Suchergebnisse - "GLYCOCONJUGATES"

Gold-Dithiocarbamato Glycoconjugates as Potential Anticancer Agents: Design, Physico-Chemical Characterization, and In Vitro Biological Activity.

Autoren: Pettenuzzo A Wölker J Marchiò L et al.

Quelle: Chembiochem : a European journal of chemical biology [Chembiochem] 2025 Nov 17; Vol. 26 (22), pp. e202500447. Date of Electronic Publication: 2025 Aug 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

MeSH-Schlagworte: Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Glycoconjugates*/chemistry , Glycoconjugates*/pharmacology , Glycoconjugates*/chemical synthesis , Gold*/chemistry , Gold*/pharmacology , Drug Design*, Humans ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Crystallography, X-Ray

Monovalent glycoconjugates of sulforaphane prevent inflammation induced by lipopolysaccharide in human dendritic cells by inhibiting NF-ĸB signalling pathway.

Autoren: Leiva-Castro C Múnera-Rodríguez AM Martínez-Bailén M et al.

Quelle: British journal of pharmacology [Br J Pharmacol] 2025 Nov; Vol. 182 (21), pp. 5157-5172. Date of Electronic Publication: 2025 Jun 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Isothiocyanates*/pharmacology , Isothiocyanates*/chemistry , Dendritic Cells*/drug effects , Dendritic Cells*/metabolism , Dendritic Cells*/immunology , Glycoconjugates*/pharmacology , Glycoconjugates*/chemistry , NF-kappa B*/metabolism , NF-kappa B*/antagonists & inhibitors , Inflammation*/chemically induced , Inflammation*/prevention & control , Inflammation*/metabolism , Inflammation*/drug therapy , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry, Humans ; Sulfoxides ; Lipopolysaccharides/pharmacology ; Signal Transduction/drug effects ; Cells, Cultured

Targeting galectin-4 with glycoconjugates of varying architectures: a multivalency étude with accent on anti-tumor effect and protection against apoptosis.

Autoren: Vopálenská A Balogová S Hovorková M et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118149. Date of Electronic Publication: 2025 Sep 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Apoptosis*/drug effects , Glycoconjugates*/pharmacology , Glycoconjugates*/chemistry , Glycoconjugates*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Galectin 4*/antagonists & inhibitors , Galectin 4*/metabolism, Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Cell Proliferation/drug effects ; Cell Line, Tumor

Rhamno-oligosaccharide-based glycoconjugates as promising vaccine candidates against Group A Streptococcus.

Autoren: Wang G Sun C Zhao J et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Dec; Vol. 333 (Pt 1), pp. 148785. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Glycoconjugates*/chemistry , Glycoconjugates*/immunology , Glycoconjugates*/pharmacology , Streptococcus pyogenes*/immunology , Streptococcal Vaccines*/immunology , Streptococcal Vaccines*/chemistry , Oligosaccharides*/chemistry , Oligosaccharides*/immunology , Streptococcal Infections*/prevention & control , Streptococcal Infections*/immunology , Streptococcal Infections*/microbiology, Humans ; Animals ; Mice ; Female

Probing the Broad-Spectrum Virus-Neutralizing Epitopes Using the High-Density Oligomannose-Conjugates and Carbohydrate Microarrays.

Autoren: Toonstra C Wu L Wang LX et al.

Quelle: Bioconjugate chemistry [Bioconjug Chem] 2025 Nov 19; Vol. 36 (11), pp. 2370-2380. Date of Electronic Publication: 2025 Oct 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE

MeSH-Schlagworte: Epitopes*/immunology , Epitopes*/chemistry , SARS-CoV-2*/immunology , Mannose*/chemistry , Mannose*/immunology , Glycoconjugates*/chemistry , Glycoconjugates*/immunology , Oligosaccharides*/immunology , Oligosaccharides*/chemistry , Antibodies, Neutralizing*/immunology, Animals ; Epitope Mapping/methods ; Microarray Analysis/methods ; COVID-19/immunology

Antiadhesive glycoconjugate metal complexes targeting pathogens Pseudomonas aeruginosa and Candida albicans .

Autoren: Wojtczak K Gillon E Bura D et al.

Quelle: Organic & biomolecular chemistry [Org Biomol Chem] 2025 Nov 05; Vol. 23 (43), pp. 9950-9964. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: MEDLINE

MeSH-Schlagworte: Candida albicans*/drug effects , Candida albicans*/physiology , Pseudomonas aeruginosa*/drug effects , Pseudomonas aeruginosa*/physiology , Glycoconjugates*/chemistry , Glycoconjugates*/pharmacology , Coordination Complexes*/pharmacology , Coordination Complexes*/chemistry , Coordination Complexes*/chemical synthesis , Antifungal Agents*/pharmacology , Antifungal Agents*/chemistry , Antifungal Agents*/chemical synthesis, Biofilms/drug effects ; Humans ; Microbial Sensitivity Tests ; Cell Adhesion/drug effects ; Molecular Structure

Immunogenicity evaluation of semisynthetic α-(1 → 3)-D,D-heptoglycan conjugates for Helicobacter pylori vaccine development.

Autoren: Zou X Xiao L Tian G et al.

Quelle: Carbohydrate research [Carbohydr Res] 2025 Nov; Vol. 557, pp. 109650. Date of Electronic Publication: 2025 Aug 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0043535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-426X (Electronic) Linking ISSN: 00086215 NLM ISO Abbreviation: Carbohydr Res Subsets: MEDLINE

MeSH-Schlagworte: Helicobacter pylori*/immunology , Helicobacter pylori*/chemistry , Bacterial Vaccines*/immunology , Bacterial Vaccines*/chemistry , Glycoconjugates*/chemistry , Glycoconjugates*/immunology , Glycoconjugates*/chemical synthesis , Vaccine Development*, Rabbits ; Animals ; Bacterial Proteins/chemistry ; Bacterial Proteins/immunology ; Lipopolysaccharides/immunology ; Lipopolysaccharides/chemistry ; Helicobacter Infections/prevention & control ; Helicobacter Infections/immunology

Design, synthesis, and in-silico studies of hydrazide-hydrazone linked coumarin glycoconjugates with possible antiproliferative activity.

Autoren: Kumar R Chauhan D Singh VK et al.

Quelle: Carbohydrate research [Carbohydr Res] 2025 Oct; Vol. 556, pp. 109620. Date of Electronic Publication: 2025 Jul 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0043535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-426X (Electronic) Linking ISSN: 00086215 NLM ISO Abbreviation: Carbohydr Res Subsets: MEDLINE

MeSH-Schlagworte: Hydrazones*/chemistry , Hydrazones*/pharmacology , Coumarins*/chemistry , Coumarins*/pharmacology , Coumarins*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Drug Design* , Glycoconjugates*/chemistry , Glycoconjugates*/pharmacology , Glycoconjugates*/chemical synthesis , Hydrazines*/chemistry , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry, Humans ; Cell Proliferation/drug effects ; Molecular Docking Simulation ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Structure-Activity Relationship ; Molecular Structure ; ErbB Receptors/metabolism ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/chemistry

Synthesis, characterization, and in vitro hypolipidemic mechanisms of sugar-SA triazole conjugates as potent pancreatic lipase inhibitors.

Autoren: Cao R Li J Sun Y et al.

Quelle: Food chemistry [Food Chem] 2025 Oct 01; Vol. 488, pp. 144876. Date of Electronic Publication: 2025 May 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Hypolipidemic Agents*/chemical synthesis , Hypolipidemic Agents*/chemistry , Hypolipidemic Agents*/pharmacology , Lipase*/antagonists & inhibitors , Lipase*/chemistry , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Triazoles*/chemical synthesis , Triazoles*/chemistry , Triazoles*/pharmacology , Gallic Acid*/chemistry , Gallic Acid*/pharmacology , Gallic Acid*/analogs & derivatives , Glycoconjugates*/chemical synthesis , Glycoconjugates*/chemistry , Glycoconjugates*/pharmacology, Click Chemistry/methods ; Solubility ; Cholesterol/chemistry ; Bile Acids and Salts/chemistry ; Glucose/chemistry ; Hydrophobic and Hydrophilic Interactions ; Molecular Docking Simulation ; Protein Structure, Secondary ; Protein Structure, Tertiary

Elucidating the Critical Attributes of Sodium Triacetoxyborohydride to Tune Glycoconjugation via Reductive Amination.

Autoren: Smith ML Sirajuddin S Santiago-Miranda AN et al.

Quelle: Bioconjugate chemistry [Bioconjug Chem] 2025 Nov 19; Vol. 36 (11), pp. 2381-2388. Date of Electronic Publication: 2025 Oct 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE

MeSH-Schlagworte: Borohydrides*/chemistry , Glycoconjugates*/chemistry, Amination ; Oxidation-Reduction ; Vaccines, Conjugate/chemistry

Sialoglycoconjugate profiling of human choroid, retinal pigment epithelium, and basal laminar deposits.

Autoren: Navratil EM Wenzel PA Flamme-Wiese MJ et al.

Quelle: Experimental eye research [Exp Eye Res] 2025 Nov; Vol. 260, pp. 110618. Date of Electronic Publication: 2025 Sep 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: England NLM ID: 0370707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0007 (Electronic) Linking ISSN: 00144835 NLM ISO Abbreviation: Exp Eye Res Subsets: MEDLINE

MeSH-Schlagworte: Retinal Pigment Epithelium*/metabolism , Choroid*/metabolism , Macular Degeneration*/metabolism , Glycoconjugates*/metabolism, Humans ; Aged ; Aged, 80 and over ; Female ; Male ; Plant Lectins/metabolism ; Middle Aged ; Ribosome Inactivating Proteins

Mass spectrometric analysis of lipid-linked oligosaccharide heterogeneity in genetically modified E. coli used for glycoconjugate bacterial vaccine production.

Autoren: Palubeckaite I Moran AB Cramer DAT et al.

Quelle: Carbohydrate polymers [Carbohydr Polym] 2025 Oct 15; Vol. 366, pp. 123928. Date of Electronic Publication: 2025 Jun 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8307156 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1344 (Electronic) Linking ISSN: 01448617 NLM ISO Abbreviation: Carbohydr Polym Subsets: MEDLINE

MeSH-Schlagworte: Escherichia coli*/genetics , Escherichia coli*/chemistry , Escherichia coli*/metabolism , Glycoconjugates*/chemistry , Lipopolysaccharides*/chemistry , Bacterial Vaccines*/chemistry , Oligosaccharides*/chemistry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods ; O Antigens/chemistry ; Vaccines, Conjugate/chemistry ; Hydrolysis ; Tandem Mass Spectrometry

Recent advances in fluorescent glycoconjugate probes for biosensing, bioimaging and targeted photodynamic therapy.

Autoren: Han HH Hu XL He XP

Quelle: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2025 Oct 07; Vol. 61 (81), pp. 15735-15758. Date of Electronic Publication: 2025 Oct 07.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE

MeSH-Schlagworte: Fluorescent Dyes*/chemistry , Glycoconjugates*/chemistry , Photochemotherapy* , Biosensing Techniques*/methods, Humans ; Optical Imaging ; Neoplasms/drug therapy ; Neoplasms/diagnostic imaging ; Animals

Recent Advances in the Development of Metal-Glycoconjugates for Medicinal Applications.

Autoren: Brescia F Titilas I Cacciapuoti S et al.

Quelle: Molecules (Basel, Switzerland) [Molecules] 2025 Aug 29; Vol. 30 (17). Date of Electronic Publication: 2025 Aug 29.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

MeSH-Schlagworte: Glycoconjugates*/chemistry , Glycoconjugates*/pharmacology , Glycoconjugates*/therapeutic use , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Neoplasms*/drug therapy , Neoplasms*/metabolism , Metals*/chemistry, Humans ; Animals ; Glucose/metabolism ; Drug Delivery Systems

Anti-adhesive glycoconjugates against Candida albicans : effect of the aromatic substituents in anti-fungal activity.

Autoren: Kessie K Doherty K Moreno L et al.

Quelle: Future medicinal chemistry [Future Med Chem] 2025 Jul; Vol. 17 (14), pp. 1659-1674. Date of Electronic Publication: 2025 Aug 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Candida albicans*/drug effects , Candida albicans*/physiology , Glycoconjugates*/pharmacology , Glycoconjugates*/chemistry , Glycoconjugates*/chemical synthesis , Antifungal Agents*/pharmacology , Antifungal Agents*/chemistry , Antifungal Agents*/chemical synthesis, Structure-Activity Relationship ; Humans ; Microbial Sensitivity Tests ; Cell Adhesion/drug effects ; Epithelial Cells/microbiology ; Epithelial Cells/drug effects

Glycoconjugation of Quinoline as an Effective Strategy for Selective Inhibition of mTORC1.

Autoren: Palit S Das T Majhi B et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Sep 25; Vol. 68 (18), pp. 19041-19061. Date of Electronic Publication: 2025 Sep 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Mechanistic Target of Rapamycin Complex 1*/antagonists & inhibitors , Mechanistic Target of Rapamycin Complex 1*/metabolism , Quinolines*/chemistry , Quinolines*/pharmacology , Quinolines*/chemical synthesis , Glycoconjugates*/pharmacology , Glycoconjugates*/chemistry , Glycoconjugates*/chemical synthesis, Animals ; Humans ; Mice ; Structure-Activity Relationship ; Autophagy/drug effects

Recent advances on the syntheses of oligosaccharides and the corresponding glycoconjugates towards development of vaccine candidates against invasive Neisseria meningitidis strains.

Autoren: Basu N Mukherjee MM Ghosh R

Quelle: Carbohydrate research [Carbohydr Res] 2025 Sep; Vol. 555, pp. 109545. Date of Electronic Publication: 2025 May 29.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0043535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-426X (Electronic) Linking ISSN: 00086215 NLM ISO Abbreviation: Carbohydr Res Subsets: MEDLINE

MeSH-Schlagworte: Glycoconjugates*/chemical synthesis , Glycoconjugates*/chemistry , Glycoconjugates*/immunology , Neisseria meningitidis*/immunology , Oligosaccharides*/chemical synthesis , Oligosaccharides*/chemistry , Oligosaccharides*/immunology , Meningococcal Vaccines*/chemistry , Meningococcal Vaccines*/chemical synthesis , Meningococcal Vaccines*/immunology, Humans

An insect β1-3-galactosyltransferase enables efficient synthesis of multi-sites T antigen glycoconjugates.

Autoren: Rong Y Mao W Wang M et al.

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Sep; Vol. 164, pp. 108870. Date of Electronic Publication: 2025 Aug 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Galactosyltransferases*/metabolism , Galactosyltransferases*/chemistry , Galactosyltransferases*/genetics , Glycoconjugates*/chemistry , Glycoconjugates*/biosynthesis , Drosophila melanogaster*/enzymology , Antigens, Tumor-Associated, Carbohydrate*/chemistry , Antigens, Tumor-Associated, Carbohydrate*/metabolism, Animals ; Molecular Structure ; Humans

Growing impact of 'Click chemistry' inspired glycohybrid 1,2,3-Triazoles in organic synthesis.

Autoren: Singh SK Sharma A Mishra N et al.

Quelle: Carbohydrate research [Carbohydr Res] 2025 Sep; Vol. 555, pp. 109571. Date of Electronic Publication: 2025 Jun 09.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0043535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-426X (Electronic) Linking ISSN: 00086215 NLM ISO Abbreviation: Carbohydr Res Subsets: MEDLINE

MeSH-Schlagworte: Triazoles*/chemistry , Click Chemistry* , Glycoconjugates*/chemistry , Glycoconjugates*/chemical synthesis, Catalysis ; Chemistry Techniques, Synthetic ; Stereoisomerism ; Molecular Structure

Anticoronavirus Activity of Uridine Glycoconjugates Containing a 1,2,3-Triazole Moiety.

Autoren: Graul M Brzuska G Wisniewska E et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Aug 28; Vol. 68 (16), pp. 17859-17873. Date of Electronic Publication: 2025 Aug 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Antiviral Agents*/chemical synthesis , Triazoles*/chemistry , Triazoles*/pharmacology , Glycoconjugates*/pharmacology , Glycoconjugates*/chemistry , Glycoconjugates*/chemical synthesis , Uridine*/pharmacology , Uridine*/chemistry , Uridine*/analogs & derivatives, Animals ; Humans ; SARS-CoV-2/drug effects ; Mice ; Murine hepatitis virus/drug effects ; Virus Replication/drug effects ; Chlorocebus aethiops ; Structure-Activity Relationship ; Vero Cells ; COVID-19 Drug Treatment