Search Results - "GTP-binding protein regulators"

Smooth operator(s): dialing up and down neurotransmitter responses by G-protein regulators.

Authors: Philibert CE Garcia-Marcos M

Source: Trends in cell biology [Trends Cell Biol] 2025 Apr; Vol. 35 (4), pp. 330-340. Date of Electronic Publication: 2024 Jul 24.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 9200566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3088 (Electronic) Linking ISSN: 09628924 NLM ISO Abbreviation: Trends Cell Biol Subsets: MEDLINE

MeSH Terms: Neurotransmitter Agents*/metabolism , GTP-Binding Proteins*/metabolism , GTP-Binding Protein Regulators*/metabolism, Humans ; Animals ; Receptors, G-Protein-Coupled/metabolism

A structural vista of phosducin-like PhLP2A-chaperonin TRiC cooperation during the ATP-driven folding cycle.

Authors: Park J Kim H Gestaut D et al.

Source: Nature communications [Nat Commun] 2024 Feb 02; Vol. 15 (1), pp. 1007. Date of Electronic Publication: 2024 Feb 02.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Protein Folding* , Actins*/metabolism , Eye Proteins* , Phosphoproteins* , GTP-Binding Protein Regulators*, Carrier Proteins/metabolism ; Chaperonins/metabolism ; Adenosine Triphosphate/metabolism ; Chaperonin Containing TCP-1/metabolism

Deduction of CDC42EP3 suppress development and progression of osteosarcoma.

Authors: Xu P Li X Tang C et al.

Source: Experimental cell research [Exp Cell Res] 2022 Mar 01; Vol. 412 (1), pp. 113018. Date of Electronic Publication: 2022 Jan 05.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0373226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2422 (Electronic) Linking ISSN: 00144827 NLM ISO Abbreviation: Exp Cell Res Subsets: MEDLINE

MeSH Terms: Bone Neoplasms/*metabolism , GTP-Binding Protein Regulators/*metabolism , Osteosarcoma/*metabolism, Adult ; Animals ; Apoptosis ; Biomarkers, Tumor/antagonists & inhibitors ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Bone Neoplasms/genetics ; Bone Neoplasms/pathology ; Cell Cycle ; Cell Line, Tumor ; Cell Proliferation ; Cell Survival ; Disease Progression ; Female ; GTP-Binding Protein Regulators/antagonists & inhibitors ; GTP-Binding Protein Regulators/genetics ; Gene Knockdown Techniques ; Heterografts ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Osteosarcoma/genetics ; Osteosarcoma/pathology

lncRNA XIST knockdown suppresses hypoxia/reoxygenation (H/R)-induced apoptosis of H9C2 cells by regulating miR-545-3p/G3BP2.

Authors: Xiao X He Z Tong S et al.

Source: IUBMB life [IUBMB Life] 2021 Sep; Vol. 73 (9), pp. 1103-1114. Date of Electronic Publication: 2021 Jul 14.

Publication Type: Journal Article

Journal Info: Publisher: Published for the International Union of Biochemistry and Molecular Biology by Taylor & Francis Country of Publication: England NLM ID: 100888706 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-6551 (Electronic) Linking ISSN: 15216543 NLM ISO Abbreviation: IUBMB Life Subsets: MEDLINE

MeSH Terms: Apoptosis*/genetics , Cell Hypoxia*/genetics , GTP-Binding Protein Regulators*/genetics , GTP-Binding Protein Regulators*/metabolism , Myocytes, Cardiac*/pathology , Myocytes, Cardiac*/physiology , RNA, Long Noncoding*/genetics, Animals ; Male ; Gene Expression Regulation ; Gene Knockdown Techniques ; MicroRNAs/genetics ; Myocardial Reperfusion Injury/pathology ; Oxygen/metabolism ; Rats, Sprague-Dawley ; Rats

CDC42EP3 is a key promoter involved in the development and progression of gastric cancer.

Authors: Chen W Zhu Y Zhang W et al.

Source: Carcinogenesis [Carcinogenesis] 2021 Oct 05; Vol. 42 (9), pp. 1179-1188.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Irl Press At Oxford University Press Country of Publication: England NLM ID: 8008055 Publication Model: Print Cited Medium: Internet ISSN: 1460-2180 (Electronic) Linking ISSN: 01433334 NLM ISO Abbreviation: Carcinogenesis Subsets: MEDLINE

MeSH Terms: Stomach Neoplasms*/genetics , Stomach Neoplasms*/pathology, GTP-Binding Protein Regulators/*metabolism, Aged ; Animals ; Apoptosis ; Cell Movement ; Cell Proliferation ; Disease Progression ; Female ; GTP-Binding Protein Regulators/genetics ; Gene Knockdown Techniques ; Gene Silencing ; Heterografts ; Humans ; Male ; Mice ; Middle Aged ; Survival Rate ; Up-Regulation

Wastewater-derived antagonistic activities of G protein-coupled receptor-acting pharmaceuticals in river water.

Authors: Ihara M Hanamoto S Ihara MO et al.

Source: Journal of applied toxicology : JAT [J Appl Toxicol] 2020 Jul; Vol. 40 (7), pp. 908-917. Date of Electronic Publication: 2020 Feb 20.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: John Wiley And Sons Country of Publication: England NLM ID: 8109495 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1263 (Electronic) Linking ISSN: 0260437X NLM ISO Abbreviation: J Appl Toxicol Subsets: MEDLINE

MeSH Terms: GTP-Binding Protein Regulators/*toxicity , Pharmaceutical Preparations/*analysis , Pharmaceutical Preparations/*chemistry , Wastewater/*chemistry , Wastewater/*toxicity , Water Pollutants, Chemical/*analysis , Water Pollutants, Chemical/*toxicity, Drug-Related Side Effects and Adverse Reactions ; Environmental Monitoring ; Fresh Water/chemistry ; GTP-Binding Protein Regulators/analysis ; Japan ; Rivers/chemistry

G3BP2 is involved in isoproterenol-induced cardiac hypertrophy through activating the NF-κB signaling pathway.

Authors: Hong HQ Lu J Fang XL et al.

Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2018 Feb; Vol. 39 (2), pp. 184-194. Date of Electronic Publication: 2017 Aug 17.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE

MeSH Terms: Cardiomegaly/*metabolism , GTP-Binding Protein Regulators/*metabolism , Myocytes, Cardiac/*metabolism , NF-kappa B/*metabolism , RNA-Binding Proteins/*metabolism, Animals ; Cardiomegaly/chemically induced ; Cardiomegaly/pathology ; Cell Nucleus/metabolism ; Disease Models, Animal ; GTP-Binding Protein Regulators/genetics ; Gene Knockdown Techniques ; Isoproterenol ; Male ; Myocytes, Cardiac/pathology ; NF-KappaB Inhibitor alpha/metabolism ; NF-kappa B/antagonists & inhibitors ; Pyrrolidines/pharmacology ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Thiocarbamates/pharmacology ; Transcription Factor RelA/metabolism

CDC42EP3 promotes glioma progression via regulation of CCND1.

Authors: Yang Z Xu T Xie T et al.

Source: Cell death & disease [Cell Death Dis] 2022 Apr 01; Vol. 13 (4), pp. 290. Date of Electronic Publication: 2022 Apr 01.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

MeSH Terms: Brain Neoplasms*/genetics , Brain Neoplasms*/pathology , Glioma*/pathology, Apoptosis/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cyclin D1/genetics ; Cyclin D1/metabolism ; GTP-Binding Protein Regulators/genetics ; GTP-Binding Protein Regulators/metabolism ; Gene Expression Regulation, Neoplastic ; Humans

Proximity-Triggered Covalent Stabilization of Low-Affinity Protein Complexes In Vitro and In Vivo.

Authors: Cigler M Müller TG Horn-Ghetko D et al.

Source: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2017 Dec 04; Vol. 56 (49), pp. 15737-15741. Date of Electronic Publication: 2017 Nov 09.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

MeSH Terms: Amino Acyl-tRNA Synthetases/*metabolism , GTP-Binding Protein Regulators/*metabolism , GTP-Binding Proteins/*metabolism , Green Fluorescent Proteins/*metabolism, Amino Acids/chemistry ; Amino Acids/metabolism ; Amino Acyl-tRNA Synthetases/chemistry ; Amino Acyl-tRNA Synthetases/genetics ; GTP-Binding Protein Regulators/chemistry ; GTP-Binding Proteins/chemistry ; Green Fluorescent Proteins/chemistry ; HEK293 Cells ; Humans ; Models, Molecular ; Mutation ; Protein Binding ; Protein Stability

An Actomyosin-Arf-GEF Negative Feedback Loop for Tissue Elongation under Stress.

Authors: West JJ Zulueta-Coarasa T Maier JA et al.

Source: Current biology : CB [Curr Biol] 2017 Aug 07; Vol. 27 (15), pp. 2260-2270.e5. Date of Electronic Publication: 2017 Jul 20.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: England NLM ID: 9107782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0445 (Electronic) Linking ISSN: 09609822 NLM ISO Abbreviation: Curr Biol Subsets: MEDLINE

MeSH Terms: Signal Transduction*, Drosophila Proteins/*genetics , Drosophila melanogaster/*genetics , GTP-Binding Protein Regulators/*genetics , Guanine Nucleotide Exchange Factors/*genetics , Zebrafish/*genetics , Zebrafish Proteins/*genetics, Animals ; Drosophila Proteins/metabolism ; Drosophila melanogaster/embryology ; Drosophila melanogaster/metabolism ; Embryo, Nonmammalian/embryology ; Embryo, Nonmammalian/metabolism ; GTP-Binding Protein Regulators/metabolism ; Guanine Nucleotide Exchange Factors/metabolism ; Zebrafish/embryology ; Zebrafish/metabolism ; Zebrafish Proteins/metabolism

The Borg family of Cdc42 effector proteins Cdc42EP1-5.

Authors: Farrugia AJ Calvo F

Source: Biochemical Society transactions [Biochem Soc Trans] 2016 Dec 15; Vol. 44 (6), pp. 1709-1716.

Publication Type: Journal Article; Review

Journal Info: Publisher: Portland Press On The Behalf Of The Biochemical Society Country of Publication: England NLM ID: 7506897 Publication Model: Print Cited Medium: Internet ISSN: 1470-8752 (Electronic) Linking ISSN: 03005127 NLM ISO Abbreviation: Biochem Soc Trans Subsets: MEDLINE

MeSH Terms: Adaptor Proteins, Signal Transducing/*metabolism , GTP-Binding Protein Regulators/*metabolism, Adaptor Proteins, Signal Transducing/genetics ; Cytoskeletal Proteins ; Cytoskeleton/metabolism ; GTP-Binding Protein Regulators/genetics ; Humans ; Models, Biological ; Multigene Family ; RNA-Binding Proteins ; Signal Transduction ; rho GTP-Binding Proteins

Heterotrimeric G-protein shuttling via Gip1 extends the dynamic range of eukaryotic chemotaxis.

Authors: Kamimura Y Miyanaga Y Ueda M

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Apr 19; Vol. 113 (16), pp. 4356-61. Date of Electronic Publication: 2016 Apr 04.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH Terms: Cell Membrane/*metabolism , Chemotaxis/*physiology , Dictyostelium/*metabolism , GTP-Binding Protein Regulators/*metabolism , Heterotrimeric GTP-Binding Proteins/*metabolism , Signal Transduction/*physiology, Cell Membrane/genetics ; Dictyostelium/genetics ; GTP-Binding Protein Regulators/genetics ; Heterotrimeric GTP-Binding Proteins/genetics

Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK/SREBP/ACC pathway but not through PDP1/PDC pathway.

Authors: Li D Xu N Hou Y et al.

Source: Molecular medicine (Cambridge, Mass.) [Mol Med] 2022 Jan 14; Vol. 28 (1), pp. 3. Date of Electronic Publication: 2022 Jan 14.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9501023 Publication Model: Electronic Cited Medium: Internet ISSN: 1528-3658 (Electronic) Linking ISSN: 10761551 NLM ISO Abbreviation: Mol Med Subsets: MEDLINE

MeSH Terms: Cognition*, Acetyl-CoA Carboxylase/*metabolism , Eye Proteins/*metabolism , GTP-Binding Protein Regulators/*metabolism , Lipid Droplets/*metabolism , Phosphoproteins/*metabolism , Protein Phosphatase 2C/*metabolism , Sleep Apnea, Obstructive/*etiology , Sleep Apnea, Obstructive/*metabolism , Sterol Regulatory Element Binding Proteins/*metabolism, Animals ; Caffeic Acids/pharmacology ; Cognitive Dysfunction ; Disease Models, Animal ; Hippocampus/metabolism ; Hypoxia/metabolism ; Learning ; Lipid Peroxidation ; MAP Kinase Signaling System ; Memory ; Mice ; Neurons ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/drug therapy

Genome-Wide CRISPR-Cas9 Screening and Identification of Potential Genes Promoting Prostate Cancer Growth and Metastasis.

Authors: Wang W Yuan D Jiang K et al.

Source: Current cancer drug targets [Curr Cancer Drug Targets] 2022; Vol. 23 (1), pp. 71-86.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 101094211 Publication Model: Print Cited Medium: Internet ISSN: 1873-5576 (Electronic) Linking ISSN: 15680096 NLM ISO Abbreviation: Curr Cancer Drug Targets Subsets: MEDLINE

MeSH Terms: Prostatic Neoplasms*/genetics , Prostatic Neoplasms*/pathology , MicroRNAs*/genetics, Humans ; Male ; Mice ; Animals ; CRISPR-Cas Systems ; Cell Line, Tumor ; Early Detection of Cancer ; GTP-Binding Protein Regulators/genetics

Structural Characterization of Phosducin and Its Complex with the 14-3-3 Protein.

Authors: Kacirova M Kosek D Kadek A et al.

Source: The Journal of biological chemistry [J Biol Chem] 2015 Jun 26; Vol. 290 (26), pp. 16246-60. Date of Electronic Publication: 2015 May 13.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

MeSH Terms: 14-3-3 Proteins/*chemistry , 14-3-3 Proteins/*metabolism , Eye Proteins/*chemistry , Eye Proteins/*metabolism , GTP-Binding Protein Regulators/*chemistry , GTP-Binding Protein Regulators/*metabolism , Phosphoproteins/*chemistry , Phosphoproteins/*metabolism, 14-3-3 Proteins/genetics ; Amino Acid Sequence ; Animals ; Binding Sites ; Eye Proteins/genetics ; GTP-Binding Protein Regulators/genetics ; Humans ; Models, Molecular ; Phosphoproteins/genetics ; Phosphorylation ; Protein Binding ; Protein Structure, Tertiary ; Rats

A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance.

Authors: Ageta-Ishihara N Yamazaki M Konno K et al.

Source: Nature communications [Nat Commun] 2015 Dec 10; Vol. 6, pp. 10090. Date of Electronic Publication: 2015 Dec 10.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Cytoskeletal Proteins/*metabolism , GTP-Binding Protein Regulators/*metabolism , GTPase-Activating Proteins/*metabolism , Glutamic Acid/*metabolism , Neuroglia/*metabolism , Septins/*metabolism, Animals ; Cerebellum/cytology ; Cerebellum/metabolism ; Cytoskeletal Proteins/genetics ; Excitatory Amino Acid Transporter 1/genetics ; Excitatory Amino Acid Transporter 1/metabolism ; GTP-Binding Protein Regulators/genetics ; GTPase-Activating Proteins/genetics ; Gene Expression Regulation/physiology ; Male ; Mice ; Mice, Knockout ; Neurons/cytology ; Neurons/metabolism ; RNA-Binding Proteins ; Septins/genetics ; rho GTP-Binding Proteins

Genetic variants associated with cytomegalovirus infection after allogeneic hematopoietic cell transplantation.

Authors: Casto AM Seo S Levine DM et al.

Source: Blood [Blood] 2021 Oct 28; Vol. 138 (17), pp. 1628-1636.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

MeSH Terms: Cytomegalovirus Infections/*genetics , Hematopoietic Stem Cell Transplantation/*adverse effects, ATP Binding Cassette Transporter, Subfamily B/genetics ; Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Cytomegalovirus/isolation & purification ; Cytomegalovirus/physiology ; Cytomegalovirus Infections/etiology ; Female ; GTP-Binding Protein Regulators/genetics ; Genome-Wide Association Study ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Transplantation, Homologous/adverse effects ; Virus Activation ; Young Adult

Cdc42 and its BORG2 and BORG3 effectors control the subcellular localization of septins between actin stress fibers and microtubules.

Authors: Salameh J Cantaloube I Benoit B et al.

Source: Current biology : CB [Curr Biol] 2021 Sep 27; Vol. 31 (18), pp. 4088-4103.e5. Date of Electronic Publication: 2021 Jul 29.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cell Press Country of Publication: England NLM ID: 9107782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0445 (Electronic) Linking ISSN: 09609822 NLM ISO Abbreviation: Curr Biol Subsets: MEDLINE

MeSH Terms: Actins*/metabolism , Septins*/genetics , Septins*/metabolism, GTP-Binding Protein Regulators/metabolism ; Microtubules/metabolism ; Stress Fibers/metabolism

The physiological roles of phosducin: from retinal function to stress-dependent hypertension.

Authors: Beetz N Hein L

Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2011 Feb; Vol. 68 (4), pp. 599-612. Date of Electronic Publication: 2010 Oct 31.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE

MeSH Terms: Eye Proteins/*analysis , Eye Proteins/*metabolism , GTP-Binding Protein Regulators/*analysis , GTP-Binding Protein Regulators/*metabolism , Hypertension/*etiology , Phosphoproteins/*analysis , Phosphoproteins/*metabolism , Retina/*metabolism, Amino Acid Sequence ; Animals ; Blood Pressure ; Eye Proteins/chemistry ; Eye Proteins/genetics ; GTP-Binding Protein Regulators/chemistry ; GTP-Binding Protein Regulators/genetics ; Humans ; Hypertension/metabolism ; Models, Molecular ; Molecular Sequence Data ; Phosphoproteins/chemistry ; Phosphoproteins/genetics ; Phylogeny ; Protein Conformation ; Protein Processing, Post-Translational ; Retina/pathology ; Retinal Diseases/metabolism ; Retinal Diseases/pathology ; Sequence Alignment

Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice.

Authors: Beetz N Harrison MD Brede M et al.

Source: The Journal of clinical investigation [J Clin Invest] 2009 Dec; Vol. 119 (12), pp. 3597-3612.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

MeSH Terms: Eye Proteins/*genetics , Eye Proteins/*physiology , GTP-Binding Protein Regulators/*genetics , GTP-Binding Protein Regulators/*physiology , Hypertension/*physiopathology , Hypertension/*prevention & control , Phosphoproteins/*genetics , Phosphoproteins/*physiology , Sympathetic Nervous System/*physiopathology, Adult ; Aged ; Alleles ; Amino Acid Sequence ; Animals ; Base Sequence ; Blood Pressure/genetics ; Blood Pressure/physiology ; DNA/genetics ; Epinephrine/physiology ; Eye Proteins/chemistry ; Female ; GTP-Binding Protein Regulators/chemistry ; GTP-Binding Protein Regulators/deficiency ; Homozygote ; Humans ; Hypertension/etiology ; Hypertension/genetics ; In Vitro Techniques ; Male ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; Models, Cardiovascular ; Models, Molecular ; Molecular Sequence Data ; Neurosecretory Systems/physiopathology ; Phenotype ; Phosphoproteins/chemistry ; Phosphoproteins/deficiency ; Polymorphism, Single Nucleotide ; Stress, Physiological