Výsledky vyhľadávania - "G2 Phase"

G2 regulatory processes require speedbump for Wee1 kinase activity.

Autori: Warga RM Kane DA

Zdroj: Developmental biology [Dev Biol] 2025 Nov; Vol. 527, pp. 165-181. Date of Electronic Publication: 2025 Aug 09.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 0372762 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-564X (Electronic) Linking ISSN: 00121606 NLM ISO Abbreviation: Dev Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Protein-Tyrosine Kinases*/metabolism , Protein-Tyrosine Kinases*/genetics , Zebrafish*/embryology , Zebrafish*/genetics , Zebrafish*/metabolism , G2 Phase Cell Cycle Checkpoints*/physiology , G2 Phase Cell Cycle Checkpoints*/genetics , Cell Cycle Proteins*/metabolism , Cell Cycle Proteins*/genetics , Zebrafish Proteins*/metabolism , Zebrafish Proteins*/genetics , G2 Phase*/physiology, Animals ; Mitosis ; Apoptosis ; Embryo, Nonmammalian

Evodiamine induces centrosome amplification with subsequent G2/M cell cycle arrest in primary vascular smooth muscle cells.

Autori: Haiss P Liu R Xian F a ďalší

Zdroj: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 2), pp. 117320. Date of Electronic Publication: 2025 Sep 09.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Quinazolines*/pharmacology , Centrosome*/drug effects , Centrosome*/metabolism , Muscle, Smooth, Vascular*/drug effects , Muscle, Smooth, Vascular*/cytology , Muscle, Smooth, Vascular*/metabolism , G2 Phase Cell Cycle Checkpoints*/drug effects , G2 Phase Cell Cycle Checkpoints*/physiology , Myocytes, Smooth Muscle*/drug effects , Myocytes, Smooth Muscle*/metabolism , Myocytes, Smooth Muscle*/cytology, Animals ; Cells, Cultured ; Rats ; Cell Proliferation/drug effects

Optimized PEGylated paclitaxel and 6-gingerol co-loaded liposomes induce G2/M phase arrest and apoptosis in MDA-MB-231 breast and A549 lung cancer cells.

Autori: Thangavelu P Gunasekaran K Periyathambi S a ďalší

Zdroj: Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2025 Dec; Vol. 53 (1), pp. 468-488. Date of Electronic Publication: 2025 Oct 27.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101594777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2169-141X (Electronic) Linking ISSN: 21691401 NLM ISO Abbreviation: Artif Cells Nanomed Biotechnol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Paclitaxel*/pharmacology , Paclitaxel*/chemistry , Paclitaxel*/pharmacokinetics , Fatty Alcohols*/chemistry , Fatty Alcohols*/pharmacology , Fatty Alcohols*/pharmacokinetics , Apoptosis*/drug effects , Polyethylene Glycols*/chemistry , Catechols*/chemistry , Catechols*/pharmacology , Catechols*/pharmacokinetics , G2 Phase Cell Cycle Checkpoints*/drug effects , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism, Humans ; Liposomes/chemistry ; A549 Cells ; Drug Liberation ; Drug Carriers/chemistry

Integrated analysis reveals survival-related genes promoting cholangiocarcinoma progression via G2/M cell cycle, with validation of cyclin B1 in tumor proliferation.

Autori: Jiang Q Liu X Yu W a ďalší

Zdroj: Scientific reports [Sci Rep] 2025 Nov 21; Vol. 15 (1), pp. 41352. Date of Electronic Publication: 2025 Nov 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cyclin B1*/genetics , Cyclin B1*/metabolism , Cholangiocarcinoma*/genetics , Cholangiocarcinoma*/pathology , Cholangiocarcinoma*/metabolism , Bile Duct Neoplasms*/genetics , Bile Duct Neoplasms*/pathology , Bile Duct Neoplasms*/metabolism , G2 Phase Cell Cycle Checkpoints*/genetics, Humans ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Disease Progression ; Cell Line, Tumor ; Gene Regulatory Networks ; Single-Cell Analysis ; Gene Expression Profiling

KIF11 promotes AML progression, and its inhibition by SB-743921 suppresses disease advancement through mitotic G2/M phase arrest.

Autori: Cai L Wang J Yang Y a ďalší

Zdroj: Cellular signalling [Cell Signal] 2025 Nov; Vol. 135, pp. 111980. Date of Electronic Publication: 2025 Jul 12.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

Výrazy zo slovníka MeSH: Kinesins*/antagonists & inhibitors , Kinesins*/metabolism , Kinesins*/genetics , Leukemia, Myeloid, Acute*/pathology , Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/metabolism , Leukemia, Myeloid, Acute*/genetics , G2 Phase Cell Cycle Checkpoints*/drug effects , M Phase Cell Cycle Checkpoints*/drug effects , Thiones*/pharmacology, Humans ; Animals ; Mice ; Disease Progression ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Apoptosis/drug effects ; Mitosis/drug effects ; Mice, Nude ; Benzamides ; Chromones

RNA binding proteins control the G 2 -M checkpoint of the germinal center B cell.

Autori: Salerno F Whale AJ Matheson LS a ďalší

Zdroj: Science immunology [Sci Immunol] 2025 Oct 31; Vol. 10 (112), pp. eadu3718. Date of Electronic Publication: 2025 Oct 31.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Germinal Center*/immunology , Germinal Center*/cytology , B-Lymphocytes*/immunology , G2 Phase Cell Cycle Checkpoints*/immunology , RNA-Binding Proteins*/immunology , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics, Animals ; Mice ; Mice, Inbred C57BL ; Mice, Knockout

Erythropoiesis-Stimulating Agent Protects Against Kidney Fibrosis by Inhibiting G2/M Cell Cycle Arrest.

Autori: Oh D Jhee JH Kim SH a ďalší

Zdroj: Cells [Cells] 2025 Oct 23; Vol. 14 (21). Date of Electronic Publication: 2025 Oct 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

Výrazy zo slovníka MeSH: G2 Phase Cell Cycle Checkpoints*/drug effects , Hematinics*/pharmacology , Hematinics*/therapeutic use , Kidney*/pathology , Kidney*/drug effects , Kidney Diseases*/pathology , Kidney Diseases*/drug therapy , Protective Agents*/pharmacology, Animals ; Fibrosis ; Humans ; Mice ; Cell Line ; Transforming Growth Factor beta/pharmacology ; Male ; Darbepoetin alfa/pharmacology ; Mice, Inbred C57BL

Targeting TXN1 Induces G2M Phase Arrest and Apoptosis of Glioma Cells Through P38 MAPK Pathway.

Autori: Zhou L Liang H Nie C a ďalší

Zdroj: Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2025 Oct; Vol. 197 (10), pp. 6849-6870. Date of Electronic Publication: 2025 Aug 20.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 8208561 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0291 (Electronic) Linking ISSN: 02732289 NLM ISO Abbreviation: Appl Biochem Biotechnol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glioma*/pathology , Glioma*/metabolism , Glioma*/genetics , Apoptosis* , p38 Mitogen-Activated Protein Kinases*/metabolism , G2 Phase Cell Cycle Checkpoints* , Brain Neoplasms*/pathology , Brain Neoplasms*/metabolism , MAP Kinase Signaling System*, Humans ; Animals ; Mice ; Cell Line, Tumor ; Mice, Nude ; Male ; Female ; Cell Proliferation

Tubulin hyperacetylation drives HMGB1 nuclear exit via the ROS-PARP1 axis, leading to rotenone-induced G2/M arrest.

Autori: Dutta S Chakraborty S Ghosh A a ďalší

Zdroj: The Journal of biological chemistry [J Biol Chem] 2025 Oct; Vol. 301 (10), pp. 110695. Date of Electronic Publication: 2025 Sep 08.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Rotenone*/pharmacology , Reactive Oxygen Species*/metabolism , Poly (ADP-Ribose) Polymerase-1*/metabolism , Poly (ADP-Ribose) Polymerase-1*/genetics , HMGB1 Protein*/metabolism , HMGB1 Protein*/genetics , Cell Nucleus*/metabolism , Cell Nucleus*/drug effects , G2 Phase Cell Cycle Checkpoints*/drug effects , Tubulin*/metabolism, Acetylation/drug effects ; Humans ; Animals ; DNA Damage ; Mitochondria/metabolism ; Mitochondria/drug effects

AR-V7 expression facilitates accelerated G2/M phase transition in castration-resistant prostate cancer.

Autori: Saini T Gupta P Raut R a ďalší

Zdroj: Experimental cell research [Exp Cell Res] 2024 May 01; Vol. 438 (1), pp. 114026. Date of Electronic Publication: 2024 Apr 09.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 0373226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2422 (Electronic) Linking ISSN: 00144827 NLM ISO Abbreviation: Exp Cell Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: G2 Phase Cell Cycle Checkpoints*/genetics , Prostatic Neoplasms, Castration-Resistant*/genetics , Prostatic Neoplasms, Castration-Resistant*/pathology , Prostatic Neoplasms, Castration-Resistant*/metabolism , Receptors, Androgen*/metabolism , Receptors, Androgen*/genetics, Humans ; Male ; Cell Line, Tumor ; Cell Proliferation/genetics ; G2 Phase/genetics ; Gene Expression Regulation, Neoplastic ; Phosphorylation ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Protein-Tyrosine Kinases/metabolism ; Protein-Tyrosine Kinases/genetics ; Serine-Arginine Splicing Factors/metabolism ; Serine-Arginine Splicing Factors/genetics

A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision.

Autori: Vorhauser J Roumeliotis TI Coupe D a ďalší

Zdroj: Molecular cell [Mol Cell] 2025 Sep 04; Vol. 85 (17), pp. 3241-3255.e11. Date of Electronic Publication: 2025 Aug 25.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cyclin-Dependent Kinase Inhibitor p21*/metabolism , Cyclin-Dependent Kinase Inhibitor p21*/genetics , Cell Proliferation* , Cyclin-Dependent Kinase 2*/metabolism , Cyclin-Dependent Kinase 2*/genetics , G2 Phase*, Oxidation-Reduction ; Humans ; Reactive Oxygen Species/metabolism ; Feedback, Physiological ; Cysteine/metabolism ; Signal Transduction ; Cellular Senescence ; Proteomics/methods ; Protein Processing, Post-Translational ; Cyclin-Dependent Kinase 4

Diosgenin enhances the effect of radiation on head and neck cancer cells through apoptosis induction, G2/M cell cycle arrest, and ROS generation.

Autori: Mohammadi M Koosha F Amini SM a ďalší

Zdroj: Medical oncology (Northwood, London, England) [Med Oncol] 2025 Sep 03; Vol. 42 (10), pp. 461. Date of Electronic Publication: 2025 Sep 03.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Diosgenin*/pharmacology , Apoptosis*/drug effects , Apoptosis*/radiation effects , Reactive Oxygen Species*/metabolism , Head and Neck Neoplasms*/radiotherapy , Head and Neck Neoplasms*/metabolism , Head and Neck Neoplasms*/pathology , Head and Neck Neoplasms*/drug therapy , Radiation-Sensitizing Agents*/pharmacology , G2 Phase Cell Cycle Checkpoints*/drug effects , G2 Phase Cell Cycle Checkpoints*/radiation effects, Humans ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/radiation effects

SORBS1 Knockdown Resists S/G2 Arrest and Apoptosis Caused by Polyphyllin H-Induced DNA Damage in Pancreatic Cancer.

Autori: Hu X Xue Y Fang F a ďalší

Zdroj: Oncology research [Oncol Res] 2025 Aug 28; Vol. 33 (9), pp. 2491-2506. Date of Electronic Publication: 2025 Aug 28 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Tech Science Press Country of Publication: United States NLM ID: 9208097 Publication Model: eCollection Cited Medium: Internet ISSN: 1555-3906 (Electronic) Linking ISSN: 09650407 NLM ISO Abbreviation: Oncol Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/metabolism , DNA Damage*/drug effects , G2 Phase Cell Cycle Checkpoints*/drug effects , G2 Phase Cell Cycle Checkpoints*/genetics , Adaptor Proteins, Signal Transducing*/genetics , Adaptor Proteins, Signal Transducing*/metabolism, Humans ; Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Mice ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Mice, Nude ; Cell Proliferation/drug effects ; Gene Knockdown Techniques ; Prognosis ; Gene Expression Regulation, Neoplastic/drug effects ; Female

Antineoplastic potential of Kushneria avicenniae pigments via modulation of the BAX/BCL-2 axis and CASP-9 pathway in inducing G2/M arrest and apoptosis in liver and breast cancer.

Autori: Almetwaly H Elmetwalli A El-Amier YA a ďalší

Zdroj: Medical oncology (Northwood, London, England) [Med Oncol] 2025 Aug 02; Vol. 42 (9), pp. 400. Date of Electronic Publication: 2025 Aug 02.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Apoptosis*/drug effects , Breast Neoplasms*/drug therapy , Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology , Caspase 9*/metabolism , bcl-2-Associated X Protein*/metabolism , Liver Neoplasms*/drug therapy , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , G2 Phase Cell Cycle Checkpoints*/drug effects , Antineoplastic Agents*/pharmacology , Pigments, Biological*/pharmacology, Humans ; Female ; MCF-7 Cells ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Hep G2 Cells ; Signal Transduction/drug effects

Ginseng glucosyl oleanolate inhibited A549 cell proliferation by inducing G2/M cell cycle arrest and ROS-mediated apoptosis in vivo/vitro.

Autori: Hu Y Ai Z Liu S a ďalší

Zdroj: Food research international (Ottawa, Ont.) [Food Res Int] 2025 Aug; Vol. 213, pp. 116573. Date of Electronic Publication: 2025 May 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science Country of Publication: Canada NLM ID: 9210143 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7145 (Electronic) Linking ISSN: 09639969 NLM ISO Abbreviation: Food Res Int Subsets: MEDLINE

Výrazy zo slovníka MeSH: Apoptosis*/drug effects , Cell Proliferation*/drug effects , Reactive Oxygen Species*/metabolism , Panax*/chemistry , G2 Phase Cell Cycle Checkpoints*/drug effects , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism, Humans ; Animals ; A549 Cells ; Mice, Nude ; Mice ; Xenograft Model Antitumor Assays ; Signal Transduction/drug effects ; Antineoplastic Agents, Phytogenic/pharmacology ; Tumor Suppressor Protein p53/metabolism ; Mice, Inbred BALB C

Synthetic selenomelanin nanoparticles radio-sensitize non-melanocytic lung cancer (A549) cells by promoting G2/M arrest.

Autori: Aishwarya J Das RP Barik A a ďalší

Zdroj: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2025 Aug; Vol. 252, pp. 114680. Date of Electronic Publication: 2025 Apr 09.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE

Výrazy zo slovníka MeSH: Nanoparticles*/chemistry , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism , Radiation-Sensitizing Agents*/pharmacology , Radiation-Sensitizing Agents*/chemistry , Radiation-Sensitizing Agents*/chemical synthesis , Melanins*/pharmacology , Melanins*/chemistry , Melanins*/chemical synthesis , G2 Phase Cell Cycle Checkpoints*/drug effects, Humans ; A549 Cells ; Apoptosis/drug effects ; Reactive Oxygen Species/metabolism ; Cell Proliferation/drug effects

E2F activity determines mitosis versus whole-genome duplication in G2-arrested cells.

Autori: Kim K Armand J Kim S a ďalší

Zdroj: Nature communications [Nat Commun] 2025 Jul 21; Vol. 16 (1), pp. 6677. Date of Electronic Publication: 2025 Jul 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Výrazy zo slovníka MeSH: Mitosis*/genetics , E2F Transcription Factors*/metabolism , E2F Transcription Factors*/genetics , G2 Phase*/genetics, Humans ; Cyclin-Dependent Kinase 2/metabolism ; Cyclin-Dependent Kinase 2/genetics ; Cyclin-Dependent Kinase 6/metabolism ; Cyclin-Dependent Kinase 6/genetics ; Forkhead Box Protein M1/metabolism ; Cell Line, Tumor ; Gene Duplication ; Phosphorylation ; Cyclin-Dependent Kinase 4/metabolism ; Cyclin-Dependent Kinase 4/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Proto-Oncogene Proteins c-myc/genetics ; Signal Transduction ; Genomic Instability ; Genome, Human ; Retinoblastoma Protein/metabolism

Skullcapflavone II induces G2/M phase arrest in hepatic stellate cells and suppresses hepatic fibrosis.

Autori: Rong G Liu J Yang Y a ďalší

Zdroj: European journal of pharmacology [Eur J Pharmacol] 2025 Jul 05; Vol. 998, pp. 177522. Date of Electronic Publication: 2025 Mar 18.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hepatic Stellate Cells*/drug effects , Hepatic Stellate Cells*/pathology , Hepatic Stellate Cells*/metabolism , Liver Cirrhosis*/pathology , Liver Cirrhosis*/drug therapy , Liver Cirrhosis*/chemically induced , Liver Cirrhosis*/metabolism , G2 Phase Cell Cycle Checkpoints*/drug effects , Flavonoids*/pharmacology , Flavonoids*/therapeutic use, Animals ; Mice ; Cell Proliferation/drug effects ; Male ; Molecular Docking Simulation ; Cell Line ; Carbon Tetrachloride ; Humans ; Mice, Inbred C57BL ; Liver/drug effects ; Liver/pathology ; Liver/metabolism

Plasticity of mitotic cyclins in promoting the G2-M transition.

Autori: Crncec A Lau HW Ng LY a ďalší

Zdroj: The Journal of cell biology [J Cell Biol] 2025 Jun 02; Vol. 224 (6). Date of Electronic Publication: 2025 Apr 09.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 0375356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8140 (Electronic) Linking ISSN: 00219525 NLM ISO Abbreviation: J Cell Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Mitosis* , Cyclin A*/metabolism , Cyclin A*/genetics , G2 Phase* , Cyclins*/metabolism, Humans ; Cell Cycle Proteins/metabolism ; Cell Cycle Proteins/genetics ; CDC2 Protein Kinase/metabolism ; CDC2 Protein Kinase/genetics ; Polo-Like Kinase 1 ; Protein Serine-Threonine Kinases/metabolism ; Protein Serine-Threonine Kinases/genetics ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins/genetics ; HeLa Cells ; Cyclin-Dependent Kinase 2/metabolism ; Cyclin-Dependent Kinase 2/genetics ; Cyclin B1/metabolism ; Cyclin B1/genetics ; Cyclin B/metabolism ; Cyclin B/genetics

3,3',5,5'-Tetramethoxybiphenyl-4,4'-diol exerts a cytotoxic effect on hepatocellular carcinoma cell lines by inducing morphological and ultrastructural alterations, G2/M cell cycle arrest and death by apoptosis via CDK1 interaction.

Autori: Inoue FSR Concato-Lopes VM Bortoleti BTDS a ďalší

Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Jun; Vol. 187, pp. 118082. Date of Electronic Publication: 2025 Apr 24.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE

Výrazy zo slovníka MeSH: Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/ultrastructure , Carcinoma, Hepatocellular*/pathology , Liver Neoplasms*/drug therapy , Liver Neoplasms*/ultrastructure , Liver Neoplasms*/pathology , Liver Neoplasms*/enzymology , Apoptosis*/drug effects , CDC2 Protein Kinase*/metabolism , G2 Phase Cell Cycle Checkpoints*/drug effects , Antineoplastic Agents*/pharmacology , Biphenyl Compounds*/pharmacology, Humans ; Cell Line, Tumor ; Cell Movement/drug effects ; Hep G2 Cells ; Reactive Oxygen Species/metabolism ; Molecular Docking Simulation ; Cell Survival/drug effects ; Autophagy/drug effects ; Mitochondria/drug effects