Search Results - "FIBROBLASTS"

Breast cancer cell coculture induces normal lung fibroblast transition to CAFs, promoting tumor cell dormancy and therapy resistance.

Authors: Klosowski ML Cronise KE Palmer EP et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 25; Vol. 122 (47), pp. e2423894122. Date of Electronic Publication: 2025 Nov 21.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH Terms: Cancer-Associated Fibroblasts*/pathology , Cancer-Associated Fibroblasts*/metabolism , Lung Neoplasms*/secondary , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism , Drug Resistance, Neoplasm* , Lung*/pathology , Lung*/cytology , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/metabolism , Triple Negative Breast Neoplasms*/drug therapy, Humans ; Coculture Techniques ; Female ; Tumor Microenvironment ; Cell Line, Tumor ; Fibroblasts/pathology ; Fibroblasts/metabolism ; Signal Transduction ; Autophagy

Cancer-associated fibroblasts promote tumor progression in fusion-positive rhabdomyosarcoma.

Authors: Sipila P Tran S Zhang C et al.

Source: Scientific reports [Sci Rep] 2025 Oct 23; Vol. 15 (1), pp. 37118. Date of Electronic Publication: 2025 Oct 23.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/pathology , Rhabdomyosarcoma*/pathology , Rhabdomyosarcoma*/genetics , Rhabdomyosarcoma*/metabolism , Oncogene Proteins, Fusion*/genetics , Oncogene Proteins, Fusion*/metabolism, Humans ; Tumor Microenvironment ; Cell Line, Tumor ; Disease Progression ; Receptors, CXCR4/metabolism ; Receptors, CXCR4/antagonists & inhibitors ; Receptors, CXCR4/genetics ; Cell Movement ; Lung Neoplasms/secondary ; Lung Neoplasms/genetics ; Cyclophosphamide/pharmacology ; Cell Proliferation ; Drug Resistance, Neoplasm ; Fibroblasts/metabolism ; Fibroblasts/pathology

FAP ⁺ fibroblasts orchestrate tumor microenvironment remodeling in renal cell carcinoma with tumor thrombus.

Authors: Ma J Huang Y Chen J et al.

Source: Nature communications [Nat Commun] 2025 Oct 23; Vol. 16 (1), pp. 9387. Date of Electronic Publication: 2025 Oct 23.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Carcinoma, Renal Cell*/pathology , Carcinoma, Renal Cell*/genetics , Carcinoma, Renal Cell*/metabolism , Tumor Microenvironment*/genetics , Kidney Neoplasms*/pathology , Kidney Neoplasms*/genetics , Kidney Neoplasms*/metabolism , Fibroblasts*/metabolism , Fibroblasts*/pathology , Gelatinases*/metabolism , Gelatinases*/genetics , Thrombosis*/pathology , Thrombosis*/genetics , Thrombosis*/metabolism , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics, Humans ; Endopeptidases/metabolism ; Cancer-Associated Fibroblasts/metabolism ; Cancer-Associated Fibroblasts/pathology ; Male ; Female ; Prognosis ; Cell Line, Tumor ; Killer Cells, Natural/immunology ; Pericytes/metabolism ; Pericytes/pathology ; Single-Cell Analysis ; Gene Expression Regulation, Neoplastic ; Middle Aged ; Membrane Proteins

Identification of a unique subpopulation of mucosal fibroblasts in colorectal cancer with tumor-restraining characteristics.

Authors: Ku J Jeong E Gong JR et al.

Source: Molecules and cells [Mol Cells] 2025 Oct; Vol. 48 (10), pp. 100263. Date of Electronic Publication: 2025 Aug 05.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 9610936 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0219-1032 (Electronic) Linking ISSN: 10168478 NLM ISO Abbreviation: Mol Cells Subsets: MEDLINE

MeSH Terms: Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/metabolism , Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/pathology , Intestinal Mucosa*/pathology, Humans ; Gene Expression Regulation, Neoplastic ; Male ; Female ; Tumor Microenvironment ; Fibroblasts

Fibroblast Supernatants Modulate Treatment Responses in Human Papillomavirus Positive and Negative Oropharyngeal Cancer Cell Lines.

Authors: Birgersson M Chabanová T Wiechec E et al.

Source: Anticancer research [Anticancer Res] 2025 Nov; Vol. 45 (11), pp. 4729-4742.

Publication Type: Journal Article

Journal Info: Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res Subsets: MEDLINE

MeSH Terms: Oropharyngeal Neoplasms*/virology , Oropharyngeal Neoplasms*/drug therapy , Oropharyngeal Neoplasms*/pathology , Oropharyngeal Neoplasms*/metabolism , Fibroblasts*/metabolism , Papillomavirus Infections*/virology , Papillomavirus Infections*/complications , Antineoplastic Agents*/pharmacology, Humans ; Cell Line, Tumor ; Docetaxel/pharmacology ; Cisplatin/pharmacology ; Cell Survival/drug effects ; Cancer-Associated Fibroblasts/metabolism ; Papillomaviridae ; Human Papillomavirus Viruses

Spatial multi-omics reveals the potential involvement of SPP1 ⁺ fibroblasts in determining metabolic heterogeneity and promoting metastatic growth of colorectal cancer liver metastasis.

Authors: Gao Y Zhang X Xia S et al.

Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Aug 06; Vol. 33 (8), pp. 3680-3700. Date of Electronic Publication: 2025 May 07.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

MeSH Terms: Liver Neoplasms*/secondary , Liver Neoplasms*/metabolism , Liver Neoplasms*/genetics , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/metabolism , Colorectal Neoplasms*/genetics , Metabolomics*/methods , Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/pathology, Humans ; Female ; Male ; Tumor Microenvironment ; Middle Aged ; Transcriptome ; Single-Cell Analysis ; Fibroblasts/metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Aged ; Multiomics

EGFRvIII-driven microenvironmental fibroblast activation and transformation accelerate oral cancer progression via lipocalin-2/STAT3 axis.

Authors: Peng HY Chang KY Chang WM et al.

Source: Neoplasia (New York, N.Y.) [Neoplasia] 2025 Aug; Vol. 66, pp. 101193. Date of Electronic Publication: 2025 Jun 04.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 100886622 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5586 (Electronic) Linking ISSN: 14765586 NLM ISO Abbreviation: Neoplasia Subsets: MEDLINE

MeSH Terms: STAT3 Transcription Factor*/metabolism , STAT3 Transcription Factor*/genetics , Tumor Microenvironment*/genetics , Lipocalin-2*/metabolism , Lipocalin-2*/genetics , ErbB Receptors*/metabolism , ErbB Receptors*/genetics , Mouth Neoplasms*/pathology , Mouth Neoplasms*/metabolism , Mouth Neoplasms*/genetics , Fibroblasts*/metabolism , Fibroblasts*/pathology , Cell Transformation, Neoplastic*/genetics , Cell Transformation, Neoplastic*/metabolism, Humans ; Animals ; Mice ; Disease Progression ; Signal Transduction ; Cell Line, Tumor ; Cancer-Associated Fibroblasts/metabolism ; Cancer-Associated Fibroblasts/pathology

Fibroblasts activated by miRs-185-5p, miR-652-5p, and miR-1246 shape the tumor microenvironment in triple-negative breast cancer via PATZ1 downregulation.

Authors: De Luca G Petrillo G Scognamiglio I et al.

Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2025 Jul 25; Vol. 82 (1), pp. 287. Date of Electronic Publication: 2025 Jul 25.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE

MeSH Terms: MicroRNAs*/genetics , MicroRNAs*/metabolism , Triple Negative Breast Neoplasms*/genetics , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/metabolism , Tumor Microenvironment*/genetics , Fibroblasts*/metabolism , Fibroblasts*/pathology , Repressor Proteins*/genetics , Repressor Proteins*/metabolism, Humans ; Female ; Down-Regulation ; Gene Expression Regulation, Neoplastic ; Cell Movement ; Cancer-Associated Fibroblasts/metabolism ; Cell Line, Tumor ; Culture Media, Conditioned/pharmacology

ATG7-deficient fibroblast promotes breast cancer progression via exosome-mediated downregulation of SCARB1.

Authors: Li K Liu T Luo Z et al.

Source: Cell death & disease [Cell Death Dis] 2025 Jul 24; Vol. 16 (1), pp. 556. Date of Electronic Publication: 2025 Jul 24.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

MeSH Terms: Breast Neoplasms*/pathology , Breast Neoplasms*/genetics , Breast Neoplasms*/metabolism , Autophagy-Related Protein 7*/metabolism , Autophagy-Related Protein 7*/deficiency , Autophagy-Related Protein 7*/genetics , Exosomes*/metabolism , Fibroblasts*/metabolism , Fibroblasts*/pathology , Lysosomal Membrane Proteins*/metabolism , Lysosomal Membrane Proteins*/genetics, Humans ; Female ; MicroRNAs/metabolism ; MicroRNAs/genetics ; Disease Progression ; Animals ; Down-Regulation ; Gene Expression Regulation, Neoplastic ; Tumor Microenvironment ; Cancer-Associated Fibroblasts/metabolism ; Cancer-Associated Fibroblasts/pathology ; Cell Proliferation/genetics ; Mice ; Cell Line, Tumor ; Cell Movement ; Mice, Inbred BALB C

p53 Deficiency in Colon Cancer Cells Promotes Tumor Progression Through the Modulation of Meflin in Fibroblasts.

Authors: Kimura E Hayashi Y Nakagawa K et al.

Source: Cancer science [Cancer Sci] 2025 Jul; Vol. 116 (7), pp. 1871-1882. Date of Electronic Publication: 2025 Apr 16.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Publishing on behalf of the Japanese Cancer Association Country of Publication: England NLM ID: 101168776 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7006 (Electronic) Linking ISSN: 13479032 NLM ISO Abbreviation: Cancer Sci Subsets: MEDLINE

MeSH Terms: Tumor Suppressor Protein p53*/deficiency , Tumor Suppressor Protein p53*/genetics , Tumor Suppressor Protein p53*/metabolism , Colonic Neoplasms*/pathology , Colonic Neoplasms*/genetics , Colonic Neoplasms*/metabolism , Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/pathology, Humans ; Animals ; Mice ; HCT116 Cells ; Cell Proliferation ; Tumor Microenvironment ; Fibroblasts/metabolism ; Disease Progression ; Coculture Techniques ; Female ; Mice, Nude ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Male

Melanoma-Keratinocyte Crosstalk Participates in Melanoma Progression with Mechanisms Partially Overlapping with Those of Cancer-Associated Fibroblasts.

Authors: Marrapodi R Kovacs D Migliano E et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Aug 15; Vol. 26 (16). Date of Electronic Publication: 2025 Aug 15.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: Melanoma*/pathology , Melanoma*/metabolism , Melanoma*/genetics , Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/pathology , Keratinocytes*/metabolism , Keratinocytes*/pathology , Cell Communication* , Skin Neoplasms*/pathology , Skin Neoplasms*/metabolism, Humans ; Tumor Microenvironment ; Coculture Techniques ; Disease Progression ; Cell Line, Tumor ; Culture Media, Conditioned/pharmacology ; Gene Expression Regulation, Neoplastic ; Cytokines/metabolism ; Fibroblasts/metabolism ; Cell Proliferation ; Extracellular Matrix/metabolism

Comprehensive single-cell transcriptomic analysis reveals fibroblast subpopulations and the prognostic association of COMT in prostate cancer progression， COMT ， COMT.

Authors: Shan W Guan B Ma W et al.

Source: Scientific reports [Sci Rep] 2025 Jul 28; Vol. 15 (1), pp. 27467. Date of Electronic Publication: 2025 Jul 28.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Prostatic Neoplasms*/genetics , Prostatic Neoplasms*/pathology , Prostatic Neoplasms*/mortality , Prostatic Neoplasms*/metabolism , Catechol O-Methyltransferase*/genetics , Catechol O-Methyltransferase*/metabolism , Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/pathology , Transcriptome*, Humans ; Male ; Single-Cell Analysis/methods ; Prognosis ; Tumor Microenvironment/genetics ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Gene Expression Profiling ; Fibroblasts/metabolism ; Biomarkers, Tumor/genetics

Identification of a fibroblast-derived gene signature reveals prognostic and therapeutic insights in pancreatic cancer.

Authors: Wang W Li H Gong J et al.

Source: Clinical and experimental medicine [Clin Exp Med] 2025 Jul 18; Vol. 25 (1), pp. 253. Date of Electronic Publication: 2025 Jul 18.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100973405 Publication Model: Electronic Cited Medium: Internet ISSN: 1591-9528 (Electronic) Linking ISSN: 15918890 NLM ISO Abbreviation: Clin Exp Med Subsets: MEDLINE

MeSH Terms: Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/mortality , Carcinoma, Pancreatic Ductal*/genetics , Carcinoma, Pancreatic Ductal*/pathology , Carcinoma, Pancreatic Ductal*/drug therapy , Carcinoma, Pancreatic Ductal*/mortality , Fibroblasts*/metabolism , Fibroblasts*/pathology , Transcriptome*, Humans ; Prognosis ; Gene Expression Regulation, Neoplastic ; Gene Expression Profiling ; Female ; Male ; Biomarkers, Tumor/genetics ; Single-Cell Analysis ; Cancer-Associated Fibroblasts ; Middle Aged

Fibroblast hierarchy dynamics during mammary gland morphogenesis and tumorigenesis.

Authors: Pascual R Cheng J De Smet AH et al.

Source: The EMBO journal [EMBO J] 2025 Jun; Vol. 44 (11), pp. 3266-3300. Date of Electronic Publication: 2025 Apr 11.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE

MeSH Terms: Mammary Glands, Animal*/growth & development , Mammary Glands, Animal*/cytology , Mammary Glands, Animal*/metabolism , Mammary Glands, Animal*/pathology , Fibroblasts*/metabolism , Fibroblasts*/pathology , Carcinogenesis*/pathology , Carcinogenesis*/genetics , Morphogenesis*, Animals ; Female ; Mice ; Cancer-Associated Fibroblasts/metabolism ; Cancer-Associated Fibroblasts/pathology ; Gene Expression Profiling ; Wnt Proteins/metabolism ; Wnt Proteins/genetics ; Antigens, CD34/metabolism ; Breast Neoplasms/pathology ; Breast Neoplasms/metabolism ; Cellular Senescence ; Single-Cell Analysis

CD105 ⁺ fibroblasts support an immunosuppressive niche in women at high risk of breast cancer initiation.

Authors: Carlson EG Lopez JC Yamaguchi Y et al.

Source: Breast cancer research : BCR [Breast Cancer Res] 2025 May 15; Vol. 27 (1), pp. 81. Date of Electronic Publication: 2025 May 15.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100927353 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-542X (Electronic) Linking ISSN: 14655411 NLM ISO Abbreviation: Breast Cancer Res Subsets: MEDLINE

MeSH Terms: Breast Neoplasms*/pathology , Breast Neoplasms*/immunology , Breast Neoplasms*/genetics , Breast Neoplasms*/metabolism , Breast Neoplasms*/etiology , Endoglin*/metabolism , Fibroblasts*/metabolism , Fibroblasts*/immunology, Humans ; Female ; Middle Aged ; Adult ; Aged ; Macrophages/immunology ; Macrophages/metabolism ; Young Adult ; Adolescent ; Coculture Techniques ; BRCA1 Protein/genetics ; Tumor Microenvironment/immunology ; Cancer-Associated Fibroblasts/metabolism ; Cancer-Associated Fibroblasts/immunology ; Cancer-Associated Fibroblasts/pathology

Periductal fibroblasts participate in liver homeostasis, fibrosis, and tumorigenesis.

Authors: Wang SS Yuan J Tang XT et al.

Source: The Journal of experimental medicine [J Exp Med] 2025 Apr 07; Vol. 222 (4). Date of Electronic Publication: 2025 Jan 31.

Publication Type: Journal Article

Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE

MeSH Terms: Homeostasis* , Fibroblasts*/pathology , Fibroblasts*/metabolism , Liver Cirrhosis*/pathology , Liver Cirrhosis*/metabolism , Liver*/pathology , Liver*/metabolism , Carcinogenesis*/pathology, Animals ; Myofibroblasts/metabolism ; Myofibroblasts/pathology ; Humans ; Cholangiocarcinoma/pathology ; Cholangiocarcinoma/metabolism ; Antigens, CD34/metabolism ; Antigens, CD34/genetics ; Mice ; Cancer-Associated Fibroblasts/pathology ; Cancer-Associated Fibroblasts/metabolism ; Receptor, Transforming Growth Factor-beta Type II/metabolism ; Bile Duct Neoplasms/pathology ; Bile Duct Neoplasms/metabolism

Enhancing fibroblast-epithelial cell communications: Serpine2 as a key molecule in Fusobacterium nucleatum -promoted colon cancer.

Authors: Li X Luo S Jiang Y et al.

Source: Frontiers in immunology [Front Immunol] 2025 Jun 26; Vol. 16, pp. 1563922. Date of Electronic Publication: 2025 Jun 26 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Fusobacterium nucleatum*/physiology , Colonic Neoplasms*/pathology , Colonic Neoplasms*/microbiology , Colonic Neoplasms*/metabolism , Colonic Neoplasms*/genetics , Colonic Neoplasms*/etiology , Cell Communication* , Fibroblasts*/metabolism , Fibroblasts*/pathology , Epithelial Cells*/metabolism , Epithelial Cells*/pathology , Fusobacterium Infections*/microbiology , Fusobacterium Infections*/complications, Humans ; Gene Expression Regulation, Neoplastic ; Cell Movement ; Cell Line, Tumor ; Cell Proliferation ; Cancer-Associated Fibroblasts

Integrative Single-Cell and Spatial Transcriptomics Analysis Reveals ECM-remodeling Cancer-associated Fibroblast-Derived POSTN as a Key Mediator in Pancreatic Ductal Adenocarcinoma Progression.

Authors: Wu Y Li S Yu H et al.

Source: International journal of biological sciences [Int J Biol Sci] 2025 May 27; Vol. 21 (8), pp. 3573-3596. Date of Electronic Publication: 2025 May 27 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE

MeSH Terms: Carcinoma, Pancreatic Ductal*/metabolism , Carcinoma, Pancreatic Ductal*/genetics , Carcinoma, Pancreatic Ductal*/pathology , Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/pathology , Cancer-Associated Fibroblasts*/metabolism , Extracellular Matrix*/metabolism , Cell Adhesion Molecules*/metabolism , Cell Adhesion Molecules*/genetics, Humans ; Cell Line, Tumor ; Epithelial-Mesenchymal Transition/genetics ; Tumor Microenvironment ; Single-Cell Analysis ; Disease Progression ; Transcriptome ; Fibroblasts/metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic

SCGB3A1-Epi and KLK10-Epi Crosstalk With Fibroblasts Promotes Liver Metastasis of Breast Cancer and Pancreatic Ductal Adenocarcinoma.

Authors: Xuan Z Wu Z Cheng L et al.

Source: Cancer medicine [Cancer Med] 2025 May; Vol. 14 (9), pp. e70904.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 101595310 Publication Model: Print Cited Medium: Internet ISSN: 2045-7634 (Electronic) Linking ISSN: 20457634 NLM ISO Abbreviation: Cancer Med Subsets: MEDLINE

MeSH Terms: Liver Neoplasms*/secondary , Liver Neoplasms*/genetics , Liver Neoplasms*/metabolism , Carcinoma, Pancreatic Ductal*/genetics , Carcinoma, Pancreatic Ductal*/pathology , Carcinoma, Pancreatic Ductal*/metabolism , Breast Neoplasms*/pathology , Breast Neoplasms*/genetics , Breast Neoplasms*/metabolism , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/metabolism , Kallikreins*/metabolism , Kallikreins*/genetics , Fibroblasts*/metabolism , Fibroblasts*/pathology, Humans ; Female ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Cancer-Associated Fibroblasts/metabolism

Spatial dissection of tumour microenvironments in gastric cancers reveals the immunosuppressive crosstalk between CCL2+ fibroblasts and STAT3 -activated macrophages.

Authors: Lee SH Lee D Choi J et al.

Source: Gut [Gut] 2025 Apr 07; Vol. 74 (5), pp. 714-727. Date of Electronic Publication: 2025 Apr 07.

Publication Type: Journal Article

Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE

MeSH Terms: Stomach Neoplasms*/immunology , Stomach Neoplasms*/pathology , Stomach Neoplasms*/genetics , Stomach Neoplasms*/metabolism , Tumor Microenvironment*/immunology , Tumor Microenvironment*/genetics , STAT3 Transcription Factor*/metabolism , Macrophages*/immunology , Macrophages*/metabolism , Chemokine CCL2*/metabolism , Fibroblasts*/metabolism , Fibroblasts*/immunology, Humans ; Cell Communication ; Animals ; Mice ; Cancer-Associated Fibroblasts ; Signal Transduction