Search Results - "ErbB Receptors"

Fluorescence-guided tumor resection with a cathepsin B-activatable, EGFR-targeted probe and a dual-mode surgical exoscope.

Authors: Sung Y Choi Y Park SM et al.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118108. Date of Electronic Publication: 2025 Aug 30.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH Terms: Cathepsin B*/metabolism , ErbB Receptors*/metabolism , ErbB Receptors*/antagonists & inhibitors , Fluorescent Dyes*/chemistry , Fluorescent Dyes*/chemical synthesis , Fluorescent Dyes*/metabolism , Fluorescent Dyes*/pharmacology , Triple Negative Breast Neoplasms*/surgery , Triple Negative Breast Neoplasms*/diagnostic imaging , Triple Negative Breast Neoplasms*/metabolism, Humans ; Animals ; Mice ; Optical Imaging ; Female ; Cetuximab/chemistry ; Cetuximab/pharmacology ; Cell Line, Tumor ; Mice, Nude ; Fluorescence ; Surgery, Computer-Assisted ; Molecular Structure

EGFR Activation and Conformational "Convergence": An Emerging Allosteric Model From Cancer Mutations.

Authors: Orellana L; Protein Dynamics and Mutation Lab, Department of Oncology-Pathology, Karolinska Institute, Sweden. Electronic address: laura.orellana@ki.se.

Source: Journal of molecular biology [J Mol Biol] 2025 Dec 15; Vol. 437 (24), pp. 169493. Date of Electronic Publication: 2025 Oct 22.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

MeSH Terms: ErbB Receptors*/genetics , ErbB Receptors*/chemistry , ErbB Receptors*/metabolism , Mutation* , Glioblastoma*/genetics , Glioblastoma*/metabolism , Neoplasms*/genetics, Humans ; Allosteric Regulation ; Protein Conformation ; Models, Molecular ; Protein Kinase Inhibitors/pharmacology

Steric disruption of EGFR oligomerization overcomes therapy resistance in non-small cell lung cancer.

Authors: Song D Jang J Lin MZ et al.

Source: Science advances [Sci Adv] 2025 Dec 05; Vol. 11 (49), pp. eady7032. Date of Electronic Publication: 2025 Dec 05.

Publication Type: Journal Article

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

MeSH Terms: Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/metabolism , Carcinoma, Non-Small-Cell Lung*/genetics , Carcinoma, Non-Small-Cell Lung*/pathology , ErbB Receptors*/genetics , ErbB Receptors*/metabolism , ErbB Receptors*/chemistry , ErbB Receptors*/antagonists & inhibitors , Drug Resistance, Neoplasm*/genetics , Drug Resistance, Neoplasm*/drug effects , Lung Neoplasms*/drug therapy , Lung Neoplasms*/metabolism , Lung Neoplasms*/genetics , Lung Neoplasms*/pathology , Protein Multimerization*/drug effects, Humans ; Protein Kinase Inhibitors/pharmacology ; Mutation ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Signal Transduction/drug effects

Design and synthesis of lactam analogs of andrographolide and discovery of their anticancer activity as dual EGFR and VEGFR2 inhibitors.

Authors: Chen R Zhang L Su J et al.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 05; Vol. 299, pp. 118042. Date of Electronic Publication: 2025 Aug 05.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH Terms: Diterpenes*/pharmacology , Diterpenes*/chemistry , Diterpenes*/chemical synthesis , Vascular Endothelial Growth Factor Receptor-2*/antagonists & inhibitors , Vascular Endothelial Growth Factor Receptor-2*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , ErbB Receptors*/antagonists & inhibitors , ErbB Receptors*/metabolism , Drug Design* , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry , Drug Discovery*, Humans ; Animals ; Mice ; Cell Proliferation/drug effects ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Apoptosis/drug effects ; Molecular Structure ; Dose-Response Relationship, Drug ; Mice, Inbred BALB C ; Cell Line, Tumor ; Female ; Angiogenesis Inhibitors/pharmacology ; Angiogenesis Inhibitors/chemical synthesis ; Angiogenesis Inhibitors/chemistry ; Human Umbilical Vein Endothelial Cells

Allogeneic stem cell-engineered EGFRvIII-specific CAR-NKT cells for treating glioblastoma with enhanced efficacy and safety.

Authors: Li YR Zhu Y Li Z et al.

Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Dec 03; Vol. 33 (12), pp. 6041-6062. Date of Electronic Publication: 2025 Sep 12.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

MeSH Terms: Glioblastoma*/therapy , Glioblastoma*/immunology , Glioblastoma*/pathology , Receptors, Chimeric Antigen*/genetics , Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/metabolism , Immunotherapy, Adoptive*/methods , ErbB Receptors*/immunology , ErbB Receptors*/genetics , Natural Killer T-Cells*/immunology , Natural Killer T-Cells*/metabolism , Natural Killer T-Cells*/transplantation , Brain Neoplasms*/therapy , Brain Neoplasms*/immunology , Brain Neoplasms*/pathology, Humans ; Animals ; Mice ; Xenograft Model Antitumor Assays ; Cell Line, Tumor ; Tumor Microenvironment/immunology ; Disease Models, Animal ; Receptors, Antigen, T-Cell

N-phenylquinazolin-4-amine-based EGFR TKIs suppress pulmonary fibrosis by modulating the EGFR/ERBB3 axis in epithelial-macrophage interaction.

Authors: Kim JH Choi SH Nam JK et al.

Source: Communications biology [Commun Biol] 2025 Dec 01; Vol. 8 (1), pp. 1723. Date of Electronic Publication: 2025 Dec 01.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

MeSH Terms: ErbB Receptors*/metabolism , ErbB Receptors*/antagonists & inhibitors , ErbB Receptors*/genetics , Receptor, ErbB-3*/metabolism , Receptor, ErbB-3*/genetics , Pulmonary Fibrosis*/drug therapy , Pulmonary Fibrosis*/metabolism , Protein Kinase Inhibitors*/pharmacology , Quinazolines*/pharmacology , Macrophages, Alveolar*/drug effects , Macrophages, Alveolar*/metabolism, Animals ; Mice ; Humans ; Signal Transduction/drug effects ; Mice, Inbred C57BL ; Male ; Quinazolinones/pharmacology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Bleomycin ; Disease Models, Animal

UCH-L1 regulates eye differentiation-related genes and modulates EGFR signalling in Drosophila melanogaster .

Authors: Tuan NA Thuoc TL Thao DTP

Source: Fly [Fly (Austin)] 2025 Dec; Vol. 19 (1), pp. 2580003. Date of Electronic Publication: 2025 Nov 13.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101470897 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-6942 (Electronic) Linking ISSN: 19336934 NLM ISO Abbreviation: Fly (Austin) Subsets: MEDLINE

MeSH Terms: Drosophila Proteins*/metabolism , Drosophila Proteins*/genetics , Drosophila melanogaster*/genetics , Drosophila melanogaster*/growth & development , Drosophila melanogaster*/metabolism , ErbB Receptors*/metabolism , ErbB Receptors*/genetics , Ubiquitin Thiolesterase*/metabolism , Ubiquitin Thiolesterase*/genetics , Receptors, Invertebrate Peptide*/metabolism , Receptors, Invertebrate Peptide*/genetics , Eye*/growth & development , Eye*/metabolism, Animals ; Signal Transduction ; Cell Differentiation/genetics ; Gene Expression Regulation, Developmental

An innovative approach to development of new pyrazolylquinolin-2-one hybrids as dual EGFR and BRAF ^V600E inhibitors.

Authors: Hawwas MM Mancy AS Ramadan M et al.

Source: Molecular diversity [Mol Divers] 2025 Dec; Vol. 29 (6), pp. 6379-6400. Date of Electronic Publication: 2025 Mar 08.

Publication Type: Journal Article

Journal Info: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

MeSH Terms: Proto-Oncogene Proteins B-raf*/antagonists & inhibitors , Proto-Oncogene Proteins B-raf*/genetics , Proto-Oncogene Proteins B-raf*/metabolism , ErbB Receptors*/antagonists & inhibitors , ErbB Receptors*/genetics , ErbB Receptors*/metabolism , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Quinolones*/chemistry , Quinolones*/pharmacology , Pyrazoles*/chemistry , Pyrazoles*/pharmacology, Humans ; Cell Line, Tumor ; Molecular Docking Simulation ; Cell Proliferation/drug effects ; Structure-Activity Relationship ; Apoptosis/drug effects ; Drug Screening Assays, Antitumor

Design, synthesis, and antiproliferative activity of new 5-ethylsulfonyl-indazole-3-carbohydrazides as dual EGFR/VEGFR-2 kinases inhibitors.

Authors: Al-Wahaibi LH Abou-Zied HA Mahmoud MA et al.

Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2516075. Date of Electronic Publication: 2025 Jun 24.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

MeSH Terms: ErbB Receptors*/antagonists & inhibitors , ErbB Receptors*/metabolism , Vascular Endothelial Growth Factor Receptor-2*/antagonists & inhibitors , Vascular Endothelial Growth Factor Receptor-2*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry , Drug Design* , Indazoles*/chemistry , Indazoles*/pharmacology , Indazoles*/chemical synthesis , Hydrazines*/pharmacology , Hydrazines*/chemistry , Hydrazines*/chemical synthesis, Humans ; Cell Proliferation/drug effects ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Molecular Structure ; Dose-Response Relationship, Drug ; Molecular Docking Simulation ; Apoptosis/drug effects ; Cell Line, Tumor

A KSHV-targeted small molecule efficiently blocks SARS-CoV-2 infection via inhibiting expression of EGFR and Cyclin A2.

Authors: Dong Z Wang X Hu G et al.

Source: Emerging microbes & infections [Emerg Microbes Infect] 2025 Dec; Vol. 14 (1), pp. 2440490. Date of Electronic Publication: 2024 Dec 19.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE

MeSH Terms: Herpesvirus 8, Human*/drug effects , Herpesvirus 8, Human*/genetics , Herpesvirus 8, Human*/physiology , SARS-CoV-2*/drug effects , SARS-CoV-2*/genetics , ErbB Receptors*/metabolism , ErbB Receptors*/genetics , COVID-19*/virology , COVID-19*/metabolism , Cyclin A2*/genetics , Cyclin A2*/metabolism, Humans ; Animals ; Mice ; Virus Replication/drug effects ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19 Drug Treatment ; Mice, Nude ; Sarcoma, Kaposi/virology ; Sarcoma, Kaposi/drug therapy ; Mice, Inbred BALB C

Rapid kinase activity detection and kinetic analysis using a convenient EGFR FRET-based detection probe.

Authors: Jaengwang K Pommayon S Sonklin C et al.

Source: Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2025 Dec; Vol. 1869 (12), pp. 130854. Date of Electronic Publication: 2025 Sep 08.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731726 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8006 (Electronic) Linking ISSN: 03044165 NLM ISO Abbreviation: Biochim Biophys Acta Gen Subj Subsets: MEDLINE

MeSH Terms: Fluorescence Resonance Energy Transfer*/methods , ErbB Receptors*/metabolism , ErbB Receptors*/genetics , Biosensing Techniques*/methods, Kinetics ; Humans ; Protein Kinase Inhibitors/pharmacology ; Fluorescent Dyes/chemistry

Discovery and structural-activity relationship of N-benzyl-2-fluorobenzamides as EGFR/HDAC3 dual-target inhibitors for the treatment of triple-negative breast cancer.

Authors: Ge GH Guo S Li TT et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Dec 01; Vol. 128, pp. 130362. Date of Electronic Publication: 2025 Aug 05.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

MeSH Terms: Triple Negative Breast Neoplasms*/drug therapy , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/metabolism , ErbB Receptors*/antagonists & inhibitors , ErbB Receptors*/metabolism , Histone Deacetylases*/metabolism , Histone Deacetylase Inhibitors*/chemistry , Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemical synthesis , Histone Deacetylase Inhibitors*/therapeutic use , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/therapeutic use , Benzamides*/chemistry , Benzamides*/pharmacology , Benzamides*/chemical synthesis , Benzamides*/therapeutic use , Drug Discovery*, Humans ; Structure-Activity Relationship ; Cell Proliferation/drug effects ; Cell Line, Tumor ; Female ; Animals ; Drug Screening Assays, Antitumor ; Apoptosis/drug effects ; Mice ; Molecular Structure ; Dose-Response Relationship, Drug ; Cell Movement/drug effects

Injury-induced Neuregulin-EGFR signaling from muscle mobilizes stem cells for whole-body regeneration in acoels.

Authors: Stevens B Popp R Valera H et al.

Source: Developmental biology [Dev Biol] 2025 Dec; Vol. 528, pp. 105-116. Date of Electronic Publication: 2025 Sep 06.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372762 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-564X (Electronic) Linking ISSN: 00121606 NLM ISO Abbreviation: Dev Biol Subsets: MEDLINE

MeSH Terms: Regeneration*/physiology , Signal Transduction*/physiology , ErbB Receptors*/metabolism , ErbB Receptors*/genetics , Muscles*/metabolism , Stem Cells*/cytology , Stem Cells*/metabolism , Neuregulin-1*/metabolism , Neuregulin-1*/genetics , Neuregulins*/metabolism , Neuregulins*/genetics, Animals ; RNA Interference ; Cell Movement ; Wound Healing

Surface plasmon resonance microscopy reveals N-glycosylation driven modulation of affinity and avidity of ErbB receptors in whole single pancreatic cancer cells.

Authors: Aguilar Díaz de León JS Thirumurthy M Ly N

Source: Glycobiology [Glycobiology] 2025 Nov 29; Vol. 35 (12).

Publication Type: Journal Article

Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9104124 Publication Model: Print Cited Medium: Internet ISSN: 1460-2423 (Electronic) Linking ISSN: 09596658 NLM ISO Abbreviation: Glycobiology Subsets: MEDLINE

MeSH Terms: Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/pathology , ErbB Receptors*/metabolism , ErbB Receptors*/immunology , Receptor, ErbB-2*/metabolism , Receptor, ErbB-3*/metabolism, Humans ; Glycosylation ; Surface Plasmon Resonance ; Cell Line, Tumor ; Trastuzumab

Identification of internalizing ScFvs for EGFR inhibition and apoptosis induction in cholangiocarcinoma cells.

Authors: Sayinta A Duangdara J Sumphanapai T et al.

Source: Scientific reports [Sci Rep] 2025 Nov 19; Vol. 15 (1), pp. 40648. Date of Electronic Publication: 2025 Nov 19.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: ErbB Receptors*/antagonists & inhibitors , ErbB Receptors*/metabolism , ErbB Receptors*/chemistry , Cholangiocarcinoma*/pathology , Cholangiocarcinoma*/metabolism , Cholangiocarcinoma*/drug therapy , Apoptosis*/drug effects , Single-Chain Antibodies*/pharmacology , Single-Chain Antibodies*/metabolism , Single-Chain Antibodies*/chemistry , Single-Chain Antibodies*/immunology , Bile Duct Neoplasms*/pathology , Bile Duct Neoplasms*/metabolism, Humans ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Molecular Docking Simulation ; Phosphorylation/drug effects ; Protein Binding ; Peptide Library ; Protein Kinase Inhibitors/pharmacology

Identification of Datura metel phytochemicals as potential EGFR inhibitors in lung cancer.

Authors: Pandey P Joshi P Rawat S et al.

Source: Scientific reports [Sci Rep] 2025 Nov 17; Vol. 15 (1), pp. 40083. Date of Electronic Publication: 2025 Nov 17.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: ErbB Receptors*/antagonists & inhibitors , ErbB Receptors*/metabolism , ErbB Receptors*/chemistry , Lung Neoplasms*/drug therapy , Lung Neoplasms*/metabolism , Phytochemicals*/pharmacology , Phytochemicals*/chemistry , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Antineoplastic Agents, Phytogenic*/pharmacology , Antineoplastic Agents, Phytogenic*/chemistry, Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-akt/chemistry ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors

Ligand- and integrin-independent mechano-sensitive EGFR activation in lung cancer cells.

Authors: Shaikh A Mohan A Collins M et al.

Source: Journal of cell science [J Cell Sci] 2025 Nov 15; Vol. 138 (22). Date of Electronic Publication: 2025 Nov 24.

Publication Type: Journal Article

Journal Info: Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9137 (Electronic) Linking ISSN: 00219533 NLM ISO Abbreviation: J Cell Sci Subsets: MEDLINE

MeSH Terms: ErbB Receptors*/chemistry , ErbB Receptors*/metabolism , Lung Neoplasms*/metabolism , Lung Neoplasms*/pathology, Humans ; Mutation ; Ligands ; Extracellular Matrix/metabolism ; Mechanotransduction, Cellular ; A549 Cells ; Integrins/metabolism ; Enzyme Activation ; src-Family Kinases/metabolism ; Cell Adhesion ; Cell Movement

Examining the 2-aryl-5-nitrobenzofuran-based hydrazones for anti-breast (MCF-7) cancer activity, potential to induce cell cycle arrest and inhibit receptor tyrosine kinases (VEGFR-2 & EGFR).

Authors: Nkoana JK More GK Elhenawy AA et al.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 15; Vol. 298, pp. 118018. Date of Electronic Publication: 2025 Aug 04.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH Terms: Vascular Endothelial Growth Factor Receptor-2*/antagonists & inhibitors , Vascular Endothelial Growth Factor Receptor-2*/metabolism , Benzofurans*/chemistry , Benzofurans*/pharmacology , ErbB Receptors*/antagonists & inhibitors , ErbB Receptors*/metabolism , Hydrazones*/pharmacology , Hydrazones*/chemistry , Hydrazones*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Cell Cycle Checkpoints*/drug effects , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/chemical synthesis , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism, Humans ; MCF-7 Cells ; Drug Screening Assays, Antitumor ; Structure-Activity Relationship ; Molecular Structure ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Animals ; Chlorocebus aethiops ; Apoptosis/drug effects ; Vero Cells ; Molecular Docking Simulation ; Female

Precision Chemoradiotherapy via EGFR Targeting with Radiotherapy-Activated Drug Conjugates.

Authors: Lin S Luo J Yang J et al.

Source: Journal of medicinal chemistry [J Med Chem] 2025 Nov 13; Vol. 68 (21), pp. 22769-22778. Date of Electronic Publication: 2025 Oct 23.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH Terms: ErbB Receptors*/metabolism , ErbB Receptors*/antagonists & inhibitors , Chemoradiotherapy* , Immunoconjugates*/pharmacology , Immunoconjugates*/chemistry , Immunoconjugates*/therapeutic use , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use, Animals ; Humans ; Mice ; Cell Line, Tumor ; Azo Compounds/chemistry ; Azo Compounds/pharmacology ; Mice, Nude ; Female ; Mice, Inbred BALB C ; Xenograft Model Antitumor Assays

TLR9 signaling requires ligand-induced phosphorylation of two specific tyrosine residues by EGFR and Syk.

Authors: Veleeparambil M Wang C Kessler PM et al.

Source: MBio [mBio] 2025 Nov 12; Vol. 16 (11), pp. e0027625. Date of Electronic Publication: 2025 Sep 22.

Publication Type: Journal Article

Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

MeSH Terms: Syk Kinase*/metabolism , Syk Kinase*/genetics , Toll-Like Receptor 9*/metabolism , Toll-Like Receptor 9*/genetics , ErbB Receptors*/metabolism , ErbB Receptors*/genetics , Signal Transduction* , Tyrosine*/metabolism, Phosphorylation ; Animals ; Humans ; Mice ; src-Family Kinases/metabolism ; src-Family Kinases/genetics ; Ligands