triphosphate, Astrocytes, Animals, Amino Acids, Cells, Cultured

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38341839
https://repository.publisso.de/resource/frl:6492228