Výsledky vyhledávání - "Epithelial-Mesenchymal Transition"

Epithelial‑mesenchymal plasticity and cisplatin resistance in germ cell tumors: Mechanisms and emerging therapeutic strategies (Review).

Autoři: Gomes ESB De Souza TM Oliveira ALP a další

Zdroj: International journal of oncology [Int J Oncol] 2025 Dec; Vol. 67 (6). Date of Electronic Publication: 2025 Oct 17.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9306042 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-2423 (Electronic) Linking ISSN: 10196439 NLM ISO Abbreviation: Int J Oncol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Cisplatin*/therapeutic use , Cisplatin*/pharmacology , Drug Resistance, Neoplasm*/genetics , Drug Resistance, Neoplasm*/drug effects , Neoplasms, Germ Cell and Embryonal*/drug therapy , Neoplasms, Germ Cell and Embryonal*/pathology , Neoplasms, Germ Cell and Embryonal*/genetics , Epithelial-Mesenchymal Transition*/drug effects , Epithelial-Mesenchymal Transition*/genetics , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/pharmacology, Humans ; Animals

Pharmacological inhibition of JNK-MAPK disrupts cigarette smoke-induced RUNX2/Galectin-3 -driven EMT and cancer stemness in lung adenocarcinoma cells.

Autoři: Chhetri K Sharma JR Vasita R a další

Zdroj: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 3), pp. 117399. Date of Electronic Publication: 2025 Oct 03.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Epithelial-Mesenchymal Transition*/drug effects , Epithelial-Mesenchymal Transition*/physiology , Core Binding Factor Alpha 1 Subunit*/metabolism , Core Binding Factor Alpha 1 Subunit*/genetics , Galectin 3*/metabolism , Galectin 3*/genetics , Adenocarcinoma of Lung*/metabolism , Adenocarcinoma of Lung*/pathology , Lung Neoplasms*/metabolism , Lung Neoplasms*/pathology , Lung Neoplasms*/drug therapy , Neoplastic Stem Cells*/drug effects , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Smoke*/adverse effects , Protein Kinase Inhibitors*/pharmacology , JNK Mitogen-Activated Protein Kinases*/antagonists & inhibitors , JNK Mitogen-Activated Protein Kinases*/metabolism , Cigarette Smoking*/adverse effects, Humans ; A549 Cells ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/physiology ; Reactive Oxygen Species/metabolism ; Blood Proteins ; Galectins

Captopril alleviates radiation-induced pulmonary fibrosis by suppressing PAI-1 expression and cytoskeleton-dependent epithelial-to-mesenchymal transition.

Autoři: Xia C Shao L Ma L a další

Zdroj: European journal of pharmacology [Eur J Pharmacol] 2025 Oct 15; Vol. 1005, pp. 178045. Date of Electronic Publication: 2025 Aug 06.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Epithelial-Mesenchymal Transition*/drug effects , Epithelial-Mesenchymal Transition*/radiation effects , Captopril*/pharmacology , Captopril*/therapeutic use , Pulmonary Fibrosis*/pathology , Pulmonary Fibrosis*/metabolism , Pulmonary Fibrosis*/etiology , Pulmonary Fibrosis*/drug therapy , Plasminogen Activator Inhibitor 1*/metabolism , Plasminogen Activator Inhibitor 1*/genetics , Cytoskeleton*/drug effects , Cytoskeleton*/metabolism , Cytoskeleton*/radiation effects , Radiation Injuries, Experimental*/pathology , Radiation Injuries, Experimental*/metabolism , Radiation Injuries, Experimental*/drug therapy, Animals ; Male ; Humans ; Mice ; A549 Cells ; Mice, Inbred C57BL ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/radiation effects ; Lung/drug effects ; Lung/pathology ; Lung/radiation effects ; Lung/metabolism

Molecular Adaptations to Repeated Radiation Exposure in Triple-Negative Breast Cancer: Dysregulation of Cell Adhesion, Mitochondrial Function, and Epithelial-Mesenchymal Transition.

Autoři: Dickinson N Murray A Davis M a další

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 01; Vol. 26 (19). Date of Electronic Publication: 2025 Oct 01.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Epithelial-Mesenchymal Transition*/radiation effects , Epithelial-Mesenchymal Transition*/genetics , Triple Negative Breast Neoplasms*/radiotherapy , Triple Negative Breast Neoplasms*/genetics , Triple Negative Breast Neoplasms*/metabolism , Triple Negative Breast Neoplasms*/pathology , Mitochondria*/radiation effects , Mitochondria*/metabolism , Mitochondria*/genetics , Cell Adhesion*/radiation effects , Cell Adhesion*/genetics , Radiation Tolerance*/genetics, Humans ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic/radiation effects ; Membrane Potential, Mitochondrial/radiation effects

Shikonin alleviates renal tubulointerstitial fibrosis in diabetic nephropathy via CCR5/ TGF-β1 signaling axis mediating EMT.

Autoři: Wang X Li H Zuo W a další

Zdroj: European journal of pharmacology [Eur J Pharmacol] 2025 Dec 05; Vol. 1008, pp. 178289. Date of Electronic Publication: 2025 Oct 30.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Naphthoquinones*/pharmacology , Naphthoquinones*/therapeutic use , Transforming Growth Factor beta1*/metabolism , Diabetic Nephropathies*/drug therapy , Diabetic Nephropathies*/pathology , Diabetic Nephropathies*/metabolism , Epithelial-Mesenchymal Transition*/drug effects , Receptors, CCR5*/metabolism , Kidney Tubules*/pathology , Kidney Tubules*/drug effects , Kidney Tubules*/metabolism, Animals ; Fibrosis ; Signal Transduction/drug effects ; Mice ; Male ; Mice, Inbred C57BL ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/pathology ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/metabolism

Phase Separation of PHLDB2 Drives EMT and Tumor Progression in Triple-Negative Breast Cancer.

Autoři: Zhang M Liang C Chen T a další

Zdroj: Cancer medicine [Cancer Med] 2025 Dec; Vol. 14 (23), pp. e71308.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 101595310 Publication Model: Print Cited Medium: Internet ISSN: 2045-7634 (Electronic) Linking ISSN: 20457634 NLM ISO Abbreviation: Cancer Med Subsets: MEDLINE

Výrazy ze slovníku MeSH: Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/genetics , Triple Negative Breast Neoplasms*/metabolism , Epithelial-Mesenchymal Transition*/genetics, Humans ; Animals ; Female ; Mice ; Cell Proliferation ; Disease Progression ; Cell Line, Tumor ; Cell Movement ; Gene Expression Regulation, Neoplastic ; Lung Neoplasms/secondary ; Lung Neoplasms/genetics ; Gene Expression Profiling ; Xenograft Model Antitumor Assays ; Phase Separation

THBS1 Contributes to Chemoresistance in Ovarian Clear Cell Carcinoma via Promoting Epithelial-Mesenchymal Transition.

Autoři: Ye D Liu Y Cheng A a další

Zdroj: The journal of gene medicine [J Gene Med] 2025 Dec; Vol. 27 (12), pp. e70058.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: John Wiley & Sons Country of Publication: England NLM ID: 9815764 Publication Model: Print Cited Medium: Internet ISSN: 1521-2254 (Electronic) Linking ISSN: 1099498X NLM ISO Abbreviation: J Gene Med Subsets: MEDLINE

Výrazy ze slovníku MeSH: Drug Resistance, Neoplasm*/genetics , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/drug therapy , Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/metabolism , Epithelial-Mesenchymal Transition*/genetics , Thrombospondin 1*/genetics , Thrombospondin 1*/metabolism , Adenocarcinoma, Clear Cell*/genetics , Adenocarcinoma, Clear Cell*/drug therapy , Adenocarcinoma, Clear Cell*/pathology , Adenocarcinoma, Clear Cell*/metabolism, Humans ; Female ; Gene Expression Regulation, Neoplastic ; Prognosis ; Cell Line, Tumor ; Middle Aged ; Biomarkers, Tumor/genetics

Rho kinase 2 promotes epithelial-mesenchymal transition and proliferation in human prostate cancer PC-3 cells.

Autoři: Hossain A Yamamura A Nayeem MJ a další

Zdroj: Journal of pharmacological sciences [J Pharmacol Sci] 2025 Dec; Vol. 159 (4), pp. 229-241. Date of Electronic Publication: 2025 Sep 20.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Japanese Pharmacological Society Country of Publication: Japan NLM ID: 101167001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1347-8648 (Electronic) Linking ISSN: 13478613 NLM ISO Abbreviation: J Pharmacol Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: rho-Associated Kinases*/genetics , rho-Associated Kinases*/physiology , rho-Associated Kinases*/metabolism , Epithelial-Mesenchymal Transition*/genetics , Cell Proliferation*/genetics , Prostatic Neoplasms*/pathology , Prostatic Neoplasms*/genetics, Humans ; Male ; Animals ; PC-3 Cells ; Cadherins/metabolism ; Cell Movement/genetics ; Mice ; Cell Line, Tumor ; Gene Knockdown Techniques

Targeting MED8 enhances sorafenib sensitivity in hepatocellular carcinoma by disrupting epithelial-mesenchymal transition mechanisms.

Autoři: Li M You X Yuan T a další

Zdroj: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2574988. Date of Electronic Publication: 2025 Oct 21.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Sorafenib*/pharmacology , Sorafenib*/chemistry , Epithelial-Mesenchymal Transition*/drug effects , Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Liver Neoplasms*/drug therapy , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Mediator Complex*/metabolism , Mediator Complex*/antagonists & inhibitors , Mediator Complex*/genetics, Humans ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Dose-Response Relationship, Drug ; Structure-Activity Relationship ; Apoptosis/drug effects ; Molecular Structure ; Tumor Cells, Cultured ; Cell Line, Tumor ; Drug Resistance, Neoplasm/drug effects

TGFβ1‑induced epithelial‑mesenchymal transition is associated with stathmin downregulation and increased microtubule stability in bronchial epithelial cells.

Autoři: Mohamad Hasan NAH Lee YZ Tham CL a další

Zdroj: Molecular medicine reports [Mol Med Rep] 2025 Dec; Vol. 32 (6). Date of Electronic Publication: 2025 Sep 19.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-3004 (Electronic) Linking ISSN: 17912997 NLM ISO Abbreviation: Mol Med Rep Subsets: MEDLINE

Výrazy ze slovníku MeSH: Epithelial-Mesenchymal Transition*/drug effects , Stathmin*/metabolism , Stathmin*/genetics , Transforming Growth Factor beta1*/pharmacology , Transforming Growth Factor beta1*/metabolism , Microtubules*/metabolism , Microtubules*/drug effects , Epithelial Cells*/metabolism , Epithelial Cells*/drug effects , Epithelial Cells*/cytology , Bronchi*/cytology , Bronchi*/metabolism, Humans ; Cell Line ; Cell Movement/drug effects ; Down-Regulation ; Cadherins/metabolism ; Benzamides ; Dioxoles

Co-delivery of shikonin and JQ1 inhibits triple-negative breast tumor progression and lung metastasis through inhibition of epithelial-mesenchymal transition and vasculogenic mimicry.

Autoři: Xu XY Kalambhe DR Yu Y a další

Zdroj: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2025 Dec; Vol. 46 (12), pp. 3314-3326. Date of Electronic Publication: 2025 Jul 14.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE

Výrazy ze slovníku MeSH: Triple Negative Breast Neoplasms*/drug therapy , Triple Negative Breast Neoplasms*/pathology , Lung Neoplasms*/secondary , Lung Neoplasms*/drug therapy , Lung Neoplasms*/prevention & control , Epithelial-Mesenchymal Transition*/drug effects , Triazoles*/administration & dosage , Triazoles*/pharmacology , Triazoles*/therapeutic use , Naphthoquinones*/administration & dosage , Naphthoquinones*/pharmacology , Naphthoquinones*/therapeutic use , Azepines*/administration & dosage , Azepines*/pharmacology , Azepines*/therapeutic use , Neovascularization, Pathologic*/drug therapy , Antineoplastic Agents*/administration & dosage , Antineoplastic Agents*/pharmacology, Animals ; Humans ; Female ; Mice, Inbred BALB C ; Cell Line, Tumor ; Mice ; Mice, Nude ; Apoptosis/drug effects

Desulfovibrio vulgaris flagellin exacerbates colorectal cancer through activating LRRC19/TRAF6/TAK1 pathway.

Autoři: Dong Y Meng F Wang J a další

Zdroj: Gut microbes [Gut Microbes] 2025 Dec; Vol. 17 (1), pp. 2446376. Date of Electronic Publication: 2024 Dec 24.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE

Výrazy ze slovníku MeSH: Colorectal Neoplasms*/metabolism , Colorectal Neoplasms*/microbiology , Colorectal Neoplasms*/pathology , TNF Receptor-Associated Factor 6*/metabolism , TNF Receptor-Associated Factor 6*/genetics , Flagellin*/metabolism , Flagellin*/genetics , MAP Kinase Kinase Kinases*/metabolism , MAP Kinase Kinase Kinases*/genetics , Epithelial-Mesenchymal Transition* , Desulfovibrio vulgaris*/metabolism , Desulfovibrio vulgaris*/genetics, Animals ; Humans ; Mice ; Signal Transduction ; Membrane Proteins/metabolism ; Membrane Proteins/genetics ; Cell Proliferation ; Cell Line, Tumor ; Mice, Inbred C57BL ; Ubiquitination ; Male ; Intracellular Signaling Peptides and Proteins

SCG2 Transcriptionally Activated by SP1 Promotes Nasal Epithelial Cell Proliferation and Epithelial Mesenchymal Transition.

Autoři: Zhan J Qiu Q Chen Z a další

Zdroj: The American journal of pathology [Am J Pathol] 2025 Dec; Vol. 195 (12), pp. 2387-2399. Date of Electronic Publication: 2025 Sep 12.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 0370502 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-2191 (Electronic) Linking ISSN: 00029440 NLM ISO Abbreviation: Am J Pathol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Epithelial-Mesenchymal Transition*/genetics , Epithelial-Mesenchymal Transition*/physiology , Cell Proliferation*/physiology , Sp1 Transcription Factor*/metabolism , Sp1 Transcription Factor*/genetics , Epithelial Cells*/metabolism , Epithelial Cells*/pathology , Nasal Polyps*/pathology , Nasal Polyps*/metabolism , Nasal Polyps*/genetics , Nasal Mucosa*/metabolism , Nasal Mucosa*/pathology, Humans ; Sinusitis/pathology ; Sinusitis/metabolism ; Sinusitis/genetics ; Rhinitis/pathology ; Rhinitis/metabolism ; Rhinitis/genetics ; Glycogen Synthase Kinase 3 beta/metabolism ; Cells, Cultured ; Transcriptional Activation ; Male ; Female ; Signal Transduction

Asiatic acid inhibits endothelial-to-mesenchymal transition in diabetic kidney disease by reducing acetyl-CoA production via targeting ACSS2.

Autoři: Lin RH Chen JC Xu SS a další

Zdroj: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 2), pp. 117311. Date of Electronic Publication: 2025 Sep 06.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Diabetic Nephropathies*/metabolism , Diabetic Nephropathies*/drug therapy , Diabetic Nephropathies*/pathology , Acetyl Coenzyme A*/biosynthesis , Acetyl Coenzyme A*/antagonists & inhibitors , Acetyl Coenzyme A*/metabolism , Pentacyclic Triterpenes*/pharmacology , Pentacyclic Triterpenes*/therapeutic use , Epithelial-Mesenchymal Transition*/drug effects , Epithelial-Mesenchymal Transition*/physiology , Coenzyme A Ligases*/metabolism , Coenzyme A Ligases*/antagonists & inhibitors , Coenzyme A Ligases*/genetics, Animals ; Mice ; Male ; Humans ; Mice, Inbred C57BL ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/drug therapy ; Molecular Docking Simulation/methods

Bosutinib alleviates peritoneal fibrosis by regulating mesothelial-to-mesenchymal transition through inhibition of the PI3K/AKT pathway.

Autoři: Wang Q Dou H Zhang L a další

Zdroj: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 4), pp. 117412. Date of Electronic Publication: 2025 Oct 08.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Aniline Compounds*/pharmacology , Aniline Compounds*/therapeutic use , Peritoneal Fibrosis*/drug therapy , Peritoneal Fibrosis*/metabolism , Peritoneal Fibrosis*/pathology , Epithelial-Mesenchymal Transition*/drug effects , Epithelial-Mesenchymal Transition*/physiology , Quinolines*/pharmacology , Quinolines*/therapeutic use , Proto-Oncogene Proteins c-akt*/metabolism , Proto-Oncogene Proteins c-akt*/antagonists & inhibitors , Nitriles*/pharmacology , Nitriles*/therapeutic use , Phosphatidylinositol 3-Kinases*/metabolism , Phosphoinositide-3 Kinase Inhibitors*, Animals ; Mice ; Humans ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Male ; Cell Line ; Mice, Inbred C57BL ; Peritoneal Dialysis/adverse effects ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug

Mechanistic insights into FUNDC2P4 and HSF1 regulation of EMT in residual hepatocellular carcinoma following insufficient radiofrequency ablation.

Autoři: Tang N Yang L Huang C a další

Zdroj: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group [Int J Hyperthermia] 2025 Dec; Vol. 42 (1), pp. 2553210. Date of Electronic Publication: 2025 Sep 03.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8508395 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-5157 (Electronic) Linking ISSN: 02656736 NLM ISO Abbreviation: Int J Hyperthermia Subsets: MEDLINE

Výrazy ze slovníku MeSH: Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/radiotherapy , Liver Neoplasms*/pathology , Liver Neoplasms*/genetics , Liver Neoplasms*/metabolism , Epithelial-Mesenchymal Transition* , Heat Shock Transcription Factors*/metabolism , Heat Shock Transcription Factors*/genetics , Radiofrequency Ablation*/methods , Membrane Proteins*/metabolism , Membrane Proteins*/genetics, Humans ; Cell Line, Tumor

Harmine inhibits ovarian cancer migration and invasion and epithelial-mesenchymal transition (EMT) by inhibiting HDAC7 to restore RECK expression.

Autoři: Bao Y Zhu J Mao X a další

Zdroj: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 4), pp. 117391. Date of Electronic Publication: 2025 Oct 07.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Epithelial-Mesenchymal Transition*/drug effects , Epithelial-Mesenchymal Transition*/physiology , Ovarian Neoplasms*/drug therapy , Ovarian Neoplasms*/metabolism , Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/genetics , Histone Deacetylases*/metabolism , Histone Deacetylases*/genetics , Cell Movement*/drug effects , Cell Movement*/physiology , GPI-Linked Proteins*/genetics , GPI-Linked Proteins*/biosynthesis , GPI-Linked Proteins*/antagonists & inhibitors , GPI-Linked Proteins*/metabolism , Harmine*/pharmacology , Harmine*/therapeutic use , Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/therapeutic use, Female ; Humans ; Animals ; Cell Line, Tumor ; Neoplasm Invasiveness ; Mice, Nude ; Mice ; Xenograft Model Antitumor Assays/methods ; Mice, Inbred BALB C ; Gene Expression Regulation, Neoplastic/drug effects ; Dose-Response Relationship, Drug

IgG expressed by renal tubular epithelial cells in epithelial mesenchymal transformation and interstitial fibrosis in diabetic kidney disease.

Autoři: Wang X Deng Z Wang Y

Zdroj: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2458764. Date of Electronic Publication: 2025 Feb 03.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

Výrazy ze slovníku MeSH: Epithelial-Mesenchymal Transition* , Diabetic Nephropathies*/pathology , Diabetic Nephropathies*/metabolism , Kidney Tubules*/pathology , Kidney Tubules*/metabolism , Kidney Tubules*/cytology , Epithelial Cells*/metabolism , Epithelial Cells*/pathology , Immunoglobulin G*/metabolism , Immunoglobulin G*/genetics, Humans ; Fibrosis ; Animals ; Mice ; Male ; Transforming Growth Factor beta1/metabolism ; Female ; Middle Aged ; Fibronectins/metabolism ; Actins/metabolism

β-lapachone impairs viability, migration, and epithelial-mesenchymal transition in mammary tumor spheroids.

Autoři: Coelho LL Vianna MM da Silva DM a další

Zdroj: BMC cancer [BMC Cancer] 2025 Nov 26; Vol. 25 (1), pp. 1826. Date of Electronic Publication: 2025 Nov 26.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE

Výrazy ze slovníku MeSH: Naphthoquinones*/pharmacology , Epithelial-Mesenchymal Transition*/drug effects , Spheroids, Cellular*/drug effects , Spheroids, Cellular*/pathology , Cell Movement*/drug effects , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism, Humans ; Female ; Cell Survival/drug effects ; MCF-7 Cells ; Cadherins/metabolism ; Vimentin/metabolism ; Tumor Cells, Cultured

Cepharanthine inhibits the proliferation and epithelial-mesenchymal transition of oral squamous cell carcinoma via HMGA2/FOXL2 axis.

Autoři: Huang Y Huang J Zhang X

Zdroj: BMC pharmacology & toxicology [BMC Pharmacol Toxicol] 2025 Nov 25; Vol. 26 (1), pp. 197. Date of Electronic Publication: 2025 Nov 25.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101590449 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-6511 (Electronic) Linking ISSN: 20506511 NLM ISO Abbreviation: BMC Pharmacol Toxicol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Epithelial-Mesenchymal Transition*/drug effects , Benzylisoquinolines*/pharmacology , Benzylisoquinolines*/therapeutic use , HMGA2 Protein*/metabolism , Mouth Neoplasms*/drug therapy , Mouth Neoplasms*/metabolism , Mouth Neoplasms*/pathology , Carcinoma, Squamous Cell*/drug therapy , Carcinoma, Squamous Cell*/metabolism , Carcinoma, Squamous Cell*/pathology , Antineoplastic Agents, Phytogenic*/pharmacology , Antineoplastic Agents, Phytogenic*/therapeutic use, Humans ; Cell Proliferation/drug effects ; Cell Line, Tumor ; Animals ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Apoptosis/drug effects ; Cell Movement/drug effects ; Mice, Nude ; Mice ; Mice, Inbred BALB C ; Benzodioxoles