Suchergebnisse - "Fumarates/*pharmacology"

Diroximel Fumarate in Patients with Relapsing–Remitting Multiple Sclerosis: NEDA-3 After Re-Baselining in the Phase 3 EVOLVE-MS-1 Study

Autoren: James D. Bowen Jessica Stulc Samuel F. Hunter et al.

Quelle: Adv Ther

Schlagwörter: Adult, Male, Brief Report, Dimethyl Fumarate, Middle Aged, Magnetic Resonance Imaging, Multiple Sclerosis, Relapsing-Remitting, Treatment Outcome, Fumarates, Double-Blind Method, Disease Progression, Humans, Female, Double-Blind Method [MeSH], Female [MeSH], Disease Progression [MeSH], Adult [MeSH], Diroximel fumarate, Disease-modifying therapies, Humans [MeSH], Dimethyl fumarate, Treatment Outcome [MeSH], Fumarates/therapeutic use [MeSH], Middle Aged [MeSH], Dimethyl Fumarate/therapeutic use [MeSH], Efficacy, Re-baselining, No Evidence of Disease Activity (NEDA), Magnetic Resonance Imaging [MeSH], Multiple sclerosis, Male [MeSH], Multiple Sclerosis, Relapsing-Remitting/drug therapy [MeSH], Fumarates/pharmacology [MeSH], Immunosuppressive Agents/therapeutic use [MeSH], Immunosuppressive Agents

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38878121
https://repository.publisso.de/resource/frl:6501302

Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism

Autoren: F. Chen W. A. M. Elgaher M. Winterhoff et al.

Quelle: Nat Metab

Schlagwörter: 0301 basic medicine, ddc:500, Letter, Carboxy-Lyases, Immunology, name=Internal Medicine, Antiviral Agents, Catalysis, name=Cell Biology, 03 medical and health sciences, Applied immunology, Fumarates, Macrophages/metabolism, Humans, Metabolomics, Fumarates/pharmacology, Inflammation, 0303 health sciences, name=Physiology (medical), Antiviral Agents/metabolism, Macrophages, FOS: Clinical medicine, Inflammation/metabolism, Maleates, 3. Good health, Diabetes and Metabolism, Oxidative Stress, Metabolism, Interferons, name=Endocrinology, Maleates/pharmacology

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/35655026

Systemic and tissue-specific effects of aliskiren on the RAAS and carbohydrate/lipid metabolism in obese patients with hypertension.

Autoren: Engeli, S. May, M. Nussberger, J. et al.

Schlagwörter: Adipose Tissue/drug effects, Adipose Tissue/metabolism, Adult, Amides/pharmacology, Amides/therapeutic use, Amlodipine/pharmacology, Amlodipine/therapeutic use, Angiotensin II/metabolism, Antihypertensive Agents/pharmacology, Antihypertensive Agents/therapeutic use, Blood Glucose/drug effects, Double-Blind Method, Female, Fumarates/pharmacology, Fumarates/therapeutic use, Glucose/metabolism, Humans, Hypertension/blood, Hypertension/drug therapy, Hypertension/etiology, Hypertension/metabolism, Insulin/blood, Lipolysis/drug effects, Male, Microdialysis, Middle Aged, Muscle, Skeletal/drug effects, Skeletal/metabolism, Obesity/blood

Relation: Journal of the American Society of Hypertension; https://iris.unil.ch/handle/iris/226152; serval:BIB_82F1124E75DA; 000408288300006

Verfügbarkeit: https://iris.unil.ch/handle/iris/226152
https://doi.org/10.1016/j.jash.2017.06.002

Comparative Effect of a Renin Inhibitor and a Thiazide Diuretic on Renal Tissue Oxygenation in Hypertensive Patients.

Autoren: Vakilzadeh, N. Muller, M.E. Forni, V. et al.

Schlagwörter: Adult, Aged, Amides/pharmacology, Amides/therapeutic use, Antihypertensive Agents/pharmacology, Antihypertensive Agents/therapeutic use, Female, Fumarates/pharmacology, Fumarates/therapeutic use, Humans, Hydrochlorothiazide/pharmacology, Hydrochlorothiazide/therapeutic use, Hypertension/diagnosis, Hypertension/drug therapy, Kidney/drug effects, Kidney/metabolism, Male, Middle Aged, Oxygen Consumption/drug effects, Oxygen Consumption/physiology, Prospective Studies, Renin/antagonists & inhibitors, Single-Blind Method

Relation: Kidney and Blood Pressure Research; https://iris.unil.ch/handle/iris/206052; serval:BIB_E3EA18BB8ACD; 000364209500010

Verfügbarkeit: https://iris.unil.ch/handle/iris/206052
https://doi.org/10.1159/000368530

Angiotensinogen and C3 compete for renin-induced complement activation

Autoren: Kristoffersson, Ann-Charlotte Sköld, Albin Welinder, Charlotte et al.

Quelle: Frontiers in Immunology; 16, no 1563868 (2025) ; ISSN: 1664-3224

Schlagwörter: Immunology in the Medical Area (including Cell and Immunotherapy), Angiotensinogen/metabolism, Renin/metabolism, Humans, Complement Activation/immunology, Complement C3/metabolism, Amides/pharmacology, Recombinant Proteins/metabolism, Complement C3a/metabolism, Fumarates/pharmacology

Relation: http://dx.doi.org/10.3389/fimmu.2025.1563868; scopus:105003204821; pmid:40242769

Verfügbarkeit: https://lup.lub.lu.se/record/f4843e17-2771-4f8c-9c89-62539a9427c8
https://doi.org/10.3389/fimmu.2025.1563868

The renin angiotensin system (RAS) mediates bifunctional growth regulation in melanoma and is a novel target for therapeutic intervention

Autoren: Alexander Renziehausen Hexiao Wang Bhavya Rao et al.

Quelle: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
instname

Schlagwörter: Type 2/genetics, 0301 basic medicine, Embryo, Nonmammalian, Pyridines, name=Cancer Research, Angiotensin-Converting Enzyme Inhibitors, Angiotensin receptor, Cell Proliferation/drug effects, Renin-Angiotensin System, Angiotensin, Fumarates, Fumarates/pharmacology, Molecular Targeted Therapy, Neoplasm Metastasis, Melanoma, Zebrafish, Cells, Cultured, Imidazoles/pharmacology, Pyridines/pharmacology, 0303 health sciences, Cultured, Nonmammalian, Tumor, Angiotensin II, Imidazoles, Antihypertensive Agents/pharmacology, DNA Methylation/drug effects, 3. Good health, Embryo, Receptor, Cells, name=Genetics, Angiotensin-Converting Enzyme Inhibitors/pharmacology, Receptor, Angiotensin, Type 2, Receptor, Angiotensin, Type 1, Cell Line, Melanoma/genetics, 03 medical and health sciences, Cell Line, Tumor, Animals, Humans, Antihypertensive Agents, Amides/pharmacology, Cell Proliferation, epigenetics, name=Molecular Biology, DNA Methylation, Xenograft Model Antitumor Assays, Amides, Renin-Angiotensin System/drug effects, Angiotensin II/pharmacology, Molecular Targeted Therapy/methods, Type 1/genetics

Dateibeschreibung: application/pdf

Zugangs-URL: https://discovery.dundee.ac.uk/ws/files/29557175/Author_Accepted_Manuscript.pdf
https://pubmed.ncbi.nlm.nih.gov/30478450
http://hdl.handle.net/10668/13242
https://discovery.dundee.ac.uk/ws/files/29557175/Author_Accepted_Manuscript.pdf
https://www.ncbi.nlm.nih.gov/pubmed/30478450
https://pubmed.ncbi.nlm.nih.gov/30478450/
https://www.nature.com/articles/s41388-018-0563-y
https://europepmc.org/article/MED/30478450
https://mdanderson.elsevierpure.com/en/publications/the-renin-angiotensin-system-ras-mediates-bifunctional-growth-reg
https://hdl.handle.net/10668/13242

Impact of aliskiren on some hemostatic parameters in experimental arterial thrombosis in rats

Autoren: Adam Hermanowicz Wlodzimierz Buczko Piotr Buczko et al.

Quelle: Pharmacological Reports. 67:173-178

Schlagwörter: Male, Platelet Aggregation, Blood Pressure, Thrombosis - complications, Disease models, Hemostasis - drug effects, Hypertension - complications, Amides - pharmacology, 03 medical and health sciences, Hypertension - drug therapy, 0302 clinical medicine, Fumarates, Plasminogen Activator Inhibitor 1, Blood coagulation - drug effects, Animals, animal, Plasminogen activator inhibitor 1 - blood, Antihypertensive agents - therapeutic use, Blood Coagulation, Antihypertensive Agents, Blood coagulation factors - drug effects, Thrombosis - blood, Amides - therapeutic use, Hemostasis, Tissue plasminogen activator - blood, Blood pressure - drug effects, Thrombosis, Thrombosis - drug therapy, Amides, Blood Coagulation Factors, Rats, 3. Good health, Disease Models, Animal, Platelet aggregation - drug effects, Antihypertensive agents - pharmacology, Tissue Plasminogen Activator, Fumarates - pharmacology, Hypertension, Fumarates - therapeutic use

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/25712636
https://www.sciencedirect.com/science/article/pii/S1734114014002825#!
https://pubmed.ncbi.nlm.nih.gov/25712636/
https://www.ncbi.nlm.nih.gov/pubmed/25712636
https://www.sciencedirect.com/science/article/pii/S1734114014002825
https://europepmc.org/article/MED/25712636
https://link.springer.com/article/10.1016/j.pharep.2014.08.021

Renin inhibition with aliskiren lowers circulating endothelial progenitor cells in patients with early atherosclerosis

Autoren: Flammer, A J Gossl, M Li, J et al.

Weitere Verfasser: Flammer, A J Gossl, M Li, J et al.

Quelle: Journal of Hypertension. 31:632-635

Schlagwörter: Fumarates/*pharmacology, Stem Cells, 610 Medicine & health, 1314 Physiology, Stem Cells/*pathology, Atherosclerosis, Amides, 2705 Cardiology and Cardiovascular Medicine, 03 medical and health sciences, 0302 clinical medicine, Fumarates, 2724 Internal Medicine, Endothelium/*pathology, Renin, 10209 Clinic for Cardiology, Humans, Renin/*antagonists & inhibitors, Amides/*pharmacology, Endothelium, Atherosclerosis/*pathology

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/23615219
https://www.ncbi.nlm.nih.gov/pubmed/23615219
https://mayoclinic.pure.elsevier.com/en/publications/renin-inhibition-with-aliskiren-lowers-circulating-endothelial-pr

Aliskiren inhibits experimental venous thrombosis in two-kidney one- clip hypertensive rats

Autoren: Agnieszka Leszczynska Justyna Magdalena Hermanowicz Adam Hermanowicz et al.

Quelle: Thrombosis Research. 131:e39-e44

Schlagwörter: Male, 0301 basic medicine, Dose-response relationship, Enzyme inhibitors - pharmacology, Venous thrombosis - etiology, Wistar, Venous thrombosis - drug therapy, Administration, Oral, Blood Pressure, renovascular - etiology, Kidney, Fibrinolytic agents - administration & dosage, Nitric oxide - metabolism, Fibrinolysis - drug effects, Biomarkers - blood, oral, Amides - pharmacology, 0302 clinical medicine, Fumarates, renovascular - blood, renovascular - drug therapy, animal, Nitric oxide synthase - metabolism, Enzyme Inhibitors, Nitric oxide synthase - antagonists & inhibitors, Tissue plasminogen activator - blood, Fibrinolysis, drug, 3. Good health, Hypertension, Renovascular, Hypoglycemic agents - pharmacology, Administration, Fumarates - pharmacology, Hypertension, Blood platelets - metabolism, Blood Platelets, Disease models, renovascular - physiopathology, Nitric Oxide, Venous thrombosis - blood, Blood platelets - drug effects, renovascular - metabolism, 03 medical and health sciences, Fibrinolytic Agents, Kidney - blood supply, Animals, Hypoglycemic Agents, Fibrinolytic agents - pharmacology, Plasminogen activator inhibitor 1 - blood, Ligation, Dose-Response Relationship, Drug, Fumarates - administration & dosage, Blood pressure - drug effects, Renal artery - surgery, Amides, Epoprostenol, Rats, Platelet activation - drug effects, Disease Models, Animal, Epoprostenol - metabolism, Hypoglycemic agents - administration & dosage, Venous thrombosis - metabolism, Nitric Oxide Synthase, Amides - administration & dosage, Biomarkers

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/23174623
https://pubmed.ncbi.nlm.nih.gov/23174623/
https://www.sciencedirect.com/science/article/pii/S0049384812008006
http://www.sciencedirect.com/science/article/pii/S0049384812008006

Aliskiren, a Direct Renin Inhibitor, in Clinical Practice: A New Approach in the Treatment of Hypertension

Autoren: Moutzouri, E. Florentin, M. Elisaf, M. S. et al.

Quelle: Current Vascular Pharmacology. 8:344-362

Schlagwörter: Clinical Trials as Topic, Antihypertensive Agents/pharmacology/*therapeutic use, Clinical Trials as Topic/methods, Renin/*antagonists & inhibitors/metabolism, Amides/pharmacology/*therapeutic use, Amides, Hypertension/*drug therapy/metabolism, 3. Good health, 03 medical and health sciences, Treatment Outcome, 0302 clinical medicine, Fumarates, Hypertension, Renin, Fumarates/pharmacology/*therapeutic use, Animals, Humans, Signal Transduction/drug effects/physiology, Antihypertensive Agents, Signal Transduction

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/20180771
http://www.ncbi.nlm.nih.gov/pubmed/20180771
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1570-1611&volume=8&issue=3&spage=344
https://benthamscience.com/journals/current-vascular-pharmacology/volume/8/issue/3/page/344/
http://europepmc.org/abstract/MED/20180771
https://pubmed.ncbi.nlm.nih.gov/20180771/
http://olympias.lib.uoi.gr/jspui/handle/123456789/23988

Dimethylfumarate Reduces Leukocyte Rolling in Vivo through Modulation of Adhesion Molecule Expression

Autoren: Rubant, Simone A. Ludwig, Ralf J. Diehl, Sandra et al.

Quelle: Journal of Investigative Dermatology, Vol. 128, No 2 (2008) pp. 326-331

Schlagwörter: Male, Fumarates/*pharmacology, Dimethyl Fumarate, Bacterial Toxins, E-Selectin/genetics/metabolism, Down-Regulation, Cell Adhesion Molecules/genetics/*metabolism, Dermatology, In Vitro Techniques, Immunosuppressive Agents/*pharmacology, Biochemistry, Enterotoxins, Mice, 03 medical and health sciences, 0302 clinical medicine, Fumarates, Cell Adhesion, Animals, Humans, Leukocyte Rolling, Molecular Biology, Enterotoxins/pharmacology, Leukocyte Rolling/*drug effects/physiology, Cells, Cultured, Mice, Knockout, Leukocytes, Mononuclear/cytology, Bacterial Toxins/pharmacology, Venules/cytology, P-Selectin/genetics/metabolism, Cell Biology, Mice, Inbred C57BL, P-Selectin, Solubility, Down-Regulation/drug effects/immunology, Vascular Cell Adhesion Molecule-1/genetics/metabolism, Leukocytes, Mononuclear, Cell Adhesion/*drug effects/immunology, E-Selectin, Cell Adhesion Molecules, Superantigens/pharmacology, Immunosuppressive Agents

Dateibeschreibung: application/pdf

Zugangs-URL: http://www.jidonline.org/article/S0022202X15337106/pdf
https://pubmed.ncbi.nlm.nih.gov/17671516
https://www.sciencedirect.com/science/article/abs/pii/S0022202X15337106
http://www.nature.com/jid/journal/v128/n2/full/5700996a.html
https://pubmed.ncbi.nlm.nih.gov/17671516/
https://www.jidonline.org/article/S0022-202X(15)33710-6/fulltext
https://www.ncbi.nlm.nih.gov/pubmed/17671516
https://archive-ouverte.unige.ch/unige:29882
https://archive-ouverte.unige.ch/unige:29882

Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor

Autoren: Buczko, Włodzimierz

Quelle: Pharmacological Reports. 60(5):623-631

Schlagwörter: Amides - pharmacokinetics, Amides - therapeutic use, Antihypertensive agents - pharmacokinetics, Fumarates - pharmacokinetics, Drug interactions, Amides - pharmacology, Hypertension - drug therapy, Fumarates - adverse effects, Renin - antagonists & inhibitors, Renin-angiotensin system - drug effects, Antihypertensive agents - pharmacology, Fumarates - pharmacology, Renin - blood, Animals, Humans, Antihypertensive agents - adverse effects, Amides - adverse effects, Antihypertensive agents - therapeutic use, Fumarates - therapeutic use

Plausible molecular mechanism for activation by fumarate and electron transfer of the dopamine β-mono-oxygenase reaction

Autoren: Wimalasena, D. Shyamali Jayatillake, Samantha P. Haines, Donovan C. et al.

Weitere Verfasser: Wimalasena, D. Shyamali Jayatillake, Samantha P. Haines, Donovan C. et al.

Quelle: Biochemical Journal. 367:77-85

Schlagwörter: Models, Molecular, 0301 basic medicine, Tyramine, Chemical, Ascorbic Acid, Dopamine beta-Hydroxylase, Research Support, P.H.S, Dose-Response Relationship, Electron Transport, Glutarates, 03 medical and health sciences, Fumarates, Models, Phenethylamines, Animals, Fumarates/pharmacology, Amides/pharmacology, Tyramine/pharmacology, 0303 health sciences, Binding Sites, Dose-Response Relationship, Drug, Dopamine beta-Hydroxylase/chemistry, Maleates, Molecular, Ascorbic Acid/chemistry, Glutarates/metabolism, Oxygen/metabolism, Dopamine beta-Hydroxylase/metabolism, Amides, Enzyme Activation, Oxygen, Kinetics, Models, Chemical, Spectrophotometry, Fumarates/chemistry, Phenethylamines/chemistry, Cattle, U.S. Gov't, Drug, Maleates/pharmacology

Zugangs-URL: https://europepmc.org/articles/pmc1222850?pdf=render
https://pubmed.ncbi.nlm.nih.gov/12038965
http://www.biochemj.org/content/367/1/77
https://portlandpress.com/biochemj/article/367/1/77/39899/Plausible-molecular-mechanism-for-activation-by
https://soar.wichita.edu/handle/10057/4350
https://europepmc.org/article/MED/12038965
https://www.ncbi.nlm.nih.gov/pubmed/12038965

Reduction of Dopamine β-Monooxygenase

Autoren: Wimalasena, Kandatege Dharmasena, Silpadipathialage Wimalasena, D. Shyamali et al.

Weitere Verfasser: Wimalasena, Kandatege Dharmasena, Silpadipathialage Wimalasena, D. Shyamali et al.

Quelle: Journal of Biological Chemistry. 271:26032-26043

Schlagwörter: 0301 basic medicine, Chemical, Dopamine beta-Hydroxylase, Phenylenediamines, Research Support, P.H.S, 03 medical and health sciences, 0302 clinical medicine, Fumarates, Models, Anticarcinogenic Agents, Fumarates/pharmacology, Chromatography, High Pressure Liquid, Chromatography, 0303 health sciences, Anticarcinogenic Agents/pharmacology, Hydrogen-Ion Concentration, Dopamine beta-Hydroxylase/metabolism, Enzyme Activation, Phenylenediamines/metabolism, Kinetics, Models, Chemical, High Pressure Liquid, U.S. Gov't

Dateibeschreibung: application/pdf

Zugangs-URL: http://www.jbc.org/content/271/42/26032.full.pdf
https://pubmed.ncbi.nlm.nih.gov/8824243
https://europepmc.org/abstract/MED/8824243
http://soar.wichita.edu/bitstream/handle/10057/4385/CHEM_FP_18.pdf?sequence=1
https://www.ncbi.nlm.nih.gov/pubmed/8824243
https://www.jbc.org/article/S0021-9258(18)39868-5/fulltext
https://soar.wichita.edu/bitstream/handle/10057/4385/CHEM_FP_18.pdf?sequence=1
https://www.sciencedirect.com/science/article/pii/S0021925818398685

New principle for blood pressure lowering under development / Ny princip för blodtryckssänkare på väg

Autoren: Lagercrantz, S

Quelle: Läkemedelsvärlden. 111(3):16

Reduction of dopamine beta-monooxygenase. A unified model for apparent negative cooperativity and fumarate activation

Autoren: Wimalasena, Kandatege Dharmasena, Silpadipathialage Wimalasena, D. Shyamali et al.

Weitere Verfasser: Wimalasena, Kandatege Dharmasena, Silpadipathialage Wimalasena, D. Shyamali et al.

Quelle: NLM

Schlagwörter: Research Support, U.S. Gov't, P.H.S, Anticarcinogenic Agents/pharmacology, Chromatography, High Pressure Liquid, Dopamine beta-Hydroxylase/metabolism, Enzyme Activation, Fumarates/pharmacology, Hydrogen-Ion Concentration, Kinetics, Models, Chemical, Phenylenediamines/metabolism

Geographisches Schlagwort: United States

Dateibeschreibung: 26032-43; application/pdf

Relation: The Journal of biological chemistry; J. Biol. Chem.; 8824243; 2985121R; GM45026; http://hdl.handle.net/10057/4385

Verfügbarkeit: http://hdl.handle.net/10057/4385