Search Results - "Gene Expression Regulation/*drug effects"

In vitro screening of understudied PFAS with a focus on lipid metabolism disruption

Authors: Lackson Kashobwe Faezeh Sadrabadi Albert Braeuning et al.

Source: Arch Toxicol
Archives of Toxicology

Subject Terms: 0301 basic medicine, Fluorocarbons, 0303 health sciences, HEK293T, Cell Survival, Receptors, Cytoplasmic and Nuclear, Hep G2 Cells, PFAS toxicity, Lipid Metabolism, 3. Good health, In Vitro Systems, 03 medical and health sciences, Lipid metabolism, Gene Expression Regulation, Bile acid synthesis, Humans, PPAR alpha, HepaRG, Lipid transporters, Humans [MeSH], PPAR alpha/agonists [MeSH], Cell Survival/drug effects [MeSH], Hep G2 Cells [MeSH], Lipid Metabolism/drug effects [MeSH], Receptors, Cytoplasmic and Nuclear/drug effects [MeSH], Receptors, Cytoplasmic and Nuclear/metabolism [MeSH], Gene Expression Regulation/drug effects [MeSH], Fluorocarbons/toxicity [MeSH], PPAR alpha/genetics [MeSH], PPAR alpha/metabolism [MeSH], Receptors, Cytoplasmic and Nuclear/genetics [MeSH]

Access URL: https://pubmed.ncbi.nlm.nih.gov/38953992
https://hdl.handle.net/1871.1/7821f74b-d536-4f1f-9b5a-fdb3feab1377
https://doi.org/10.1007/s00204-024-03814-2
https://research.vu.nl/en/publications/7821f74b-d536-4f1f-9b5a-fdb3feab1377
https://repository.publisso.de/resource/frl:6522162

Dexamethasone: a double-edged sword in the treatment of osteoarthritis

Authors: Tarasova, Karyna Arteaga, Maria Belen Kidtiwong, Angkana et al.

Source: Sci Rep
Scientific Reports, Vol 15, Iss 1, Pp 1-13 (2025)

Subject Terms: Triamcinolone Acetonide Pharmacology, Chondrocytes Metabolism, Science, Anti-Inflammatory Agents, Apoptosis, Chondrocytes Drug Effects, Triamcinolone, Senescence, Triamcinolone Acetonide, Article, Dexamethasone, Cellular Senescence Drug Effects, Chondrocytes, Osteoarthritis Pathology, Osteoarthritis, Humans, Inflammation Drug Therapy, Glucocorticoids, Cells, Cultured, Cellular Senescence, Osteoarthritis Drug Therapy, Cell Proliferation, Inflammation, Glucocorticoids Pharmacology, Gene Expression Profiling, Anti-Inflammatory Agents Pharmacology, Osteoarthritis Metabolism, Cell Proliferation Drug Effects, Gene Expression Regulation Drug Effects, Chondrocytes Pathology, Dexamethasone Therapeutic Use, Dexamethasone Pharmacology, Gene Expression Regulation, Medicine, Apoptosis Drug Effects

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/40195473
https://doaj.org/article/194006edd23b4f7aaa0a959c0531241b
https://phaidra.vetmeduni.ac.at/o:4102
https://doi.org/10.1038/s41598-025-96050-2

Effect of carrot intake on glucose tolerance, microbiota, and gene expression in a type 2 diabetes mouse model

Authors: Morten Kobaek‐Larsen Sina Maschek Stefanie Hansborg Kolstrup et al.

Source: Clin Transl Sci
Clinical and Translational Science, Vol 17, Iss 12, Pp n/a-n/a (2024)
Kobaek-Larsen, M, Maschek, S, Kolstrup, S H, Højlund, K, Nielsen, D S, Hansen, A K & Christensen, L P 2024, ' Effect of carrot intake on glucose tolerance, microbiota, and gene expression in a type 2 diabetes mouse model ', Clinical and Translational Science, vol. 17, no. 12, e70090 . https://doi.org/10.1111/cts.70090

Subject Terms: Male, Blood Glucose, 0301 basic medicine, Type 2/metabolism, High-Fat/adverse effects, Gene Expression Regulation/drug effects, RM1-950, Inbred C57BL, Diet, High-Fat, Article, Diabetes Mellitus, Experimental, Mice, 03 medical and health sciences, Fat-Restricted, Diabetes Mellitus, Animals, Gastrointestinal Microbiome/drug effects, Experimental/metabolism, PPAR gamma/metabolism, Diet, Fat-Restricted, 0303 health sciences, Blood Glucose/metabolism, Animal, Glucose Tolerance Test, Diet, Daucus carota, Gastrointestinal Microbiome, Mice, Inbred C57BL, PPAR gamma, Disease Models, Animal, Diabetes Mellitus, Type 2, Gene Expression Regulation, Disease Models, Therapeutics. Pharmacology, Public aspects of medicine, RA1-1270, Insulin Resistance

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39625861
https://doaj.org/article/92ee97635e164389988a9c340510be78
https://curis.ku.dk/ws/files/423684504/Clinical_Translational_Sci_2024_Kobaek_Larsen_Effect_of_carrot_intake_on_glucose_tolerance_microbiota_and_gene.pdf
https://portal.findresearcher.sdu.dk/da/publications/01e5cb2c-1519-4b97-a426-f1f5b3379d03
https://doi.org/10.1111/cts.70090

A comprehensive transcriptome characterization of individual nuclear receptor pathways in the human small intestine

Authors: Sam Willemsen Fjodor A. Yousef Yengej Jens Puschhof et al.

Contributors: Sam Willemsen Fjodor A. Yousef Yengej Jens Puschhof et al.

Source: Proc Natl Acad Sci U S A

Subject Terms: Small/metabolism, Pregnane X Receptor/metabolism, Gene Expression Regulation/drug effects, Receptors, Cytoplasmic and Nuclear, Cytoplasmic and Nuclear/metabolism, Lipid Metabolism/genetics, Receptors, Intestine, Small, Journal Article, Organoids/metabolism, Humans, Receptors, Calcitriol/metabolism, Intestine, Small/metabolism, Enterocytes/metabolism, Liver X Receptors, Liver X Receptors/metabolism, Pregnane X Receptor, Biological Sciences, Receptors, Cytoplasmic and Nuclear/metabolism, Lipid Metabolism, Intestine, Organoids, Enterocytes, Gene Expression Regulation, Calcitriol/metabolism, Receptors, Calcitriol, Transcriptome, Signal Transduction

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39475639
https://hdl.handle.net/20.500.11755/33631b73-f7ed-48b1-af5e-eeefba3a655f
https://pure.knaw.nl/portal/en/publications/33631b73-f7ed-48b1-af5e-eeefba3a655f
https://doi.org/10.1073/pnas.2411189121
https://dspace.library.uu.nl/handle/1874/458697

A comprehensive transcriptome characterization of individual nuclear receptor pathways in the human small intestine

Authors: Willemsen, Sam Yengej, Fjodor A Yousef Puschhof, Jens et al.

Contributors: Willemsen, Sam Yengej, Fjodor A Yousef Puschhof, Jens et al.

Subject Terms: Enterocytes/metabolism, Gene Expression Regulation/drug effects, Humans, Intestine, Small/metabolism, Lipid Metabolism/genetics, Liver X Receptors/metabolism, Organoids/metabolism, Pregnane X Receptor/metabolism, Receptors, Calcitriol/metabolism, Cytoplasmic and Nuclear/metabolism, Signal Transduction, Transcriptome, Journal Article

File Description: application/pdf

Relation: https://dspace.library.uu.nl/handle/1874/458697

Availability: https://dspace.library.uu.nl/handle/1874/458697

A field realistic model to assess the effects of pesticides residues and adulterants on honey bee gene expression.

Authors: El Agrebi, Noëmie De Smet, Lina Douny, Caroline et al.

Source: PLoS ONE, 19 (6), e0302183 (2024)

Subject Terms: Waxes, beeswax, Pesticide Residues, Insect Proteins, Animals, Bees/genetics, Bees/drug effects, Pupa/drug effects, Pupa/genetics, Larva/drug effects, Larva/genetics, Insect Proteins/genetics, Insect Proteins/metabolism, Gene Expression Regulation/drug effects, Pesticide Residues/toxicity, Pesticide Residues/analysis, Bees, Gene Expression Regulation, Larva, Pupa, Multidisciplinary, Life sciences, Veterinary medicine & animal health, Sciences du vivant, Médecine vétérinaire & santé animale

Relation: https://dx.plos.org/10.1371/journal.pone.0302183; urn:issn:1932-6203; https://orbi.uliege.be/handle/2268/324849; info:hdl:2268/324849; https://orbi.uliege.be/bitstream/2268/324849/1/pone.0302183.pdf; info:pmid:38923973

Availability: https://orbi.uliege.be/handle/2268/324849
https://orbi.uliege.be/bitstream/2268/324849/1/pone.0302183.pdf
https://doi.org/10.1371/journal.pone.0302183

Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins

Authors: Demoulin, Jean-Baptiste Ericsson, Johan Kallin, Anders et al.

Source: Journal of Biological Chemistry. 279(34):35392-35402

Subject Terms: 1-Phosphatidylinositol 3-Kinase/*metabolism, CCAAT-Enhancer-Binding Proteins/*metabolism, Cells, Cultured, DNA-Binding Proteins/*metabolism, Enzyme Activation/drug effects, Gene Expression Regulation/*drug effects, Humans, Membrane Lipids/*biosynthesis/*genetics, Research Support, Non-U.S. Gov't, Transcription Factors/*metabolism

File Description: print

Access URL: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-72771
https://doi.org/10.1074/jbc.M405924200

APOBEC3C, a nucleolar protein induced by genotoxins, is excluded from DNA damage sites

Authors: Daniel Constantin Gilles Dubuis María del Carmen Conde‐Rubio et al.

Source: FEBS J
The FEBS journal, vol. 289, no. 3, pp. 808-831

Subject Terms: 0301 basic medicine, 0303 health sciences, DNA End-Joining Repair, DNA Repair, Genome, Human, Cell Nucleolus/genetics, Cytidine Deaminase/genetics, DNA Breaks, Double-Stranded/drug effects, DNA Damage/drug effects, DNA Damage/genetics, DNA End-Joining Repair/genetics, DNA Repair/drug effects, DNA Repair/genetics, Etoposide/pharmacology, Gene Expression Regulation/drug effects, Genome, Human/genetics, Homologous Recombination/genetics, Humans, Multigene Family/genetics, Mutagens/pharmacology, Mutation/genetics, Tumor Suppressor Protein p53/genetics, APOBEC3C, DNA repair, cancer biology, nucleolus, p53, Original Articles, 03 medical and health sciences, Gene Expression Regulation, Cytidine Deaminase, Multigene Family, Mutation, DNA Breaks, Double-Stranded, Tumor Suppressor Protein p53, Homologous Recombination, Cell Nucleolus, DNA Damage, Etoposide, Mutagens

File Description: application/pdf

Access URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.16202
https://pubmed.ncbi.nlm.nih.gov/34528388
https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.16202
https://serval.unil.ch/notice/serval:BIB_549304C0D4F3
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_549304C0D4F30
https://serval.unil.ch/resource/serval:BIB_549304C0D4F3.P001/REF.pdf

Insects are a viable protein source for human consumption: from insect protein digestion to postprandial muscle protein synthesis in vivo in humans: a double-blind randomized trial: from insect protein digestion to postprandial muscle protein synthesis in vivo in humans: a double-blind randomized trial

Authors: Wesley JH Hermans Joan M Senden Tyler A Churchward-Venne et al.

Contributors: Wesley JH Hermans Joan M Senden Tyler A Churchward-Venne et al.

Source: Am J Clin Nutr

Subject Terms: Adult, Male, 0301 basic medicine, Gene Expression Regulation/drug effects, stable isotopes, Muscle Proteins, Dietary Proteins/administration & dosage, Young Adult, 03 medical and health sciences, Double-Blind Method, milk protein, SYNTHESIS RATES, FSR, Animals, Humans, AMINO-ACIDS, RESISTANCE EXERCISE, Tenebrio, Exercise, Muscle Proteins/genetics, 2. Zero hunger, 0303 health sciences, intrinsically labeled protein, exercise, DIETARY-PROTEIN, Milk Proteins, Postprandial Period, Milk Proteins/administration & dosage, Original Research Communications, Gene Expression Regulation, protein metabolism, WHEY, YOUNG, young adult, SKELETAL-MUSCLE, NUTRITION, Dietary Proteins, INTRINSICALLY LABELED MILK, Tenebrio/chemistry, INGESTION

File Description: application/pdf

Access URL: https://academic.oup.com/ajcn/article-pdf/114/3/934/40180525/nqab115.pdf
https://pubmed.ncbi.nlm.nih.gov/34020450
https://www.narcis.nl/publication/RecordID/oai%3Alibrary.wur.nl%3Awurpubs%2F588768
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408844
https://cris.maastrichtuniversity.nl/en/publications/insects-are-a-viable-protein-source-for-human-consumption-from-in
https://www.ncbi.nlm.nih.gov/pubmed/34020450
https://pubmed.ncbi.nlm.nih.gov/34020450/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408844
https://acuresearchbank.acu.edu.au/item/8x133/insects-are-a-viable-protein-source-for-human-consumption-from-insect-protein-digestion-to-postprandial-muscle-protein-synthesis-in-vivo-in-humans-a-double-blind-randomized-trial
https://biblio.vub.ac.be/vubir/(e9a2b74d-e36b-490d-b2d3-4ba75d35d8d1).html

Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n–3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial: A randomized, double-blind, placebo-controlled trial

Authors: Giuseppe De Vito Joan M. G. Senden Davide Susta et al.

Contributors: Giuseppe De Vito Joan M. G. Senden Davide Susta et al.

Source: Am J Clin Nutr
The American Journal of Clinical Nutrition
Murphy, C H, Flanagan, E M, De Vito, G, Susta, D, Mitchelson, K A J, de Marco Castro, E, Senden, J M G, Goessens, J P B, Mikłosz, A, Chabowski, A, Segurado, R, Corish, C A, McCarthy, S N, Egan, B, van Loon, L J C & Roche, H M 2021, 'Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial', The American Journal of Clinical Nutrition, vol. 113, no. 6, pp. 1411–1427. https://doi.org/10.1093/ajcn/nqaa449

Subject Terms: Male, Aging, Gene Expression Regulation/drug effects, Muscle Proteins, Muscle Strength/drug effects, AMINO-ACID SUPPLEMENTATION, older adult, 0302 clinical medicine, DIETARY-FAT MODIFICATION, VITAMIN-D, Muscle Proteins/genetics, Aged, 80 and over, 2. Zero hunger, LC n-3 PUFA, Physical Functional Performance, HEALTHY OLDER, Fatty Acids, Omega-3/administration & dosage, 3. Good health, Original Research Communications, muscle mass, Body Composition, Female, Muscle, Skeletal/drug effects, leucine, strength, polyunsaturated fatty acids, BODY-COMPOSITION, LC n–3 PUFA, Nutritional Status, EXERCISE, ELDERLY-PEOPLE, sarcopenia, 03 medical and health sciences, AGE, Double-Blind Method, Fatty Acids, Omega-3, Humans, Muscle Strength, Muscle, Skeletal, Aged, SERUM CYSTATIN-C, aging, biomarkers, Gene Expression Regulation, RISK-FACTORS, aged, 80 and over, protein, Biomarkers

File Description: application/pdf

Access URL: https://academic.oup.com/ajcn/article-pdf/113/6/1411/38387020/nqaa449.pdf
https://pubmed.ncbi.nlm.nih.gov/33871558
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168361
https://academic.oup.com/ajcn/article/113/6/1411/6237554
http://academic.oup.com/ajcn/article/113/6/1411/6237554
https://pubmed.ncbi.nlm.nih.gov/33871558/
https://acuresearchbank.acu.edu.au/item/8wqxw/does-supplementation-with-leucine-enriched-protein-alone-and-in-combination-with-fish-oil-derived-n-3-pufa-affect-muscle-mass-strength-physical-performance-and-muscle-protein-synthesis-in-well
https://t-stor.teagasc.ie/handle/11019/2596
http://hdl.handle.net/11019/2596
https://pure.qub.ac.uk/en/publications/420da3a1-f13f-44cd-a354-accb2c34e334
https://acuresearchbank.acu.edu.au/item/8wqxw/does-supplementation-with-leucine-enriched-protein-alone-and-in-combination-with-fish-oil-derived-n-3-pufa-affect-muscle-mass-strength-physical-performance-and-muscle-protein-synthesis-in-well
https://biblio.vub.ac.be/vubir/(3a655b9f-bde0-46af-9eda-8f4884b0fb73).html

Pharmacologic Activation of LXR Alters the Expression Profile of Tumor-Associated Macrophages and the Abundance of Regulatory T Cells in the Tumor Microenvironment

Authors: José M. Carbó Theresa E. León Joan Font-Díaz et al.

Contributors: José M. Carbó Theresa E. León Joan Font-Díaz et al.

Source: CANCER RESEARCH
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Cancer Research
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Institut de Recerca Germans Trias i Pujol (IGTP)
Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Digital.CSIC. Repositorio Institucional del CSIC
Cancer Research [ISSN 0008-5472], v. 81 (4), p. 968-985 (Febrero 2021)
accedaCRIS portal de investigación de la Universidad de las Palmas de Gran Canaria

Subject Terms: Male, 0301 basic medicine, Benzylamines, mice, Benzylamines/pharmacology, Hydrocarbons, Fluorinated, Sulfonamides/pharmacology, EMC OR-01, Gene Expression Regulation/drug effects, Mice, Transgenic, Nuclear receptors (Biochemistry), Benzoates, T-Lymphocytes, Regulatory, Mice, 03 medical and health sciences, Benzoates/pharmacology, SDG 3 - Good Health and Well-being, Mice, Inbred NOD, Liver X Receptors/agonists, Tumor-Associated Macrophages, Tumor Microenvironment, Animals, Humans, Lymphocyte Count, Càncer, Cells, Cultured, Cancer, Liver X Receptors, Sulfonamides, 0303 health sciences, Tumor-associated macrophages, Ccl17, Tumor-Associated Macrophages/drug effects, IL-4, GM-CSF, Tumor Microenvironment/drug effects, 3. Good health, GM -CSF, Mice, Inbred C57BL, T-Lymphocytes, Regulatory/drug effects, 320101 Oncología, RAW 264.7 Cells, Transcriptome/drug effects, Gene Expression Regulation, Receptors nuclears (Bioquímica), Hydrocarbons, Fluorinated/pharmacology, LXR, Transcriptome, 32 Ciencias médicas

File Description: application/pdf

Access URL: http://diposit.ub.edu/dspace/bitstream/2445/175887/1/706308.pdf
https://pubmed.ncbi.nlm.nih.gov/33361391
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5008
http://hdl.handle.net/2445/175887
https://hdl.handle.net/2445/175887
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4568
http://hdl.handle.net/10261/265390
http://hdl.handle.net/10553/112761
https://pure.eur.nl/en/publications/ca0224f7-5472-4cc7-9419-ef9648487126
https://doi.org/10.1158/0008-5472.Can-19-3360
https://cancerres.aacrjournals.org/content/early/2020/12/23/0008-5472.CAN-19-3360
https://pubmed.ncbi.nlm.nih.gov/33361391/
https://cancerres.aacrjournals.org/content/81/4/968
https://www.ncbi.nlm.nih.gov/pubmed/33361391
http://diposit.ub.edu/dspace/handle/2445/175887
https://accedacris.ulpgc.es/handle/10553/112761
https://biblio.vub.ac.be/vubir/pharmacologic-activation-of-lxr-alters-the-expression-profile-of-tumorassociated-macrophages-and-the-abundance-of-regulatory-t-cells-in-the-tumor-microenvironment(c09b9efd-48d3-4f5a-9015-4c7d5790b833).html
https://discovery-pp.ucl.ac.uk/id/eprint/10120386/

A new perspective on calmodulin-regulated calcium and ROS homeostasis upon carbon black nanoparticle exposure

Authors: Nisha Verma Mario Pink Simone Schmitz-Spanke

Source: Arch Toxicol

Subject Terms: 0301 basic medicine, 0303 health sciences, Time Factors, Dose-Response Relationship, Drug, Antioxidants, 3. Good health, Oxidative Stress, 03 medical and health sciences, A549 Cells [MeSH], Dose-Response Relationship, Drug [MeSH], Calcium/metabolism [MeSH], Antioxidants/pharmacology [MeSH], Reactive oxygen species (ROS), Calmodulin/metabolism [MeSH], Oxidative Stress/genetics [MeSH], Nanoparticles/toxicity [MeSH], Humans [MeSH], Mitochondrial ROS, Reactive Oxygen Species/metabolism [MeSH], Alveolar Epithelial Cells/pathology [MeSH], Time Factors [MeSH], Alveolar Epithelial Cells/drug effects [MeSH], Nanotoxicology, Carbon black nanoparticles, Soot/administration, Gene Expression Regulation/drug effects [MeSH], Oxidative Stress/drug effects [MeSH], Soot/toxicity [MeSH], Calcium homeostasis, Calmodulin, Gene Expression Regulation, Soot, A549 Cells, 13. Climate action, Alveolar Epithelial Cells, Humans, Nanoparticles, Calcium, ddc:610, Reactive Oxygen Species

File Description: application/pdf

Access URL: https://link.springer.com/content/pdf/10.1007/s00204-021-03032-0.pdf
https://www.researchsquare.com/article/rs-89273/v1.pdf
https://pubmed.ncbi.nlm.nih.gov/33772346
https://pubmed.ncbi.nlm.nih.gov/33772346/
https://link.springer.com/content/pdf/10.1007/s00204-021-03032-0.pdf
https://europepmc.org/article/MED/33772346
https://link.springer.com/article/10.1007/s00204-021-03032-0
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166691/
https://opus4.kobv.de/opus4-fau/files/22082/s00204-021-03032-0.pdf
https://repository.publisso.de/resource/frl:6451695

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

Authors: Ko Yung Sit Ren Sun Raveen Rathnasinghe et al.

Source: Nature, vol 586, iss 7827
Nature

Subject Terms: 0301 basic medicine, Coronaviruses, 302091 Immuntherapie, Drug Evaluation, Preclinical, Gene Expression Regulation/drug effects, Alveolar Epithelial Cells/cytology, Virus Replication, POSTMENOPAUSAL OSTEOPOROSIS, Morpholines/analysis, ONO-5334, Coronaviruses Therapeutics and Interventions, Induced Pluripotent Stem Cells/cytology, PIKFYVE, Models, 302091 Immunotherapy, Viral, 106052 Cell biology, Lung, 106022 Mikrobiologie, 0303 health sciences, Multidisciplinary, Betacoronavirus/drug effects, Alanine, Triazines, APILIMOD, Drug Synergism, Alanine/analogs & derivatives, Preclinical, Triazines/analysis, 3. Good health, EBOLA-VIRUS, Infectious Diseases, Medical Microbiology, 5.1 Pharmaceuticals, SDG 3 – Gesundheit und Wohlergehen, Pneumonia & Influenza, 106022 Microbiology, 106052 Zellbiologie, Drug, Infection, Coronavirus Infections, General Science & Technology, Morpholines, Induced Pluripotent Stem Cells, Cysteine Proteinase Inhibitors, Antiviral Agents, Models, Biological, Adenosine Monophosphate/analogs & derivatives, Cell Line, Small Molecule Libraries, Dose-Response Relationship, Betacoronavirus, 03 medical and health sciences, Rare Diseases, SDG 3 - Good Health and Well-being, Antiviral Agents/analysis, Small Molecule Libraries/analysis, KINASE, Humans, Viral/drug therapy, Pandemics, Virus Replication/drug effects, Biomedical and Clinical Sciences, Dose-Response Relationship, Drug, SARS-CoV-2, Drug Repositioning, Hydrazones, Reproducibility of Results, COVID-19, Coronavirus Infections/drug therapy, Pneumonia, Virus Internalization, Stem Cell Research, Biological, EFFICACY, Adenosine Monophosphate, COVID-19 Drug Treatment, Virus Internalization/drug effects, Good Health and Well Being, Orphan Drug, Emerging Infectious Diseases, Pyrimidines, IL-12/IL-23 INHIBITOR, Gene Expression Regulation, CATHEPSIN-L, Alveolar Epithelial Cells, REPLICATION, Drug Evaluation, Cysteine Proteinase Inhibitors/analysis

File Description: application/pdf

Access URL: https://www.nature.com/articles/s41586-020-2577-1.pdf
https://pubmed.ncbi.nlm.nih.gov/32707573
https://ucrisportal.univie.ac.at/de/publications/5e0e71b3-7b21-41ba-a0f2-eddf86ce60e7
https://doi.org/10.1038/s41586-020-2577-1
http://vlib.kmu.ac.ir/kmu/handle/kmu/891293
http://vlib.kmu.ac.ir/kmu/handle/kmu/912560
https://escholarship.org/content/qt6p88f41f/qt6p88f41f.pdf
https://escholarship.org/uc/item/6p88f41f

A pathogen‐derived metabolite induces microglial activation via odorant receptors

Authors: NaHye Lee TaeHo Cho Hongmok Kwon et al.

Contributors: NaHye Lee TaeHo Cho Hongmok Kwon et al.

Source: The FEBS Journal. 287:3841-3870

Subject Terms: Male, Models, Molecular, 0301 basic medicine, INCREASES, Protein Conformation, CX3C Chemokine Receptor 1 / genetics, Gene Expression Regulation / drug effects, STREPTOCOCCUS-PNEUMONIAE, PROTEIN, SUSCEPTIBILITY, Cytokines / genetics, Inbred C57BL, Ligands, ASTROCYTES, Odorant / physiology, Mice, DESIGN, Models, Receptors, microglial activation, Cells, Cultured, Cultured, Molecular Structure, Chemotaxis, Odorant / genetics, 3. Good health, Chemotaxis / drug effects, Microglia / metabolism, Host-Pathogen Interactions, Cytokines, Microglia, Signal Transduction, Protein Binding, Messenger / biosynthesis, EXPRESSION, Cells, CX3C Chemokine Receptor 1, odorant receptor, 03 medical and health sciences, Phagocytosis, Superoxides / metabolism, Furans / isolation & purification, OLFACTORY RECEPTORS, Animals, RNA, Messenger, pathogenic metabolite, Furans, Messenger / genetics, non-olfactory expression, DYSREGULATION, Molecular, Reactive Oxygen Species / metabolism, Mice, Inbred C57BL, Molecular Weight, Cytokines / biosynthesis, Gene Expression Regulation, Furans / pharmacology, CELLS, RNA, Streptococcus pneumoniae / metabolism, Phagocytosis / drug effects, Microglia / drug effects

Access URL: https://pubmed.ncbi.nlm.nih.gov/32003140
https://pubmed.ncbi.nlm.nih.gov/32003140/
https://febs.onlinelibrary.wiley.com/doi/pdf/10.1111/febs.15234
https://www.ncbi.nlm.nih.gov/pubmed/32003140
https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.15234

Increased hypoxic proliferative response and gene expression in erythroid progenitor cells of Andean highlanders with chronic mountain sickness

Authors: Francisco C. Villafuerte Gustavo Vizcardo-Galindo Priti Azad et al.

Source: Am J Physiol Regul Integr Comp Physiol

Subject Terms: 0301 basic medicine, Cancer Research, Physiology, Gene Expression Regulation/drug effects, Brown Adipose Tissue Function and Physiology, Altitude Sickness, Genetic and Physiological Adaptations to High-Altitude Environments, Endocrinology, Homeostasis, Erythropoiesis, Hypoxia, excessive erythrocytosis, Internal medicine, chronic mountain sickness, Erythroid Precursor Cells, 2. Zero hunger, Stem cell, Altitude, Life Sciences, Anemia, Erythropoietin/blood, Progenitor cell, Medicine, Research Article, Cell biology, Acute Mountain Sickness, Erythroid Precursor Cells/metabolism, Iron, Immunology, Cancer research, 03 medical and health sciences, GATA1, Biochemistry, Genetics and Molecular Biology, high altitude, Health Sciences, Genetics, Humans, Genetic Predisposition to Disease, Oxygen/metabolism/pharmacology, Erythropoietin, Biology, Altitude Sickness/epidemiology, FOS: Clinical medicine, Oxygen, Haematopoiesis, Gene Expression Regulation, FOS: Biological sciences, Chronic Disease, Leukocytes, Mononuclear, Metabolic Reprogramming in Cancer Biology, Andean, Transcriptome, Iron/metabolism, erythropoiesis

Access URL: https://journals.physiology.org/doi/pdf/10.1152/ajpregu.00250.2019
https://pubmed.ncbi.nlm.nih.gov/31617751
http://www.ncbi.nlm.nih.gov/pubmed/31617751
https://journals.physiology.org/doi/full/10.1152/ajpregu.00250.2019
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985794
https://www.physiology.org/doi/10.1152/ajpregu.00250.2019
https://europepmc.org/article/PMC/PMC6985794
https://pubmed.ncbi.nlm.nih.gov/31617751/

Inflammation-Related Genes Are Differentially Expressed in Lipopolysaccharide-Stimulated Peripheral Blood Mononuclear Cells after 3 Months of Resistance Training in Older Women

Authors: Lene Salimans Keliane Liberman Wilfried Cools et al.

Contributors: Lene Salimans Keliane Liberman Wilfried Cools et al.

Source: Cells
Cells, Vol 13, Iss 17, p 1416 (2024)
Salimans, L, Liberman, K, Cools, W, Njemini, R, Debacq-Chainiaux, F, Forti, L N, De Dobbeleer, L, Kooijman, R, Beyer, I & Bautmans, I 2024, 'Inflammation-Related Genes Are Differentially Expressed in Lipopolysaccharide-Stimulated Peripheral Blood Mononuclear Cells after 3 Months of Resistance Training in Older Women', Cells, vol. 13, no. 17, 1416. https://doi.org/10.3390/cells13171416

Subject Terms: Lipopolysaccharides, Inflammation, 0301 basic medicine, Leukocytes, Mononuclear/metabolism, 0303 health sciences, exercise, RNA sequence analysis, QH573-671, Gene Expression Regulation/drug effects, Resistance Training, Lipopolysaccharides/pharmacology, Article, Resistance training, 03 medical and health sciences, Gene Expression Regulation, Inflammation/genetics, gene expression, Leukocytes, Mononuclear, Humans, Female, Cytology, older adults, LPS challenge, Aged

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39272988
https://doaj.org/article/915eec89b66f4c3088ce6ac12b629502
https://researchportal.unamur.be/en/publications/b3264f3d-31b2-4dfa-9cbc-89ccc50bdbca
https://doi.org/10.3390/cells13171416
https://biblio.vub.ac.be/vubir/inflammationrelated-genes-are-differentially-expressed-in-lipopolysaccharidestimulated-peripheral-blood-mononuclear-cells-after-3-months-of-resistance-training-in-older-women(18596d67-1c0e-4eb8-b1d8-6338c4cd885d).html
https://pure.unamur.be/ws/files/106180155/cells-13-01416-v2.pdf

Mechanistic insights into steroid hormone-mediated regulation of the androgen receptor gene

Authors: Andrew D. Gillen Irene Hunter Ekkehard Ullner et al.

Contributors: Andrew D. Gillen Irene Hunter Ekkehard Ullner et al.

Source: PLoS One
PLoS ONE, Vol 19, Iss 8, p e0304183 (2024)

Subject Terms: Transcriptional repression, Transcription, Genetic, Androgen/metabolism, Science, Gene Expression Regulation/drug effects, R Medicine, Response Elements, progesterone receptor, Cell Line, SDG 3 - Good Health and Well-being, Cell Line, Tumor, Receptors, Humans, General, Androgen receptor gene, Genetic/drug effects, Tumor, Acetylation, 3. Good health, Gene Expression Regulation, Receptors, Androgen, Hormone-regulation, Medicine, Progesterone/metabolism, Receptors, Progesterone, 5' Untranslated Regions, Transcription, Research Article

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39088439
https://doaj.org/article/eddcdefe5d96463386101b02edec6aca

Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures.

Authors: Zurich, M.G. Lengacher, S. Braissant, O. et al.

Subject Terms: Animals, Astrocytes/drug effects, Astrocytes/physiology, Brain/cytology, Cell Aggregation/drug effects, Cells, Cultured, Culture Media, Serum-Free/pharmacology, Cyclic AMP/metabolism, Cyclic AMP/pharmacology, Dose-Response Relationship, Drug, Drug Interactions, Embryo, Mammalian, Extracellular Fluid/drug effects, Extracellular Fluid/metabolism, Gene Expression Regulation/drug effects, Glial Fibrillary Acidic Protein/genetics, Glial Fibrillary Acidic Protein/metabolism, Glutamate-Ammonia Ligase/genetics, Glutamate-Ammonia Ligase/metabolism, Heme Oxygenase (Decyclizing)/genetics, Heme Oxygenase (Decyclizing)/metabolism, Heme Oxygenase-1, Hydro-Lyases/metabolism, Immunohistochemistry/methods, In Situ Hybridization/methods, Mycotoxins/pharmacology

Relation: Neuroscience; 0306-4522[print], 0306-4522[linking]; https://iris.unil.ch/handle/iris/97651; serval:BIB_35682; 000231491200006

Availability: https://iris.unil.ch/handle/iris/97651
https://doi.org/10.1016/j.neuroscience.2005.04.030

Single-cell gene-expression profiling reveals qualitatively distinct CD8 T cells elicited by different gene-based vaccines.

Authors: Flatz, L. Roychoudhuri, R. Honda, M. et al.

Subject Terms: AIDS Vaccines/immunology, AIDS Vaccines/pharmacology, Animals, CD8-Positive T-Lymphocytes/metabolism, Flow Cytometry, Gene Expression Profiling, Gene Expression Regulation/drug effects, Gene Expression Regulation/immunology, Mice, Microarray Analysis, NK Cell Lectin-Like Receptor Subfamily K/metabolism, Receptors, CCR7/metabolism, CXCR3/metabolism, Immunologic/metabolism, Reverse Transcriptase Polymerase Chain Reaction, T-Box Domain Proteins/metabolism, T-Lymphocyte Subsets/metabolism

Relation: Proceedings of the National Academy of Sciences; https://iris.unil.ch/handle/iris/92789; serval:BIB_038563FC89D9; 000289265300047

Availability: https://iris.unil.ch/handle/iris/92789
https://doi.org/10.1073/pnas.1013084108

Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine.

Authors: Poirier, H. Niot, I. Monnot, M.C. et al.

Subject Terms: Animals, Antilipemic Agents, Bezafibrate/pharmacology, Butyric Acids/pharmacology, Carrier Proteins/genetics, DNA Primers, Fatty Acid-Binding Proteins, Gene Expression Regulation/drug effects, Genes, Reporter, Intestine, Small/drug effects, Small/metabolism, Linoleic Acid/pharmacology, Liver/drug effects, Liver/metabolism, Male, Mice, Inbred C57BL, Knockout, Molecular Sequence Data, Neoplasm Proteins, Nerve Tissue Proteins, Phenylurea Compounds/pharmacology, Promoter Regions, Genetic, RNA, Messenger/genetics, Receptors, Cytoplasmic and Nuclear/agonists

Relation: Biochemical Journal; 0264-6021[print], 0264-6021[linking]; https://iris.unil.ch/handle/iris/88642; serval:BIB_14E4CBE131F9; 000168360700028

Availability: https://iris.unil.ch/handle/iris/88642
https://doi.org/10.1042/0264-6021:3550481