Suchergebnisse - "GLIAL fibrillary acidic protein"

Plasma NfL and GFAP as Candidate Biomarkers of Disease Activity in NMOSD and MOGAD.

Autoren: Szilasiová J Fedičová M Vitková M et al.

Quelle: Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2025 Oct 18; Vol. 61 (10). Date of Electronic Publication: 2025 Oct 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 9425208 Publication Model: Electronic Cited Medium: Internet ISSN: 1648-9144 (Electronic) Linking ISSN: 1010660X NLM ISO Abbreviation: Medicina (Kaunas) Subsets: MEDLINE

MeSH-Schlagworte: Glial Fibrillary Acidic Protein*/blood , Glial Fibrillary Acidic Protein*/analysis , Neurofilament Proteins*/blood , Neurofilament Proteins*/analysis , Neuromyelitis Optica*/blood , Neuromyelitis Optica*/diagnosis , Neuromyelitis Optica*/physiopathology, Humans ; Biomarkers/blood ; Biomarkers/analysis ; Female ; Male ; Adult ; Middle Aged ; ROC Curve ; Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

An electrochemical immunobiosensor based on PVA/PDA/PEDOT conductive antifouling coating for direct detection of CNS injury biomarker in forensic clinical sample.

Autoren: Guo Z Wang S Wang L et al.

Quelle: Analytica chimica acta [Anal Chim Acta] 2025 Dec 22; Vol. 1380, pp. 344762. Date of Electronic Publication: 2025 Oct 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4324 (Electronic) Linking ISSN: 00032670 NLM ISO Abbreviation: Anal Chim Acta Subsets: MEDLINE

MeSH-Schlagworte: Polymers*/chemistry , Electrochemical Techniques*/methods , Bridged Bicyclo Compounds, Heterocyclic*/chemistry , Indoles*/chemistry , Biosensing Techniques*/methods , Polyvinyl Alcohol*/chemistry , Glial Fibrillary Acidic Protein*/analysis , Glial Fibrillary Acidic Protein*/blood , Glial Fibrillary Acidic Protein*/immunology, Humans ; Biomarkers/analysis ; Biomarkers/blood ; Electric Conductivity ; Immunoassay/methods ; Limit of Detection

The intermediate filament protein GFAP regulates mitochondrial fission in astrocytes.

Autoren: Xiong D Tan YS Yuan F et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Dec 02; Vol. 122 (48), pp. e2524111122. Date of Electronic Publication: 2025 Nov 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: Mitochondrial Dynamics*/physiology , Astrocytes*/metabolism , Glial Fibrillary Acidic Protein*/metabolism , Glial Fibrillary Acidic Protein*/genetics , Mitochondria*/metabolism, Dynamins/metabolism ; Dynamins/genetics ; Animals ; Mice ; Humans ; Mitochondrial Proteins/metabolism ; Intermediate Filaments/metabolism ; Alexander Disease/genetics ; Alexander Disease/metabolism ; Calcium/metabolism

Astrocytic Interleukin-33 Deficiency Reduces Glial Fibrillary Acidic Protein Expression and Exacerbates Microglial Activation and Neuronal Damage in a Chemically Induced Inflamed Frontal Cortex.

Autoren: Zheng YC Chen WY Wang CY et al.

Quelle: Journal of neurochemistry [J Neurochem] 2025 Dec; Vol. 169 (12), pp. e70310.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print Cited Medium: Internet ISSN: 1471-4159 (Electronic) Linking ISSN: 00223042 NLM ISO Abbreviation: J Neurochem Subsets: MEDLINE

MeSH-Schlagworte: Interleukin-33*/deficiency , Interleukin-33*/genetics , Astrocytes*/metabolism , Astrocytes*/pathology , Astrocytes*/drug effects , Glial Fibrillary Acidic Protein*/biosynthesis , Glial Fibrillary Acidic Protein*/metabolism , Glial Fibrillary Acidic Protein*/genetics , Microglia*/metabolism , Microglia*/pathology , Microglia*/drug effects , Frontal Lobe*/metabolism , Frontal Lobe*/pathology , Frontal Lobe*/drug effects , Neurons*/metabolism , Neurons*/pathology , Neurons*/drug effects, Animals ; Mice ; Mice, Inbred C57BL ; Cuprizone/toxicity ; Male ; Mice, Knockout

Neurological manifestations and clinical outcomes in pediatric Alexander disease: single-center cohort and identification of novel GFAP variants.

Autoren: Suthar R Sharma Y Saini AG et al.

Quelle: Brain & development [Brain Dev] 2025 Dec; Vol. 47 (6), pp. 104488. Date of Electronic Publication: 2025 Nov 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7131 (Electronic) Linking ISSN: 03877604 NLM ISO Abbreviation: Brain Dev Subsets: MEDLINE

MeSH-Schlagworte: Alexander Disease*/genetics , Alexander Disease*/physiopathology , Alexander Disease*/diagnostic imaging , Alexander Disease*/epidemiology , Glial Fibrillary Acidic Protein*/genetics, Humans ; Male ; Female ; Child ; Child, Preschool ; Cross-Sectional Studies ; Infant ; Adolescent ; Cohort Studies

Blood and CSF biomarkers for multiple sclerosis: emerging clinical applications.

Autoren: Chitnis T Magliozzi R Abdelhak A et al.

Quelle: The Lancet. Neurology [Lancet Neurol] 2025 Dec; Vol. 24 (12), pp. 1066-1078. Date of Electronic Publication: 2025 Sep 25.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 101139309 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4465 (Electronic) Linking ISSN: 14744422 NLM ISO Abbreviation: Lancet Neurol Subsets: MEDLINE

MeSH-Schlagworte: Biomarkers*/blood , Biomarkers*/cerebrospinal fluid , Multiple Sclerosis*/blood , Multiple Sclerosis*/cerebrospinal fluid , Multiple Sclerosis*/diagnosis , Neurofilament Proteins*/blood , Neurofilament Proteins*/cerebrospinal fluid , Glial Fibrillary Acidic Protein*/blood , Glial Fibrillary Acidic Protein*/cerebrospinal fluid, Humans ; Chitinase-3-Like Protein 1/blood ; Chitinase-3-Like Protein 1/cerebrospinal fluid

Plasma Profiles of Neuroglial Injury Biomarkers after Ischemic Stroke.

Autoren: Sjölin K Röyter B Forgo B et al.

Quelle: Translational stroke research [Transl Stroke Res] 2025 Dec; Vol. 16 (6), pp. 2185-2194. Date of Electronic Publication: 2025 Sep 03.

Publikationsart: Journal Article; Observational Study

Info zur Zeitschrift: Publisher: Springer Country of Publication: United States NLM ID: 101517297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-601X (Electronic) Linking ISSN: 18684483 NLM ISO Abbreviation: Transl Stroke Res Subsets: MEDLINE

MeSH-Schlagworte: Brain Ischemia*/blood , Glial Fibrillary Acidic Protein*/blood , Ischemic Stroke*/blood , Ischemic Stroke*/diagnostic imaging , Neurofilament Proteins*/blood , Neuroglia*/pathology , Neuroglia*/metabolism , tau Proteins*/blood , Ubiquitin Thiolesterase*/blood, Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Biomarkers/blood ; Cohort Studies ; Magnetic Resonance Imaging

The Role of Glial Fibrillary Acidic Protein in the Neuropathology of Alzheimer's Disease and Its Potential as a Blood Biomarker for Early Diagnosis and Progression.

Autoren: Bandara EMS Asih PR Pedrini S et al.

Quelle: Molecular neurobiology [Mol Neurobiol] 2025 Dec; Vol. 62 (12), pp. 15576-15608. Date of Electronic Publication: 2025 Jul 21.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH-Schlagworte: Alzheimer Disease*/blood , Alzheimer Disease*/diagnosis , Alzheimer Disease*/pathology , Glial Fibrillary Acidic Protein*/blood , Disease Progression*, Humans ; Biomarkers/blood ; Early Diagnosis ; Animals

Serum levels of neurofilament light chain and glial fibrillary acidic protein correlate with disease severity in patients with West Nile virus infection.

Autoren: Dinoto A Pacenti M Mariotto S et al.

Quelle: Emerging microbes & infections [Emerg Microbes Infect] 2025 Dec; Vol. 14 (1), pp. 2447606. Date of Electronic Publication: 2025 Feb 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE

MeSH-Schlagworte: West Nile Fever*/blood , West Nile Fever*/diagnosis , West Nile Fever*/pathology , West Nile Fever*/virology , Neurofilament Proteins*/blood , Glial Fibrillary Acidic Protein*/blood, Humans ; Female ; Male ; Biomarkers/blood ; Middle Aged ; Adult ; West Nile virus/physiology ; Aged ; Severity of Illness Index ; Young Adult

Overlapping autoimmune encephalitis with tripartite autoantibody positivity (NMDAR, GFAP, mGluR5) associated with papillary thyroid carcinoma: a case report.

Autoren: Chen Y Zhou G Dai K et al.

Quelle: BMC neurology [BMC Neurol] 2025 Nov 24; Vol. 25 (1), pp. 480. Date of Electronic Publication: 2025 Nov 24.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 100968555 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2377 (Electronic) Linking ISSN: 14712377 NLM ISO Abbreviation: BMC Neurol Subsets: MEDLINE

MeSH-Schlagworte: Autoantibodies*/blood , Thyroid Cancer, Papillary*/complications , Thyroid Neoplasms*/complications , Thyroid Neoplasms*/immunology , Thyroid Neoplasms*/diagnostic imaging , Hashimoto Disease*/immunology , Hashimoto Disease*/complications , Glial Fibrillary Acidic Protein*/immunology , Encephalitis*/immunology , Encephalitis*/complications , Receptors, N-Methyl-D-Aspartate*/immunology , Anti-N-Methyl-D-Aspartate Receptor Encephalitis*/immunology, Humans ; Female ; Middle Aged

SCR Disease Name: Hashimoto's encephalitis

Case Report: Efgartigimod as an additional therapy for MOG antibody-associated disease overlapping GFAP-IgG.

Autoren: Zhu Y Zhang J Li H et al.

Quelle: Frontiers in immunology [Front Immunol] 2025 Nov 17; Vol. 16, pp. 1624660. Date of Electronic Publication: 2025 Nov 17 (Print Publication: 2025).

Publikationsart: Case Reports; Journal Article

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH-Schlagworte: Myelin-Oligodendrocyte Glycoprotein*/immunology , Autoantibodies*/immunology , Autoantibodies*/blood , Immunoglobulin G*/immunology , Glial Fibrillary Acidic Protein*/immunology, Humans ; Male ; Middle Aged ; Methylprednisolone/therapeutic use ; Methylprednisolone/administration & dosage ; Treatment Outcome ; Magnetic Resonance Imaging ; Immunosuppressive Agents/therapeutic use ; Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Serum neurofilament light chain as a prognostic biomarker of glial fibrillary acidic protein autoimmunity.

Autoren: Kimura A Takekoshi A Maekawa Y et al.

Quelle: Journal of neuroimmunology [J Neuroimmunol] 2025 Nov 15; Vol. 408, pp. 578739. Date of Electronic Publication: 2025 Aug 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8421 (Electronic) Linking ISSN: 01655728 NLM ISO Abbreviation: J Neuroimmunol Subsets: MEDLINE

MeSH-Schlagworte: Neurofilament Proteins*/blood , Neurofilament Proteins*/cerebrospinal fluid , Glial Fibrillary Acidic Protein*/immunology , Autoantibodies*/blood , Autoimmunity*, Humans ; Female ; Male ; Prognosis ; Middle Aged ; Biomarkers/blood ; Biomarkers/cerebrospinal fluid ; Adult ; Aged ; Young Adult

Plasma NfL and GFAP in the preclinical stages of neurodegenerative diseases: insights from the UK Biobank.

Autoren: Buonocore J Fratto E Arcuri F et al.

Quelle: Journal of neurology [J Neurol] 2025 Nov 09; Vol. 272 (12), pp. 755. Date of Electronic Publication: 2025 Nov 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE

MeSH-Schlagworte: Glial Fibrillary Acidic Protein*/blood , Neurofilament Proteins*/blood , Neurodegenerative Diseases*/blood , Neurodegenerative Diseases*/epidemiology , Neurodegenerative Diseases*/diagnosis , Prodromal Symptoms*, Humans ; Male ; Female ; United Kingdom/epidemiology ; Aged ; Middle Aged ; Biomarkers/blood ; Biological Specimen Banks ; Amyotrophic Lateral Sclerosis/blood ; Amyotrophic Lateral Sclerosis/epidemiology ; Alzheimer Disease/blood ; Alzheimer Disease/epidemiology ; UK Biobank

Diagnostic and Prognostic Significance of Serum Biomarkers in Traumatic Spinal Cord Injury: A Prospective Cohort Study.

Autoren: Raheja A Sinha S Mansoori N et al.

Quelle: Neurology India [Neurol India] 2025 Nov 01; Vol. 73 (6), pp. 1180-1186. Date of Electronic Publication: 2025 Nov 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Medknow Publications Country of Publication: India NLM ID: 0042005 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1998-4022 (Electronic) Linking ISSN: 00283886 NLM ISO Abbreviation: Neurol India Subsets: MEDLINE

MeSH-Schlagworte: Spinal Cord Injuries*/blood , Spinal Cord Injuries*/diagnosis , Glial Fibrillary Acidic Protein*/blood , S100 Calcium Binding Protein beta Subunit*/blood, Humans ; Biomarkers/blood ; Adult ; Prognosis ; Phosphopyruvate Hydratase/blood ; Prospective Studies ; Male ; Neurofilament Proteins/blood ; Female ; Middle Aged

Auto Immune Glial Fibrillary Acidic Protein Astrocytopathy Coexistent with Positivity for Anti-NH 2 -terminal of α-enolase Antibodies.

Autoren: Matsuo J Namitome S Hara Y et al.

Quelle: Internal medicine (Tokyo, Japan) [Intern Med] 2025 Nov 01; Vol. 64 (21), pp. 3150-3154. Date of Electronic Publication: 2025 Apr 26.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Japanese Society of Internal Medicine Country of Publication: Japan NLM ID: 9204241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7235 (Electronic) Linking ISSN: 09182918 NLM ISO Abbreviation: Intern Med Subsets: MEDLINE

MeSH-Schlagworte: Glial Fibrillary Acidic Protein*/immunology , Autoantibodies*/blood , Autoantibodies*/immunology , Phosphopyruvate Hydratase*/immunology , Astrocytes*/immunology , Astrocytes*/pathology, Humans ; Female ; Middle Aged ; Hashimoto Disease/diagnosis ; Hashimoto Disease/immunology

Mutations in GFAP Alter Early Lineage Commitment of Organoids.

Autoren: Dykstra W Matusova Z Battaglia RA et al.

Quelle: Glia [Glia] 2025 Nov; Vol. 73 (11), pp. 2167-2188. Date of Electronic Publication: 2025 Jul 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8806785 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-1136 (Electronic) Linking ISSN: 08941491 NLM ISO Abbreviation: Glia Subsets: MEDLINE

MeSH-Schlagworte: Glial Fibrillary Acidic Protein*/genetics , Glial Fibrillary Acidic Protein*/metabolism , Organoids*/metabolism , Mutation*/genetics , Cell Lineage*/genetics, Induced Pluripotent Stem Cells/metabolism ; Alexander Disease/genetics ; Alexander Disease/pathology ; Humans ; Cell Differentiation/genetics ; Cell Differentiation/physiology ; Cells, Cultured

Neurovascular coupling dysfunction associated with cognition and glial fibrillary acidic protein along the Alzheimer's disease continuum.

Autoren: Chen H Guo Y Zhang Z et al.

Quelle: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2025 Nov; Vol. 108 (1), pp. 170-179. Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: SAGE Publications Country of Publication: United States NLM ID: 9814863 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE

MeSH-Schlagworte: Alzheimer Disease*/diagnostic imaging , Alzheimer Disease*/physiopathology , Alzheimer Disease*/psychology , Alzheimer Disease*/blood , Neurovascular Coupling*/physiology , Cognitive Dysfunction*/diagnostic imaging , Cognitive Dysfunction*/physiopathology , Cognitive Dysfunction*/psychology , Glial Fibrillary Acidic Protein*/blood , Brain*/diagnostic imaging , Brain*/physiopathology , Cognition*/physiology, Humans ; Male ; Female ; Aged ; Magnetic Resonance Imaging ; Cerebrovascular Circulation/physiology ; Biomarkers/blood ; Middle Aged ; Neuropsychological Tests ; Aged, 80 and over

Biomarker discovery using NUcleic Acid-Linked Immuno-Sandwich Assay in multiple sclerosis patients experiencing progression independent of relapse activity.

Autoren: Sandgren S Maceski AM Benkert P et al.

Quelle: Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2025 Nov; Vol. 31 (13), pp. 1531-1542. Date of Electronic Publication: 2025 Oct 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: SAGE Publications Country of Publication: England NLM ID: 9509185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0970 (Electronic) Linking ISSN: 13524585 NLM ISO Abbreviation: Mult Scler Subsets: MEDLINE

MeSH-Schlagworte: Disease Progression* , Glial Fibrillary Acidic Protein*/blood , Neurofilament Proteins*/blood , Multiple Sclerosis*/blood , Multiple Sclerosis*/drug therapy , Multiple Sclerosis*/diagnosis , Multiple Sclerosis, Relapsing-Remitting*/blood , Multiple Sclerosis, Relapsing-Remitting*/drug therapy, Humans ; Female ; Biomarkers/blood ; Male ; Adult ; Middle Aged ; Fingolimod Hydrochloride/therapeutic use ; Recurrence ; Cohort Studies ; Immunosuppressive Agents/therapeutic use

Stool Glial Fibrillary Acidic Protein Is Elevated in Progressive Multiple Sclerosis.

Autoren: Schwerdtfeger LA Montini F Antonini Cencicchio M et al.

Quelle: Neurology(R) neuroimmunology & neuroinflammation [Neurol Neuroimmunol Neuroinflamm] 2025 Nov; Vol. 12 (6), pp. e200466. Date of Electronic Publication: 2025 Aug 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wolters Kluwer Health/Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101636388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2332-7812 (Electronic) Linking ISSN: 23327812 NLM ISO Abbreviation: Neurol Neuroimmunol Neuroinflamm Subsets: MEDLINE

MeSH-Schlagworte: Glial Fibrillary Acidic Protein*/metabolism , Glial Fibrillary Acidic Protein*/analysis , Multiple Sclerosis, Chronic Progressive*/metabolism , Multiple Sclerosis, Chronic Progressive*/diagnosis , Multiple Sclerosis, Chronic Progressive*/physiopathology , Feces*/chemistry , Multiple Sclerosis, Relapsing-Remitting*/metabolism , Multiple Sclerosis, Relapsing-Remitting*/diagnosis, Humans ; Female ; Male ; Adult ; Middle Aged ; Follow-Up Studies ; Disease Progression ; Biomarkers/analysis ; Biomarkers/metabolism

Astrocytic-OTUD7B ameliorates murine experimental autoimmune encephalomyelitis by stabilizing glial fibrillary acidic protein and preventing inflammation.

Autoren: Harit K Yi W Jeron A et al.

Quelle: Nature communications [Nat Commun] 2025 Oct 20; Vol. 16 (1), pp. 9279. Date of Electronic Publication: 2025 Oct 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Encephalomyelitis, Autoimmune, Experimental*/metabolism , Encephalomyelitis, Autoimmune, Experimental*/immunology , Encephalomyelitis, Autoimmune, Experimental*/pathology , Encephalomyelitis, Autoimmune, Experimental*/genetics , Astrocytes*/metabolism , Glial Fibrillary Acidic Protein*/metabolism , Glial Fibrillary Acidic Protein*/genetics , Deubiquitinating Enzymes*/metabolism , Deubiquitinating Enzymes*/genetics, Animals ; Mice ; Mice, Inbred C57BL ; Inflammation/metabolism ; Ubiquitination ; Female ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Multiple Sclerosis/metabolism ; Multiple Sclerosis/immunology ; NF-kappa B/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; CD4-Positive T-Lymphocytes/immunology