Search Results - "FERROPTOSIS"

Ferroptosis in liver fibrosis and its potential intervention strategy.

Authors: Zhu W Fu L Cui Y et al.

Source: Cell biology and toxicology [Cell Biol Toxicol] 2025 Nov 25; Vol. 41 (1), pp. 152. Date of Electronic Publication: 2025 Nov 25.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 8506639 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6822 (Electronic) Linking ISSN: 07422091 NLM ISO Abbreviation: Cell Biol Toxicol Subsets: MEDLINE

MeSH Terms: Ferroptosis*/physiology , Ferroptosis*/drug effects , Liver Cirrhosis*/pathology , Liver Cirrhosis*/metabolism, Humans ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Animals ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Liver/pathology ; Liver/metabolism

Targeting the PRSS3-PAR2-ERK1/2 axis inhibits malignancy and regulates chemosensitivity and resistance through ferroptosis in breast cancer.

Authors: Tian R Li D Lan C et al.

Source: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 16; Vol. 241, pp. 642-658. Date of Electronic Publication: 2025 Oct 03.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH Terms: Ferroptosis*/drug effects , Ferroptosis*/genetics , Drug Resistance, Neoplasm*/genetics , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/genetics , Breast Neoplasms*/metabolism , Receptor, PAR-2*/metabolism , Receptor, PAR-2*/genetics, Humans ; Female ; Animals ; Mice ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Mitogen-Activated Protein Kinase 3/metabolism ; Mitogen-Activated Protein Kinase 3/genetics ; MAP Kinase Signaling System ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 1/genetics ; Xenograft Model Antitumor Assays

Histone H3 acetylation reverses radioresistance in breast cancers through BRD3-mediated inhibition of RAD51 and inducing ferroptosis.

Authors: Ye DM Qiu Y Cai JM et al.

Source: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 16; Vol. 241, pp. 760-772. Date of Electronic Publication: 2025 Oct 03.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH Terms: Breast Neoplasms*/radiotherapy , Breast Neoplasms*/genetics , Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology , Radiation Tolerance*/genetics , Histones*/metabolism , Histones*/genetics , Ferroptosis*/genetics , Ferroptosis*/radiation effects , Rad51 Recombinase*/genetics , Rad51 Recombinase*/metabolism, Humans ; Acetylation ; Female ; Gene Expression Regulation, Neoplastic/radiation effects ; Reactive Oxygen Species/metabolism ; Cell Line, Tumor ; Animals ; Phospholipid Hydroperoxide Glutathione Peroxidase/genetics ; Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism ; Promoter Regions, Genetic ; Bromodomain Containing Proteins ; Transcription Factors

ENO1 blockade augment ferroptosis susceptibility in TKIs-resistant CML through GPX4 autophagic degradation.

Authors: Hongwei P Xintong Y Zhiwei C et al.

Source: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 16; Vol. 241, pp. 899-913. Date of Electronic Publication: 2025 Sep 19.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH Terms: Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/drug therapy , Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/genetics , Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/pathology , Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/metabolism , Ferroptosis*/drug effects , Ferroptosis*/genetics , Drug Resistance, Neoplasm*/genetics , Drug Resistance, Neoplasm*/drug effects , Tumor Suppressor Proteins*/genetics , Tumor Suppressor Proteins*/metabolism , Tumor Suppressor Proteins*/antagonists & inhibitors , Phosphopyruvate Hydratase*/genetics , Phosphopyruvate Hydratase*/antagonists & inhibitors , Phosphopyruvate Hydratase*/metabolism , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/antagonists & inhibitors , DNA-Binding Proteins*/metabolism , Protein Kinase Inhibitors*/pharmacology, Humans ; Autophagy/drug effects ; Animals ; Mice ; K562 Cells ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Female ; Signal Transduction/drug effects ; Xenograft Model Antitumor Assays ; Male ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Biomarkers, Tumor

Lipid peroxidation-induced cell death in Rett syndrome.

Authors: Guiotto A Vallese A Cordone V et al.

Source: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 16; Vol. 241, pp. 243-257. Date of Electronic Publication: 2025 Sep 18.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH Terms: Rett Syndrome*/metabolism , Rett Syndrome*/pathology , Rett Syndrome*/genetics , Ferroptosis*/drug effects , Ferroptosis*/genetics , Lipid Peroxidation*/drug effects , Fibroblasts*/metabolism , Fibroblasts*/drug effects , Fibroblasts*/pathology, Humans ; Female ; Reactive Oxygen Species/metabolism ; Iron/metabolism ; Methyl-CpG-Binding Protein 2/genetics ; Methyl-CpG-Binding Protein 2/metabolism ; Phenylenediamines/pharmacology ; Mitochondria/metabolism ; Mitochondria/drug effects ; Cells, Cultured ; Cyclohexylamines/pharmacology ; Cell Death ; Mutation ; Carbolines ; Piperazines

Targeting ferroptosis and ferritinophagy improves tooth extraction socket healing in type 2 diabetes mellitus via human bone marrow mesenchymal stem cells modulation.

Authors: Li J Xu F Yu Y et al.

Source: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 16; Vol. 241, pp. 732-747. Date of Electronic Publication: 2025 Oct 11.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH Terms: Autophagy*/drug effects , Autophagy*/genetics , Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/pathology , Ferroptosis*/drug effects , Ferroptosis*/genetics , Nanoparticle Drug Delivery System* , Tooth Extraction*/adverse effects , Tooth Socket*/injuries , Tooth Socket*/physiology , Wound Healing*/drug effects , Wound Healing*/genetics , Diabetes Mellitus, Experimental*/complications , Diabetes Mellitus, Experimental*/pathology, Adult ; Animals ; Female ; Humans ; Male ; Rats ; Chitosan ; Hydrogels/administration & dosage ; Hydrogels/pharmacology ; Mesenchymal Stem Cells ; Rats, Sprague-Dawley ; Benzofurans ; Phosphorus ; Nuclear Receptor Coactivators/genetics ; Gene Knockout Techniques ; Chelating Agents ; Deferoxamine/pharmacology ; Adenine/pharmacology ; Adenine/analogs & derivatives

Bletilla striata polysaccharide protects against UVA-induced skin damage by activating Nrf2/HO-1 signaling and inhibiting ferroptosis.

Authors: Wang M Zhang Y Jiao J et al.

Source: Carbohydrate polymers [Carbohydr Polym] 2025 Dec 15; Vol. 370, pp. 124360. Date of Electronic Publication: 2025 Sep 12.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8307156 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1344 (Electronic) Linking ISSN: 01448617 NLM ISO Abbreviation: Carbohydr Polym Subsets: MEDLINE

MeSH Terms: NF-E2-Related Factor 2*/metabolism , Polysaccharides*/pharmacology , Polysaccharides*/chemistry , Ultraviolet Rays*/adverse effects , Orchidaceae*/chemistry , Heme Oxygenase-1*/metabolism , Ferroptosis*/drug effects , Ferroptosis*/radiation effects , Skin*/drug effects , Skin*/radiation effects , Skin*/metabolism , Skin*/pathology, Animals ; Mice ; Signal Transduction/drug effects ; Humans ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Keratinocytes/radiation effects ; Antioxidants/pharmacology ; Mice, Inbred C57BL

Integration of scRNA-seq and bulk RNA-seq reveals that macrophage ferroptosis inhibits MSC osteogenic differentiation in inflammatory microenvironments.

Authors: Liu J Ou S Wen J et al.

Source: International immunopharmacology [Int Immunopharmacol] 2025 Dec 10; Vol. 167, pp. 115744. Date of Electronic Publication: 2025 Oct 29.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH Terms: Ferroptosis*/genetics , Ferroptosis*/immunology , Macrophages*/immunology , Macrophages*/physiology , Macrophages*/metabolism , Mesenchymal Stem Cells*/physiology , Osteogenesis*/genetics, Animals ; Cell Differentiation ; Mice ; Humans ; Cellular Microenvironment ; RNA-Seq ; Mice, Inbred C57BL ; Inflammation/immunology ; Male ; Bone Regeneration ; Phospholipid Hydroperoxide Glutathione Peroxidase ; Single-Cell Gene Expression Analysis

Ferroptosis as a precise target for tumor-associated neutrophils: From molecular insights to targeted therapies.

Authors: Zhao D Guo M Zhang Y et al.

Source: International immunopharmacology [Int Immunopharmacol] 2025 Dec 10; Vol. 167, pp. 115647. Date of Electronic Publication: 2025 Oct 15.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH Terms: Ferroptosis*/drug effects , Ferroptosis*/immunology , Neutrophils*/immunology , Neutrophils*/drug effects , Neutrophils*/metabolism , Neoplasms*/immunology , Neoplasms*/drug therapy , Neoplasms*/therapy , Neoplasms*/pathology, Humans ; Animals ; Tumor Microenvironment/immunology ; Iron/metabolism ; Molecular Targeted Therapy

Targeted inhibition of METTL3 reprograms alveolar echinococcosis progression: attenuating ferroptosis by downregulating ACSL4 and reversing macrophage M2 polarization.

Authors: Chen J Ma Y Fan B et al.

Source: International immunopharmacology [Int Immunopharmacol] 2025 Dec 10; Vol. 167, pp. 115660. Date of Electronic Publication: 2025 Oct 14.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH Terms: Ferroptosis*/drug effects , Ferroptosis*/genetics , Coenzyme A Ligases*/genetics , Coenzyme A Ligases*/metabolism , Macrophages*/drug effects , Macrophages*/immunology , Echinococcosis, Hepatic*/drug therapy , Echinococcosis, Hepatic*/immunology , Echinococcosis, Hepatic*/pathology, Animals ; Humans ; Mice ; Long-Chain-Fatty-Acid-CoA Ligase ; Down-Regulation ; RAW 264.7 Cells ; Echinococcus multilocularis ; Disease Models, Animal ; Male ; Disease Progression ; Mice, Inbred C57BL ; Reactive Oxygen Species/metabolism ; Female ; Echinococcosis

SCR Disease Name: Alveolar echinococcosis

Roflumilast mitigates idiopathic pulmonary fibrosis via inhibition of iron accumulation and ferroptosis.

Authors: Feng L Han S Li Y et al.

Source: European journal of pharmacology [Eur J Pharmacol] 2025 Dec 05; Vol. 1008, pp. 178385. Date of Electronic Publication: 2025 Nov 18.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH Terms: Ferroptosis*/drug effects , Benzamides*/pharmacology , Benzamides*/therapeutic use , Aminopyridines*/pharmacology , Aminopyridines*/therapeutic use , Idiopathic Pulmonary Fibrosis*/drug therapy , Idiopathic Pulmonary Fibrosis*/pathology , Idiopathic Pulmonary Fibrosis*/metabolism , Idiopathic Pulmonary Fibrosis*/chemically induced , Iron*/metabolism, Animals ; Mice ; Bleomycin ; Male ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Cyclopropanes/pharmacology ; Cyclopropanes/therapeutic use ; Lung/drug effects ; Lung/pathology ; Lung/metabolism ; Reactive Oxygen Species/metabolism ; Mice, Inbred C57BL ; Humans ; Disease Models, Animal ; Cyclic AMP Response Element-Binding Protein/metabolism

Comprehensive bioinformatics analysis of ferroptosis-related genes and immune cell infiltration in LPS-induced acute lung injury.

Authors: Xu G Hao J Wang X et al.

Source: International immunopharmacology [Int Immunopharmacol] 2025 Dec 03; Vol. 166, pp. 115507. Date of Electronic Publication: 2025 Sep 15.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH Terms: Ferroptosis*/genetics , Ferroptosis*/immunology , Acute Lung Injury*/immunology , Acute Lung Injury*/genetics , Acute Lung Injury*/chemically induced , Early Growth Response Protein 1*/genetics , Early Growth Response Protein 1*/metabolism, Animals ; Lipopolysaccharides/immunology ; MicroRNAs/genetics ; Computational Biology ; Mice ; Mice, Inbred C57BL ; Disease Models, Animal ; Lung/immunology ; Lung/pathology ; Male ; Humans

Identification of ferroptosis-related genes as diagnostic biomarkers and therapeutic targets in sorafenib-resistant HCC via machine learning and experimental validation.

Authors: Zhang J Geng W Sun H et al.

Source: International immunopharmacology [Int Immunopharmacol] 2025 Dec 03; Vol. 166, pp. 115557. Date of Electronic Publication: 2025 Sep 21.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH Terms: Ferroptosis*/genetics , Ferroptosis*/drug effects , Sorafenib*/therapeutic use , Sorafenib*/pharmacology , Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/diagnosis , Drug Resistance, Neoplasm*/genetics , Liver Neoplasms*/drug therapy , Liver Neoplasms*/genetics , Liver Neoplasms*/diagnosis , Biomarkers, Tumor*/genetics , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/pharmacology, Humans ; Machine Learning ; Autophagy-Related Protein-1 Homolog/genetics ; Cell Line, Tumor ; Kelch-Like ECH-Associated Protein 1/genetics ; Gene Expression Regulation, Neoplastic ; Coenzyme A Ligases/genetics ; Intracellular Signaling Peptides and Proteins

CCNE1 Exerts a Protective Effect on Parkinson's Disease by Regulating Ferroptosis-Related Proteins.

Authors: Fu J Zhao J Mi N et al.

Source: Brain and behavior [Brain Behav] 2025 Dec; Vol. 15 (12), pp. e71110.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101570837 Publication Model: Print Cited Medium: Internet ISSN: 2162-3279 (Electronic) NLM ISO Abbreviation: Brain Behav Subsets: MEDLINE

MeSH Terms: Ferroptosis*/genetics , Ferroptosis*/physiology , Parkinson Disease*/genetics , Parkinson Disease*/metabolism , Cyclin E*/metabolism , Cyclin E*/genetics , Oncogene Proteins*/metabolism , Oncogene Proteins*/genetics, Humans ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Quantitative Trait Loci/genetics

Tannic acid prevents UVB-induced skin photoaging by regulating ferroptosis through NRF2/SLC7A11/GPX4 signaling.

Authors: Chen Z Ye L Zhu L et al.

Source: Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2025 Dec; Vol. 273, pp. 113309. Date of Electronic Publication: 2025 Nov 15.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Sequoia Country of Publication: Switzerland NLM ID: 8804966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2682 (Electronic) Linking ISSN: 10111344 NLM ISO Abbreviation: J Photochem Photobiol B Subsets: MEDLINE

MeSH Terms: Ultraviolet Rays*/adverse effects , NF-E2-Related Factor 2*/metabolism , Skin Aging*/drug effects , Skin Aging*/radiation effects , Ferroptosis*/drug effects , Ferroptosis*/radiation effects , Tannins*/pharmacology , Tannins*/chemistry , Signal Transduction*/drug effects , Signal Transduction*/radiation effects , Phospholipid Hydroperoxide Glutathione Peroxidase*/metabolism, Animals ; Humans ; Mice ; Mice, Inbred BALB C ; Reactive Oxygen Species/metabolism ; Fibroblasts/metabolism ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Fibroblasts/radiation effects ; Oxidative Stress/drug effects ; Oxidative Stress/radiation effects ; Skin/radiation effects ; Skin/metabolism ; Skin/cytology ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Antioxidants ; Cell Line ; Polyphenols

Astaxanthin suppress ferroptosis through the Akt1-FoxO3a signaling pathway to alleviates brain injury after intracerebral hemorrhage.

Authors: Zhang J Hua Q Gao L et al.

Source: Journal of pharmacological sciences [J Pharmacol Sci] 2025 Dec; Vol. 159 (4), pp. 310-321. Date of Electronic Publication: 2025 Oct 17.

Publication Type: Journal Article

Journal Info: Publisher: Japanese Pharmacological Society Country of Publication: Japan NLM ID: 101167001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1347-8648 (Electronic) Linking ISSN: 13478613 NLM ISO Abbreviation: J Pharmacol Sci Subsets: MEDLINE

MeSH Terms: Ferroptosis*/drug effects , Ferroptosis*/genetics , Cerebral Hemorrhage*/complications , Cerebral Hemorrhage*/drug therapy , Signal Transduction*/drug effects , Signal Transduction*/genetics , Proto-Oncogene Proteins c-akt*/metabolism , Forkhead Box Protein O3*/metabolism , Forkhead Box Protein O3*/genetics , Brain Injuries*/etiology , Brain Injuries*/prevention & control , Brain Injuries*/drug therapy, Animals ; Xanthophylls/pharmacology ; Xanthophylls/therapeutic use ; Oxidative Stress/drug effects ; Male ; Rats ; Rats, Sprague-Dawley ; Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism ; Phospholipid Hydroperoxide Glutathione Peroxidase/genetics ; PC12 Cells ; Disease Models, Animal ; Cell Survival/drug effects ; Up-Regulation/drug effects

Hypericin-mediated photodynamic therapy promotes apoptosis and inhibits fibrosis by inducing HMOX1-mediated ferroptosis in hypertrophic scar fibroblasts.

Authors: Li X Chen Z Liu M et al.

Source: Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2025 Dec; Vol. 273, pp. 113303. Date of Electronic Publication: 2025 Nov 07.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Sequoia Country of Publication: Switzerland NLM ID: 8804966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2682 (Electronic) Linking ISSN: 10111344 NLM ISO Abbreviation: J Photochem Photobiol B Subsets: MEDLINE

MeSH Terms: Ferroptosis*/drug effects , Ferroptosis*/radiation effects , Heme Oxygenase-1*/metabolism , Heme Oxygenase-1*/genetics , Photochemotherapy* , Apoptosis*/drug effects , Apoptosis*/radiation effects , Perylene*/analogs & derivatives , Perylene*/pharmacology , Perylene*/therapeutic use , Perylene*/chemistry , Cicatrix, Hypertrophic*/pathology , Cicatrix, Hypertrophic*/drug therapy , Cicatrix, Hypertrophic*/metabolism , Photosensitizing Agents*/pharmacology , Photosensitizing Agents*/chemistry, Humans ; Fibroblasts/metabolism ; Fibroblasts/drug effects ; Fibroblasts/cytology ; Anthracenes ; Fibrosis ; Reactive Oxygen Species/metabolism ; Cell Proliferation/drug effects ; Cell Proliferation/radiation effects ; Cell Movement/drug effects ; Cell Movement/radiation effects ; Lipid Peroxidation/drug effects ; Up-Regulation/drug effects

Rab27b-mediated CAFs derived exosomal miR-22-3p suppresses ferroptosis and promotes cisplatin resistance in osteosarcoma.

Authors: Duan W Niu X Liu Y et al.

Source: Cellular signalling [Cell Signal] 2025 Dec; Vol. 136, pp. 112125. Date of Electronic Publication: 2025 Sep 17.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

MeSH Terms: Osteosarcoma*/drug therapy , Osteosarcoma*/genetics , Osteosarcoma*/metabolism , Osteosarcoma*/pathology , MicroRNAs*/metabolism , MicroRNAs*/genetics , Cisplatin*/pharmacology , Cisplatin*/therapeutic use , Drug Resistance, Neoplasm*/genetics , Drug Resistance, Neoplasm*/drug effects , Ferroptosis*/drug effects , Ferroptosis*/genetics , Exosomes*/metabolism , Exosomes*/genetics , rab GTP-Binding Proteins*/metabolism , rab GTP-Binding Proteins*/genetics , Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/pathology , Bone Neoplasms*/drug therapy , Bone Neoplasms*/genetics , Bone Neoplasms*/metabolism , Bone Neoplasms*/pathology, Humans ; Animals ; PTEN Phosphohydrolase/metabolism ; Cell Line, Tumor ; Mice ; Mice, Nude ; Gene Expression Regulation, Neoplastic

RGS4 inhibits glioma cells sensitivity to radiotherapy and temozolomide by regulating ferroptosis.

Authors: Zhu H Qian C Ge Y et al.

Source: The International journal of neuroscience [Int J Neurosci] 2025 Dec; Vol. 135 (12), pp. 1479-1493. Date of Electronic Publication: 2024 Sep 18.

Publication Type: Journal Article

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 0270707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1563-5279 (Electronic) Linking ISSN: 00207454 NLM ISO Abbreviation: Int J Neurosci Subsets: MEDLINE

MeSH Terms: Ferroptosis*/drug effects , Ferroptosis*/genetics , Glioma*/genetics , Glioma*/therapy , Glioma*/metabolism , Glioma*/radiotherapy , RGS Proteins*/metabolism , RGS Proteins*/genetics , Brain Neoplasms*/genetics , Brain Neoplasms*/therapy , Brain Neoplasms*/metabolism , Temozolomide*/pharmacology , Chemoradiotherapy* , Antineoplastic Agents, Alkylating*/pharmacology , Radiation Tolerance*/genetics, Humans ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/drug effects

Activation of the Nrf2/HO-1/GPX4 pathway by cGAMP Mitigates oxidative stress and ferroptosis in ischaemic stroke.

Authors: Li X Qian S Hou Z et al.

Source: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 2), pp. 117334. Date of Electronic Publication: 2025 Sep 14.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH Terms: Ferroptosis*/drug effects , Ferroptosis*/physiology , Oxidative Stress*/drug effects , Oxidative Stress*/physiology , NF-E2-Related Factor 2*/metabolism , Ischemic Stroke*/metabolism , Ischemic Stroke*/drug therapy , Ischemic Stroke*/pathology , Phospholipid Hydroperoxide Glutathione Peroxidase*/metabolism , Nucleotides, Cyclic*/pharmacology , Nucleotides, Cyclic*/therapeutic use , Heme Oxygenase-1*/metabolism, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Membrane Proteins