Suchergebnisse - "GELATINASES"

Comparative evaluation of three ¹⁸ F-fluorinated FAP ligands in rodent tumor models.

Autoren: Hoffmann C Gröner B Bahutski V et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 05; Vol. 299, pp. 118103. Date of Electronic Publication: 2025 Aug 27.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Fluorine Radioisotopes*/chemistry , Membrane Proteins*/metabolism , Membrane Proteins*/antagonists & inhibitors , Gelatinases*/metabolism , Gelatinases*/antagonists & inhibitors , Radiopharmaceuticals*/chemistry , Radiopharmaceuticals*/chemical synthesis , Radiopharmaceuticals*/pharmacokinetics , Radiopharmaceuticals*/pharmacology , Serine Endopeptidases*/metabolism, Animals ; Humans ; Mice ; Ligands ; Rats ; Cell Line, Tumor ; Positron-Emission Tomography ; Molecular Structure ; Tissue Distribution ; Endopeptidases ; Male

Anti-FAP CAR-NK cells as a novel targeted therapy against cervical cancer and cancer-associated fibroblasts.

Autoren: Polten R Kutle I Stalp JL et al.

Quelle: Oncoimmunology [Oncoimmunology] 2025 Dec; Vol. 14 (1), pp. 2556714. Date of Electronic Publication: 2025 Sep 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101570526 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2162-402X (Electronic) Linking ISSN: 21624011 NLM ISO Abbreviation: Oncoimmunology Subsets: MEDLINE

MeSH-Schlagworte: Uterine Cervical Neoplasms*/therapy , Uterine Cervical Neoplasms*/immunology , Uterine Cervical Neoplasms*/pathology , Killer Cells, Natural*/immunology , Killer Cells, Natural*/transplantation , Killer Cells, Natural*/metabolism , Serine Endopeptidases*/immunology , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics , Cancer-Associated Fibroblasts*/immunology , Cancer-Associated Fibroblasts*/metabolism , Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/genetics , Membrane Proteins*/immunology , Membrane Proteins*/antagonists & inhibitors , Membrane Proteins*/metabolism , Gelatinases*/immunology , Gelatinases*/antagonists & inhibitors , Gelatinases*/metabolism , Gelatinases*/genetics , Immunotherapy, Adoptive*/methods, Humans ; Female ; Tumor Microenvironment/immunology ; Endopeptidases ; Cell Line, Tumor ; Coculture Techniques

Theranostics targeting fibroblast activation protein in the pan-cancer field.

Autoren: Li Y Jing X Liu Q et al.

Quelle: International journal of cancer [Int J Cancer] 2025 Dec 01; Vol. 157 (11), pp. 2209-2223. Date of Electronic Publication: 2025 Jul 31.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE

MeSH-Schlagworte: Neoplasms*/diagnostic imaging , Neoplasms*/therapy , Neoplasms*/metabolism , Theranostic Nanomedicine*/methods , Membrane Proteins*/metabolism , Membrane Proteins*/antagonists & inhibitors , Serine Endopeptidases*/metabolism , Gelatinases*/metabolism , Gelatinases*/antagonists & inhibitors, Humans ; Positron Emission Tomography Computed Tomography/methods ; Cancer-Associated Fibroblasts/metabolism ; Endopeptidases ; Animals ; Molecular Targeted Therapy/methods

Novel Pyridine-Based Fibroblast Activation Protein-Targeted Tracers: Design, Synthesis, and PET Imaging Evaluation for Tumors.

Autoren: Yu Z Huang Y Jiang Z et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Nov 27; Vol. 68 (22), pp. 24560-24578. Date of Electronic Publication: 2025 Nov 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Pyridines*/chemistry , Pyridines*/chemical synthesis , Pyridines*/pharmacology , Pyridines*/pharmacokinetics , Positron-Emission Tomography*/methods , Drug Design* , Serine Endopeptidases*/metabolism , Membrane Proteins*/metabolism , Membrane Proteins*/antagonists & inhibitors , Gelatinases*/metabolism , Gelatinases*/antagonists & inhibitors , Radiopharmaceuticals*/chemical synthesis , Radiopharmaceuticals*/chemistry , Radiopharmaceuticals*/pharmacokinetics , Neoplasms*/diagnostic imaging, Humans ; Animals ; Gallium Radioisotopes ; Endopeptidases ; Mice ; Structure-Activity Relationship ; Cell Line, Tumor

GH replacement therapy in adults stimulates fibroblast activation protein-α activity.

Autoren: Bæk A Pedersen AKN Billeskov TB et al.

Quelle: European journal of endocrinology [Eur J Endocrinol] 2025 Nov 26; Vol. 193 (6), pp. 659-666.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 9423848 Publication Model: Print Cited Medium: Internet ISSN: 1479-683X (Electronic) Linking ISSN: 08044643 NLM ISO Abbreviation: Eur J Endocrinol Subsets: MEDLINE

MeSH-Schlagworte: Human Growth Hormone*/deficiency , Human Growth Hormone*/therapeutic use , Serine Endopeptidases*/blood , Serine Endopeptidases*/metabolism , Gelatinases*/blood , Gelatinases*/metabolism , Membrane Proteins*/blood , Membrane Proteins*/metabolism , Hormone Replacement Therapy* , Hypopituitarism*/drug therapy , Hypopituitarism*/blood, Humans ; Adult ; Male ; Female ; Middle Aged ; Fibroblast Growth Factors/blood ; Endopeptidases ; Biomarkers/blood ; Collagen/metabolism ; Procollagen/blood ; Young Adult

Fibroblast Activation Protein Alpha (FAP) Expression Is Associated with Disease Recurrence and Poor Response to Tyrosine Kinase Inhibitors in Advanced Clear Cell Renal Cell Carcinoma.

Autoren: Riaza Montes M Suárez B Solano-Iturri JD et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 17; Vol. 26 (22). Date of Electronic Publication: 2025 Nov 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Renal Cell*/drug therapy , Carcinoma, Renal Cell*/pathology , Carcinoma, Renal Cell*/metabolism , Carcinoma, Renal Cell*/mortality , Gelatinases*/metabolism , Gelatinases*/genetics , Kidney Neoplasms*/drug therapy , Kidney Neoplasms*/metabolism , Kidney Neoplasms*/pathology , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics , Protein Kinase Inhibitors*/therapeutic use , Protein Kinase Inhibitors*/pharmacology , Membrane Proteins*/metabolism , Membrane Proteins*/genetics , Neoplasm Recurrence, Local*/metabolism , Neoplasm Recurrence, Local*/pathology , Neoplasm Recurrence, Local*/drug therapy, Humans ; Male ; Female ; Middle Aged ; Aged ; Endopeptidases ; Prognosis ; Adult ; Biomarkers, Tumor/metabolism ; Cancer-Associated Fibroblasts/metabolism ; Cancer-Associated Fibroblasts/pathology ; Aged, 80 and over ; Disease-Free Survival ; Tyrosine Kinase Inhibitors

Synthesis and Evaluation of Novel ^99m Tc-Labeled Fibroblast Activation Protein Inhibitors Containing Cyclohexane as Promising Tumor Tracers.

Autoren: Ruan Q Diao L Ding D et al.

Quelle: Molecular pharmaceutics [Mol Pharm] 2025 Nov 03; Vol. 22 (11), pp. 7121-7131. Date of Electronic Publication: 2025 Oct 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

MeSH-Schlagworte: Membrane Proteins*/antagonists & inhibitors , Membrane Proteins*/metabolism , Cyclohexanes*/chemistry , Radiopharmaceuticals*/chemistry , Gelatinases*/antagonists & inhibitors , Gelatinases*/metabolism , Serine Endopeptidases*/metabolism , Technetium*/chemistry , Neoplasms*/diagnostic imaging , Neoplasms*/metabolism, Animals ; Mice ; Humans ; Tissue Distribution ; Tomography, Emission-Computed, Single-Photon/methods ; Cell Line, Tumor ; Endopeptidases ; Mice, Inbred BALB C ; Female ; Mice, Nude

A novel FAP-targeting antibody-exatecan conjugate improves immune checkpoint blockade by reversing immunosuppressive microenvironment in pancreatic cancer.

Autoren: Wei X Wu J Cao W et al.

Quelle: Oncogene [Oncogene] 2025 Nov; Vol. 44 (43), pp. 4114-4129. Date of Electronic Publication: 2025 Sep 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE

MeSH-Schlagworte: Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/immunology , Pancreatic Neoplasms*/pathology , Tumor Microenvironment*/drug effects , Tumor Microenvironment*/immunology , Immunoconjugates*/pharmacology , Serine Endopeptidases*/immunology , Immune Checkpoint Inhibitors*/pharmacology , Membrane Proteins*/antagonists & inhibitors , Membrane Proteins*/immunology , Camptothecin*/analogs & derivatives , Camptothecin*/pharmacology , Gelatinases*/antagonists & inhibitors , Gelatinases*/immunology, Humans ; Animals ; Mice ; Endopeptidases ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Female

FAP-α in soft tissue and bone sarcomas: A new potential diagnostic and therapeutic biomarker in the era of precision medicine.

Autoren: Bracigliano A Clemente O Peddio A et al.

Quelle: Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2025 Nov; Vol. 215, pp. 104852. Date of Electronic Publication: 2025 Jul 14.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Scientific Publishers Country of Publication: Netherlands NLM ID: 8916049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0461 (Electronic) Linking ISSN: 10408428 NLM ISO Abbreviation: Crit Rev Oncol Hematol Subsets: MEDLINE

MeSH-Schlagworte: Biomarkers, Tumor*/metabolism , Biomarkers, Tumor*/genetics , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics , Gelatinases*/metabolism , Gelatinases*/genetics , Sarcoma*/diagnosis , Sarcoma*/metabolism , Sarcoma*/therapy , Bone Neoplasms*/diagnosis , Bone Neoplasms*/metabolism , Bone Neoplasms*/therapy , Membrane Proteins*/metabolism , Membrane Proteins*/genetics , Soft Tissue Neoplasms*/diagnosis , Soft Tissue Neoplasms*/metabolism , Soft Tissue Neoplasms*/therapy , Osteosarcoma*/diagnosis , Osteosarcoma*/metabolism , Osteosarcoma*/therapy, Humans ; Precision Medicine/methods ; Endopeptidases ; Tumor Microenvironment ; Animals

Recent advances in nuclear medicine and their role in inflammatory arthritis: focus on the emerging role of FAPI PET/CT.

Autoren: Schmidkonz C Kuwert T Götz TI et al.

Quelle: Skeletal radiology [Skeletal Radiol] 2025 Nov; Vol. 54 (11), pp. 2243-2252. Date of Electronic Publication: 2024 Nov 25.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7701953 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2161 (Electronic) Linking ISSN: 03642348 NLM ISO Abbreviation: Skeletal Radiol Subsets: MEDLINE

MeSH-Schlagworte: Positron Emission Tomography Computed Tomography*/methods , Positron Emission Tomography Computed Tomography*/trends , Arthritis*/diagnostic imaging , Membrane Proteins*/antagonists & inhibitors , Membrane Proteins*/metabolism , Gelatinases*/antagonists & inhibitors , Gelatinases*/metabolism , Serine Endopeptidases*/metabolism, Humans ; Radiopharmaceuticals ; Endopeptidases

Structure-Property Investigation of New "KetoFAPI" Inhibitors of Fibroblast Activation Protein (FAP): Discovery of Highly Potent, Selective Compounds with Prolonged Residence Times and Promising Radiotheranostic Potential.

Autoren: Brzeminski P Verhulst E Fabisiak A et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Oct 23; Vol. 68 (20), pp. 21739-21765. Date of Electronic Publication: 2025 Oct 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Serine Endopeptidases*/metabolism , Gelatinases*/antagonists & inhibitors , Gelatinases*/metabolism , Membrane Proteins*/antagonists & inhibitors , Membrane Proteins*/metabolism , Serine Proteinase Inhibitors*/pharmacology , Serine Proteinase Inhibitors*/chemistry , Serine Proteinase Inhibitors*/pharmacokinetics , Serine Proteinase Inhibitors*/chemical synthesis, Structure-Activity Relationship ; Animals ; Humans ; Mice ; Endopeptidases ; Prolyl Oligopeptidases ; Cell Line, Tumor ; Drug Discovery ; Female

FAP ⁺ fibroblasts orchestrate tumor microenvironment remodeling in renal cell carcinoma with tumor thrombus.

Autoren: Ma J Huang Y Chen J et al.

Quelle: Nature communications [Nat Commun] 2025 Oct 23; Vol. 16 (1), pp. 9387. Date of Electronic Publication: 2025 Oct 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Renal Cell*/pathology , Carcinoma, Renal Cell*/genetics , Carcinoma, Renal Cell*/metabolism , Tumor Microenvironment*/genetics , Kidney Neoplasms*/pathology , Kidney Neoplasms*/genetics , Kidney Neoplasms*/metabolism , Fibroblasts*/metabolism , Fibroblasts*/pathology , Gelatinases*/metabolism , Gelatinases*/genetics , Thrombosis*/pathology , Thrombosis*/genetics , Thrombosis*/metabolism , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics, Humans ; Endopeptidases/metabolism ; Cancer-Associated Fibroblasts/metabolism ; Cancer-Associated Fibroblasts/pathology ; Male ; Female ; Prognosis ; Cell Line, Tumor ; Killer Cells, Natural/immunology ; Pericytes/metabolism ; Pericytes/pathology ; Single-Cell Analysis ; Gene Expression Regulation, Neoplastic ; Middle Aged ; Membrane Proteins

A General Strategy to Develop Highly Sensitive FAPα Fluorescent Probes for Invasive Cancer Detection.

Autoren: Feng Y Xie C Ren TB et al.

Quelle: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Oct 06; Vol. 64 (41), pp. e202512588. Date of Electronic Publication: 2025 Aug 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

MeSH-Schlagworte: Fluorescent Dyes*/chemistry , Fluorescent Dyes*/chemical synthesis , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/analysis , Serine Endopeptidases*/chemistry , Membrane Proteins*/metabolism , Membrane Proteins*/analysis , Membrane Proteins*/chemistry , Gelatinases*/metabolism , Gelatinases*/analysis , Gelatinases*/chemistry , Neoplasms*/diagnosis , Neoplasms*/pathology , Neoplasms*/diagnostic imaging, Humans ; Molecular Docking Simulation ; Endopeptidases ; Optical Imaging ; Cell Movement ; Neoplasm Invasiveness

Pioneering QSAR Modeling Study of FAP-Targeting Radiopharmaceuticals Used in Oncology.

Autoren: Fatehi D Hajimahdi Z Mosayebnia M

Quelle: Chemical biology & drug design [Chem Biol Drug Des] 2025 Oct; Vol. 106 (4), pp. e70177.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262549 Publication Model: Print Cited Medium: Internet ISSN: 1747-0285 (Electronic) Linking ISSN: 17470277 NLM ISO Abbreviation: Chem Biol Drug Des Subsets: MEDLINE

MeSH-Schlagworte: Quantitative Structure-Activity Relationship* , Radiopharmaceuticals*/chemistry , Radiopharmaceuticals*/metabolism , Radiopharmaceuticals*/pharmacology , Membrane Proteins*/antagonists & inhibitors , Membrane Proteins*/metabolism , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/chemistry , Gelatinases*/antagonists & inhibitors , Gelatinases*/metabolism, Humans ; Endopeptidases ; Neoplasms/drug therapy ; Hydrogen Bonding ; Least-Squares Analysis

Fibroblast Activation Protein Promotes Pulmonary Artery Hypertension via Activation of the PTEN/PI3K/Akt Pathway.

Autoren: Zhu M Xu F Zhu L et al.

Quelle: Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 2025 Oct 01; Vol. 86 (4), pp. 391-407. Date of Electronic Publication: 2025 Oct 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7902492 Publication Model: Electronic Cited Medium: Internet ISSN: 1533-4023 (Electronic) Linking ISSN: 01602446 NLM ISO Abbreviation: J Cardiovasc Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: PTEN Phosphohydrolase*/metabolism , Proto-Oncogene Proteins c-akt*/metabolism , Gelatinases*/metabolism , Gelatinases*/genetics , Fibroblasts*/enzymology , Fibroblasts*/pathology , Fibroblasts*/drug effects , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics , Pulmonary Artery*/enzymology , Pulmonary Artery*/physiopathology , Pulmonary Artery*/pathology , Pulmonary Artery*/drug effects , Membrane Proteins*/metabolism , Membrane Proteins*/genetics , Vascular Remodeling*/drug effects , Pulmonary Arterial Hypertension*/enzymology , Pulmonary Arterial Hypertension*/physiopathology , Pulmonary Arterial Hypertension*/pathology , Pulmonary Arterial Hypertension*/genetics , Phosphatidylinositol 3-Kinase*/metabolism , Arterial Pressure*, Animals ; Signal Transduction ; Humans ; Male ; Disease Models, Animal ; Early Growth Response Protein 1/metabolism ; Early Growth Response Protein 1/genetics ; Cells, Cultured ; Mice, Inbred C57BL ; Endopeptidases ; Cell Proliferation ; Cell Movement ; Rats, Sprague-Dawley

Development of Multivalent FAP-Targeted Small Molecule-Drug Conjugates with Tailored MMAE Release Kinetics.

Autoren: Bocci M Principi L Neri D et al.

Quelle: Molecular cancer therapeutics [Mol Cancer Ther] 2025 Oct 01; Vol. 24 (10), pp. 1487-1496.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

MeSH-Schlagworte: Serine Endopeptidases*/metabolism , Gelatinases*/antagonists & inhibitors , Gelatinases*/metabolism , Immunoconjugates*/pharmacology , Immunoconjugates*/chemistry , Membrane Proteins*/antagonists & inhibitors , Membrane Proteins*/metabolism , Small Molecule Libraries*/pharmacology , Small Molecule Libraries*/chemistry , Oligopeptides*/chemistry , Oligopeptides*/pharmacology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry, Humans ; Animals ; Mice ; Endopeptidases ; Xenograft Model Antitumor Assays ; Kinetics ; Cell Line, Tumor ; Tissue Distribution ; Female

Development of novel ¹⁸ F-labelled FAP-targeting tracers with improved pharmacokinetics: From preclinical optimization to clinical translation.

Autoren: Feng D Li B Yang J et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118152. Date of Electronic Publication: 2025 Sep 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Fluorine Radioisotopes*/chemistry , Radiopharmaceuticals*/pharmacokinetics , Radiopharmaceuticals*/chemistry , Radiopharmaceuticals*/chemical synthesis , Gelatinases*/metabolism , Membrane Proteins*/metabolism , Serine Endopeptidases*/metabolism, Humans ; Animals ; Mice ; Positron-Emission Tomography ; Molecular Structure ; Tissue Distribution ; Structure-Activity Relationship ; Endopeptidases

Inflammatory 68 Ga FAPI-46 Uptake Mimicking a Sister Mary Joseph's Nodule in a Case of Gastric Signet Ring Cell Carcinoma.

Autoren: Tosunoğlu Z Bozkurt M Erdamar S et al.

Quelle: Clinical nuclear medicine [Clin Nucl Med] 2025 Dec 01; Vol. 50 (12), pp. e708-e709. Date of Electronic Publication: 2025 May 14.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Lippincott Country of Publication: United States NLM ID: 7611109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-0229 (Electronic) Linking ISSN: 03639762 NLM ISO Abbreviation: Clin Nucl Med Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Signet Ring Cell*/diagnostic imaging , Carcinoma, Signet Ring Cell*/metabolism , Carcinoma, Signet Ring Cell*/pathology , Stomach Neoplasms*/diagnostic imaging , Stomach Neoplasms*/metabolism , Stomach Neoplasms*/pathology , Sister Mary Joseph's Nodule*/diagnostic imaging , Inflammation*/diagnostic imaging , Membrane Proteins*/metabolism , Gelatinases*/metabolism, Humans ; Diagnosis, Differential ; Positron Emission Tomography Computed Tomography ; Gallium Radioisotopes ; Biological Transport ; Male ; Female ; Endopeptidases

A preliminary study on the safety and efficacy of ¹⁷⁷ Lu-FAP-2286 in gastrointestinal tumours with positive FAP expression.

Autoren: Bai X Zhang N Liu H et al.

Quelle: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2025 Dec; Vol. 213, pp. 111195. Date of Electronic Publication: 2025 Oct 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8407192 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0887 (Electronic) Linking ISSN: 01678140 NLM ISO Abbreviation: Radiother Oncol Subsets: MEDLINE

MeSH-Schlagworte: Gastrointestinal Neoplasms*/radiotherapy , Gastrointestinal Neoplasms*/metabolism , Lutetium*/therapeutic use , Lutetium*/adverse effects , Membrane Proteins*/metabolism , Gelatinases*/metabolism , Serine Endopeptidases*/metabolism , Radioisotopes*/therapeutic use , Radioisotopes*/adverse effects, Humans ; Male ; Female ; Middle Aged ; Prospective Studies ; Aged ; Endopeptidases

A novel bivalent albumin binder for enhanced tumor retention of a fibroblast activation protein-targeted radioligand.

Autoren: Nakashima K Yamaguchi K Saito K et al.

Quelle: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2025 Nov 27; Vol. 61 (96), pp. 19072-19075. Date of Electronic Publication: 2025 Nov 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE

MeSH-Schlagworte: Albumins*/chemistry , Albumins*/metabolism , Membrane Proteins*/metabolism , Gelatinases*/metabolism , Serine Endopeptidases*/metabolism , Lysine*/chemistry , Lysine*/analogs & derivatives , Radiopharmaceuticals*/chemistry , Radiopharmaceuticals*/pharmacokinetics , Neoplasms*/diagnostic imaging , Neoplasms*/metabolism, Animals ; Humans ; Mice ; Cell Line, Tumor ; Ligands ; Endopeptidases/metabolism