Výsledky vyhľadávania - "Fibroblast Growth Factor-23"

Pemigatinib suppresses liver fibrosis and subsequent osteodystrophy in mice.

Autori: Mihara T Tsuru Y Kurosawa T a ďalší

Zdroj: Hepatology communications [Hepatol Commun] 2025 Jan 07; Vol. 9 (1). Date of Electronic Publication: 2025 Jan 07 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 101695860 Publication Model: eCollection Cited Medium: Internet ISSN: 2471-254X (Electronic) Linking ISSN: 2471254X NLM ISO Abbreviation: Hepatol Commun Subsets: MEDLINE

Výrazy zo slovníka MeSH: Fibroblast Growth Factor-23* , Liver Cirrhosis*/drug therapy , Fibroblast Growth Factors*/metabolism , Fibroblast Growth Factors*/blood, Animals ; Mice ; Humans ; Disease Models, Animal ; Rats ; Male ; Pyrimidines/therapeutic use ; Pyrimidines/pharmacology ; Carbon Tetrachloride ; Mice, Inbred C57BL ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/metabolism ; Bone Diseases, Metabolic/drug therapy ; Bone Diseases, Metabolic/etiology

Treatment Advances in Tumor-Induced Osteomalacia.

Autori: Hartley IR Roszko KL

Zdroj: Calcified tissue international [Calcif Tissue Int] 2025 Jan 04; Vol. 116 (1), pp. 24. Date of Electronic Publication: 2025 Jan 04.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7905481 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0827 (Electronic) Linking ISSN: 0171967X NLM ISO Abbreviation: Calcif Tissue Int Subsets: MEDLINE

Výrazy zo slovníka MeSH: Osteomalacia*/etiology , Fibroblast Growth Factor-23* , Paraneoplastic Syndromes*/therapy , Fibroblast Growth Factors*/metabolism, Humans ; Neoplasms, Connective Tissue/therapy ; Neoplasms, Connective Tissue/etiology ; Hypophosphatemia/therapy ; Hypophosphatemia/etiology ; Antibodies, Monoclonal, Humanized

SCR Disease Name: Oncogenic osteomalacia

Base of Skull & Spinal Canal Narrowing in an Adolescent with Autosomal Recessive Hypophosphatemic Rickets Type 2.

Autori: Gokul PR Jarvis C Kassab G a ďalší

Zdroj: Calcified tissue international [Calcif Tissue Int] 2025 Jan 03; Vol. 116 (1), pp. 20. Date of Electronic Publication: 2025 Jan 03.

Spôsob vydávania: Case Reports; Journal Article

Informácie o časopise: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7905481 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0827 (Electronic) Linking ISSN: 0171967X NLM ISO Abbreviation: Calcif Tissue Int Subsets: MEDLINE

Výrazy zo slovníka MeSH: Fibroblast Growth Factor-23* , Pyrophosphatases*/genetics, Humans ; Female ; Child ; Phosphoric Diester Hydrolases/genetics ; Familial Hypophosphatemic Rickets/genetics ; Familial Hypophosphatemic Rickets/complications ; Skull/diagnostic imaging ; Skull/pathology

Mutant Fam20c knock-in mice recapitulate both lethal and non-lethal human Raine Syndrome.

Autori: Chen M Sun D Yee SP a ďalší

Zdroj: BMC molecular and cell biology [BMC Mol Cell Biol] 2025 Jan 02; Vol. 26 (1), pp. 1. Date of Electronic Publication: 2025 Jan 02.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101741148 Publication Model: Electronic Cited Medium: Internet ISSN: 2661-8850 (Electronic) Linking ISSN: 26618850 NLM ISO Abbreviation: BMC Mol Cell Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Extracellular Matrix Proteins*/genetics , Extracellular Matrix Proteins*/metabolism , Gene Knock-In Techniques* , Osteosclerosis*/genetics , Osteosclerosis*/metabolism , Osteosclerosis*/pathology , Fibroblast Growth Factor-23* , Disease Models, Animal*, Animals ; Mice ; Humans ; Familial Hypophosphatemic Rickets/genetics ; Familial Hypophosphatemic Rickets/metabolism ; Familial Hypophosphatemic Rickets/pathology ; Microcephaly/genetics ; Mutation ; Cleft Palate/genetics ; Exophthalmos/genetics ; Exophthalmos/pathology ; Fibroblast Growth Factors/genetics ; Fibroblast Growth Factors/metabolism ; Phenotype ; Mice, Transgenic ; Anemia, Dyserythropoietic, Congenital/genetics ; Anemia, Dyserythropoietic, Congenital/pathology ; Male ; Abnormalities, Multiple ; Calcium-Binding Proteins

SCR Disease Name: Raine syndrome

Analytical interference of Burosumab therapy on intact fibroblast growth factor 23 (iFGF23) measurements using an immunoassay: preliminary evaluation.

Autori: Brescia V Lovero R Fontana A a ďalší

Zdroj: Journal of immunoassay & immunochemistry [J Immunoassay Immunochem] 2025 Jan 02; Vol. 46 (1), pp. 89-105. Date of Electronic Publication: 2024 Nov 04.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 100963688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-4230 (Electronic) Linking ISSN: 15321819 NLM ISO Abbreviation: J Immunoassay Immunochem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Fibroblast Growth Factor-23* , Fibroblast Growth Factors*/antagonists & inhibitors , Fibroblast Growth Factors*/immunology , Fibroblast Growth Factors*/blood , Antibodies, Monoclonal, Humanized*/immunology, Humans ; Immunoassay/methods ; Antibodies, Monoclonal/immunology

Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy.

Autori: Schnicker NJ Xu Z Amir M a ďalší

Zdroj: Scientific reports [Sci Rep] 2025 Jan 02; Vol. 15 (1), pp. 543. Date of Electronic Publication: 2025 Jan 02.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Fibroblast Growth Factor-23* , Cryoelectron Microscopy*/methods , Klotho Proteins*, Humans ; Protein Conformation ; Glucuronidase/metabolism ; Glucuronidase/chemistry ; Fibroblast Growth Factors/metabolism ; Fibroblast Growth Factors/chemistry ; Models, Molecular ; Protein Binding ; Protein Domains

Update on current and emerging treatment paradigms for hyperphosphatemia in chronic kidney disease.

Autori: Salera D Bellasi A Del Vecchio L a ďalší

Zdroj: Expert opinion on pharmacotherapy [Expert Opin Pharmacother] 2025 Jan; Vol. 26 (1), pp. 85-100. Date of Electronic Publication: 2024 Dec 16.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 100897346 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-7666 (Electronic) Linking ISSN: 14656566 NLM ISO Abbreviation: Expert Opin Pharmacother Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hyperphosphatemia*/drug therapy , Hyperphosphatemia*/etiology , Renal Insufficiency, Chronic*/complications , Renal Insufficiency, Chronic*/drug therapy , Fibroblast Growth Factor-23* , Chelating Agents*/therapeutic use , Chelating Agents*/adverse effects , Phosphates*/metabolism, Humans ; Animals ; Medication Adherence

A Rare Case of Tumor-Induced Osteomalacia Due to Mesenchymal Tumor at Foramen Magnum Diagnosed Preoperatively on 68 Ga DOTATATE PET/CT.

Autori: Mouli C Lila A Gondhane A a ďalší

Zdroj: Clinical nuclear medicine [Clin Nucl Med] 2025 Jan 01; Vol. 50 (1), pp. e53-e54. Date of Electronic Publication: 2024 Oct 21.

Spôsob vydávania: Journal Article; Case Reports

Informácie o časopise: Publisher: Lippincott Country of Publication: United States NLM ID: 7611109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-0229 (Electronic) Linking ISSN: 03639762 NLM ISO Abbreviation: Clin Nucl Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Osteomalacia*/diagnostic imaging , Positron Emission Tomography Computed Tomography* , Organometallic Compounds* , Fibroblast Growth Factor-23* , Foramen Magnum*/diagnostic imaging, Humans ; Male ; Adult ; Neoplasms, Connective Tissue/diagnostic imaging ; Mesenchymoma/diagnostic imaging ; Mesenchymoma/complications ; Mesenchymoma/surgery ; Paraneoplastic Syndromes

SCR Disease Name: Oncogenic osteomalacia

Effective bone healing after corrective osteotomy in a patient with FGF23-related hypophosphatemic disease using short-term burosumab treatment.

Autori: Chiu HS Tsai MM Wang TM a ďalší

Zdroj: Journal of the Formosan Medical Association = Taiwan yi zhi [J Formos Med Assoc] 2025 Jan; Vol. 124 (1), pp. 87-90. Date of Electronic Publication: 2024 Oct 06.

Spôsob vydávania: Case Reports; Journal Article

Informácie o časopise: Publisher: Formosan Medical Association, Elsevier Country of Publication: Singapore NLM ID: 9214933 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0929-6646 (Print) Linking ISSN: 09296646 NLM ISO Abbreviation: J Formos Med Assoc Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antibodies, Monoclonal, Humanized*/therapeutic use , Fibroblast Growth Factor-23* , Fibroblast Growth Factors* , Osteotomy*, Humans ; Male ; Antibodies, Monoclonal/therapeutic use ; Familial Hypophosphatemic Rickets/drug therapy ; Familial Hypophosphatemic Rickets/surgery ; Adolescent

Emerging concepts on the FGF23 regulation and activity.

Autori: Rivoira MA Peralta López ME Areco V a ďalší

Zdroj: Molecular and cellular biochemistry [Mol Cell Biochem] 2025 Jan; Vol. 480 (1), pp. 75-89. Date of Electronic Publication: 2024 Apr 06.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4919 (Electronic) Linking ISSN: 03008177 NLM ISO Abbreviation: Mol Cell Biochem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Fibroblast Growth Factor-23* , Fibroblast Growth Factors*/metabolism, Humans ; Animals ; Signal Transduction ; Osteomalacia/metabolism

Autosomal dominant hypophosphatemic rickets: a case report of two sisters with a novel FGF-23 mutation.

Autori: Mumbach G Florenzano P Quinteros J a ďalší

Zdroj: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [Osteoporos Int] 2025 Nov; Vol. 36 (11), pp. 2337-2341. Date of Electronic Publication: 2025 Jul 31.

Spôsob vydávania: Case Reports; Journal Article

Informácie o časopise: Publisher: Springer International Country of Publication: England NLM ID: 9100105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-2965 (Electronic) Linking ISSN: 0937941X NLM ISO Abbreviation: Osteoporos Int Subsets: MEDLINE

Výrazy zo slovníka MeSH: Familial Hypophosphatemic Rickets*/genetics , Familial Hypophosphatemic Rickets*/diagnostic imaging , Fibroblast Growth Factors*/genetics , Mutation*, Humans ; Fibroblast Growth Factor-23 ; Female ; Middle Aged ; Adult ; DNA Mutational Analysis

Calcium-Based Phosphate Binder Induces Osteomalacia in a Rat Model of Adynamic Bone Disease.

Autori: de Oliveira Truyts TP Ferreira JC Neves KR a ďalší

Zdroj: Calcified tissue international [Calcif Tissue Int] 2025 Dec 01; Vol. 116 (1), pp. 139. Date of Electronic Publication: 2025 Dec 01.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7905481 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0827 (Electronic) Linking ISSN: 0171967X NLM ISO Abbreviation: Calcif Tissue Int Subsets: MEDLINE

Výrazy zo slovníka MeSH: Osteomalacia*/chemically induced , Osteomalacia*/metabolism , Calcium Carbonate*/adverse effects , Calcium Carbonate*/pharmacology , Bone Diseases*, Animals ; Rats, Wistar ; Rats ; Disease Models, Animal ; Fibroblast Growth Factor-23 ; Male ; Sevelamer ; Hyperphosphatemia/drug therapy ; Phosphates/metabolism ; Renal Insufficiency, Chronic/complications ; Bone and Bones/drug effects ; Bone and Bones/metabolism ; Fibroblast Growth Factors

Evaluation of serum FGF23 and serum magnesium levels in dogs and cats with acute kidney injury.

Autori: Miyagawa A Ishizaka M Miyakawa H a ďalší

Zdroj: Veterinary journal (London, England : 1997) [Vet J] 2025 Dec; Vol. 314, pp. 106495. Date of Electronic Publication: 2025 Nov 19.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Balliere Tindall Country of Publication: England NLM ID: 9706281 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2971 (Electronic) Linking ISSN: 10900233 NLM ISO Abbreviation: Vet J Subsets: MEDLINE

Výrazy zo slovníka MeSH: Magnesium*/blood , Cat Diseases*/blood , Fibroblast Growth Factors*/blood , Dog Diseases*/blood , Acute Kidney Injury*/veterinary , Acute Kidney Injury*/blood, Animals ; Dogs ; Cats ; Fibroblast Growth Factor-23 ; Male ; Cross-Sectional Studies ; Female

Immunofluorescent characterization of Klotho and FGF23 in clear cell renal cell carcinoma: A pilot study.

Autori: Racetin A Kelam N Glavina Durdov M a ďalší

Zdroj: Acta histochemica [Acta Histochem] 2025 Dec; Vol. 127 (4), pp. 152298. Date of Electronic Publication: 2025 Nov 14.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Gustav Fischer Verlag Country of Publication: Germany NLM ID: 0370320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0372 (Electronic) Linking ISSN: 00651281 NLM ISO Abbreviation: Acta Histochem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Carcinoma, Renal Cell*/metabolism , Carcinoma, Renal Cell*/pathology , Carcinoma, Renal Cell*/mortality , Glucuronidase*/metabolism , Glucuronidase*/genetics , Fibroblast Growth Factors*/metabolism , Kidney Neoplasms*/metabolism , Kidney Neoplasms*/pathology , Kidney Neoplasms*/mortality, Humans ; Fibroblast Growth Factor-23 ; Klotho Proteins ; Pilot Projects ; Male ; Female ; Middle Aged ; Aged ; Fluorescent Antibody Technique ; Biomarkers, Tumor/metabolism ; Prognosis

The genetic polymorphism of XPR1 associated with Fanconi syndrome in Chinese patients with X-linked hypophosphatemia.

Autori: Han S Li X Liu W a ďalší

Zdroj: Journal of endocrinological investigation [J Endocrinol Invest] 2025 Dec; Vol. 48 (12), pp. 2869-2878. Date of Electronic Publication: 2025 Aug 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer Country of Publication: Italy NLM ID: 7806594 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1720-8386 (Electronic) Linking ISSN: 03914097 NLM ISO Abbreviation: J Endocrinol Invest Subsets: MEDLINE

Výrazy zo slovníka MeSH: Familial Hypophosphatemic Rickets*/genetics , Familial Hypophosphatemic Rickets*/complications , Familial Hypophosphatemic Rickets*/epidemiology , Fanconi Syndrome*/genetics , Fanconi Syndrome*/epidemiology , Polymorphism, Single Nucleotide*, Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Humans ; Male ; Case-Control Studies ; China/epidemiology ; Fibroblast Growth Factor-23 ; Genetic Predisposition to Disease ; MicroRNAs/genetics ; Prognosis ; Xenotropic and Polytropic Retrovirus Receptor/genetics ; East Asian People/genetics ; Sodium-Phosphate Cotransporter Proteins, Type IIa ; Sodium-Phosphate Cotransporter Proteins, Type IIc

Performance of novel biomarkers for prediction of diabetic kidney disease in patients with diabetes mellitus.

Autori: Zou LX Hou ZL Qian CH a ďalší

Zdroj: Annals of medicine [Ann Med] 2025 Dec; Vol. 57 (1), pp. 2562996. Date of Electronic Publication: 2025 Sep 25.

Spôsob vydávania: Journal Article; Observational Study; Validation Study

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8906388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2060 (Electronic) Linking ISSN: 07853890 NLM ISO Abbreviation: Ann Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Diabetes Mellitus, Type 1*/complications , Diabetes Mellitus, Type 1*/urine , Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/urine , Diabetic Nephropathies*/diagnosis , Diabetic Nephropathies*/etiology , Diabetic Nephropathies*/urine, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Angiopoietin-Like Protein 4/urine ; Biomarkers/urine ; Chemokine CCL2/urine ; Cross-Sectional Studies ; Fibroblast Growth Factor-23 ; Fibroblast Growth Factors/urine ; Growth Differentiation Factor 15/urine ; Lipocalin-2/urine ; Osteopontin/urine ; Predictive Value of Tests ; Prospective Studies ; ROC Curve

Serum fibroblast growth factor 23 and kidney injury molecule-1 in the prediction of acute kidney injury in critically-ill patients.

Autori: Zhang L Wang L Yan B a ďalší

Zdroj: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2575918. Date of Electronic Publication: 2025 Oct 28.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

Výrazy zo slovníka MeSH: Acute Kidney Injury*/blood , Acute Kidney Injury*/diagnosis , Hepatitis A Virus Cellular Receptor 1*/blood , Fibroblast Growth Factors*/blood, Humans ; Male ; Female ; Critical Illness ; Biomarkers/blood ; Middle Aged ; Prospective Studies ; Fibroblast Growth Factor-23 ; Aged ; ROC Curve ; Intensive Care Units ; Severity of Illness Index ; Adult ; Predictive Value of Tests ; Prognosis

Advancing Patient Evidence in XLH (APEX): Baseline analysis of a global data unification program.

Autori: Carpenter TO Fukumoto S Haffner D a ďalší

Zdroj: Bone [Bone] 2025 Dec; Vol. 201, pp. 117649. Date of Electronic Publication: 2025 Sep 15.

Spôsob vydávania: Journal Article; Observational Study

Informácie o časopise: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8504048 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2763 (Electronic) Linking ISSN: 18732763 NLM ISO Abbreviation: Bone Subsets: MEDLINE

Výrazy zo slovníka MeSH: Familial Hypophosphatemic Rickets*/epidemiology , Familial Hypophosphatemic Rickets*/genetics , Familial Hypophosphatemic Rickets*/therapy , Familial Hypophosphatemic Rickets*/physiopathology, Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Young Adult ; Fibroblast Growth Factor-23

Dysregulation of bone and myocardial inorganic phosphate transporters and downstream cell signals in early-stage mild chronic kidney disease-mineral and bone disorder: An experimental study.

Autori: Bogdanova E Sadykov A Ivanova G a ďalší

Zdroj: Bone [Bone] 2025 Dec; Vol. 201, pp. 117653. Date of Electronic Publication: 2025 Sep 18.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8504048 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2763 (Electronic) Linking ISSN: 18732763 NLM ISO Abbreviation: Bone Subsets: MEDLINE

Výrazy zo slovníka MeSH: Myocardium*/metabolism , Myocardium*/pathology , Bone and Bones*/metabolism , Bone and Bones*/pathology , Chronic Kidney Disease-Mineral and Bone Disorder*/metabolism , Chronic Kidney Disease-Mineral and Bone Disorder*/pathology , Signal Transduction* , Phosphate Transport Proteins*/metabolism, Animals ; Male ; Fibroblast Growth Factor-23 ; Rats, Inbred SHR ; Rats ; Phosphates/metabolism ; Phosphates/blood ; Sodium-Phosphate Cotransporter Proteins, Type III/metabolism ; Fibroblast Growth Factors

Fibroblast growth factor-23 remodels vascular extracellular matrix via glycosaminoglycan induction: implications for calcification in chronic kidney disease.

Autori: Freise C Jernej T Metzkow S a ďalší

Zdroj: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2567528. Date of Electronic Publication: 2025 Oct 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glycosaminoglycans*/metabolism , Renal Insufficiency, Chronic*/complications , Renal Insufficiency, Chronic*/metabolism , Renal Insufficiency, Chronic*/pathology , Fibroblast Growth Factors*/metabolism , Fibroblast Growth Factors*/pharmacology , Vascular Calcification*/metabolism , Vascular Calcification*/etiology , Vascular Calcification*/pathology , Extracellular Matrix*/metabolism, Fibroblast Growth Factor-23 ; Humans ; Rats ; Animals ; Muscle, Smooth, Vascular/metabolism ; Muscle, Smooth, Vascular/cytology ; Muscle, Smooth, Vascular/pathology ; Muscle, Smooth, Vascular/drug effects ; Cells, Cultured ; Glucuronidase/metabolism ; Klotho Proteins ; Endothelial Cells/metabolism ; Endothelial Cells/drug effects ; Myocytes, Smooth Muscle/metabolism ; Hyaluronic Acid/metabolism ; Signal Transduction