Search Results - "Excitation Contraction Coupling"

Interactive Role of the DHPR β 1a SH3 Domain in Skeletal Muscle Excitation-Contraction Coupling.

Authors: Karunasekara Y Aditya S Norris NC et al.

Source: Biomolecules [Biomolecules] 2025 Nov 17; Vol. 15 (11). Date of Electronic Publication: 2025 Nov 17.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE

MeSH Terms: Calcium Channels, L-Type*/metabolism , Calcium Channels, L-Type*/chemistry , Calcium Channels, L-Type*/genetics , Muscle, Skeletal*/metabolism , Muscle, Skeletal*/physiology , src Homology Domains* , Excitation Contraction Coupling*, Animals ; Ryanodine Receptor Calcium Release Channel/metabolism ; Ryanodine Receptor Calcium Release Channel/chemistry ; Protein Binding ; Humans

Divergent actions of Ca V 1.1 voltage-sensing domain III in activating EC coupling and channel gating.

Authors: Pelizzari S Campiglio M Fernández-Quintero ML et al.

Source: Biophysical journal [Biophys J] 2025 Dec 02; Vol. 124 (23), pp. 4228-4242. Date of Electronic Publication: 2025 Oct 09.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0370626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-0086 (Electronic) Linking ISSN: 00063495 NLM ISO Abbreviation: Biophys J Subsets: MEDLINE

MeSH Terms: Calcium Channels, L-Type*/metabolism , Calcium Channels, L-Type*/chemistry , Calcium Channels, L-Type*/genetics , Ion Channel Gating* , Excitation Contraction Coupling*, Animals ; Protein Domains ; Humans ; HEK293 Cells

Mechano-energetic uncoupling in heart failure.

Authors: Aksentijevic D Sedej S Fauconnier J et al.

Source: Nature reviews. Cardiology [Nat Rev Cardiol] 2025 Oct; Vol. 22 (10), pp. 773-797. Date of Electronic Publication: 2025 Jun 22.

Publication Type: Journal Article; Review

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101500075 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1759-5010 (Electronic) Linking ISSN: 17595002 NLM ISO Abbreviation: Nat Rev Cardiol Subsets: MEDLINE

MeSH Terms: Heart Failure*/physiopathology , Heart Failure*/metabolism , Energy Metabolism* , Mitochondria, Heart*/metabolism , Excitation Contraction Coupling*, Humans ; Oxidative Stress ; Animals

Minimal changes in excitation-contraction coupling in spastic human muscle.

Authors: Wang Z Hoffman EM Litchy WJ et al.

Source: Journal of neurophysiology [J Neurophysiol] 2025 Oct 01; Vol. 134 (4), pp. 1069-1074. Date of Electronic Publication: 2025 Sep 05.

Publication Type: Journal Article

Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 0375404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1598 (Electronic) Linking ISSN: 00223077 NLM ISO Abbreviation: J Neurophysiol Subsets: MEDLINE

MeSH Terms: Muscle Spasticity*/physiopathology , Muscle, Skeletal*/physiopathology , Excitation Contraction Coupling*/physiology , Muscle Contraction*, Humans ; Middle Aged ; Male ; Adult ; Female ; Aged

Proteins of the Triadic Excitation-Contraction Coupling Complex in Skeletal Muscle.

Authors: Chang T Yee RSZ Rodney GG et al.

Source: Cold Spring Harbor perspectives in biology [Cold Spring Harb Perspect Biol] 2025 Oct 01; Vol. 17 (10). Date of Electronic Publication: 2025 Oct 01.

Publication Type: Journal Article; Review

Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 101513680 Publication Model: Electronic Cited Medium: Internet ISSN: 1943-0264 (Electronic) Linking ISSN: 19430264 NLM ISO Abbreviation: Cold Spring Harb Perspect Biol Subsets: MEDLINE

MeSH Terms: Muscle, Skeletal*/physiology , Muscle, Skeletal*/metabolism , Excitation Contraction Coupling*/physiology , Muscle Proteins*/metabolism, Humans ; Animals ; Calcium Channels, L-Type/metabolism ; Ryanodine Receptor Calcium Release Channel/metabolism ; Calcium/metabolism ; Sarcoplasmic Reticulum/metabolism ; Membrane Proteins/metabolism

STAC3 binding to CaV1.1 II-III loop is nonessential but critically supports skeletal muscle excitation-contraction coupling.

Authors: Tuinte WE Török E Tuluc P et al.

Source: JCI insight [JCI Insight] 2025 Aug 08; Vol. 10 (15). Date of Electronic Publication: 2025 Aug 08 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

MeSH Terms: Muscle, Skeletal*/metabolism , Muscle, Skeletal*/physiology , Excitation Contraction Coupling*/physiology , Excitation Contraction Coupling*/genetics , Calcium Channels, L-Type*/metabolism , Calcium Channels, L-Type*/genetics, Humans ; Ryanodine Receptor Calcium Release Channel/metabolism ; Ryanodine Receptor Calcium Release Channel/genetics ; Animals ; Mutation ; Protein Binding ; Mice ; Caveolin 1

RyR1-mediated Ca ²⁺ -induced Ca ²⁺ release plays a negligible role in excitation-contraction coupling of normal skeletal muscle.

Authors: Kobayashi T Yamazawa T Kurebayashi N et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Aug 26; Vol. 122 (34), pp. e2500449122. Date of Electronic Publication: 2025 Aug 21.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH Terms: Ryanodine Receptor Calcium Release Channel*/metabolism , Ryanodine Receptor Calcium Release Channel*/genetics , Muscle, Skeletal*/metabolism , Muscle, Skeletal*/physiology , Calcium*/metabolism , Excitation Contraction Coupling*/physiology, Animals ; Mice ; Sarcoplasmic Reticulum/metabolism ; Calcium Signaling ; Malignant Hyperthermia/genetics ; Malignant Hyperthermia/metabolism ; Mutation ; Muscle Contraction

The Yin and Yang of Heartbeats: Magnesium-Calcium Antagonism Is Essential for Cardiac Excitation-Contraction Coupling.

Authors: Marabelli C Santiago DJ Priori SG

Source: Cells [Cells] 2025 Aug 18; Vol. 14 (16). Date of Electronic Publication: 2025 Aug 18.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

MeSH Terms: Magnesium*/metabolism , Excitation Contraction Coupling*/drug effects , Calcium*/metabolism, Humans ; Animals ; Ryanodine Receptor Calcium Release Channel/metabolism

Mechanically Matched Heart-on-a-Chip Platform Mediated Maturation of Excitation-Contraction Coupling.

Authors: Han J Xu X Li J et al.

Source: ACS nano [ACS Nano] 2025 Jul 08; Vol. 19 (26), pp. 24052-24066. Date of Electronic Publication: 2025 Jun 26.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE

MeSH Terms: Myocytes, Cardiac*/cytology , Myocytes, Cardiac*/metabolism , Excitation Contraction Coupling* , Lab-On-A-Chip Devices*, Animals ; Dimethylpolysiloxanes/chemistry ; Elastic Modulus ; Rats

Evidence for intermittent coupling of intramyocardial small, engineered heart tissues acutely implanted into rabbit myocardium.

Authors: Huethorst E Bishop MJ Burton FL et al.

Source: Cardiovascular research [Cardiovasc Res] 2025 Sep 29; Vol. 121 (11), pp. 1697-1711.

Publication Type: Journal Article

Journal Info: Publisher: Oxford Journals Country of Publication: England NLM ID: 0077427 Publication Model: Print Cited Medium: Internet ISSN: 1755-3245 (Electronic) Linking ISSN: 00086363 NLM ISO Abbreviation: Cardiovasc Res Subsets: MEDLINE

MeSH Terms: Myocytes, Cardiac*/transplantation , Myocytes, Cardiac*/metabolism , Myocytes, Cardiac*/drug effects , Tissue Engineering*/methods , Induced Pluripotent Stem Cells*/metabolism , Induced Pluripotent Stem Cells*/transplantation , Myocardial Contraction* , Myocardium*/metabolism , Excitation Contraction Coupling*, Animals ; Rabbits ; Time Factors ; Humans ; Isolated Heart Preparation ; Action Potentials ; Calcium Signaling ; Cells, Cultured ; Heart Rate ; Hydrogels ; Regeneration

D-limonene complexed with hydroxypropyl-β-cyclodextrin prevents impaired cardiac excitation-contraction coupling by reducing oxidative stress and cardiac apoptosis in an animal model of cardiotoxicity induced by doxorubicin.

Authors: Durço AO Souza DS Lima Conceição MR et al.

Source: Chemico-biological interactions [Chem Biol Interact] 2025 Sep 05; Vol. 418, pp. 111580. Date of Electronic Publication: 2025 May 27.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

MeSH Terms: Oxidative Stress*/drug effects , Apoptosis*/drug effects , Doxorubicin*/toxicity , Cardiotoxicity*/prevention & control , Cardiotoxicity*/pathology , Cardiotoxicity*/drug therapy , Cardiotoxicity*/metabolism , 2-Hydroxypropyl-beta-cyclodextrin*/chemistry , 2-Hydroxypropyl-beta-cyclodextrin*/pharmacology , Limonene*/chemistry , Limonene*/pharmacology , Excitation Contraction Coupling*/drug effects, Animals ; Mice ; Male ; Disease Models, Animal ; Reactive Oxygen Species/metabolism ; Calcium/metabolism ; Myocardium/pathology ; Myocardium/metabolism ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Calcium Channels, L-Type/metabolism

Functional analysis of JPH2-knockout cardiomyocytes identifies ECCD as a novel indicator in a human cardiac modelJPH2.

Authors: Guo T Wang H Wu F et al.

Source: Stem cell research & therapy [Stem Cell Res Ther] 2025 May 09; Vol. 16 (1), pp. 234. Date of Electronic Publication: 2025 May 09.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE

MeSH Terms: Myocytes, Cardiac*/metabolism , Myocytes, Cardiac*/cytology , Membrane Proteins*/genetics , Membrane Proteins*/metabolism , Excitation Contraction Coupling*, Humans ; Calcium/metabolism ; Human Embryonic Stem Cells/metabolism ; Human Embryonic Stem Cells/cytology ; Myocardial Contraction ; Animals ; CRISPR-Cas Systems ; Muscle Proteins

Preventing Site-Specific Calpain Proteolysis of Junctophilin-2 Protects Against Stress-Induced Excitation-Contraction Uncoupling and Heart Failure Development.

Authors: Wang J Chen B Shi Q et al.

Source: Circulation [Circulation] 2025 Jan 14; Vol. 151 (2), pp. 171-187. Date of Electronic Publication: 2024 Sep 18.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4539 (Electronic) Linking ISSN: 00097322 NLM ISO Abbreviation: Circulation Subsets: MEDLINE

MeSH Terms: Calpain*/metabolism , Heart Failure*/metabolism , Heart Failure*/physiopathology , Heart Failure*/prevention & control , Heart Failure*/genetics , Excitation Contraction Coupling* , Membrane Proteins*/metabolism , Membrane Proteins*/genetics , Myocytes, Cardiac*/metabolism , Myocytes, Cardiac*/pathology, Animals ; Mice ; Proteolysis ; Male ; Mice, Inbred C57BL ; Disease Models, Animal ; Muscle Proteins

Subspace-located catalase prevents membrane degradation and dyssynchronization of local calcium release in adult cardiomyocytes.

Authors: Tavi P Naumenko N Mutikainen M et al.

Source: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 16; Vol. 241, pp. 807-817. Date of Electronic Publication: 2025 Oct 10.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH Terms: Catalase*/metabolism , Catalase*/genetics , Catalase*/antagonists & inhibitors , Myocytes, Cardiac*/metabolism , Calcium*/metabolism, Animals ; Mice ; Sarcoplasmic Reticulum/metabolism ; Calcium Signaling ; Cells, Cultured ; Ryanodine Receptor Calcium Release Channel/metabolism ; Ryanodine Receptor Calcium Release Channel/genetics ; Excitation Contraction Coupling ; Reactive Oxygen Species/metabolism ; Male ; Oxidative Stress ; Heart Ventricles ; Mice, Inbred C57BL

The foundation of excitation-contraction coupling in skeletal muscle: communication between the transverse tubules and sarcoplasmic reticulum.

Authors: Rall JA; Department of Physiology and Cell Biology, College of MedicineOhio State University, Columbus, Ohio, United States.

Source: Advances in physiology education [Adv Physiol Educ] 2024 Dec 01; Vol. 48 (4), pp. 759-769. Date of Electronic Publication: 2024 Aug 08.

Publication Type: Journal Article

Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100913944 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1229 (Electronic) Linking ISSN: 10434046 NLM ISO Abbreviation: Adv Physiol Educ Subsets: MEDLINE

MeSH Terms: Sarcoplasmic Reticulum*/metabolism , Sarcoplasmic Reticulum*/physiology , Muscle, Skeletal*/metabolism , Muscle, Skeletal*/physiology , Excitation Contraction Coupling*/physiology, Humans ; Animals ; Ryanodine Receptor Calcium Release Channel/metabolism ; Physiology ; Calcium/metabolism

Histidine-rich calcium-binding protein: a molecular integrator of cardiac excitation-contraction coupling.

Authors: Mackrill JJ; Department of Physiology, School of Medicine, College of Medicine and Health, University College Cork, Cork, T12 XF62, Ireland.

Source: The Journal of experimental biology [J Exp Biol] 2024 Oct 15; Vol. 227 (20). Date of Electronic Publication: 2024 Oct 23.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Company Of Biologists Limited Country of Publication: England NLM ID: 0243705 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9145 (Electronic) Linking ISSN: 00220949 NLM ISO Abbreviation: J Exp Biol Subsets: MEDLINE

MeSH Terms: Calcium-Binding Proteins*/metabolism , Calcium-Binding Proteins*/chemistry , Calcium-Binding Proteins*/genetics , Excitation Contraction Coupling*/physiology, Animals ; Humans

Ca V 1.1 voltage-sensing domain III exclusively controls skeletal muscle excitation-contraction coupling.

Authors: Pelizzari S Heiss MC Fernández-Quintero ML et al.

Source: Nature communications [Nat Commun] 2024 Aug 28; Vol. 15 (1), pp. 7440. Date of Electronic Publication: 2024 Aug 28.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Calcium*/metabolism , Calcium Channels, L-Type*/metabolism , Calcium Channels, L-Type*/genetics , Calcium Channels, L-Type*/chemistry , Excitation Contraction Coupling* , Molecular Dynamics Simulation* , Muscle, Skeletal*/metabolism , Protein Domains*, Humans ; Action Potentials/physiology ; HEK293 Cells ; Ion Channel Gating ; Muscle Contraction/physiology ; Mutation

Activation of G Protein-Coupled Estrogen Receptor (GPER) Negatively Modulates Cardiac Excitation-Contraction Coupling (ECC) through the PI3K/NOS/NO Pathway.

Authors: Diaz-Zegarra LA Espejo MS Ibañez AM et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 19; Vol. 25 (16). Date of Electronic Publication: 2024 Aug 19.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: Excitation Contraction Coupling*/drug effects , Myocytes, Cardiac*/metabolism , Myocytes, Cardiac*/drug effects , Nitric Oxide*/metabolism , Phosphatidylinositol 3-Kinases*/metabolism , Receptors, G-Protein-Coupled*/metabolism, Animals ; Male ; Rats ; Estradiol/pharmacology ; Estradiol/metabolism ; Nitric Oxide Synthase/metabolism ; Rats, Wistar ; Receptors, Estrogen/metabolism ; Signal Transduction/drug effects

(Cardiac) complexity needs interaction.

Authors: De Coster T; Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, PO 9600, Leiden, 2333 ZA, The Netherlands. t.j.c.de_coster@lumc.nl.; Netherlands Heart Institute, Moreelsepark 1, Utrecht, 3511EP, The Netherlands. t.j.c.de_coster@lumc.nl.

Source: Scientific reports [Sci Rep] 2025 Sep 19; Vol. 15 (1), pp. 32618. Date of Electronic Publication: 2025 Sep 19.

Publication Type: Review; Editorial

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Heart*/physiology , Heart*/physiopathology, Humans ; Arrhythmias, Cardiac/physiopathology ; Models, Cardiovascular ; Excitation Contraction Coupling ; Animals

Defined Composition of Culture Media Promotes Rodent Neonatal Cardiomyocyte Maturation and Enables Functional Neuro-Cardiac Co-Culture.

Authors: Borile G Dokshokova L Moro N et al.

Source: Cells [Cells] 2025 Sep 13; Vol. 14 (18). Date of Electronic Publication: 2025 Sep 13.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

MeSH Terms: Myocytes, Cardiac*/cytology , Myocytes, Cardiac*/metabolism , Myocytes, Cardiac*/drug effects , Culture Media*/pharmacology , Culture Media*/chemistry , Neurons*/cytology , Neurons*/metabolism , Neurons*/drug effects, Animals ; Coculture Techniques/methods ; Animals, Newborn ; Rats ; Calcium/metabolism ; Excitation Contraction Coupling/drug effects