Search Results - "FLAVONES"

Coumarins and flavones with anti-inflammatory activity isolated from the branches and leaves of Daphne retusa .

Authors: Xu Y Li YX Sa KR et al.

Source: Journal of Asian natural products research [J Asian Nat Prod Res] 2025 Dec; Vol. 27 (12), pp. 1766-1776. Date of Electronic Publication: 2024 Feb 19.

Publication Type: Journal Article

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 100888334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-2213 (Electronic) Linking ISSN: 10286020 NLM ISO Abbreviation: J Asian Nat Prod Res Subsets: MEDLINE

MeSH Terms: Daphne*/chemistry , Flavones*/pharmacology , Flavones*/chemistry , Flavones*/isolation & purification , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , Anti-Inflammatory Agents*/isolation & purification , Coumarins*/pharmacology , Coumarins*/chemistry , Coumarins*/isolation & purification , Drugs, Chinese Herbal*/chemistry , Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/isolation & purification, Mice ; Plant Leaves/chemistry ; Animals ; RAW 264.7 Cells ; Molecular Structure ; Lipopolysaccharides/pharmacology ; Nitric Oxide/biosynthesis ; Molecular Docking Simulation ; Plant Stems/chemistry

Antidepressant activity of flavones from traditional Chinese medicine: a meta-analysis.

Authors: Wang Q Lu Y Mi X et al.

Source: Pharmaceutical biology [Pharm Biol] 2025 Dec; Vol. 63 (1), pp. 156-169. Date of Electronic Publication: 2025 Feb 25.

Publication Type: Journal Article; Meta-Analysis; Systematic Review

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9812552 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-5116 (Electronic) Linking ISSN: 13880209 NLM ISO Abbreviation: Pharm Biol Subsets: MEDLINE

MeSH Terms: Antidepressive Agents*/pharmacology , Antidepressive Agents*/isolation & purification , Flavones*/pharmacology , Flavones*/isolation & purification , Depression*/drug therapy , Drugs, Chinese Herbal*/pharmacology, Animals ; Mice ; Medicine, Chinese Traditional/methods ; Disease Models, Animal ; Behavior, Animal/drug effects

Polymethoxyflavones from Kaempferia parviflora stimulate melanogenesis by blocking the TPC2 channel.

Authors: Poungcho P Tang R Hairani R et al.

Source: Scientific reports [Sci Rep] 2025 Nov 18; Vol. 15 (1), pp. 40344. Date of Electronic Publication: 2025 Nov 18.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Melanins*/biosynthesis , Zingiberaceae*/chemistry , Flavones*/pharmacology , Flavones*/chemistry, Humans ; Animals ; Cell Line, Tumor ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Mice ; Monophenol Monooxygenase/metabolism ; Melanogenesis

An in silico investigation of the binding of flavones with CREB1 oncogene G-quadruplex DNA.

Authors: Agrawal P Nair MS

Source: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2025 Oct; Vol. 43 (16), pp. 9317-9330. Date of Electronic Publication: 2025 Mar 05.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-0254 (Electronic) Linking ISSN: 07391102 NLM ISO Abbreviation: J Biomol Struct Dyn Subsets: MEDLINE

MeSH Terms: G-Quadruplexes* , Flavones*/chemistry , Flavones*/metabolism , Cyclic AMP Response Element-Binding Protein*/chemistry , Cyclic AMP Response Element-Binding Protein*/genetics , Cyclic AMP Response Element-Binding Protein*/metabolism , DNA*/chemistry , Oncogenes*, Molecular Docking Simulation ; Molecular Dynamics Simulation ; Thermodynamics ; Protein Binding ; Hydrogen Bonding ; Humans ; Binding Sites ; Ligands

Discrimination of isomeric dihydroflavone and chalcone by the boosting optimal collision energy-liquid chromatography-tandem mass spectrometry: A case study of pharmacokinetics in honey-fried licorice.

Authors: Li Y Cao Y Wang T et al.

Source: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2025 Dec 15; Vol. 1267, pp. 124785. Date of Electronic Publication: 2025 Sep 03.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-376X (Electronic) Linking ISSN: 15700232 NLM ISO Abbreviation: J Chromatogr B Analyt Technol Biomed Life Sci Subsets: MEDLINE

MeSH Terms: Tandem Mass Spectrometry*/methods , Glycyrrhiza*/chemistry , Chalcones*/pharmacokinetics , Chalcones*/chemistry , Chalcones*/blood , Flavones*/pharmacokinetics , Flavones*/chemistry , Flavones*/blood , Chalcone*/pharmacokinetics , Chalcone*/chemistry , Chalcone*/blood, Isomerism ; Animals ; Rats ; Honey/analysis ; Chromatography, Liquid/methods ; Male ; Rats, Sprague-Dawley

Nobiletin and Tangeretin facilitate interfacial migration and inhibit lipid digestion through their binding interactions with bile salts.

Authors: Huang X Li W Pan F et al.

Source: Food chemistry [Food Chem] 2025 Dec 15; Vol. 495 (Pt 1), pp. 146232. Date of Electronic Publication: 2025 Sep 03.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH Terms: Flavones*/chemistry , Flavones*/pharmacology , Flavones*/metabolism , Bile Acids and Salts*/chemistry , Bile Acids and Salts*/metabolism , Plant Extracts*/chemistry, Digestion/drug effects ; Lipid Metabolism/drug effects ; Citrus/chemistry ; Lipase/chemistry ; Lipase/antagonists & inhibitors ; Lipase/metabolism ; Humans ; Lipolysis/drug effects ; Molecular Dynamics Simulation

Ameliorative Potential of Synthetic Flavone-Derivative in Diabetes-Associated Neurodegeneration.

Authors: Sen K Sakarwal A Ram H et al.

Source: Molecular nutrition & food research [Mol Nutr Food Res] 2025 Dec; Vol. 69 (23), pp. e70172. Date of Electronic Publication: 2025 Jul 17.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101231818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-4133 (Electronic) Linking ISSN: 16134125 NLM ISO Abbreviation: Mol Nutr Food Res Subsets: MEDLINE

MeSH Terms: Neuroprotective Agents*/pharmacology , Flavones*/pharmacology , Flavones*/chemistry , Diabetes Mellitus, Type 2*/complications , Neurodegenerative Diseases*/drug therapy , Neurodegenerative Diseases*/etiology, Animals ; Male ; Molecular Docking Simulation ; Hippocampus/drug effects ; Hippocampus/metabolism ; Hippocampus/pathology ; PPAR gamma/metabolism ; PPAR gamma/genetics ; Molecular Dynamics Simulation ; Cerebral Cortex/drug effects ; Cerebral Cortex/pathology ; Cerebral Cortex/metabolism ; Rats ; Glucose Transporter Type 3/metabolism ; Glucose Transporter Type 3/genetics

Tangeretin formulated in a self-nano-emulsifying drug-delivery system (SNEDDS) alleviates symptoms of rheumatoid arthritis by antagonizing M1 macrophages polarization.

Authors: Huan QC Mai CT Wan HY et al.

Source: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Nov 25; Vol. 148, pp. 157313. Date of Electronic Publication: 2025 Sep 23.

Publication Type: Journal Article

Journal Info: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

MeSH Terms: Macrophages*/drug effects , Macrophages*/metabolism , Arthritis, Rheumatoid*/drug therapy , Flavones*/pharmacology , Flavones*/pharmacokinetics , Flavones*/administration & dosage , Drug Delivery Systems* , Arthritis, Experimental*/drug therapy, Animals ; Mice ; RAW 264.7 Cells ; Rats ; Male ; Rats, Sprague-Dawley ; Emulsions ; Biological Availability ; Glycolysis/drug effects ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/pharmacokinetics

Metabolomic effects of total flavone of Abelmoschus manihot (L.) medik. on patients with radiation-induced heart disease.

Authors: Niu R Wang X Jia Q et al.

Source: Scientific reports [Sci Rep] 2025 Nov 19; Vol. 15 (1), pp. 40840. Date of Electronic Publication: 2025 Nov 19.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Metabolomics*/methods , Flavones*/pharmacology , Flavones*/therapeutic use , Abelmoschus*/chemistry , Heart Diseases*/etiology , Heart Diseases*/drug therapy , Heart Diseases*/metabolism , Heart Diseases*/blood , Metabolome*/drug effects , Radiation Injuries*/drug therapy , Radiation Injuries*/metabolism , Plant Extracts*/pharmacology, Humans ; Male ; Middle Aged ; Female ; Aged

Quantification of gossypetin, myricetin, quercetin and isorhamnetin in mouse plasma: Pharmacokinetic profiling after oral administration of total flavone of Abelmoschi Corolla.

Authors: Chen X Wang Y Li P et al.

Source: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2025 Nov 15; Vol. 265, pp. 117039. Date of Electronic Publication: 2025 Jun 18.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

MeSH Terms: Quercetin*/analogs & derivatives , Quercetin*/blood , Quercetin*/pharmacokinetics , Flavonoids*/blood , Flavonoids*/pharmacokinetics , Abelmoschus*/chemistry , Flavones*/pharmacokinetics , Flavones*/blood , Plant Extracts*/pharmacokinetics , Plant Extracts*/administration & dosage, Animals ; Mice ; Chromatography, High Pressure Liquid/methods ; Tandem Mass Spectrometry/methods ; Male ; Administration, Oral ; Reproducibility of Results

Redox and Bioenergetic Modulation by Acacetin Attenuated Neuropathic Allodynia in Mice with Diet-induced Diabetes.

Authors: Fan Y Zhou W Zhu Z et al.

Source: Molecular neurobiology [Mol Neurobiol] 2025 Nov 07; Vol. 63 (1), pp. 7. Date of Electronic Publication: 2025 Nov 07.

Publication Type: Journal Article

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH Terms: Hyperalgesia*/drug therapy , Hyperalgesia*/complications , Hyperalgesia*/metabolism , Energy Metabolism*/drug effects , Neuralgia*/drug therapy , Neuralgia*/metabolism , Neuralgia*/complications , Flavones*/pharmacology , Flavones*/therapeutic use , Diet, High-Fat*/adverse effects , Diabetes Mellitus, Experimental*/complications , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Experimental*/metabolism, Animals ; Male ; Mice, Inbred C57BL ; Oxidation-Reduction/drug effects ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/pathology ; Ganglia, Spinal/metabolism ; Mice ; Diabetic Neuropathies/drug therapy ; Oxidative Stress/drug effects ; Sciatic Nerve/drug effects ; Sciatic Nerve/physiopathology ; Mitochondria/metabolism ; Mitochondria/drug effects ; Blood Glucose/metabolism

Stress Fingerprints of Phyllocoptruta oleivora Infestation: from Pomology to Polymethoxyflavones in Citrus sinensis.

Authors: Ti̇ri̇ng G Erşatir M Ayman E et al.

Source: Journal of chemical ecology [J Chem Ecol] 2025 Nov 07; Vol. 51 (6), pp. 107. Date of Electronic Publication: 2025 Nov 07.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 7505563 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-1561 (Electronic) Linking ISSN: 00980331 NLM ISO Abbreviation: J Chem Ecol Subsets: MEDLINE

MeSH Terms: Citrus sinensis*/chemistry , Citrus sinensis*/parasitology , Citrus sinensis*/metabolism , Citrus sinensis*/physiology , Mites*/physiology , Flavones*/metabolism , Flavones*/chemistry , Flavones*/analysis, Animals ; Fruit/chemistry ; Fruit/metabolism ; Fruit/parasitology ; Stress, Physiological ; Plant Diseases/parasitology ; Phytochemicals/analysis

Protective Effects of Hispidulin Against Oleic Acid-induced Acute Kidney Injury in Rats: Integrated Enzymatic and Molecular Docking Analysis.

Authors: Avcı B Uguz H Sulumer AN et al.

Source: Chemistry & biodiversity [Chem Biodivers] 2025 Nov; Vol. 22 (11), pp. e01269. Date of Electronic Publication: 2025 Jul 01.

Publication Type: Journal Article

Journal Info: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

MeSH Terms: Molecular Docking Simulation* , Oleic Acid* , Acute Kidney Injury*/chemically induced , Acute Kidney Injury*/drug therapy , Acute Kidney Injury*/metabolism , Acute Kidney Injury*/pathology , Acute Kidney Injury*/prevention & control , Flavones*/pharmacology , Flavones*/chemistry , Protective Agents*/pharmacology , Protective Agents*/chemistry, Animals ; Male ; Rats ; Rats, Sprague-Dawley ; Acetylcholinesterase/metabolism ; Butyrylcholinesterase/metabolism ; Glutathione Transferase/metabolism ; Molecular Structure

A novel non-nad-based PARP1 inhibitor, Japoflavone B, triggered Caspase-3/GSDME-mediated pyroptosis through ROS/p38/p53 pathway in NSCLC.

Authors: Wan H Wei J Wang Y et al.

Source: Chemico-biological interactions [Chem Biol Interact] 2025 Oct 22; Vol. 420, pp. 111693. Date of Electronic Publication: 2025 Aug 04.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

MeSH Terms: Pyroptosis*/drug effects , Poly (ADP-Ribose) Polymerase-1*/antagonists & inhibitors , Poly (ADP-Ribose) Polymerase-1*/metabolism , Signal Transduction*/drug effects , Poly(ADP-ribose) Polymerase Inhibitors*/pharmacology , Poly(ADP-ribose) Polymerase Inhibitors*/chemistry , Poly(ADP-ribose) Polymerase Inhibitors*/therapeutic use , Flavones*/pharmacology , Flavones*/chemistry , Flavones*/therapeutic use, Humans ; Reactive Oxygen Species/metabolism ; Lung Neoplasms/pathology ; Lung Neoplasms/metabolism ; Lung Neoplasms/drug therapy ; Caspase 3/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Animals ; Tumor Suppressor Protein p53/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism ; Mice ; Cell Line, Tumor ; Mice, Nude ; Cell Proliferation/drug effects ; Mice, Inbred BALB C ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Gasdermins

Multifaceted Biological Activity of Selected Flavone C -Monoglucosides.

Authors: Zielińska D Zieliński H

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 17; Vol. 26 (20). Date of Electronic Publication: 2025 Oct 17.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: Antioxidants*/pharmacology , Antioxidants*/chemistry , Glucosides*/pharmacology , Glucosides*/chemistry , Flavonoids*/pharmacology , Flavonoids*/chemistry , Flavones*/chemistry , Flavones*/pharmacology, Acetylcholinesterase/metabolism ; Acetylcholinesterase/chemistry ; Apigenin/chemistry ; Apigenin/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/chemistry ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemistry ; Quercetin/pharmacology ; Quercetin/chemistry ; Glycation End Products, Advanced/metabolism ; Glycation End Products, Advanced/antagonists & inhibitors ; Peptidyl-Dipeptidase A/metabolism ; Luteolin

Exploring alternative therapeutic options for multidrug-resistant N. Gonorrhoeae : the potential of 7,8-dihydroxyflavone.

Authors: Qi Y Xie Q Lin J et al.

Source: Sexually transmitted infections [Sex Transm Infect] 2025 Oct 16; Vol. 101 (7), pp. 483-486. Date of Electronic Publication: 2025 Oct 16.

Publication Type: Journal Article

Journal Info: Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 9805554 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-3263 (Electronic) Linking ISSN: 13684973 NLM ISO Abbreviation: Sex Transm Infect Subsets: MEDLINE

MeSH Terms: Neisseria gonorrhoeae*/drug effects , Neisseria gonorrhoeae*/genetics , Neisseria gonorrhoeae*/isolation & purification , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Drug Resistance, Multiple, Bacterial*/genetics , Drug Resistance, Multiple, Bacterial*/drug effects , Flavones*/pharmacology , Flavones*/therapeutic use , Gonorrhea*/drug therapy , Gonorrhea*/microbiology, Microbial Sensitivity Tests ; Humans ; Multilocus Sequence Typing ; Genotype ; Azithromycin/pharmacology ; RNA, Ribosomal, 23S/genetics

Tangeretin protects the kidney from ischemia-reperfusion injury by inhibiting inflammatory response through downregulation of MAOA.

Authors: Gao J Liu X Huang J et al.

Source: International immunopharmacology [Int Immunopharmacol] 2025 Oct 10; Vol. 163, pp. 115242. Date of Electronic Publication: 2025 Jul 18.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH Terms: Reperfusion Injury*/drug therapy , Reperfusion Injury*/pathology , Monoamine Oxidase*/metabolism , Monoamine Oxidase*/genetics , Flavones*/pharmacology , Flavones*/therapeutic use , Kidney*/drug effects , Kidney*/pathology , Acute Kidney Injury*/drug therapy , Acute Kidney Injury*/pathology , Anti-Inflammatory Agents*/therapeutic use , Anti-Inflammatory Agents*/pharmacology, Animals ; Male ; Mice ; Down-Regulation ; Molecular Docking Simulation ; Disease Models, Animal ; Mice, Inbred C57BL ; Signal Transduction/drug effects ; Humans ; Apoptosis/drug effects ; NF-kappa B/metabolism ; Molecular Dynamics Simulation ; Inflammation/drug therapy

Protective mechanism of moslosooflavone against hypobaric hypoxia-induced brain injury: insights from network pharmacology and in vivo validation.

Authors: Yang C Xin Y Wang G et al.

Source: European journal of pharmacology [Eur J Pharmacol] 2025 Oct 05; Vol. 1004, pp. 178001. Date of Electronic Publication: 2025 Jul 25.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH Terms: Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use , Flavones*/pharmacology , Flavones*/therapeutic use , Brain Injuries*/etiology , Brain Injuries*/metabolism , Brain Injuries*/pathology , Brain Injuries*/prevention & control , Brain Injuries*/drug therapy, Animals ; Network Pharmacology ; Molecular Docking Simulation ; Mice ; Signal Transduction/drug effects ; Protein Interaction Maps/drug effects ; Male ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Brain/drug effects ; Brain/metabolism ; Brain/pathology

Caffeoylquinic acid esters, lignans and flavones from Yua thomsonii with cytotoxic and nitric oxide inhibitory activities.

Authors: Cuong DV Hanh TTH Cuong NX et al.

Source: Natural product research [Nat Prod Res] 2025 Oct; Vol. 39 (19), pp. 5471-5480. Date of Electronic Publication: 2024 Apr 25.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE

MeSH Terms: Nitric Oxide*/antagonists & inhibitors , Quinic Acid*/analogs & derivatives , Quinic Acid*/chemistry , Quinic Acid*/pharmacology , Quinic Acid*/isolation & purification , Lignans*/chemistry , Lignans*/pharmacology , Lignans*/isolation & purification , Flavones*/chemistry , Flavones*/pharmacology , Flavones*/isolation & purification , Antineoplastic Agents, Phytogenic*/pharmacology , Antineoplastic Agents, Phytogenic*/chemistry , Antineoplastic Agents, Phytogenic*/isolation & purification, Molecular Structure ; Humans ; Esters/chemistry ; Animals

Licoisoflavone A inhibits colorectal cancer cell proliferation through targeting CDK2-Cyclin E1 axis-mediated cell cycle transition.

Authors: Cui J Chen H Chen Y et al.

Source: Biochemical pharmacology [Biochem Pharmacol] 2025 Oct; Vol. 240, pp. 117124. Date of Electronic Publication: 2025 Jul 04.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH Terms: Cyclin-Dependent Kinase 2*/metabolism , Cyclin-Dependent Kinase 2*/antagonists & inhibitors , Cyclin-Dependent Kinase 2*/genetics , Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/metabolism , Colorectal Neoplasms*/pathology , Cell Proliferation*/drug effects , Cell Proliferation*/physiology , Cyclin E*/metabolism , Cyclin E*/antagonists & inhibitors , Oncogene Proteins*/metabolism , Oncogene Proteins*/antagonists & inhibitors , Flavones*/pharmacology , Flavones*/therapeutic use, Humans ; Animals ; Mice ; HCT116 Cells ; Mice, Nude ; Molecular Docking Simulation/methods ; Mice, Inbred BALB C ; Xenograft Model Antitumor Assays/methods ; Cell Line, Tumor ; Male ; Dose-Response Relationship, Drug