Suchergebnisse - "Genome-Wide Association Study"

Leveraging Genome-wide Association Studies to Identify Pathogenic Variants for Breast Cancer Among Multiple Continents.

Autoren: Admanegara PPS Yulianti R Rahmawati D et al.

Quelle: Anticancer research [Anticancer Res] 2025 Dec; Vol. 45 (12), pp. 5351-5367.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res Subsets: MEDLINE

MeSH-Schlagworte: Genome-Wide Association Study*/methods , Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Breast Neoplasms*/drug therapy , Polymorphism, Single Nucleotide* , Genetic Predisposition to Disease*, Humans ; Female ; Quantitative Trait Loci ; Biomarkers, Tumor/genetics ; Gene Frequency

Twenty years of genome-wide association studies: Health translation challenges and AI opportunities.

Autoren: Huang J McLean GR Franke A

Quelle: European journal of human genetics : EJHG [Eur J Hum Genet] 2025 Dec; Vol. 33 (12), pp. 1579-1584. Date of Electronic Publication: 2025 Oct 14.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9302235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5438 (Electronic) Linking ISSN: 10184813 NLM ISO Abbreviation: Eur J Hum Genet Subsets: MEDLINE

MeSH-Schlagworte: Genome-Wide Association Study*/history , Genome-Wide Association Study*/trends , Genome-Wide Association Study*/methods , Artificial Intelligence*/trends , Translational Research, Biomedical*/trends, Humans

An application of the MR-Horse method to reduce selection bias in genome-wide association studies of disease progression.

Autoren: Donovan K Torres J Zhu D et al.

Quelle: European journal of human genetics : EJHG [Eur J Hum Genet] 2025 Dec; Vol. 33 (12), pp. 1677-1683. Date of Electronic Publication: 2025 Jun 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9302235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5438 (Electronic) Linking ISSN: 10184813 NLM ISO Abbreviation: Eur J Hum Genet Subsets: MEDLINE

MeSH-Schlagworte: Genome-Wide Association Study*/methods , Genome-Wide Association Study*/standards, Humans ; Disease Progression ; Selection Bias ; Bayes Theorem ; Mendelian Randomization Analysis/methods ; Genetic Pleiotropy ; Models, Genetic

Genome-wide association study of seedling leaf rust resistance in European winter wheat cultivars.

Autoren: Czembor PC Piechota U Song J et al.

Quelle: Journal of applied genetics [J Appl Genet] 2025 Dec; Vol. 66 (4), pp. 853-869. Date of Electronic Publication: 2025 Jun 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: England NLM ID: 9514582 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3883 (Electronic) Linking ISSN: 12341983 NLM ISO Abbreviation: J Appl Genet Subsets: MEDLINE

MeSH-Schlagworte: Triticum*/genetics , Triticum*/microbiology , Disease Resistance*/genetics , Plant Diseases*/genetics , Plant Diseases*/microbiology , Genome-Wide Association Study* , Seedlings*/genetics , Seedlings*/microbiology, Quantitative Trait Loci ; Genotype ; Puccinia/pathogenicity ; Phenotype ; Chromosome Mapping ; Basidiomycota/pathogenicity

SCR Organism: Puccinia triticina

Utilising genomic association data for causal inference in anorexia nervosa.

Autoren: Adams DM Cairns MJ

Quelle: Mammalian genome : official journal of the International Mammalian Genome Society [Mamm Genome] 2025 Dec; Vol. 36 (4), pp. 1042-1062. Date of Electronic Publication: 2025 Jul 10.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Springer-Verlag Country of Publication: United States NLM ID: 9100916 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1777 (Electronic) Linking ISSN: 09388990 NLM ISO Abbreviation: Mamm Genome Subsets: MEDLINE

MeSH-Schlagworte: Anorexia Nervosa*/genetics , Genome-Wide Association Study*/methods , Genetic Predisposition to Disease*, Humans ; Polymorphism, Single Nucleotide ; Genomics/methods ; Multifactorial Inheritance ; Animals

Multivariate genome-wide analysis reveals shared genetic architecture and brain structural correlates of human cognitive abilities.

Autoren: Chen H Liao Y Tang L et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 24; Vol. 15 (1), pp. 41596. Date of Electronic Publication: 2025 Nov 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Genome-Wide Association Study* , Cognition*/physiology , Brain*/physiology , Brain*/anatomy & histology , Brain*/diagnostic imaging, Humans ; Polymorphism, Single Nucleotide ; Genetic Predisposition to Disease ; Male ; Multifactorial Inheritance ; Phenotype ; Female ; Multivariate Analysis

Large-scale multi-trait genome-wide analysis for inflammatory bowel disease reveals new insights into its molecular mechanisms and emphasizes the roles of systemic immune regulation.

Autoren: Zhu Z Shi L Li H et al.

Quelle: Briefings in bioinformatics [Brief Bioinform] 2025 Nov 01; Vol. 26 (6).

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 100912837 Publication Model: Print Cited Medium: Internet ISSN: 1477-4054 (Electronic) Linking ISSN: 14675463 NLM ISO Abbreviation: Brief Bioinform Subsets: MEDLINE

MeSH-Schlagworte: Genome-Wide Association Study* , Inflammatory Bowel Diseases*/genetics , Inflammatory Bowel Diseases*/immunology , Quantitative Trait Loci*, Humans ; Genetic Predisposition to Disease ; Crohn Disease/genetics ; Crohn Disease/immunology ; Colitis, Ulcerative/genetics ; Colitis, Ulcerative/immunology ; Animals

Alzheimer's disease multi-ancestry genome-wide interaction and stratified study with smoking.

Autoren: Dacey R Hou L Gurnani A et al.

Quelle: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Nov; Vol. 21 (11), pp. e70922.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

MeSH-Schlagworte: Alzheimer Disease*/genetics , Gene-Environment Interaction* , Genome-Wide Association Study* , Smoking*/genetics, Aged ; Female ; Humans ; Male ; Middle Aged ; Black or African American/genetics ; Brain/metabolism ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci ; White/genetics

Genome-wide association study and fine-mapping using imputed sequences to prioritize candidate genes for 30 complex traits in 50,309 Holstein bulls.

Autoren: Wang J Gao Y Toghiani S et al.

Quelle: Journal of dairy science [J Dairy Sci] 2025 Nov; Vol. 108 (11), pp. 12506-12518. Date of Electronic Publication: 2025 Sep 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Dairy Science Association Country of Publication: United States NLM ID: 2985126R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-3198 (Electronic) Linking ISSN: 00220302 NLM ISO Abbreviation: J Dairy Sci Subsets: MEDLINE

MeSH-Schlagworte: Genome-Wide Association Study*/veterinary, Animals ; Cattle/genetics ; Phenotype ; Male ; Breeding ; Genotype ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci

Applying weighted Cox regression to genome-wide association studies of time-to-event phenotypes.

Autoren: Li Y Ma Y Xu H et al.

Quelle: Nature computational science [Nat Comput Sci] 2025 Nov; Vol. 5 (11), pp. 1064-1079. Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Nature Country of Publication: United States NLM ID: 101775476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8457 (Electronic) Linking ISSN: 26628457 NLM ISO Abbreviation: Nat Comput Sci Subsets: MEDLINE

MeSH-Schlagworte: Genome-Wide Association Study*/methods , Genome-Wide Association Study*/statistics & numerical data, Humans ; Phenotype ; Proportional Hazards Models ; Diabetes Mellitus, Type 2/genetics ; Computer Simulation ; Gene Frequency ; Coronary Artery Disease/genetics ; Polymorphism, Single Nucleotide

A Modification to Two-Stage Least Squares With Genetic Applications.

Autoren: Fang L Pan W

Quelle: Statistics in medicine [Stat Med] 2025 Nov; Vol. 44 (25-27), pp. e70308.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: England NLM ID: 8215016 Publication Model: Print Cited Medium: Internet ISSN: 1097-0258 (Electronic) Linking ISSN: 02776715 NLM ISO Abbreviation: Stat Med Subsets: MEDLINE

MeSH-Schlagworte: Genome-Wide Association Study*/statistics & numerical data , Genome-Wide Association Study*/methods, Humans ; Least-Squares Analysis ; Computer Simulation ; Transcriptome ; Models, Statistical ; Sample Size

European-based polygenic risk score and genome-wide association study of B-cell non-Hodgkin lymphoma subtypes in Israeli Jews and Palestinian Arabs.

Autoren: Kleinstern G Robinson DP Abu Seir R et al.

Quelle: British journal of haematology [Br J Haematol] 2025 Nov; Vol. 207 (5), pp. 1832-1841. Date of Electronic Publication: 2025 Aug 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE

MeSH-Schlagworte: Jews*/genetics , Arabs*/genetics , Genome-Wide Association Study* , Multifactorial Inheritance*, Humans ; Female ; Male ; Israel/epidemiology ; Polymorphism, Single Nucleotide ; Middle Aged ; Genetic Predisposition to Disease ; Aged ; Adult ; Risk Factors ; Case-Control Studies ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/ethnology ; Genetic Risk Score

Genome-wide association study for loci associated with positive antinuclear antibodies.

Autoren: Cui J Yee J Guan H et al.

Quelle: Seminars in arthritis and rheumatism [Semin Arthritis Rheum] 2025 Oct; Vol. 74, pp. 152794. Date of Electronic Publication: 2025 Jul 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 1306053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-866X (Electronic) Linking ISSN: 00490172 NLM ISO Abbreviation: Semin Arthritis Rheum Subsets: MEDLINE

MeSH-Schlagworte: Antibodies, Antinuclear*/blood , Antibodies, Antinuclear*/genetics , Antibodies, Antinuclear*/immunology , Genome-Wide Association Study*, Humans ; Female ; Male ; Middle Aged ; Adult ; Genetic Predisposition to Disease ; Genotype ; Aged ; Alleles ; Polymorphism, Single Nucleotide ; Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology

Genome-wide interaction study with body mass index identifies CYP7A1 and GIPR as genetic modulators of metabolic dysfunction-associated steatotic liver disease.

Autoren: Jamialahmadi O Mujica E Morris L et al.

Quelle: Clinical and molecular hepatology [Clin Mol Hepatol] 2025 Oct; Vol. 31 (4), pp. 1252-1268. Date of Electronic Publication: 2025 Jun 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Korean Association for the Study of the Liver Country of Publication: Korea (South) NLM ID: 101586730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2287-285X (Electronic) Linking ISSN: 22872728 NLM ISO Abbreviation: Clin Mol Hepatol Subsets: MEDLINE

MeSH-Schlagworte: Body Mass Index* , Genome-Wide Association Study* , Cholesterol 7-alpha-Hydroxylase*/genetics , Cholesterol 7-alpha-Hydroxylase*/metabolism , Fatty Liver*/genetics , Fatty Liver*/pathology, Humans ; Male ; Female ; Polymorphism, Single Nucleotide ; Animals ; Alanine Transaminase/blood ; Zebrafish ; Middle Aged ; Liver/metabolism ; Liver/pathology ; Aged ; Adaptor Proteins, Signal Transducing

Genetic relationship between epilepsy and mental disorders: A comprehensive GWAS analysis.

Autoren: Abudusalamu R Maimaiti A Han W et al.

Quelle: Epilepsy & behavior : E&B [Epilepsy Behav] 2025 Oct; Vol. 171, pp. 110500. Date of Electronic Publication: 2025 Jun 02.

Publikationsart: Journal Article; Meta-Analysis

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 100892858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-5069 (Electronic) Linking ISSN: 15255050 NLM ISO Abbreviation: Epilepsy Behav Subsets: MEDLINE

MeSH-Schlagworte: Genome-Wide Association Study* , Epilepsy*/genetics , Epilepsy*/epidemiology , Mental Disorders*/genetics , Genetic Predisposition to Disease*/genetics, Humans ; Mendelian Randomization Analysis

sIL-6R impact on aortic aneurysm: Genetic evidence from FinnGen and GWAS.

Autoren: Wang M Teng T Mo D et al.

Quelle: International journal of cardiology [Int J Cardiol] 2025 Dec 15; Vol. 441, pp. 133786. Date of Electronic Publication: 2025 Aug 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8200291 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1874-1754 (Electronic) Linking ISSN: 01675273 NLM ISO Abbreviation: Int J Cardiol Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Interleukin-6*/genetics , Receptors, Interleukin-6*/blood , Genome-Wide Association Study*/methods , Aortic Aneurysm*/genetics , Aortic Aneurysm*/blood , Aortic Aneurysm*/epidemiology , Aortic Aneurysm*/diagnosis , Polymorphism, Single Nucleotide*/genetics , Genetic Predisposition to Disease*/genetics, Humans ; Mendelian Randomization Analysis/methods ; Male ; Finland/epidemiology ; Female ; Risk Factors

A cross-tissue transcriptome-wide association study identifies novel candidate genes associated with brain glymphatic system function.

Autoren: Zhu X Wang S Zhang S et al.

Quelle: Molecular brain [Mol Brain] 2025 Dec 05; Vol. 18 (1), pp. 90. Date of Electronic Publication: 2025 Dec 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101468876 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-6606 (Electronic) Linking ISSN: 17566606 NLM ISO Abbreviation: Mol Brain Subsets: MEDLINE

MeSH-Schlagworte: Genome-Wide Association Study* , Transcriptome*/genetics , Glymphatic System*/physiology , Glymphatic System*/metabolism , Brain*/metabolism , Brain*/physiology , Organ Specificity*/genetics, Humans ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/genetics ; Mendelian Randomization Analysis ; Diffusion Tensor Imaging

A genome-wide association study identifies the GPM6A locus associated with age at onset in ALS.

Autoren: Nakamura R Tohnai G Atsuta N et al.

Körperschaften: Nakamura R Tohnai G Atsuta N et al.

Quelle: Communications biology [Commun Biol] 2025 Dec 05; Vol. 8 (1), pp. 1720. Date of Electronic Publication: 2025 Dec 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

MeSH-Schlagworte: Amyotrophic Lateral Sclerosis*/genetics , Amyotrophic Lateral Sclerosis*/epidemiology , Genome-Wide Association Study* , GPI-Linked Proteins*/genetics, Humans ; Age of Onset ; Female ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Aged ; Genetic Predisposition to Disease ; Adult ; Japan

ML-MAGES enables multivariate genetic association analyses with genes and effect size shrinkage.

Autoren: Liu X Crawford L Ramachandran S

Quelle: Genome research [Genome Res] 2025 Dec 03; Vol. 35 (12), pp. 2691-2700. Date of Electronic Publication: 2025 Dec 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9518021 Publication Model: Electronic Cited Medium: Internet ISSN: 1549-5469 (Electronic) Linking ISSN: 10889051 NLM ISO Abbreviation: Genome Res Subsets: MEDLINE

MeSH-Schlagworte: Genome-Wide Association Study*/methods , Machine Learning*, Humans ; Neural Networks, Computer ; Quantitative Trait Loci ; Polymorphism, Single Nucleotide ; Models, Genetic ; Cluster Analysis ; Computer Simulation ; Multivariate Analysis

BayesRVAT enhances rare-variant association testing through Bayesian aggregation of functional annotations.

Autoren: Nappi A Shilova L Karaletsos T et al.

Quelle: Genome research [Genome Res] 2025 Dec 03; Vol. 35 (12), pp. 2682-2690. Date of Electronic Publication: 2025 Dec 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9518021 Publication Model: Electronic Cited Medium: Internet ISSN: 1549-5469 (Electronic) Linking ISSN: 10889051 NLM ISO Abbreviation: Genome Res Subsets: MEDLINE

MeSH-Schlagworte: Molecular Sequence Annotation* , Genome-Wide Association Study*/methods , Genetic Variation*, Bayes Theorem ; Humans ; Retinal Diseases/genetics ; Models, Genetic ; Machine Learning ; Genetic Predisposition to Disease