Výsledky vyhledávání - "GLIOSIS"

Eye-Targeted A20 Gene Therapy Alleviates Ischemic Retinopathy by Reducing Pathologic Neovascularization, Gliosis, and Neuronal Apoptosis.

Autoři: Essayagh S Aridi T Turunen T a další

Zdroj: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Nov 30; Vol. 39 (22), pp. e71226.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

Výrazy ze slovníku MeSH: Apoptosis* , Genetic Therapy*/methods , Gliosis*/therapy , Gliosis*/genetics , Gliosis*/pathology , Gliosis*/metabolism , Tumor Necrosis Factor alpha-Induced Protein 3*/genetics , Tumor Necrosis Factor alpha-Induced Protein 3*/metabolism , Neurons*/pathology , Neurons*/metabolism , Ischemia*/therapy , Ischemia*/genetics , Ischemia*/pathology , Neovascularization, Pathologic*/therapy , Neovascularization, Pathologic*/genetics , Retinal Neovascularization*/therapy , Retinal Neovascularization*/genetics , Retinal Neovascularization*/pathology , Retinal Diseases*/therapy , Retinal Diseases*/genetics , Retinal Diseases*/pathology, Animals ; Humans ; Mice ; Mice, Inbred C57BL ; Retina/metabolism ; Retina/pathology

Reactive astrogliosis and microgliosis in animal models of focally induced seizures: A systematic review and multivariate multilevel meta-analysis.

Autoři: Egilmez A Yen SF Pauletti A a další

Zdroj: Epilepsy & behavior : E&B [Epilepsy Behav] 2025 Nov; Vol. 172, pp. 110694. Date of Electronic Publication: 2025 Sep 05.

Způsob vydávání: Journal Article; Meta-Analysis; Systematic Review

Informace o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 100892858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-5069 (Electronic) Linking ISSN: 15255050 NLM ISO Abbreviation: Epilepsy Behav Subsets: MEDLINE

Výrazy ze slovníku MeSH: Gliosis*/etiology , Gliosis*/pathology , Microglia*/pathology , Seizures*/pathology , Seizures*/chemically induced, Animals ; Astrocytes/pathology ; Disease Models, Animal ; Multilevel Analysis

Challenges in the management of epilepsy associated with posterior gliosis secondary to perinatal brain injury.

Autoři: Udani V; Department of Pediatrics, PD Hinduja National Hospital & Medical Research Center, Veer Savarkar Marg, Mahim, Mumbai 400020, India. Electronic address: vrajesh.udani@gmail.com.

Zdroj: Epilepsy & behavior : E&B [Epilepsy Behav] 2025 Oct; Vol. 171, pp. 110645. Date of Electronic Publication: 2025 Aug 27.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 100892858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-5069 (Electronic) Linking ISSN: 15255050 NLM ISO Abbreviation: Epilepsy Behav Subsets: MEDLINE

Výrazy ze slovníku MeSH: Brain Injuries*/complications , Drug Resistant Epilepsy*/etiology , Drug Resistant Epilepsy*/therapy , Epilepsy*/etiology , Epilepsy*/therapy , Gliosis*/etiology , Gliosis*/complications , Gliosis*/therapy, Humans ; Anticonvulsants/therapeutic use ; Electroencephalography ; Magnetic Resonance Imaging

Perinatal Ethanol Exposure Induces Astrogliosis and Decreases GRP55/PEA-Mediated Neuroprotection in Hippocampal Astrocytes of the 3×Tg Alzheimer's Animal Model.

Autoři: Rodríguez-Pozo M Pacheco-Sánchez B Ben Rabaa M a další

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 18; Vol. 26 (22). Date of Electronic Publication: 2025 Nov 18.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Astrocytes*/metabolism , Astrocytes*/drug effects , Astrocytes*/pathology , Ethanol*/adverse effects , Ethanol*/toxicity , Hippocampus*/metabolism , Hippocampus*/pathology , Hippocampus*/drug effects , Alzheimer Disease*/metabolism , Alzheimer Disease*/pathology , Alzheimer Disease*/genetics , Gliosis*/metabolism , Gliosis*/pathology , Gliosis*/chemically induced , Prenatal Exposure Delayed Effects*/metabolism , Prenatal Exposure Delayed Effects*/pathology , Neuroprotection*/drug effects, Animals ; Female ; Pregnancy ; Disease Models, Animal ; Male ; Mice ; Mice, Transgenic ; Cells, Cultured ; Receptors, Cannabinoid/metabolism

Long intervals between repetitive concussions reduce risk of cognitive impairment and limit microglial activation, astrogliosis, and tauopathy in adolescent rats.

Autoři: Hirata Y Kin K Nagase T a další

Zdroj: Scientific reports [Sci Rep] 2025 Nov 18; Vol. 15 (1), pp. 40522. Date of Electronic Publication: 2025 Nov 18.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Výrazy ze slovníku MeSH: Brain Concussion*/complications , Brain Concussion*/pathology , Brain Concussion*/physiopathology , Microglia*/pathology , Microglia*/metabolism , Gliosis*/pathology , Gliosis*/etiology , Cognitive Dysfunction*/etiology , Cognitive Dysfunction*/pathology , Cognitive Dysfunction*/prevention & control , Tauopathies*/etiology , Tauopathies*/pathology , Tauopathies*/metabolism , Tauopathies*/prevention & control, Animals ; Male ; Rats ; Disease Models, Animal ; Prefrontal Cortex/pathology ; Prefrontal Cortex/metabolism ; Rats, Sprague-Dawley ; Time Factors ; tau Proteins/metabolism

Temporal Progression of Recognition Memory Impairment, Astrogliosis, and Cholinergic Dysfunction in the Streptozotocin Rat Model of Sporadic Alzheimer's Disease.

Autoři: Niño-Rivero S Cabral R Fleitas J a další

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 12; Vol. 26 (22). Date of Electronic Publication: 2025 Nov 12.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Alzheimer Disease*/pathology , Alzheimer Disease*/metabolism , Alzheimer Disease*/chemically induced , Alzheimer Disease*/physiopathology , Gliosis*/pathology , Gliosis*/metabolism , Memory Disorders*/pathology , Memory Disorders*/metabolism , Memory Disorders*/physiopathology, Animals ; Streptozocin/toxicity ; Rats ; Disease Models, Animal ; Male ; Hippocampus/pathology ; Hippocampus/metabolism ; Recognition, Psychology ; Rats, Wistar ; Disease Progression

PARP1-TRPM2-PKC cascade distinctly regulates reactive astrogliosis and clasmatodendrosis through NF-κB and AKT pathways in the hippocampus of chronic epilepsy rats.

Autoři: Kim JE Wang SH Kang TC

Zdroj: Scientific reports [Sci Rep] 2025 Nov 03; Vol. 15 (1), pp. 38371. Date of Electronic Publication: 2025 Nov 03.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Výrazy ze slovníku MeSH: TRPM Cation Channels*/metabolism , TRPM Cation Channels*/genetics , Hippocampus*/metabolism , Hippocampus*/pathology , Proto-Oncogene Proteins c-akt*/metabolism , NF-kappa B*/metabolism , Poly (ADP-Ribose) Polymerase-1*/metabolism , Epilepsy*/metabolism , Epilepsy*/pathology , Gliosis*/metabolism , Gliosis*/pathology, Animals ; Rats ; Signal Transduction ; Astrocytes/metabolism ; Astrocytes/pathology ; Male ; Rats, Sprague-Dawley ; Chronic Disease ; Disease Models, Animal

Neuroprotective Effects of Erythropoietin in Fetal Alcohol Spectrum Disorder: BDNF Upregulation, Reduced Astrogliosis, and Anxiety Relief.

Autoři: Rafaiee R Mohseni F

Zdroj: Journal of studies on alcohol and drugs [J Stud Alcohol Drugs] 2025 Nov; Vol. 86 (6), pp. 917-927. Date of Electronic Publication: 2025 Mar 21.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Alcohol Research Documentation, Inc., Rutgers, The State University of New Jersey Country of Publication: United States NLM ID: 101295847 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-4114 (Electronic) Linking ISSN: 19371888 NLM ISO Abbreviation: J Stud Alcohol Drugs Subsets: MEDLINE

Výrazy ze slovníku MeSH: Erythropoietin*/pharmacology , Erythropoietin*/administration & dosage , Erythropoietin*/therapeutic use , Anxiety*/drug therapy , Anxiety*/prevention & control , Anxiety*/metabolism , Brain-Derived Neurotrophic Factor*/metabolism , Brain-Derived Neurotrophic Factor*/biosynthesis , Fetal Alcohol Spectrum Disorders*/drug therapy , Fetal Alcohol Spectrum Disorders*/metabolism , Fetal Alcohol Spectrum Disorders*/psychology , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/administration & dosage , Neuroprotective Agents*/therapeutic use , Gliosis*/prevention & control , Gliosis*/drug therapy , Gliosis*/chemically induced, Animals ; Rats ; Female ; Pregnancy ; Ethanol/toxicity ; Up-Regulation/drug effects ; Male ; Hippocampus/drug effects ; Hippocampus/metabolism ; Rats, Sprague-Dawley ; Animals, Newborn

The ionizing zwitterionic oxime antidote attenuates gliosis in mice exposed to sarin.

Autoři: Maček Hrvat N Puljko B Sit RK a další

Zdroj: Chemico-biological interactions [Chem Biol Interact] 2025 Nov 01; Vol. 421, pp. 111767. Date of Electronic Publication: 2025 Sep 30.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

Výrazy ze slovníku MeSH: Sarin*/toxicity , Oximes*/pharmacology , Oximes*/therapeutic use , Oximes*/chemistry , Gliosis*/chemically induced , Gliosis*/drug therapy , Gliosis*/pathology , Gliosis*/metabolism , Antidotes*/pharmacology , Antidotes*/therapeutic use , Antidotes*/chemistry, Animals ; Mice ; Male ; Acetylcholinesterase/metabolism ; Brain/drug effects ; Brain/metabolism ; Brain/pathology ; Neurons/drug effects ; Neurons/metabolism ; Glial Fibrillary Acidic Protein/metabolism ; Calcium-Binding Proteins/metabolism ; Mice, Inbred C57BL

Pharmacological inhibition of SPAK-NKCC1 complex attenuates astrogliosis and restores cerebral blood flow in a mouse model of VCID.

Autoři: Habib K Sultan MT Jahan I a další

Zdroj: Acta neuropathologica communications [Acta Neuropathol Commun] 2025 Oct 24; Vol. 13 (1), pp. 216. Date of Electronic Publication: 2025 Oct 24.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE

Výrazy ze slovníku MeSH: Gliosis*/drug therapy , Gliosis*/metabolism , Gliosis*/pathology , Cerebrovascular Circulation*/drug effects , Cerebrovascular Circulation*/physiology , Solute Carrier Family 12, Member 2*/metabolism , Protein Serine-Threonine Kinases*/antagonists & inhibitors , Protein Serine-Threonine Kinases*/metabolism , Dementia, Vascular*/drug therapy , Dementia, Vascular*/metabolism , Dementia, Vascular*/pathology, Animals ; Mice ; Mice, Inbred C57BL ; Disease Models, Animal ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/pathology ; Blood-Brain Barrier/metabolism ; Male

Seizure evolution in a mouse model of West syndrome involves complex and time-dependent synapse remodeling, gliosis and alterations in lipid metabolism.

Autoři: Ma R Kang M Kim GH a další

Zdroj: PLoS biology [PLoS Biol] 2025 Oct 09; Vol. 23 (10), pp. e3003192. Date of Electronic Publication: 2025 Oct 09 (Print Publication: 2025).

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Spasms, Infantile*/metabolism , Spasms, Infantile*/genetics , Spasms, Infantile*/physiopathology , Spasms, Infantile*/pathology , Lipid Metabolism*/physiology , Seizures*/metabolism , Seizures*/physiopathology , Seizures*/pathology , Seizures*/genetics , Gliosis*/metabolism , Gliosis*/pathology , Synapses*/metabolism , Synapses*/pathology, Animals ; Disease Models, Animal ; Mice ; Male ; Brain/metabolism ; Brain/pathology ; Female ; Electroencephalography ; Mice, Inbred C57BL ; Humans

Autophagy activated by the AMPK/mTOR/ULK1 pathway involves AURKB-mediated microgliosis in neuropathic pain.

Autoři: Xu M Wang Z Wu Z a další

Zdroj: Brain, behavior, and immunity [Brain Behav Immun] 2025 Oct; Vol. 129, pp. 948-959. Date of Electronic Publication: 2025 Jul 26.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE

Výrazy ze slovníku MeSH: Neuralgia*/immunology , Neuralgia*/pathology , Neuralgia*/physiopathology , Microglia*/metabolism , Microglia*/pathology , Gliosis*/immunology , Gliosis*/pathology , Gliosis*/physiopathology , Autophagy*/drug effects , Autophagy*/immunology , Aurora Kinase B*/genetics , Aurora Kinase B*/metabolism, AMP-Activated Protein Kinases/antagonists & inhibitors ; AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Autophagy-Related Protein-1 Homolog/metabolism ; Signal Transduction/drug effects ; Signal Transduction/immunology ; Gene Knockdown Techniques ; Lipopolysaccharides/administration & dosage ; Lipopolysaccharides/immunology ; Disease Models, Animal ; Rats, Sprague-Dawley ; Male ; Animals ; Rats ; HEK293 Cells ; Humans ; Protein Kinase Inhibitors/administration & dosage ; Animals, Genetically Modified ; Pyrazoles ; Pyrimidines

Shear Conditioning Promotes Microvascular Endothelial Barrier Resilience in a Human BBB-on-a-Chip Model of Systemic Inflammation Leading to Astrogliosis.

Autoři: Chen K Linares IM Trempel MA a další

Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Nov; Vol. 12 (43), pp. e08271. Date of Electronic Publication: 2025 Aug 27.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

Výrazy ze slovníku MeSH: Blood-Brain Barrier*/metabolism , Gliosis*/metabolism , Inflammation*/metabolism , Inflammation*/physiopathology , Endothelial Cells*/metabolism, Humans ; Lab-On-A-Chip Devices ; Astrocytes/metabolism ; Stress, Mechanical ; Microvessels/metabolism

Authors' response to letter to the editor: Sex differences in neuropathological response to traumatic brain injury: increased neuronal loss and astrogliosis in females.

Autoři: Rauk Z Setkowicz Z

Zdroj: Brain structure & function [Brain Struct Funct] 2025 Oct 06; Vol. 230 (8), pp. 153. Date of Electronic Publication: 2025 Oct 06.

Způsob vydávání: Letter; Journal Article

Informace o časopise: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101282001 Publication Model: Electronic Cited Medium: Internet ISSN: 1863-2661 (Electronic) Linking ISSN: 18632653 NLM ISO Abbreviation: Brain Struct Funct Subsets: MEDLINE

Výrazy ze slovníku MeSH: Brain Injuries, Traumatic*/pathology , Gliosis*/pathology , Neurons*/pathology , Sex Characteristics*, Animals ; Female ; Male ; Astrocytes/pathology

Tremor, sensory-motor polyneuropathy and cerebral gliosis in klinefelter's syndrome.

Autoři: Melchionda D Martire G Avolio C

Zdroj: Acta neurologica Belgica [Acta Neurol Belg] 2025 Oct; Vol. 125 (5), pp. 1469-1473. Date of Electronic Publication: 2025 Aug 09.

Způsob vydávání: Case Reports; Letter

Informace o časopise: Publisher: Springer Country of Publication: Italy NLM ID: 0247035 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2240-2993 (Electronic) Linking ISSN: 03009009 NLM ISO Abbreviation: Acta Neurol Belg Subsets: MEDLINE

Výrazy ze slovníku MeSH: Gliosis*/etiology , Klinefelter Syndrome*/complications , Polyneuropathies*/etiology , Tremor*/etiology, Humans ; Male ; Magnetic Resonance Imaging

UDPG/P2Y 14 -STAT1 axis mediates LPS-induced reactive astrogliosis.

Autoři: Wang MY Deng YH Ran XF a další

Zdroj: Neuropharmacology [Neuropharmacology] 2026 Feb 01; Vol. 283, pp. 110723. Date of Electronic Publication: 2025 Oct 14.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

Výrazy ze slovníku MeSH: Astrocytes*/metabolism , Astrocytes*/drug effects , STAT1 Transcription Factor*/metabolism , Gliosis*/metabolism , Gliosis*/chemically induced , Uridine Diphosphate Glucose*/metabolism , Uridine Diphosphate Glucose*/pharmacology , Receptors, Purinergic P2*/metabolism, Animals ; Mice ; Lipopolysaccharides/pharmacology ; Lipopolysaccharides/toxicity ; Mice, Inbred C57BL ; Cells, Cultured ; Cerebral Cortex/metabolism ; Cerebral Cortex/drug effects ; Signal Transduction/drug effects ; Male

Worsened axonal injury and gliosis following diffuse brain injury in male and female mice with neurofilament light gene deletion.

Autoři: Doust YV Rowe RK Langley RC a další

Zdroj: Experimental neurology [Exp Neurol] 2026 Feb; Vol. 396, pp. 115520. Date of Electronic Publication: 2025 Oct 22.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Gliosis*/pathology , Gliosis*/genetics , Gliosis*/metabolism , Gliosis*/etiology , Neurofilament Proteins*/genetics , Neurofilament Proteins*/deficiency , Gene Deletion* , Brain Injuries, Diffuse*/pathology , Brain Injuries, Diffuse*/metabolism , Diffuse Axonal Injury*/pathology , Diffuse Axonal Injury*/genetics , Diffuse Axonal Injury*/metabolism , Axons*/pathology, Animals ; Male ; Female ; Mice ; Mice, Knockout ; Mice, Inbred C57BL ; Microglia/pathology ; Microglia/metabolism ; Sex Characteristics

Tibolone Improves Motor Recovery and Regulates Neuroinflammation and Gliosis in a Model of Traumatic Spinal Cord Injury.

Autoři: Freyermuth-Trujillo X Sánchez-Torres S Orozco-Barrios CE a další

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Aug 27; Vol. 26 (17). Date of Electronic Publication: 2025 Aug 27.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Spinal Cord Injuries*/drug therapy , Spinal Cord Injuries*/metabolism , Spinal Cord Injuries*/physiopathology , Spinal Cord Injuries*/pathology , Gliosis*/drug therapy , Gliosis*/metabolism , Gliosis*/pathology , Recovery of Function*/drug effects , Norpregnenes*/pharmacology , Norpregnenes*/therapeutic use , Neuroinflammatory Diseases*/drug therapy , Neuroinflammatory Diseases*/metabolism , Neuroprotective Agents*/pharmacology, Animals ; Male ; Rats ; Rats, Sprague-Dawley ; Disease Models, Animal ; Glial Fibrillary Acidic Protein/metabolism ; Calcium-Binding Proteins/metabolism ; Cytokines/metabolism ; Microfilament Proteins/metabolism

Novel insights into pathomechanisms of retinal neuronal degeneration and reactive gliosis in a murine model of G M1 -gangliosidosis.

Autoři: Jubran L Wannemacher R Ulianytska A a další

Zdroj: Scientific reports [Sci Rep] 2025 Aug 13; Vol. 15 (1), pp. 29674. Date of Electronic Publication: 2025 Aug 13.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Výrazy ze slovníku MeSH: Gliosis*/pathology , Gliosis*/metabolism , Retinal Degeneration*/pathology , Retinal Degeneration*/metabolism , Retinal Degeneration*/genetics , Gangliosidosis, GM1*/pathology , Gangliosidosis, GM1*/metabolism , Gangliosidosis, GM1*/genetics , Gangliosidosis, GM1*/complications, Animals ; Disease Models, Animal ; Mice ; Mice, Knockout ; Retinal Ganglion Cells/metabolism ; Retinal Ganglion Cells/pathology ; Glutamate-Ammonia Ligase/metabolism ; Glutamate-Ammonia Ligase/genetics ; Glial Fibrillary Acidic Protein/metabolism ; Microglia/metabolism ; Microglia/pathology ; Retina/pathology ; Retina/metabolism ; Ependymoglial Cells/metabolism ; Ependymoglial Cells/pathology

GADD45G operates as a pathological sensor orchestrating reactive gliosis and neurodegeneration.

Autoři: Shen T Tai W Jiang D a další

Zdroj: Neuron [Neuron] 2025 Jul 09; Vol. 113 (13), pp. 2176-2195.e10. Date of Electronic Publication: 2025 May 22.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE

Výrazy ze slovníku MeSH: Gliosis*/pathology , Gliosis*/metabolism , Gliosis*/genetics , Astrocytes*/metabolism , Astrocytes*/pathology , Alzheimer Disease*/pathology , Alzheimer Disease*/metabolism , Antigens, Differentiation*/metabolism , Antigens, Differentiation*/genetics , Nerve Degeneration*/pathology , Nerve Degeneration*/metabolism, Animals ; Mice ; Humans ; Signal Transduction/physiology ; Mice, Transgenic ; Mice, Inbred C57BL ; Neurons/metabolism ; Neurons/pathology