Search Results - "Fenton OS"

Integration of TLR7/8 agonists into lipid nanoparticles enhances antigen-specific immune responses to N1-methyl-Ψ-modified mRNA-LNP vaccines.

Authors: Choi, Huijeong Lee, Seonghyun Kim, Hyejin et al.

Source: Journal of Biological Engineering; 11/19/2025, Vol. 19 Issue 1, p1-18, 18p

Subject Terms: IMMUNE response, VACCINE development, LIPOSOMES, RNA modification & restriction, TOLL-like receptor agonists, SARS-CoV-2, PAPILLOMAVIRUSES, IMMUNOTHERAPY

Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis—Brief Report.

Authors: Clift, Cassandra L. Blaser, Mark C. Bartoli-Leonard, Francesca et al.

Source: Arteriosclerosis, Thrombosis & Vascular Biology; Oct2025, Vol. 45 Issue 10, p1928-1934, 7p

Nanoparticles in gynecologic cancers: a bibliometric and visualization analysis.

Authors: Zhou, Yunzhe Chen, Lizhang Wang, Tingting

Source: Frontiers in Oncology; 2025, p1-15, 15p

Subject Terms: FEMALE reproductive organs, GOLD nanoparticles, GYNECOLOGIC cancer, BIBLIOMETRICS, NANOPARTICLES analysis

Synergistic effect of nucleoside modification and ionizable lipid composition on translation and immune responses to mRNA vaccines.

Authors: Danz, Hillary Dauner, Allison Sharma, Shraddha et al.

Source: NPJ Vaccines; 9/29/2025, Vol. 10 Issue 1, p1-13, 13p

Subject Terms: IMMUNE response, VACCINES, PROTEIN synthesis, NUCLEOSIDE synthesis, VACCINE effectiveness, NANOPARTICLES, INFLAMMATION, IMMUNOGENETICS

Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades.

Authors: Kirtane, Ameya R. Bi, Jianling Rajesh, Netra U. et al.

Source: Nature Biomedical Engineering; Aug2025, Vol. 9 Issue 8, p1240-1253, 14p

Preclinical development of an mRNA-based multiepitope immunotherapeutic for glioblastoma.

Authors: Lutz, Johannes Feist, Randi K. Sonntag, Tim et al.

Source: Cancer Immunology, Immunotherapy; Nov2025, Vol. 74 Issue 11, p1-13, 13p

Subject Terms: IMMUNOTHERAPY, GLIOBLASTOMA multiforme, T cells, LIPOSOMES, CLINICAL trials, MESSENGER RNA, OVERALL survival, TUMOR antigens

Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering.

Authors: Padilla, Marshall S. Mrksich, Kaitlin Wang, Yiming et al.

Source: Nature Communications; 1/24/2025, Vol. 16 Issue 1, p1-19, 19p

Subject Terms: GENOME editing, LIVER cells, DRUG carriers, T cells, MESSENGER RNA, CATIONIC lipids, GENE transfection

Two new alkaloids from the endophytic fungus Aspergillus fumigatus SAS10 isolated from the mangrove tree Sonneratia apetala.

Authors: Chen, Zanhong Liu, Haisheng Ding, Bo et al.

Source: Natural Product Research; Apr2025, Vol. 39 Issue 7, p2012-2017, 6p

Subject Terms: ASPERGILLUS fumigatus, ENDOPHYTIC fungi, ANTIBACTERIAL agents, ALKALOIDS, MANGROVE plants

Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation.

Authors: Su, Kexin Shi, Lu Sheng, Tao et al.

Source: Nature Communications; 7/5/2024, Vol. 15 Issue 1, p1-12, 12p

Subject Terms: GENETIC translation, MESSENGER RNA, LIPIDS, CATIONIC lipids, NANOPARTICLES, GENE expression

Artificial intelligence-driven rational design of ionizable lipids for mRNA delivery.

Authors: Wang, Wei Chen, Kepan Jiang, Ting et al.

Source: Nature Communications; 12/30/2024, Vol. 15 Issue 1, p1-17, 17p

Subject Terms: VIRTUAL high-throughput screening (Drug development), HIGH throughput screening (Drug development), STRUCTURE-activity relationships, COVID-19 vaccines, ARTIFICIAL intelligence

mRNA delivery enabled by metal–organic nanoparticles.

Authors: Gu, Yuang Chen, Jingqu Wang, Zhaoran et al.

Source: Nature Communications; 11/8/2024, Vol. 15 Issue 1, p1-15, 15p

Subject Terms: GENE expression, ETHYLENE glycol, INTRAVENOUS therapy, GENOME editing, NANOPARTICLES

The role of Tat in HIV latency and reactivation.

Authors: Margolis, David M. Browne, Edward P.

Source: Frontiers in Immunology; 2025, p1-9, 9p

Subject Terms: HIV, TAT protein, ANTIRETROVIRAL agents, BIOCHEMISTRY, DORMANCY (Biology), MESSENGER RNA

Spleen-targeted NeoPol-mL242 mRNA vaccine induces robust T-cell responses in a hepatocellular carcinoma model.

Authors: Wu, Yufei Sun, Gongrui Ren, Wendan et al.

Source: Journal of Nanobiotechnology; 9/2/2025, Vol. 23 Issue 1, p1-17, 17p

Molecular mechanism of nano-vitamin A-mediated regulation of intramuscular fat deposition involving noncoding RNAs in pigs.

Authors: Li, Meng Cai, Wenrun Li, Ruotong et al.

Source: BMC Genomics; 8/6/2025, Vol. 26 Issue 1, p1-16, 16p

Subject Terms: NON-coding RNA, MEAT quality, LINCRNA, CIRCULAR RNA, VITAMIN A, ADIPOSE tissues, GENETIC regulation, MICRORNA

Spi1 aggravates neuropathic pain by modulating Clec7a-mediated neuroinflammation and microglial phagocytosis.

Authors: Xu, Yin Liu, Xinli Chen, Hui et al.

Source: Journal of Headache & Pain; 7/10/2025, Vol. 26 Issue 1, p1-20, 20p

Subject Terms: NEURALGIA, IN vitro studies, RESEARCH funding, POLYMERASE chain reaction, TRANSCRIPTION factors, NEUROINFLAMMATION, FLUORESCENT antibody technique, SPINAL cord injuries, GENE expression, MICE, RNA, ANIMAL experimentation, WESTERN immunoblotting, CYTOKINES, CELL receptors, PHAGOCYTOSIS, SEQUENCE analysis, ALLODYNIA, TUMOR necrosis factors, INTERLEUKINS

Nanoformulations Downregulating METTL16 Combined with mRNA Tumor Vaccines Suppress Triple-Negative Breast Cancer and Prevent Metastasis.

Authors: Wang, Runying Zhang, Yufeng Du, Shubo et al.

Source: International Journal of Nanomedicine; Jul2025, Vol. 20, p8951-8966, 16p

Dual-responsive synthetic gene circuit for dynamic biologic drug delivery via inflammatory and circadian signaling pathways.

Authors: Cimino, Amanda Pat, Fiona Oyebamiji, Omolabake et al.

Source: Journal of Biological Engineering; 5/19/2025, Vol. 19 Issue 1, p1-12, 12p

Subject Terms: GENE regulatory networks, INDUCED pluripotent stem cells, JUVENILE idiopathic arthritis, SYNTHETIC genes, DRUG receptors, CIRCADIAN rhythms

Engineered nanoparticles potentials in male reproduction.

Authors: Zhao, Feifei Fan, Mengyu Jing, Zhiyang et al.

Source: Andrology; May2025, Vol. 13 Issue 4, p694-705, 12p

Subject Terms: TESTICULAR diseases, DRUG bioavailability, OLDER people, NANOCARRIERS, TREATMENT effectiveness

Application of mRNA Immunotherapy Technology in Epstein-Barr Virus-related Refractory Malignant Tumors

Contributors: Xingchen Peng, professor

Source: A Phase I Study of mRNA Vaccine for Patients With EBV-positive Advanced Malignant Tumors
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Taylor GS, Jia H, Harrington K, Lee LW, Turner J, Ladell K, Price DA, Tanday M, Matthews J, Roberts C, Edwards C, McGuigan L, Hartley A, Wilson S, Hui EP, Chan AT, Rickinson AB, Steven NM. A recombinant modified vaccinia ankara vaccine encoding Epstein-Barr Virus (EBV) target antigens: a phase I trial in UK patients with EBV-positive cancer. Clin Cancer Res. 2014 Oct 1;20(19):5009-22. doi: 10.1158/1078-0432.CCR-14-1122-T. Epub 2014 Aug 14.
Hui EP, Taylor GS, Jia H, Ma BB, Chan SL, Ho R, Wong WL, Wilson S, Johnson BF, Edwards C, Stocken DD, Rickinson AB, Steven NM, Chan AT. Phase I trial of recombinant modified vaccinia ankara encoding Epstein-Barr viral tumor antigens in nasopharyngeal carcinoma patients. Cancer Res. 2013 Mar 15;73(6):1676-88. doi: 10.1158/0008-5472.CAN-12-2448. Epub 2013 Jan 24.
Si Y, Deng Z, Lan G, Du H, Wang Y, Si J, Wei J, Weng J, Qin Y, Huang B, Yang Y, Qin Y. The Safety and Immunological Effects of rAd5-EBV-LMP2 Vaccine in Nasopharyngeal Carcinoma Patients: A Phase I Clinical Trial and Two-Year Follow-Up. Chem Pharm Bull (Tokyo). 2016;64(8):1118-23. doi: 10.1248/cpb.c16-00114.
Chia WK, Wang WW, Teo M, Tai WM, Lim WT, Tan EH, Leong SS, Sun L, Chen JJ, Gottschalk S, Toh HC. A phase II study evaluating the safety and efficacy of an adenovirus-DeltaLMP1-LMP2 transduced dendritic cell vaccine in patients with advanced metastatic nasopharyngeal carcinoma. Ann Oncol. 2012 Apr;23(4):997-1005. doi: 10.1093/annonc/mdr341. Epub 2011 Aug 4.
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Reinhard K, Rengstl B, Oehm P, Michel K, Billmeier A, Hayduk N, Klein O, Kuna K, Ouchan Y, Woll S, Christ E, Weber D, Suchan M, Bukur T, Birtel M, Jahndel V, Mroz K, Hobohm K, Kranz L, Diken M, Kuhlcke K, Tureci O, Sahin U. An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors. Science. 2020 Jan 24;367(6476):446-453. doi: 10.1126/science.aay5967. Epub 2020 Jan 2.
Wang F, Qin Z, Lu H, He S, Luo J, Jin C, Song X. Clinical translation of gene medicine. J Gene Med. 2019 Jul;21(7):e3108. doi: 10.1002/jgm.3108. Epub 2019 Jul 15.
Fenton OS, Kauffman KJ, McClellan RL, Kaczmarek JC, Zeng MD, Andresen JL, Rhym LH, Heartlein MW, DeRosa F, Anderson DG. Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs. Angew Chem Int Ed Engl. 2018 Oct 8;57(41):13582-13586. doi: 10.1002/anie.201809056. Epub 2018 Sep 14.
Miao L, Li L, Huang Y, Delcassian D, Chahal J, Han J, Shi Y, Sadtler K, Gao W, Lin J, Doloff JC, Langer R, Anderson DG. Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation. Nat Biotechnol. 2019 Oct;37(10):1174-1185. doi: 10.1038/s41587-019-0247-3. Epub 2019 Sep 30.
Hou X, Zhang X, Zhao W, Zeng C, Deng B, McComb DW, Du S, Zhang C, Li W, Dong Y. Author Correction: Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis. Nat Nanotechnol. 2020 Jul;15(7):615. doi: 10.1038/s41565-020-0675-8.

Tissue Reconstruction and Drug Release System Utilizing Natural Polymer-Based Biomaterial Silk Fibroin: An Analysis Based on Traditional Chinese Medicine.

Authors: Chhajed, Mahavir Chhajed, Atika Joshi, Shrikant et al.

Source: Journal of Pharmaceutical Innovation; Dec2025, Vol. 20 Issue 6, p1-29, 29p