Výsledky vyhledávání - "GABA-A Receptor Agonists"

Barriers to discontinuing benzodiazepine receptor agonists in older adults: a survey of older adults across Europe.

Autoři: Shapoval V de Saint Hubert M Pétein C a další

Zdroj: Age and ageing [Age Ageing] 2025 Nov 28; Vol. 54 (12).

Způsob vydávání: Journal Article; Multicenter Study

Informace o časopise: Publisher: Oxford University Press Country of Publication: England NLM ID: 0375655 Publication Model: Print Cited Medium: Internet ISSN: 1468-2834 (Electronic) Linking ISSN: 00020729 NLM ISO Abbreviation: Age Ageing Subsets: MEDLINE

Výrazy ze slovníku MeSH: GABA-A Receptor Agonists*/adverse effects , GABA-A Receptor Agonists*/administration & dosage , Health Knowledge, Attitudes, Practice* , Sleep Wake Disorders*/drug therapy , Sleep Wake Disorders*/psychology , Sleep Wake Disorders*/diagnosis , Sleep Wake Disorders*/physiopathology , Sleep*/drug effects, Humans ; Aged ; Male ; Female ; Cross-Sectional Studies ; Europe ; Aged, 80 and over ; Age Factors ; Surveys and Questionnaires ; Adaptation, Psychological

Effect of chronic benzodiazepine and benzodiazepine receptor agonist use on sleep architecture and brain oscillations in older adults with chronic insomnia.

Autoři: Barbaux L Perrault AA Cross NE a další

Zdroj: Sleep [Sleep] 2025 Oct 13; Vol. 48 (10).

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Oxford University Press Country of Publication: United States NLM ID: 7809084 Publication Model: Print Cited Medium: Internet ISSN: 1550-9109 (Electronic) Linking ISSN: 01618105 NLM ISO Abbreviation: Sleep Subsets: MEDLINE

Výrazy ze slovníku MeSH: Sleep Initiation and Maintenance Disorders*/drug therapy , Sleep Initiation and Maintenance Disorders*/physiopathology , Benzodiazepines*/adverse effects , Benzodiazepines*/therapeutic use , Benzodiazepines*/pharmacology , Benzodiazepines*/administration & dosage , GABA-A Receptor Agonists*/adverse effects , GABA-A Receptor Agonists*/therapeutic use , GABA-A Receptor Agonists*/pharmacology , Brain*/drug effects , Brain*/physiopathology , Sleep*/drug effects, Humans ; Female ; Aged ; Male ; Electroencephalography/drug effects ; Polysomnography ; Middle Aged ; Aged, 80 and over

Barriers to and Enablers of Supporting Deprescribing Benzodiazepines in Older Adults: A Survey of European Nonphysician Healthcare Professionals.

Autoři: Shapoval V Evrard P Sibille FX a další

Zdroj: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2025 Oct; Vol. 137 (4), pp. e70100.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Blackwell Country of Publication: England NLM ID: 101208422 Publication Model: Print Cited Medium: Internet ISSN: 1742-7843 (Electronic) Linking ISSN: 17427835 NLM ISO Abbreviation: Basic Clin Pharmacol Toxicol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Deprescriptions* , Benzodiazepines*/adverse effects , Benzodiazepines*/therapeutic use , Benzodiazepines*/administration & dosage , Attitude of Health Personnel* , Health Personnel*/psychology , GABA-A Receptor Agonists*/administration & dosage , GABA-A Receptor Agonists*/adverse effects , GABA-A Receptor Agonists*/therapeutic use, Humans ; Male ; Female ; Europe ; Middle Aged ; Adult ; Surveys and Questionnaires ; Aged

Deprescribing Benzodiazepine Receptor Agonists in Older Adults and People With Cognitive Impairment: A Systematic Review.

Autoři: McEvoy AM Langford AV Liau SJ a další

Zdroj: Journal of the American Geriatrics Society [J Am Geriatr Soc] 2025 Sep; Vol. 73 (9), pp. 2905-2913. Date of Electronic Publication: 2025 May 07.

Způsob vydávání: Journal Article; Systematic Review

Informace o časopise: Publisher: Blackwell Science Country of Publication: United States NLM ID: 7503062 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-5415 (Electronic) Linking ISSN: 00028614 NLM ISO Abbreviation: J Am Geriatr Soc Subsets: MEDLINE

Výrazy ze slovníku MeSH: Benzodiazepines*/therapeutic use , Benzodiazepines*/adverse effects , Cognitive Dysfunction*/complications , Deprescriptions* , GABA-A Receptor Agonists*/therapeutic use , GABA-A Receptor Agonists*/adverse effects , GABA-A Receptor Agonists*/administration & dosage , Sleep Initiation and Maintenance Disorders*/drug therapy, Aged ; Aged, 80 and over ; Humans

Equipping physicians for benzodiazepine receptor agonists deprescription in older adults: theory-based development of the BE-SAFE intervention.

Autoři: Sibille FX Salbert J Bolt L a další

Zdroj: Research in social & administrative pharmacy : RSAP [Res Social Adm Pharm] 2025 Sep; Vol. 21 (9), pp. 714-721. Date of Electronic Publication: 2025 May 21.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 101231974 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-8150 (Electronic) Linking ISSN: 15517411 NLM ISO Abbreviation: Res Social Adm Pharm Subsets: MEDLINE

Výrazy ze slovníku MeSH: Physicians* , Deprescriptions* , GABA-A Receptor Agonists*/therapeutic use , GABA-A Receptor Agonists*/adverse effects , GABA-A Receptor Agonists*/administration & dosage, Humans ; Aged ; Europe ; Male ; Sleep Wake Disorders/drug therapy

Zolpidem suppresses cortical spreading depolarization and protects against ischemia/reperfusion injury and resulting neurological dysfunctions.

Autoři: Pomierny B Kucharczyk MW Krzyżanowska W a další

Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Aug; Vol. 189, pp. 118320. Date of Electronic Publication: 2025 Jul 04.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE

Výrazy ze slovníku MeSH: Zolpidem*/pharmacology , Zolpidem*/pharmacokinetics , Reperfusion Injury*/physiopathology , Reperfusion Injury*/prevention & control , Reperfusion Injury*/drug therapy , Reperfusion Injury*/metabolism , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/pharmacokinetics , Cortical Spreading Depression*/drug effects , GABA-A Receptor Agonists*/pharmacology , GABA-A Receptor Agonists*/pharmacokinetics, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Disease Models, Animal ; Rats ; Rats, Sprague-Dawley

Cryo-EM structures of ρ1 GABA A receptors with antagonist and agonist drugs.

Autoři: Fan C Cowgill J Howard RJ a další

Zdroj: Nature communications [Nat Commun] 2025 Aug 01; Vol. 16 (1), pp. 7077. Date of Electronic Publication: 2025 Aug 01.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Výrazy ze slovníku MeSH: Receptors, GABA-A*/metabolism , Receptors, GABA-A*/chemistry , Receptors, GABA-A*/ultrastructure , GABA-A Receptor Antagonists*/pharmacology , GABA-A Receptor Antagonists*/chemistry , GABA-A Receptor Antagonists*/metabolism , GABA-A Receptor Agonists*/pharmacology , GABA-A Receptor Agonists*/chemistry, Cryoelectron Microscopy ; Humans ; Molecular Dynamics Simulation ; Protein Binding ; Ligands ; HEK293 Cells ; Animals ; Anticonvulsants/pharmacology ; Anticonvulsants/chemistry

A subtype-selective photoswitchable agonist for precise manipulation of GABA A receptors.

Autoři: Lopez SMM Lee JR Lin WC

Zdroj: British journal of pharmacology [Br J Pharmacol] 2025 Aug; Vol. 182 (16), pp. 3870-3883. Date of Electronic Publication: 2025 Apr 27.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Receptors, GABA-A*/metabolism , GABA-A Receptor Agonists*/pharmacology , GABA-A Receptor Agonists*/chemistry , Azo Compounds*/pharmacology , Azo Compounds*/chemistry, Humans ; HEK293 Cells ; Animals ; Neurons/drug effects ; Neurons/metabolism ; Cells, Cultured

GABA A and GABA B Receptor Agonists Promote the Hypothalamic-Pituitary-Ovarian Axis in the Postfertilization Model Poecilia sphenops.

Autoři: Hotha A Ganesh CB

Zdroj: Molecular reproduction and development [Mol Reprod Dev] 2025 Jul; Vol. 92 (7), pp. e70041.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8903333 Publication Model: Print Cited Medium: Internet ISSN: 1098-2795 (Electronic) Linking ISSN: 1040452X NLM ISO Abbreviation: Mol Reprod Dev Subsets: MEDLINE

Výrazy ze slovníku MeSH: Ovary*/drug effects , Ovary*/metabolism , Hypothalamo-Hypophyseal System*/drug effects , Hypothalamo-Hypophyseal System*/metabolism , Poecilia*/metabolism , GABA-B Receptor Agonists*/pharmacology , GABA-A Receptor Agonists*/pharmacology, Animals ; Female ; Gonadotropin-Releasing Hormone/metabolism ; Muscimol/pharmacology ; Baclofen/pharmacology ; Receptors, GABA-B/metabolism ; Receptors, GABA-A/metabolism

Chronic α5-GABA-A Receptor Potentiation Promotes Mouse Adult Hippocampal Neurogenesis.

Autoři: Prevot TD Marcotte M David DJ a další

Zdroj: Hippocampus [Hippocampus] 2025 Jul; Vol. 35 (4), pp. e70019.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Wiley Country of Publication: United States NLM ID: 9108167 Publication Model: Print Cited Medium: Internet ISSN: 1098-1063 (Electronic) Linking ISSN: 10509631 NLM ISO Abbreviation: Hippocampus Subsets: MEDLINE

Výrazy ze slovníku MeSH: Neurogenesis*/drug effects , Neurogenesis*/physiology , Hippocampus*/drug effects , Hippocampus*/cytology , Hippocampus*/physiology , Hippocampus*/metabolism , Receptors, GABA-A*/metabolism , GABA-A Receptor Agonists*/pharmacology, Animals ; Male ; Fluoxetine/pharmacology ; Mice ; Doublecortin Protein ; Cell Proliferation/drug effects ; Neurons/drug effects ; Neurons/physiology ; Selective Serotonin Reuptake Inhibitors/pharmacology ; Ki-67 Antigen/metabolism ; Cell Survival/drug effects

A systematic review of manipulations to pharmaceutical dosage forms used in psychotropic tapering plans.

Autoři: O'Brien D Healy AM Harkin A a další

Zdroj: British journal of clinical pharmacology [Br J Clin Pharmacol] 2025 Jul; Vol. 91 (7), pp. 1899-1913. Date of Electronic Publication: 2025 Apr 27.

Způsob vydávání: Journal Article; Systematic Review

Informace o časopise: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Antidepressive Agents*/administration & dosage , Drug Tapering*/methods , GABA-A Receptor Agonists*/administration & dosage , Psychotropic Drugs*/administration & dosage, Humans ; Chemistry, Pharmaceutical/methods ; Dosage Forms ; Drug Compounding/methods ; Tablets

Use of Drugs Affecting GABA A Receptors and the Risk of Developing Alzheimer's Disease and Dementia: a Meta-Analysis and Literature Review.

Autoři: Vakili K Fathi M Ebrahimi R a další

Zdroj: Molecular neurobiology [Mol Neurobiol] 2025 Jul; Vol. 62 (7), pp. 9449-9468. Date of Electronic Publication: 2025 Mar 20.

Způsob vydávání: Journal Article; Meta-Analysis; Review

Informace o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Alzheimer Disease*/chemically induced , Alzheimer Disease*/metabolism , Alzheimer Disease*/epidemiology , Receptors, GABA-A*/metabolism , Dementia*/chemically induced , Dementia*/metabolism , GABA-A Receptor Agonists*/adverse effects, Humans ; Zolpidem/adverse effects ; Risk Factors ; Benzodiazepines/adverse effects

Ethanol-induced rapid eye movement sleep suppression in rats: Comparison with subtype-selective GABA A receptor compounds.

Autoři: Reeves-Darby JA Berro LF Hembree HL a další

Zdroj: Journal of psychopharmacology (Oxford, England) [J Psychopharmacol] 2025 Jul; Vol. 39 (7), pp. 744-755. Date of Electronic Publication: 2025 Jun 20.

Způsob vydávání: Journal Article; Comparative Study

Informace o časopise: Publisher: Sage Publications Country of Publication: United States NLM ID: 8907828 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1461-7285 (Electronic) Linking ISSN: 02698811 NLM ISO Abbreviation: J Psychopharmacol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Ethanol*/pharmacology , Receptors, GABA-A*/metabolism , Receptors, GABA-A*/drug effects , Sleep, REM*/drug effects , GABA-A Receptor Agonists*/pharmacology, Animals ; Rats, Sprague-Dawley ; Rats ; Male ; Electroencephalography/drug effects ; Zolpidem ; Electromyography ; Wakefulness/drug effects ; Pyridines/pharmacology ; Alprazolam/pharmacology ; Isoxazoles

Brexanolone, zuranolone and related neurosteroid GABA A receptor positive allosteric modulators for postnatal depression.

Autoři: Wilson CA Robertson L Ayre K a další

Zdroj: The Cochrane database of systematic reviews [Cochrane Database Syst Rev] 2025 Jun 26; Vol. 6. Cochrane AN: CD014624. Date of Electronic Publication: 2025 Jun 26.

Způsob vydávání: Journal Article; Systematic Review; Meta-Analysis; Review

Informace o časopise: Publisher: Wiley Country of Publication: England NLM ID: 100909747 Publication Model: Electronic Cited Medium: Internet ISSN: 1469-493X (Electronic) Linking ISSN: 13616137 NLM ISO Abbreviation: Cochrane Database Syst Rev Subsets: MEDLINE

Výrazy ze slovníku MeSH: Pregnanolone*/therapeutic use , Pregnanolone*/analogs & derivatives , Pregnanolone*/adverse effects , Depression, Postpartum*/drug therapy , Pregnanes*/therapeutic use , Pregnanes*/adverse effects , Neurosteroids*/therapeutic use , Neurosteroids*/adverse effects , Antidepressive Agents*/therapeutic use , Antidepressive Agents*/adverse effects , Thiophenes*/therapeutic use , Thiophenes*/adverse effects , GABA-A Receptor Agonists*/therapeutic use , GABA-A Receptor Agonists*/adverse effects, Humans ; Female ; Randomized Controlled Trials as Topic ; Receptors, GABA-A ; Adult ; Drug Combinations ; beta-Cyclodextrins

Association between gestational hypnotic benzodiazepine receptor agonists exposure and adverse pregnancy outcomes: a systematic review and meta-analysis.

Autoři: Wang X Xu J Mo Y a další

Zdroj: Archives of women's mental health [Arch Womens Ment Health] 2025 Jun; Vol. 28 (3), pp. 503-514. Date of Electronic Publication: 2024 Sep 24.

Způsob vydávání: Journal Article; Meta-Analysis; Systematic Review

Informace o časopise: Publisher: Springer Country of Publication: Austria NLM ID: 9815663 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-1102 (Electronic) Linking ISSN: 14341816 NLM ISO Abbreviation: Arch Womens Ment Health Subsets: MEDLINE

Výrazy ze slovníku MeSH: GABA-A Receptor Agonists*/adverse effects , GABA-A Receptor Agonists*/therapeutic use , Hypnotics and Sedatives*/adverse effects , Pregnancy Complications*/drug therapy , Pregnancy Outcome*/epidemiology, Female ; Humans ; Infant, Newborn ; Pregnancy ; Infant, Low Birth Weight ; Infant, Small for Gestational Age ; Premature Birth/chemically induced ; Premature Birth/epidemiology

Z hypnotics in the management of narcolepsy: a case series.

Autoři: Aboukasm A Reffi AN Drake CL

Zdroj: Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine [J Clin Sleep Med] 2025 May 01; Vol. 21 (5), pp. 753-756.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: American Academy of Sleep Medicine Country of Publication: United States NLM ID: 101231977 Publication Model: Print Cited Medium: Internet ISSN: 1550-9397 (Electronic) Linking ISSN: 15509389 NLM ISO Abbreviation: J Clin Sleep Med Subsets: MEDLINE

Výrazy ze slovníku MeSH: Narcolepsy*/drug therapy , Zolpidem*/therapeutic use , Hypnotics and Sedatives*/therapeutic use , Eszopiclone*/therapeutic use , GABA-A Receptor Agonists*/therapeutic use, Humans ; Male ; Female ; Adult ; Middle Aged ; Treatment Outcome ; Retrospective Studies ; Young Adult

Zolpidem for the Management of Catatonia: A Systematic Review.

Autoři: Gunther M Tran N Jiang S

Zdroj: Journal of the Academy of Consultation-Liaison Psychiatry [J Acad Consult Liaison Psychiatry] 2025 Jan-Feb; Vol. 66 (1), pp. 49-56. Date of Electronic Publication: 2024 Nov 09.

Způsob vydávání: Journal Article; Systematic Review

Informace o časopise: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101775059 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2667-2960 (Electronic) Linking ISSN: 26672960 NLM ISO Abbreviation: J Acad Consult Liaison Psychiatry Subsets: MEDLINE

Výrazy ze slovníku MeSH: Zolpidem*/therapeutic use , Zolpidem*/pharmacology , Catatonia*/drug therapy , GABA-A Receptor Agonists*/therapeutic use , GABA-A Receptor Agonists*/pharmacology , Pyridines*/therapeutic use , Hypnotics and Sedatives*, Humans ; Adult ; Lorazepam/therapeutic use

Benzodiazepine-receptor agonist prescription in a population of hospitalised patients in four psychogeriatric units in Switzerland.

Autoři: Dalmau I Ribas M Sauser J Gillès de Pélichy E a další

Zdroj: Journal of sleep research [J Sleep Res] 2025 Feb; Vol. 34 (1), pp. e14317. Date of Electronic Publication: 2024 Aug 07.

Způsob vydávání: Journal Article; Research Support, Non-U.S. Gov't

Informace o časopise: Publisher: Published on behalf of the European Sleep Research Society by Blackwell Scientific Publications Country of Publication: England NLM ID: 9214441 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2869 (Electronic) Linking ISSN: 09621105 NLM ISO Abbreviation: J Sleep Res Subsets: MEDLINE

Výrazy ze slovníku MeSH: Hospitalization*/statistics & numerical data , GABA-A Receptor Agonists*/therapeutic use , Drug Prescriptions*/statistics & numerical data , Benzodiazepines*/therapeutic use , Practice Patterns, Physicians'*/statistics & numerical data, Humans ; Female ; Male ; Cross-Sectional Studies ; Aged ; Switzerland ; Retrospective Studies ; Aged, 80 and over

Sleep should not be this difficult: An interpretive descriptive study of older adults' perspectives on behaviour change elements in Sleepwell and experiences with benzodiazepine discontinuation.

Autoři: Katmeh T Gardner DM Kiepek N a další

Zdroj: Journal of sleep research [J Sleep Res] 2025 Feb; Vol. 34 (1), pp. e14282. Date of Electronic Publication: 2024 Jun 30.

Způsob vydávání: Journal Article; Research Support, Non-U.S. Gov't

Informace o časopise: Publisher: Published on behalf of the European Sleep Research Society by Blackwell Scientific Publications Country of Publication: England NLM ID: 9214441 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2869 (Electronic) Linking ISSN: 09621105 NLM ISO Abbreviation: J Sleep Res Subsets: MEDLINE

Výrazy ze slovníku MeSH: Benzodiazepines*/adverse effects , Cognitive Behavioral Therapy*/methods , GABA-A Receptor Agonists*/adverse effects , Sleep Initiation and Maintenance Disorders*/therapy , Sleep Initiation and Maintenance Disorders*/drug therapy , Sleep Initiation and Maintenance Disorders*/psychology, Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Qualitative Research ; Randomized Controlled Trials as Topic

[The use of zolpidem in the treatment of acute and chronic insomnia].

Transliterovaný název: Primenenie zolpidema v lechenii ostroi i khronicheskoi insomnii.

Autoři: Zhuravleva MV Luchinina EV Gorbachev NA a další

Zdroj: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2025; Vol. 125 (5. Vyp. 2), pp. 52-56.

Způsob vydávání: Journal Article; Review; English Abstract

Informace o časopise: Publisher: Media Sfera Country of Publication: Russia (Federation) NLM ID: 9712194 Publication Model: Print Cited Medium: Print ISSN: 1997-7298 (Print) Linking ISSN: 19977298 NLM ISO Abbreviation: Zh Nevrol Psikhiatr Im S S Korsakova Subsets: MEDLINE

Výrazy ze slovníku MeSH: Sleep Initiation and Maintenance Disorders*/drug therapy , Pyridines*/therapeutic use , Pyridines*/pharmacokinetics , Pyridines*/pharmacology , Hypnotics and Sedatives*/therapeutic use , Hypnotics and Sedatives*/pharmacokinetics , GABA-A Receptor Agonists*/therapeutic use , Sleep Aids, Pharmaceutical*/therapeutic use, Zolpidem ; Humans ; Chronic Disease ; Acute Disease