Výsledky vyhľadávania - "Fibroblasts / metabolism"

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

Autori: Lalitha Thiagarajan Rosa Sanchez‐Alvarez Chiho Kambara a ďalší

Zdroj: FEBS Lett
Thiagarajan, L, Sanchez-Alvarez, R, Kambara, C, Rajasekar, P, Wang, Y, Halloy, F, Hall, J, Stark, H-J, Martin, I, Boukamp, P & Kurinna, S 2025, 'miRNA-29 regulates epidermal and mesenchymal functions in skin repair', FEBS Letters, vol. 599, no. 12, pp. 1795-1817. https://doi.org/10.1002/1873-3468.70051
FEBS Letters

Predmety: Fibroblasts/metabolism, keratinocytes, miRNA-CLIP, Mesoderm/metabolism, Cell Adhesion/genetics, mRNA, Extracellular Matrix/metabolism, Wound Healing/genetics, MicroRNAs/genetics, adhesion, Keratinocytes/metabolism, Gene Expression Regulation, fibroblasts, Humans, Skin/metabolism, miRNA, Epidermis/metabolism, Research Article

Popis súboru: application/application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40285401
http://hdl.handle.net/20.500.11850/734065

Vitronectin regulates lung tissue remodeling and emphysema in chronic obstructive pulmonary disease

Autori: Liu G. Hsu A. C. Geirnaert S. a ďalší

Zdroj: Molecular Therapy. 33:917-932

Predmety: Male, Chronic Obstructive/metabolism, Knockout, Lung/metabolism, Vitronectin/metabolism, Pulmonary Disease, Urokinase-Type Plasminogen Activator/metabolism, Pulmonary Disease, Chronic Obstructive, Mice, Matrix Metalloproteinase 12, Collagen/metabolism, Animals, Humans, Matrix Metalloproteinase 12/metabolism, Vitronectin, RNA, Small Interfering, Lung, Fibroblasts/metabolism, Mice, Knockout, Animal, Pulmonary Emphysema/metabolism, Fibroblasts, Urokinase-Type Plasminogen Activator, Disease Models, Animal, Pulmonary Emphysema, Small Interfering/genetics, Disease Models, RNA, Airway Remodeling, Collagen, COPD, emphysema, remodeling, uPA pathway, vitronectin, Signal Transduction

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39838644

Fibrillin-1 G234D mutation in the hybrid1 domain causes tight skin associated with dysregulated elastogenesis and increased collagen cross-linking in mice

Autori: ASM Sakhawat Hossain Maria Thea Rane Dela Cruz Clarin Kenichi Kimura a ďalší

Zdroj: Matrix Biol
Hossain, A S, Clarin, M T R D C, Kimura, K, Biggin, G, Taga, Y, Uto, K, Yamagishi, A, Motoyama, E, Narenmandula, Mizuno, K, Nakamura, C, Asano, K, Ohtsuki, S, Nakamura, T, Kanki, S, Baldock, C, Raja, E & Yanagisawa, H 2025, 'Fibrillin-1 G234D mutation in the hybrid1 domain causes tight skin associated with dysregulated elastogenesis and increased collagen cross-linking in mice', Matrix biology : journal of the International Society for Matrix Biology, vol. 135, pp. 24-38. https://doi.org/10.1016/j.matbio.2024.11.006

Predmety: Fibroblasts/metabolism, Microfibrils/metabolism, Extracellular Matrix/metabolism, Article, Mice, Fibrillin-1/genetics, Protein Domains, Adipokines, Collagen/metabolism, Mutation, Elastic Tissue/metabolism, Animals, Humans, Skin/metabolism

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39615636
https://research.manchester.ac.uk/en/publications/79d3da43-3a4f-4653-9d32-c9ec15b50f02
https://doi.org/10.1016/j.matbio.2024.11.006

Brain malformations and seizures by impaired chaperonin function of TRiC

Autori: Florian Kraft Piere Rodriguez-Aliaga Weimin Yuan a ďalší

Prispievatelia: Florian Kraft Piere Rodriguez-Aliaga Weimin Yuan a ďalší

Zdroj: Science

Predmety: Male, Adult, 0301 basic medicine, Protein Folding, Proteome, Seizures/diagnostic imaging, Proteome/metabolism, Fibroblasts -- metabolism, Medizin, 03 medical and health sciences, Chaperonin Containing TCP-1 -- chemistry -- genetics -- metabolism, Seizures -- diagnostic imaging -- genetics -- metabolism, Seizures, Intellectual Disability, Journal Article, Humans, Intellectual Disability -- genetics -- metabolism, Protein Subunits/metabolism, Caenorhabditis elegans, Fibroblasts/metabolism, 0303 health sciences, Chaperonin Containing TCP-1/chemistry, Brain, Sciences bio-médicales et agricoles, Fibroblasts, Magnetic Resonance Imaging, Intellectual Disability/genetics, [SDV] Life Sciences [q-bio], Protein Subunits, Brain/abnormalities, Protein Subunits -- metabolism -- genetics, Brain -- abnormalities -- diagnostic imaging -- metabolism, Human medicine, Transcriptome, Engineering sciences. Technology, Chaperonin Containing TCP-1, Proteome -- metabolism

Popis súboru: application/pdf; 1 full-text file(s): application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39480921
https://pure.eur.nl/en/publications/508ccf25-179c-41f4-a176-b954448b417d
https://doi.org/10.1126/science.adp8721
https://dspace.library.uu.nl/handle/1874/458800
https://repository.uantwerpen.be/docstore/d:irua:27443
https://hdl.handle.net/10067/2113760151162165141
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85208290432
https://doi.org/10.1126/science.adp8721
https://www.ncbi.nlm.nih.gov/pubmed/39480921

Single-cell transcriptome combined with genetic tracing reveals a roadmap of fibrosis formation during proliferative vitreoretinopathy

Autori: Mengyu Liao Zhisheng Ye Yumeng Zhao a ďalší

Zdroj: Liao, M, Ye, Z, Zhao, Y, Nan, J, Liu, Y, Yao, X, Yang, T, Guo, J, Jin, X, Zhang, H, You, C, Xu, H, Yu, J, Chen, Y, Wang, X & Yan, H 2025, 'Single-cell transcriptome combined with genetic tracing reveals a roadmap of fibrosis formation during proliferative vitreoretinopathy', Proceedings of the National Academy of Sciences of the United States of America, vol. 122, no. 37, e2424487122. https://doi.org/10.1073/pnas.2424487122

Predmety: Fibroblasts/metabolism, Mice, Retinal Pigment Epithelium/metabolism, Thrombospondin 1/genetics, Epithelial-Mesenchymal Transition/genetics, Fibrosis/genetics, Single-Cell Analysis/methods, Vitreoretinopathy, Proliferative/pathology, Animals, Humans, Transcriptome/genetics

Popis súboru: application/pdf

Prístupová URL adresa: https://pure.qub.ac.uk/en/publications/756c00b1-da54-484d-9506-825248dfb31b

Fibrolytic vaccination against ADAM12 reduces desmoplasia in preclinical pancreatic adenocarcinomas

Autori: Chen, Jing Sobecki, Michal Krzywinska, Ewelina a ďalší

Prispievatelia: Chen, Jing Sobecki, Michal Krzywinska, Ewelina a ďalší

Zdroj: EMBO Mol Med
EMBO Molecular Medicine, Vol 16, Iss 12, Pp 3033-3056 (2024)

Predmety: Cancer-Associated Fibroblasts Immunology, Medicine (General), Adenocarcinoma Immunology, 10017 Institute of Anatomy, Cancer-Associated Fibroblasts Pathology, 10184 Institute of Veterinary Pathology, ADAM12 Protein Metabolism, Pancreatic Neoplasms Prevention & Control, ADAM12 Protein, 610 Medicine & health, QH426-470, CD8-Positive T-Lymphocytes, Adenocarcinoma, 10263 Institute of Experimental Immunology, Cancer Vaccines, Mice, CD8-Positive T-Lymphocytes Immunology, R5-920, Cancer-Associated Fibroblasts, Report, Carcinoma, Pancreatic Ductal Pathology, Genetics, Mice Inbred C57BL, Adenocarcinoma Pathology, Animals, Humans, Cancer Vaccines Immunology, Pancreatic Adenocarcinoma, Cancer Vaccines Administration & Dosage, Cancer-Associated Fibroblasts Metabolism, Disease Models Animal, Vaccination, Fibrosis, Pancreatic Neoplasms, Mice, Inbred C57BL, Disease Models, Animal, Pancreatic Neoplasms Immunology, 1313 Molecular Medicine, 11401 Comprehensive Cancer Center Zurich, Pancreatic Neoplasms Pathology, Carcinoma Pancreatic Ductal Therapy, Adenocarcinoma Therapy, 570 Life sciences, biology, Immunotherapy, Carcinoma Pancreatic Ductal Immunology, Carcinoma, Pancreatic Ductal

Popis súboru: application/pdf; chen_et_al_2024_fibrolytic_vaccination_against_adam12_reduces_desmoplasia_in_preclinical_pancreatic_adenocarcinomas.pdf - application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39478152
https://doaj.org/article/32a6bfacd9884de49c5ed19adffba64c
https://phaidra.vetmeduni.ac.at/o:3794
https://doi.org/10.1038/s44321-024-00157-4

Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in heart failure with preserved ejection fraction

Autori: Jan D. Lanzer Laura M. Wienecke Ricardo O. Ramirez Flores a ďalší

Zdroj: Basic Res Cardiol

Predmety: Heart Failure, Male, Gene Expression Profiling, Stroke Volume, Original Contribution, Fibroblasts, Fibrosis, Ventricular Function, Left, Mice, Inbred C57BL, Disease Models, Animal, Mice, Ventricular Function, Left [MeSH], Mice, Inbred C57BL [MeSH], Fibroblasts/pathology [MeSH], Heart Failure/genetics [MeSH], Male [MeSH], Single-Cell Analysis [MeSH], Stroke Volume [MeSH], Fibroblast activation, Disease Models, Animal [MeSH], Fibroblasts/metabolism [MeSH], Heart Failure/metabolism [MeSH], Female [MeSH], Fibrosis [MeSH], Heart Failure/physiopathology [MeSH], Humans [MeSH], Angiopoietin-like 4, Animals [MeSH], Heart failure with preserved ejection fraction (HFpEF), Mice [MeSH], Transcriptome [MeSH], Gene Expression Profiling [MeSH], Heart Failure/pathology [MeSH], Single-cell RNA sequencing, Immune activation, Animals, Humans, Female, Single-Cell Analysis, Transcriptome

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39311911
https://repository.publisso.de/resource/frl:6507408

iPSC‐Derived Liver Organoids as a Tool to Study Medium Chain Acyl‐CoA Dehydrogenase Deficiency

Autori: Ligia A. Kiyuna José M. Horcas‐Nieto Christoff Odendaal a ďalší

Zdroj: J Inherit Metab Dis

Predmety: Liver/metabolism, Fibroblasts/metabolism, iPSC, Inborn Errors/metabolism, Induced Pluripotent Stem Cells, MCADD, peroxisomes, Cell Differentiation, coenzyme a, Fibroblasts, Lipid Metabolism, Acyl-CoA Dehydrogenase/deficiency, Lipid Metabolism, Inborn Errors, Acyl-CoA Dehydrogenase, Organoids, Induced Pluripotent Stem Cells/metabolism, Liver, Organoids/metabolism, Humans, Original Article, organoids, medium-chain acyl-carnitines

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40199742
https://hdl.handle.net/1871.1/ae592ce2-9b35-4996-8f03-2defd948393a
https://research.vu.nl/en/publications/ae592ce2-9b35-4996-8f03-2defd948393a
https://doi.org/10.1002/jimd.70028
https://research.rug.nl/en/publications/cb7aa94c-d6d6-4e92-9d3a-f1fb77b30a46
https://hdl.handle.net/11370/cb7aa94c-d6d6-4e92-9d3a-f1fb77b30a46
https://doi.org/10.1002/jimd.70028

Dynamic substrate topographies drive actin- and vimentin-mediated nuclear mechanoprotection events in human fibroblasts

Autori: Bril, Maaike Boesveld, Jules N. Coelho-Rato, Leila S. a ďalší

Zdroj: BMC Biol
BMC Biology, Vol 23, Iss 1, Pp 1-16 (2025)

Predmety: Fibroblasts/metabolism, Cell Nucleus, Dynamic topography, Mechanotransduction, QH301-705.5, Vimentin/metabolism, Histone modifications, Research, Histones/metabolism, Fibroblasts, Mechanotransduction, Cellular, Nucleus, Actins, Histones, Actins/metabolism, Cell Nucleus/metabolism, DNA damage, Humans, Vimentin, Cellular, Biology (General)

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40189524
https://doaj.org/article/cdd0d24d571843c487d9eeb2071befaf

COL10A1 expression distinguishes a subset of cancer-associated fibroblasts present in the stroma of high-risk basal cell carcinoma

Autori: Esposito, Mauro Yerly, Laura Shukla, Prachi a ďalší

Prispievatelia: Esposito, Mauro Yerly, Laura Shukla, Prachi a ďalší

Zdroj: The British journal of dermatology, vol. 191, no. 5, pp. 775-790

Predmety: Male, 0301 basic medicine, 0303 health sciences, Skin Neoplasms, LMZ Competence Centre Language and Medicine Zurich, Humans, Carcinoma, Basal Cell/pathology, Carcinoma, Basal Cell/genetics, Carcinoma, Basal Cell/metabolism, Skin Neoplasms/pathology, Skin Neoplasms/genetics, Skin Neoplasms/metabolism, Cancer-Associated Fibroblasts/pathology, Cancer-Associated Fibroblasts/metabolism, Tumor Microenvironment, Laser Capture Microdissection, Female, Single-Cell Analysis, Aged, Middle Aged, Skin/pathology, RNA-Seq, 10177 Dermatology Clinic, 610 Medicine & health, 2708 Dermatology, 03 medical and health sciences, Cancer-Associated Fibroblasts, Carcinoma, Basal Cell, Biomarkers, Tumor, 11493 Department of Quantitative Biomedicine, Skin

Popis súboru: application/pdf; ZORA_ljae258.pdf - application/pdf; ZORA_264519.pdf - application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38916477
https://serval.unil.ch/notice/serval:BIB_41ED2ED028E5
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_41ED2ED028E53
https://serval.unil.ch/resource/serval:BIB_41ED2ED028E5.P001/REF.pdf

Cell–cell contacts prevent t-BuOOH-triggered ferroptosis and cellular damage in vitro by regulation of intracellular calcium

Autori: Dagmar Faust Christine Wenz Stefanie Holm a ďalší

Prispievatelia: Dagmar Faust Christine Wenz Stefanie Holm a ďalší

Zdroj: Arch Toxicol

Predmety: Membrane Potential, Mitochondrial, 0301 basic medicine, 0303 health sciences, 610 Medizin, Cell Communication, Fibroblasts, Mice, Oxidative Stress, 03 medical and health sciences, tert-Butylhydroperoxide, Molecular Toxicology, 610 Medical sciences, Cell Line, Tumor, Ferroptosis, Humans, Animals, Calcium, DNA Breaks, Double-Stranded, Lipid Peroxidation, Cell–cell contacts, Calcium/metabolism [MeSH], Cell Line, Tumor [MeSH], Membrane Potential, Mitochondrial/drug effects [MeSH], Fibroblasts/drug effects [MeSH], Humans [MeSH], DNA Breaks, Double-Stranded/drug effects [MeSH], Animals [MeSH], Ferroptosis/drug effects [MeSH], Lipid Peroxidation/drug effects [MeSH], Mice [MeSH], Cell Communication/drug effects [MeSH], tert-Butylhydroperoxide/toxicity [MeSH], Oxidative Stress/drug effects [MeSH], Toxicity, Fibroblasts/metabolism [MeSH]

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38814333
https://repository.publisso.de/resource/frl:6507370

Ischemia does not provoke the full immune training repertoire in human cardiac fibroblasts

Autori: Constantin Mann Carolin van Alst Simone Gorressen a ďalší

Zdroj: Naunyn-Schmiedeberg's Archives of Pharmacology
Naunyn Schmiedebergs Arch Pharmacol

Predmety: Male, 0301 basic medicine, 0303 health sciences, L-Lactate Dehydrogenase, Research, Myocardium, TOR Serine-Threonine Kinases, Medizin, Myocardial Reperfusion Injury, Fibroblasts, Hypoxia-Inducible Factor 1, alpha Subunit, Mice, Inbred C57BL, 03 medical and health sciences, Humans, Animals, Cytokines, L-Lactate Dehydrogenase/metabolism [MeSH], Mice, Inbred C57BL [MeSH], Glycolysis, Myocardial Reperfusion Injury/metabolism [MeSH], Fibroblasts/drug effects [MeSH], Humans [MeSH], Cytokines/metabolism [MeSH], Animals [MeSH], Inflammasome, Ischemia, Male [MeSH], Cardiac fibroblasts, Hypoxia-Inducible Factor 1, alpha Subunit/metabolism [MeSH], Cells, Cultured [MeSH], Myocardial Reperfusion Injury/immunology [MeSH], TOR Serine-Threonine Kinases/metabolism [MeSH], Myocardium/immunology [MeSH], Myocardial, Fibroblasts/metabolism [MeSH], Trained immunity, Myocardium/metabolism [MeSH], Cells, Cultured

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38652279
https://repository.publisso.de/resource/frl:6493326

Loss-of-function variants affecting the STAGA complex component SUPT7L cause a developmental disorder with generalized lipodystrophy

Autori: Johannes Kopp Leonard A. Koch Hristiana Lyubenova a ďalší

Prispievatelia: Johannes Kopp Leonard A. Koch Hristiana Lyubenova a ďalší

Zdroj: Hum Genet
Humangenetik, 143(5):683-694

Predmety: Male, 0301 basic medicine, DNA Repair, Lipodystrophy, Mutation, Missense, [SDV.GEN] Life Sciences [q-bio]/Genetics, Aberrant splicing, 03 medical and health sciences, Transcription Factors/genetics [MeSH], Humans [MeSH], Wiedemann-Rautenstrauch syndrome, Loss of Function Mutation [MeSH], DNA Damage [MeSH], Mutation, Missense [MeSH], DNA Repair/genetics [MeSH], Original Investigation, Male [MeSH], Progeroid disorder, STAGA complex, Lipodystrophy, Congenital Generalized/genetics [MeSH], Fetal Growth Retardation/genetics [MeSH], HeLa Cells [MeSH], Fibroblasts/metabolism [MeSH], Lipodystrophy/genetics [MeSH], Lipodystrophy, Congenital Generalized, Loss of Function Mutation, Biowissenschaften, Biologie, Humans, 0303 health sciences, Fetal Growth Retardation, SUPT7L, Fibroblasts, Cardiovascular and Metabolic Diseases, DNA Damage, HeLa Cells, Transcription Factors

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38592547
https://edoc.mdc-berlin.de/id/eprint/25055/1/25055oa.pdf
https://resolver.sub.uni-goettingen.de/purl?gro-2/143049
https://hal.science/hal-04577292v1
https://hal.science/hal-04577292v1/document
https://doi.org/10.1007/s00439-024-02669-y
https://repository.publisso.de/resource/frl:6509351

Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts

Autori: Andrea Eigentler Florian Handle Silvia Schanung a ďalší

Zdroj: Oncogene

Predmety: Male, Receptors, Glucocorticoid, Cancer-Associated Fibroblasts, 38/77, 631/80/86/820, 13/21, Cell Line, Tumor [MeSH], Prostatic Neoplasms/metabolism [MeSH], Prostatic Neoplasms/drug therapy [MeSH], Receptors, Glucocorticoid/metabolism [MeSH], Male [MeSH], Prostate/pathology [MeSH], 45/91, 82/51, 631/80/79/750, Fibroblasts/metabolism [MeSH], 13/2, 38/32, Glucocorticoids/metabolism [MeSH], 631/80/86/2363, Humans [MeSH], Receptors, Glucocorticoid/genetics [MeSH], 631/67/589/466, Glucocorticoids/therapeutic use [MeSH], Prostatic Neoplasms/genetics [MeSH], Cancer-Associated Fibroblasts/metabolism [MeSH], Article, Glucocorticoids/pharmacology [MeSH], 96/106, article, Tumor Microenvironment [MeSH], Cell Line, Tumor, Prostate, Tumor Microenvironment, Humans, Prostatic Neoplasms, Fibroblasts, Glucocorticoids, 3. Good health

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38017134
https://repository.publisso.de/resource/frl:6497328

Advanced Metabolic Reprogramming

Autori: Mohamed, Anwar

Predmety: Mesenchymal Stem Cells/metabolism, Tumor Microenvironment/genetics, Tumor Microenvironment/physiology, Glutamine addiction, Systems Biology/economics, Tumour vulnerability, Medical Oncology, Clinical oncology, Tumor Microenvironment/radiation effects, Glycolysis inhibition, Bioenergetic collapse, Tumor Microenvironment, Integrative Oncology/ethics, Hematopoietic Stem Cells/metabolism, ECS modulation, Cancer Biology, Stem Cells/metabolism, Artificial Intelligence in Healthcare, Cancer stem cells, Systems Biology, Multipotent Stem Cells/metabolism, Mitochondrial targeting, Precision oncology, Cancer metabolism, Tumor Microenvironment/drug effects, Oncology, Cardio-Oncology, Cancer Pain/etiology, Neural Stem Cells/metabolism, Oncology protocol design, Functional medicine, Metabolic kill-switch, Psycho-Oncology, Embryonic Stem Cells/metabolism, Metabolic escape, Cancer Pain/metabolism, Stem Cell Factor/metabolism, Mitochondrial Medicine, Neoplastic Stem Cells/metabolism, Tumor Microenvironment/immunology, Integrative Oncology, Stem cell metabolism, AI-driven therapy, Systems Biology/education, Cancer-Associated Fibroblasts/metabolism, Systems Biology/ethics, Tumour microenvironment, Systems Biology/classification, Systems Biology/trends, Induced Pluripotent Stem Cells/metabolism, Pluripotent Stem Cells/metabolism, Therapeutic stacking

The proteomic landscape of Toxoplasma gondii extracellular vesicles across diverse host cell types

Autori: Cruz-Bustos, Teresa Feix, Anna Sophia Hummel, Karin a ďalší

Zdroj: Front Cell Infect Microbiol
Frontiers in Cellular and Infection Microbiology, Vol 15 (2025)

Predmety: Proteomics, Toxoplasmosis Parasitology, Proteome, Swine, proteome, Fibroblasts Parasitology, Toxoplasma gondii, Epithelial Cells Parasitology, Epithelial Cells Metabolism, Microbiology, Fibroblasts Metabolism, Cell Line, Host-Parasite Interactions, Chlorocebus Aethiops, Extracellular Vesicles Metabolism, Extracellular Vesicles, Mice, exovesicles, Cellular and Infection Microbiology, Chlorocebus aethiops, Animals, Humans, Toxoplasmosis Metabolism, Epithelial Cells, mass-spectrometry, Fibroblasts, QR1-502, Host-Pathogen Interactions, Toxoplasma Metabolism, microvesicles, Toxoplasma, Toxoplasmosis

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40171158
https://doaj.org/article/5a18b0f3763d4d3a8ff9a2630866d6eb
https://phaidra.vetmeduni.ac.at/o:4065
https://doi.org/10.3389/fcimb.2025.1565684

Regulation of fibronectin and collagens type I, III and VI by TNF-α, TGF-β, IL-13, and tofacitinib

Autori: Frederik S. Gillesberg Martin Pehrsson Anne-Christine Bay-Jensen a ďalší

Zdroj: Sci Rep
Scientific Reports, Vol 15, Iss 1, Pp 1-13 (2025)
Gillesberg, F S, Pehrsson, M, Bay-Jensen, A-C, Frederiksen, P, Karsdal, M, Deleuran, B W, Kragstrup, T W, Kubo, S, Tanaka, Y & Mortensen, J H 2025, 'Regulation of fibronectin and collagens type I, III and VI by TNF-α, TGF-β, IL-13, and tofacitinib', Scientific Reports, vol. 15, no. 1, 1087, pp. 1087. https://doi.org/10.1038/s41598-024-84151-3

Predmety: Male, Piperidines/pharmacology, Science, Wound healing, Collagen Type I/metabolism, Article, Collagen Type I, Collagen Type III/metabolism, Arthritis, Rheumatoid, Transforming Growth Factor beta1, Piperidines, Transforming Growth Factor beta, Humans, Pyrroles, Pyrimidines/pharmacology, Cells, Cultured, Fibroblasts/metabolism, Tumor Necrosis Factor-alpha/metabolism, Interleukin-13, Tumor Necrosis Factor-alpha, Interleukin-13/metabolism, Fibro-inflammation, Fibroblasts, Middle Aged, Fibrosis, Fibronectins, Pyrroles/pharmacology, Pyrimidines, Collagen Type III, JAK inhibitor, Arthritis, Rheumatoid/drug therapy, Tofacitinib, Transforming Growth Factor beta1/metabolism, Medicine, Female, Collagen, Fibronectins/metabolism, Transforming Growth Factor beta/metabolism

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39774197
https://doaj.org/article/b6d0a3d18baf4a989c336a53188a5b62
https://pure.au.dk/portal/en/publications/1bca5269-5b28-42a0-bf13-22ed042f576a
https://doi.org/10.1038/s41598-024-84151-3
http://www.scopus.com/inward/record.url?scp=85214254085&partnerID=8YFLogxK

Genomic evidence for the suitability of Göttingen Minipigs with a rare seizure phenotype as a model for human epilepsy

Autori: Pardis Najafi Christian Reimer Jonathan D. Gilthorpe a ďalší

Prispievatelia: Pardis Najafi Christian Reimer Jonathan D. Gilthorpe a ďalší

Zdroj: Neurogenetics

Predmety: Voltage-gated calcium channel, 0301 basic medicine, Neurologi, Swine, Medical Genetics and Genomics, 03 medical and health sciences, Seizures, Animals, Humans, Transcriptomics, 0303 health sciences, Epilepsy, Genomics, Fibroblasts, Seizure, Medicinsk genetik och genomik, 3. Good health, Disease Models, Animal, Phenotype, Neurology, Göttingen Minipigs, Swine, Miniature, Original Article, Transcriptome, Swine, Miniature/genetics [MeSH], Swine [MeSH], Humans [MeSH], Seizures/genetics [MeSH], Genomics/methods [MeSH], Animals [MeSH], Transcriptome [MeSH], Phenotype [MeSH], Disease Models, Animal [MeSH], Epilepsy/genetics [MeSH], Fibroblasts/metabolism [MeSH]

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38383918
https://resolver.sub.uni-goettingen.de/purl?gro-2/142136
https://repository.publisso.de/resource/frl:6500825
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-221647

An adaptable in silico ensemble model of the arachidonic acid cascade

Autori: Megan Uttley Grace Horne Areti Tsigkinopoulou a ďalší

Zdroj: Mol Omics
Uttley, M, Turner Horne, G, Tsigkinopoulou, A, Del Carratore, F, Hawari, A, Kiezel-Tsugunova, M, Kendall, A, Jones, J, Messenger, D, Kaur Bhogal, R, Breitling, R & Nicolaou, A 2024, 'An adaptable in silico ensemble model of the arachidonic acid cascade', Molecular Omics, vol. 20, no. 7, pp. 453-468. https://doi.org/10.1039/d3mo00187c

Predmety: Fibroblasts/metabolism, Lipidomics/methods, Keratinocytes, 0301 basic medicine, 0303 health sciences, Calcimycin/pharmacology, Arachidonic Acid, Eicosanoids/metabolism, Fibroblasts, Biological, Models, Biological, Arachidonic Acid/metabolism, Cell Line, Chemistry, 03 medical and health sciences, Keratinocytes/metabolism, Models, Lipidomics, Humans, Eicosanoids, Computer Simulation, Monte Carlo Method, Calcimycin

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38860509
https://research.manchester.ac.uk/en/publications/a50d6f00-a13b-47f1-ba6c-64138d4082d3
https://doi.org/10.1039/d3mo00187c
https://research.manchester.ac.uk/en/publications/a50d6f00-a13b-47f1-ba6c-64138d4082d3
https://doi.org/10.1039/d3mo00187c
https://pure.manchester.ac.uk/ws/files/351728853/Uttley_MolOmics_2024.pdf
http://www.scopus.com/inward/record.url?scp=85195886793&partnerID=8YFLogxK

Nuclear lamin A/C phosphorylation by loss of androgen receptor leads to cancer-associated fibroblast activation

Autori: Soumitra Ghosh Jovan Isma Paola Ostano a ďalší

Zdroj: Nat Commun
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Nature communications, vol. 15, no. 1, pp. 7984

Predmety: Cell Nucleus, Male, Nuclear Envelope, Science, Fibroblasts, Lamin Type A, Article, Cancer-Associated Fibroblasts, Receptors, Androgen, Protein Phosphatase 1, Humans, Receptors, Androgen/metabolism, Receptors, Androgen/genetics, Lamin Type A/metabolism, Lamin Type A/genetics, Phosphorylation, Cancer-Associated Fibroblasts/metabolism, Cancer-Associated Fibroblasts/pathology, Cell Nucleus/metabolism, Protein Phosphatase 1/metabolism, Protein Phosphatase 1/genetics, Fibroblasts/metabolism, Nuclear Envelope/metabolism, Tumor Microenvironment

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39266569
https://doaj.org/article/ecacd5c27cbc40799626a289a8be3460
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_39467E97F3A55
https://serval.unil.ch/resource/serval:BIB_39467E97F3A5.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_39467E97F3A5