Search Results - "GROWTH differentiation factors"

Growth Differentiation Factor 11 Attenuates Photoaging through Ferroptosis Pathway in SZ95 Sebocytes.

Authors: Liu Y Zeng J Liu X et al.

Source: The American journal of pathology [Am J Pathol] 2025 Dec; Vol. 195 (12), pp. 2356-2372. Date of Electronic Publication: 2025 Sep 12.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0370502 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-2191 (Electronic) Linking ISSN: 00029440 NLM ISO Abbreviation: Am J Pathol Subsets: MEDLINE

MeSH Terms: Ferroptosis*/radiation effects , Ferroptosis*/physiology , Growth Differentiation Factors*/metabolism , Growth Differentiation Factors*/genetics , Bone Morphogenetic Proteins*/metabolism , Bone Morphogenetic Proteins*/genetics , Sebaceous Glands*/metabolism , Sebaceous Glands*/radiation effects , Sebaceous Glands*/pathology , Sebaceous Glands*/cytology , Skin Aging*/radiation effects, Humans ; Ultraviolet Rays/adverse effects ; Cell Line ; Apoptosis/radiation effects ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Cellular Senescence/radiation effects

GDF11 alleviates glucocorticoid-induced osteonecrosis of the femoral head by regulating angiogenesis via the PI3K-AKT-eNOS pathway.

Authors: Liu Z Yu L Zhang Y et al.

Source: Communications biology [Commun Biol] 2025 Nov 25; Vol. 8 (1), pp. 1682. Date of Electronic Publication: 2025 Nov 25.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

MeSH Terms: Glucocorticoids*/adverse effects , Nitric Oxide Synthase Type III*/metabolism , Nitric Oxide Synthase Type III*/genetics , Proto-Oncogene Proteins c-akt*/metabolism , Growth Differentiation Factors*/metabolism , Growth Differentiation Factors*/genetics , Bone Morphogenetic Proteins*/metabolism , Bone Morphogenetic Proteins*/genetics , Femur Head Necrosis*/chemically induced , Femur Head Necrosis*/metabolism , Phosphatidylinositol 3-Kinases*/metabolism, Animals ; Humans ; Rats, Sprague-Dawley ; Male ; Rats ; Human Umbilical Vein Endothelial Cells ; Signal Transduction ; Femur Head/pathology ; Neovascularization, Physiologic ; Methylprednisolone ; Angiogenesis

Growth differentiation factor 11 modulates metabolism, mitigating the pro-tumoral behavior provided by M2-like macrophages in hepatocellular carcinoma-derived cells.

Authors: Escobedo-Calvario A Chávez-Rodríguez L Souza-Arroyo V et al.

Source: World journal of gastroenterology [World J Gastroenterol] 2025 Oct 28; Vol. 31 (40), pp. 111307.

Publication Type: Journal Article

Journal Info: Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN: 2219-2840 (Electronic) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE

MeSH Terms: Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/immunology , Carcinoma, Hepatocellular*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/immunology , Liver Neoplasms*/metabolism , Growth Differentiation Factors*/pharmacology , Growth Differentiation Factors*/metabolism , Tumor-Associated Macrophages*/metabolism , Tumor-Associated Macrophages*/immunology , Tumor-Associated Macrophages*/drug effects , Bone Morphogenetic Proteins*/pharmacology , Bone Morphogenetic Proteins*/metabolism , Macrophages*/metabolism, Humans ; Coculture Techniques ; Cell Proliferation/drug effects ; Cell Line, Tumor ; Tumor Microenvironment/immunology ; Tumor Microenvironment/drug effects ; Signal Transduction/drug effects ; Culture Media, Conditioned ; THP-1 Cells ; Cell Differentiation/drug effects ; Recombinant Proteins/pharmacology ; Cell Movement/drug effects

GDF11 alleviates spinal cord injury in rats by modulating microglia polarization through Smad2/3 and MAPK/NFκB signaling pathways.

Authors: Wang Z Zhang Y Liu W et al.

Source: International immunopharmacology [Int Immunopharmacol] 2025 Oct 10; Vol. 163, pp. 115197. Date of Electronic Publication: 2025 Jul 16.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH Terms: Microglia*/drug effects , Microglia*/physiology , Spinal Cord Injuries*/drug therapy , Spinal Cord Injuries*/immunology , Spinal Cord Injuries*/metabolism , Spinal Cord Injuries*/pathology , Growth Differentiation Factors*/therapeutic use , Growth Differentiation Factors*/pharmacology , Bone Morphogenetic Proteins*/therapeutic use , Bone Morphogenetic Proteins*/pharmacology , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/therapeutic use, Animals ; Rats ; NF-kappa B/metabolism ; Rats, Sprague-Dawley ; Smad3 Protein/metabolism ; Signal Transduction/drug effects ; Smad2 Protein/metabolism ; Male ; Macrophages/drug effects ; Disease Models, Animal ; MAP Kinase Signaling System/drug effects

GDF11-secreting cell transplant efficiently ameliorates age-related pulmonary fibrosis.

Authors: Guo L Duchesneau P Jong ED et al.

Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Oct 01; Vol. 33 (10), pp. 5131-5148. Date of Electronic Publication: 2025 Jul 16.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

MeSH Terms: Pulmonary Fibrosis*/therapy , Pulmonary Fibrosis*/metabolism , Pulmonary Fibrosis*/pathology , Pulmonary Fibrosis*/genetics , Pulmonary Fibrosis*/etiology , Growth Differentiation Factors*/genetics , Growth Differentiation Factors*/metabolism , Bone Morphogenetic Proteins*/genetics , Bone Morphogenetic Proteins*/metabolism , Aging*/genetics, Animals ; Mice ; Disease Models, Animal ; Bleomycin ; Humans ; Mouse Embryonic Stem Cells/metabolism ; Mouse Embryonic Stem Cells/transplantation

GDF-11 stimulates human extravillous trophoblast cell invasion by upregulating ANGPTL4 expression.

Authors: Wu Z Fang L Dang X et al.

Source: Reproduction (Cambridge, England) [Reproduction] 2025 Oct 13; Vol. 170 (5). Date of Electronic Publication: 2025 Oct 13 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Published for the Society for Reproduction and Fertility by BioScientifica Country of Publication: England NLM ID: 100966036 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1741-7899 (Electronic) Linking ISSN: 14701626 NLM ISO Abbreviation: Reproduction Subsets: MEDLINE

MeSH Terms: Trophoblasts*/metabolism , Trophoblasts*/pathology , Trophoblasts*/drug effects , Angiopoietin-Like Protein 4*/metabolism , Angiopoietin-Like Protein 4*/genetics , Bone Morphogenetic Proteins*/metabolism , Bone Morphogenetic Proteins*/genetics , Bone Morphogenetic Proteins*/pharmacology , Cell Movement* , Growth Differentiation Factors*/metabolism, Humans ; Female ; Pregnancy ; Up-Regulation ; Signal Transduction ; Receptor, Transforming Growth Factor-beta Type I/metabolism ; Receptor, Transforming Growth Factor-beta Type I/genetics ; Smad3 Protein/metabolism ; Placentation ; Pre-Eclampsia/metabolism ; Pre-Eclampsia/pathology ; Pre-Eclampsia/genetics ; Adult ; Activin Receptors, Type I/metabolism ; Extravillous Trophoblasts

Growth differentiation factor 11 attenuates sepsis-associated acute kidney injury by reducing inflammation and coagulation via PGC-1α/Nrf2 activation.

Authors: Wang HW Wu MM Zhu MM et al.

Source: Cellular & molecular biology letters [Cell Mol Biol Lett] 2025 Aug 28; Vol. 30 (1), pp. 102. Date of Electronic Publication: 2025 Aug 28.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9607427 Publication Model: Electronic Cited Medium: Internet ISSN: 1689-1392 (Electronic) Linking ISSN: 14258153 NLM ISO Abbreviation: Cell Mol Biol Lett Subsets: MEDLINE

MeSH Terms: Acute Kidney Injury*/etiology , Acute Kidney Injury*/metabolism , Acute Kidney Injury*/pathology , Sepsis*/complications , Sepsis*/metabolism , Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha*/metabolism , NF-E2-Related Factor 2*/metabolism , Growth Differentiation Factors*/metabolism , Growth Differentiation Factors*/genetics , Growth Differentiation Factors*/pharmacology , Inflammation*/pathology , Inflammation*/metabolism , Bone Morphogenetic Proteins*/metabolism , Bone Morphogenetic Proteins*/genetics , Bone Morphogenetic Proteins*/pharmacology, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Signal Transduction ; Kidney/pathology ; Kidney/metabolism

GDF11 downregulates FOXP3 in T-cell acute lymphoblastic leukemia-derived cells and associates with restraining aggressiveness.

Authors: SáNCHEZ-RODRíGUEZ M Lazzarini-Lechuga R Souza-Arroyo V et al.

Source: Oncology research [Oncol Res] 2025 Jul 18; Vol. 33 (8), pp. 2075-2084. Date of Electronic Publication: 2025 Jul 18 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Tech Science Press Country of Publication: United States NLM ID: 9208097 Publication Model: eCollection Cited Medium: Internet ISSN: 1555-3906 (Electronic) Linking ISSN: 09650407 NLM ISO Abbreviation: Oncol Res Subsets: MEDLINE

MeSH Terms: Growth Differentiation Factors*/metabolism , Growth Differentiation Factors*/genetics , Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/pathology , Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/metabolism , Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/genetics , Forkhead Transcription Factors*/genetics , Forkhead Transcription Factors*/metabolism , Bone Morphogenetic Proteins*/metabolism , Bone Morphogenetic Proteins*/genetics, Humans ; Jurkat Cells ; Cell Movement ; Cell Proliferation ; Down-Regulation ; Reactive Oxygen Species/metabolism ; Mitochondria/metabolism

Activated GDF11/8 subforms predict cardiovascular events and mortality in humans.

Authors: Walker RG Kato T Ben Driss L et al.

Source: Nature communications [Nat Commun] 2025 Jul 15; Vol. 16 (1), pp. 6534. Date of Electronic Publication: 2025 Jul 15.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Growth Differentiation Factors*/blood , Growth Differentiation Factors*/metabolism , Cardiovascular Diseases*/mortality , Cardiovascular Diseases*/blood , Bone Morphogenetic Proteins*/blood , Bone Morphogenetic Proteins*/metabolism , Myostatin*/blood , Myostatin*/metabolism , Myostatin*/genetics, Humans ; Male ; Female ; Middle Aged ; Aptamers, Nucleotide/metabolism ; Aged ; Risk Factors ; Biomarkers/blood

GDF11 Regulates M1 and M2 Polarization of BV2 Microglial Cells via p38 MAPK Signaling Pathway.

Authors: Zhao X Qin R Li G et al.

Source: Molecular neurobiology [Mol Neurobiol] 2025 Jul; Vol. 62 (7), pp. 9290-9305. Date of Electronic Publication: 2025 Mar 18.

Publication Type: Journal Article

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH Terms: Microglia*/metabolism , Microglia*/drug effects , Growth Differentiation Factors*/metabolism , Growth Differentiation Factors*/pharmacology , p38 Mitogen-Activated Protein Kinases*/metabolism , MAP Kinase Signaling System*/drug effects , MAP Kinase Signaling System*/physiology , Cell Polarity*/drug effects , Bone Morphogenetic Proteins*/metabolism , Bone Morphogenetic Proteins*/pharmacology, Animals ; Mice ; Cell Line ; Lipopolysaccharides/pharmacology ; Cell Proliferation/drug effects ; Cell Movement/drug effects ; Apoptosis/drug effects ; Phenotype

GDF11 protects against mitochondrial-dysfunction-dependent NLRP3 inflammasome activation to attenuate osteoarthritis.

Authors: Zhang P Zhai H Zhang S et al.

Source: Journal of advanced research [J Adv Res] 2025 Jul; Vol. 73, pp. 501-515. Date of Electronic Publication: 2024 Aug 03.

Publication Type: Journal Article

Journal Info: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE

MeSH Terms: NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , NLR Family, Pyrin Domain-Containing 3 Protein*/genetics , Growth Differentiation Factors*/metabolism , Growth Differentiation Factors*/genetics , Growth Differentiation Factors*/pharmacology , Osteoarthritis*/metabolism , Osteoarthritis*/pathology , Osteoarthritis*/drug therapy , Inflammasomes*/metabolism , Bone Morphogenetic Proteins*/metabolism , Bone Morphogenetic Proteins*/genetics , Bone Morphogenetic Proteins*/pharmacology , Mitochondria*/metabolism, Animals ; Mice ; Chondrocytes/metabolism ; Chondrocytes/drug effects ; Mice, Knockout ; Humans ; Tumor Necrosis Factor-alpha/metabolism ; Disease Models, Animal ; Male ; Mice, Inbred C57BL ; Cells, Cultured

GDF11 Alleviates Vascular Calcification in VitD 3 -Overloaded Mice Through Inhibition of Inflammatory NF-κB Signal.

Authors: Huang J Liang Q Ye Y et al.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Jun 15; Vol. 39 (11), pp. e70677.

Publication Type: Journal Article

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH Terms: Growth Differentiation Factors*/metabolism , Growth Differentiation Factors*/genetics , Vascular Calcification*/metabolism , Vascular Calcification*/pathology , Vascular Calcification*/chemically induced , NF-kappa B*/metabolism , Bone Morphogenetic Proteins*/metabolism , Bone Morphogenetic Proteins*/genetics , Signal Transduction*/drug effects , Cholecalciferol*, Animals ; Mice ; Rats ; Male ; Humans ; Muscle, Smooth, Vascular/metabolism ; Muscle, Smooth, Vascular/pathology ; Mice, Inbred C57BL ; Myocytes, Smooth Muscle/metabolism ; Inflammation/metabolism ; Cells, Cultured

The influence of the geroprotective cytokine on the transcriptome of young and senescent mesenchymal stem cells.

Authors: Kondratyeva LG Matveeva DK Ezdakova MI et al.

Source: BMC research notes [BMC Res Notes] 2025 Apr 24; Vol. 18 (1), pp. 195. Date of Electronic Publication: 2025 Apr 24.

Publication Type: Journal Article

Journal Info: Publisher: Biomed Central Country of Publication: England NLM ID: 101462768 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-0500 (Electronic) Linking ISSN: 17560500 NLM ISO Abbreviation: BMC Res Notes Subsets: MEDLINE

MeSH Terms: Mesenchymal Stem Cells*/metabolism , Mesenchymal Stem Cells*/drug effects , Mesenchymal Stem Cells*/cytology , Transcriptome*/drug effects , Cellular Senescence*/drug effects , Cellular Senescence*/genetics , Growth Differentiation Factors*/pharmacology , Growth Differentiation Factors*/metabolism , Bone Morphogenetic Proteins*/pharmacology , Bone Morphogenetic Proteins*/genetics , Bone Morphogenetic Proteins*/metabolism , Aging*, Humans ; Cells, Cultured

GDF11 alleviates cardiac ischemia/reperfusion injury by suppressing the mtDNA damage-inflammatory response axis.

Authors: Zhao D Wang Z Chen Y et al.

Source: European journal of pharmacology [Eur J Pharmacol] 2025 Apr 15; Vol. 993, pp. 177392. Date of Electronic Publication: 2025 Feb 15.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH Terms: Myocardial Reperfusion Injury*/pathology , Myocardial Reperfusion Injury*/metabolism , Myocardial Reperfusion Injury*/genetics , Myocardial Reperfusion Injury*/drug therapy , Growth Differentiation Factors*/pharmacology , Growth Differentiation Factors*/genetics , Growth Differentiation Factors*/therapeutic use , DNA, Mitochondrial*/genetics , DNA, Mitochondrial*/metabolism , DNA, Mitochondrial*/drug effects , Bone Morphogenetic Proteins*/pharmacology , Bone Morphogenetic Proteins*/therapeutic use , Bone Morphogenetic Proteins*/genetics , DNA Damage*/drug effects, Animals ; Mice ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Male ; Rats ; Cell Line ; Mice, Inbred C57BL ; Reactive Oxygen Species/metabolism ; Inflammasomes/metabolism ; Myocardial Infarction/pathology ; Inflammation ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Disease Models, Animal

Recombinant GDF11 Promotes Recovery in a Rat Permanent Ischemia Model of Subacute Stroke.

Authors: Cohen OS Sinha M Wang Y et al.

Source: Stroke [Stroke] 2025 Apr; Vol. 56 (4), pp. 996-1009. Date of Electronic Publication: 2025 Feb 05.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0235266 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4628 (Electronic) Linking ISSN: 00392499 NLM ISO Abbreviation: Stroke Subsets: MEDLINE

MeSH Terms: Growth Differentiation Factors*/pharmacology , Growth Differentiation Factors*/therapeutic use , Recovery of Function*/drug effects , Bone Morphogenetic Proteins*/pharmacology , Bone Morphogenetic Proteins*/therapeutic use , Stroke*/drug therapy , Ischemic Stroke*/drug therapy , Brain Ischemia*/drug therapy, Animals ; Rats, Sprague-Dawley ; Rats ; Male ; Disease Models, Animal ; Recombinant Proteins/pharmacology ; Recombinant Proteins/therapeutic use

Comprehensive analysis of GDFs as therapeutic targets and prognosis biomarkers in gastric cancer.

Authors: Zhu M Hong J Liu X et al.

Source: Medicine [Medicine (Baltimore)] 2025 Mar 28; Vol. 104 (13), pp. e41976.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

MeSH Terms: Stomach Neoplasms*/genetics , Stomach Neoplasms*/mortality , Stomach Neoplasms*/metabolism , Stomach Neoplasms*/therapy , Biomarkers, Tumor*/genetics , Biomarkers, Tumor*/metabolism , Growth Differentiation Factors*/genetics , Growth Differentiation Factors*/metabolism, Humans ; Prognosis ; Gene Expression Profiling ; Growth Differentiation Factor 15 ; Gene Expression Regulation, Neoplastic

gdf11 is required for pronephros/cloaca development through targeting TGF-β signaling.

Authors: Tian X Yao W Tan J et al.

Source: Scientific reports [Sci Rep] 2025 Mar 07; Vol. 15 (1), pp. 8052. Date of Electronic Publication: 2025 Mar 07.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Growth Differentiation Factors*/metabolism , Growth Differentiation Factors*/genetics , Bone Morphogenetic Proteins*/genetics , Bone Morphogenetic Proteins*/metabolism , Signal Transduction* , Transforming Growth Factor beta*/metabolism , Kidney*/embryology , Kidney*/metabolism , Zebrafish Proteins*/genetics , Zebrafish Proteins*/metabolism, Animals ; Zebrafish/embryology ; Zebrafish/genetics ; Mice ; Gene Expression Regulation, Developmental ; Organogenesis/genetics

Gdf11 regulates left-right asymmetry development through TGF-β signal.

Authors: Yao W Wei Z Tian X et al.

Source: Cell proliferation [Cell Prolif] 2025 Mar; Vol. 58 (3), pp. e13765. Date of Electronic Publication: 2024 Oct 15.

Publication Type: Journal Article

Journal Info: Publisher: Published for the Cell Kinetics Society, the European Study Group for Cell Proliferation, and the International Cell Cycle Society by Blackwell Scientific Publications Country of Publication: England NLM ID: 9105195 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2184 (Electronic) Linking ISSN: 09607722 NLM ISO Abbreviation: Cell Prolif Subsets: MEDLINE

MeSH Terms: Zebrafish*/embryology , Zebrafish*/metabolism , Zebrafish*/genetics , Growth Differentiation Factors*/metabolism , Growth Differentiation Factors*/genetics , Transforming Growth Factor beta*/metabolism , Bone Morphogenetic Proteins*/metabolism , Bone Morphogenetic Proteins*/genetics , Body Patterning* , Zebrafish Proteins*/metabolism , Zebrafish Proteins*/genetics, Animals ; Signal Transduction ; Gene Expression Regulation, Developmental

GDF11 Mitigates Neuropathic Pain via Regulation of Microglial Polarization and Neuroinflammation through TGF-βR1/SMAD2/NF-κB Pathway in Male Mice.

Authors: Liu T Zhang L

Source: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2025 Feb 12; Vol. 20 (1), pp. 20. Date of Electronic Publication: 2025 Feb 12.

Publication Type: Journal Article

Journal Info: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 101256586 Publication Model: Electronic Cited Medium: Internet ISSN: 1557-1904 (Electronic) Linking ISSN: 15571890 NLM ISO Abbreviation: J Neuroimmune Pharmacol Subsets: MEDLINE

MeSH Terms: Microglia*/drug effects , Microglia*/metabolism , Bone Morphogenetic Proteins*/pharmacology , Bone Morphogenetic Proteins*/therapeutic use , Growth Differentiation Factors*/pharmacology , Growth Differentiation Factors*/therapeutic use , Neuralgia*/metabolism , Neuralgia*/drug therapy , Smad2 Protein*/metabolism , Neuroinflammatory Diseases*/metabolism , Neuroinflammatory Diseases*/drug therapy , Receptor, Transforming Growth Factor-beta Type I*/metabolism, Animals ; Male ; Mice ; NF-kappa B/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Cell Polarity/drug effects ; Cell Polarity/physiology ; Mice, Inbred C57BL

Protogenin facilitates trunk-to-tail HOX code transition via modulating GDF11/SMAD2 signaling in mammalian embryos.

Authors: Hung YS Lin WM Wang YC et al.

Source: Communications biology [Commun Biol] 2024 Dec 19; Vol. 7 (1), pp. 1669. Date of Electronic Publication: 2024 Dec 19.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

MeSH Terms: Smad2 Protein*/metabolism , Smad2 Protein*/genetics , Signal Transduction* , Bone Morphogenetic Proteins*/metabolism , Bone Morphogenetic Proteins*/genetics , Mice, Knockout* , Growth Differentiation Factors*/metabolism , Growth Differentiation Factors*/genetics , Gene Expression Regulation, Developmental*, Animals ; Mice ; Embryo, Mammalian/metabolism ; Homeodomain Proteins/metabolism ; Homeodomain Proteins/genetics ; Humans ; Body Patterning/genetics ; Embryonic Development/genetics ; Epidermal Growth Factor ; Membrane Glycoproteins ; Neoplasm Proteins