Search Results - "Epimedium"

Holistic approach for plant species circumscription integrating standard barcodes, chloroplast genomes, single-copy nuclear genes and micro-morphological data: a case study in Epimedium (Berberidaceae).

Authors: Fan YJ Li CG Ma C et al.

Source: BMC genomics [BMC Genomics] 2025 Oct 17; Vol. 26 (1), pp. 931. Date of Electronic Publication: 2025 Oct 17.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100965258 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2164 (Electronic) Linking ISSN: 14712164 NLM ISO Abbreviation: BMC Genomics Subsets: MEDLINE

MeSH Terms: Epimedium*/genetics , Epimedium*/classification , Epimedium*/anatomy & histology , DNA Barcoding, Taxonomic*/methods , Genome, Chloroplast*, Phylogeny ; Genes, Plant ; Cell Nucleus/genetics

Epimedium brevicornu Maxim.-derived extracellular vesicle-like particles stimulate VEGF-mediated angiogenesis to alleviate postmenopausal osteoporosis.

Authors: Cai X Qiu T Shen J et al.

Source: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Nov 25; Vol. 148, pp. 157259. Date of Electronic Publication: 2025 Sep 15.

Publication Type: Journal Article

Journal Info: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

MeSH Terms: Osteoporosis, Postmenopausal*/drug therapy , Epimedium*/chemistry , Extracellular Vesicles*/chemistry , Vascular Endothelial Growth Factor A*/metabolism , Neovascularization, Physiologic*/drug effects, Female ; Animals ; Humans ; Mice ; Human Umbilical Vein Endothelial Cells/drug effects ; Cell Proliferation/drug effects ; Osteogenesis/drug effects ; Apoptosis/drug effects ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; Cell Differentiation/drug effects ; Mesenchymal Stem Cells/drug effects ; Angiogenesis

Study on the Screening of Anti-Osteoporosis Components in Processed Epimedium-Based on Spectrum-Effect Analysis.

Authors: Liang J Liu J Sun W et al.

Source: Chemistry & biodiversity [Chem Biodivers] 2025 Nov; Vol. 22 (11), pp. e02936. Date of Electronic Publication: 2025 Jul 10.

Publication Type: Journal Article

Journal Info: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

MeSH Terms: Epimedium*/chemistry , Osteoporosis*/drug therapy , Osteoporosis*/metabolism , Antioxidants*/pharmacology , Antioxidants*/chemistry , Antioxidants*/isolation & purification , Drugs, Chinese Herbal*/chemistry , Drugs, Chinese Herbal*/pharmacology, Animals ; Zebrafish ; Molecular Docking Simulation ; Mice ; Biphenyl Compounds/antagonists & inhibitors ; Chromatography, High Pressure Liquid ; Tandem Mass Spectrometry ; Picrates/antagonists & inhibitors ; Hydrogen Peroxide/antagonists & inhibitors ; Hydrogen Peroxide/pharmacology ; Molecular Structure ; Flavonoids/pharmacology ; Flavonoids/chemistry ; Flavonoids/isolation & purification

The endogenous fungus Colletotrichum endophyticum from Korean epimedium Nakai promoted the growth of the model plant Arabidopsis thaliana.

Authors: Rui J Mingxuan Z Yucui L et al.

Source: Archives of microbiology [Arch Microbiol] 2025 Oct 24; Vol. 207 (12), pp. 333. Date of Electronic Publication: 2025 Oct 24.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0410427 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-072X (Electronic) Linking ISSN: 03028933 NLM ISO Abbreviation: Arch Microbiol Subsets: MEDLINE

MeSH Terms: Arabidopsis*/growth & development , Arabidopsis*/microbiology , Epimedium*/microbiology , Colletotrichum*/isolation & purification , Colletotrichum*/physiology , Colletotrichum*/classification , Colletotrichum*/metabolism , Endophytes*/physiology , Endophytes*/isolation & purification, Plant Roots/growth & development ; Plant Roots/microbiology

Investigating the molecular mechanism of epimedium herb in treating rheumatoid arthritis through network pharmacology, molecular docking, and experimental validation.

Authors: Ding C Liu Q You X et al.

Source: Molecular diversity [Mol Divers] 2025 Oct; Vol. 29 (5), pp. 4061-4081. Date of Electronic Publication: 2025 Jan 16.

Publication Type: Journal Article

Journal Info: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

MeSH Terms: Epimedium*/chemistry , Arthritis, Rheumatoid*/drug therapy , Arthritis, Rheumatoid*/metabolism , Arthritis, Rheumatoid*/pathology , Molecular Docking Simulation* , Network Pharmacology* , Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/chemistry, Animals ; Mice ; Synoviocytes/drug effects ; Synoviocytes/metabolism ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/pathology ; Apoptosis/drug effects ; Humans ; Mice, Inbred DBA ; Male

CaR-Derived Column Was Prepared to Discover Multiple Active Constituents Simultaneously From Epimedii Folium.

Authors: He W Zhao P Li K

Source: Biomedical chromatography : BMC [Biomed Chromatogr] 2025 Dec; Vol. 39 (12), pp. e70255.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 8610241 Publication Model: Print Cited Medium: Internet ISSN: 1099-0801 (Electronic) Linking ISSN: 02693879 NLM ISO Abbreviation: Biomed Chromatogr Subsets: MEDLINE

MeSH Terms: Epimedium*/chemistry , Drugs, Chinese Herbal*/chemistry , Drugs, Chinese Herbal*/analysis , Receptors, Calcium-Sensing*/metabolism , Receptors, Calcium-Sensing*/chemistry , Plant Extracts*/chemistry, Molecular Docking Simulation ; Flavonoids/analysis ; Flavonoids/metabolism ; Flavonoids/chemistry ; Humans

Icariside II: natural occurrence, biotransformation, pharmacological activity, synthetic modification, pharmacokinetics, and bioavailability.

Authors: Ni HTN Linh NN Nhung PTT et al.

Source: The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2025 Oct 30; Vol. 77 (11), pp. 1491-1512.

Publication Type: Journal Article; Systematic Review; Review

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0376363 Publication Model: Print Cited Medium: Internet ISSN: 2042-7158 (Electronic) Linking ISSN: 00223573 NLM ISO Abbreviation: J Pharm Pharmacol Subsets: MEDLINE

MeSH Terms: Flavonoids*/pharmacokinetics , Flavonoids*/pharmacology , Flavonoids*/chemistry , Flavonoids*/isolation & purification , Epimedium*/chemistry, Humans ; Biological Availability ; Animals ; Biotransformation

Research on the Metabolites and Biological Activities of the Endophytic Fungus Ilyonectria cyclaminicola From Epimedium koreanum Nakai.

Authors: Jiang R Zou M Yan L et al.

Source: Chemistry & biodiversity [Chem Biodivers] 2025 Oct; Vol. 22 (10), pp. e02731. Date of Electronic Publication: 2025 Jun 16.

Publication Type: Journal Article

Journal Info: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

MeSH Terms: Epimedium*/microbiology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/isolation & purification , Anti-Bacterial Agents*/metabolism , Antioxidants*/pharmacology , Antioxidants*/chemistry , Antioxidants*/isolation & purification , Antioxidants*/metabolism , Hypocreales*/metabolism , Hypocreales*/chemistry, Animals ; Zebrafish ; Biphenyl Compounds/antagonists & inhibitors ; Microbial Sensitivity Tests ; Flavonoids/pharmacology ; Flavonoids/chemistry ; Picrates/antagonists & inhibitors ; Fermentation ; Molecular Structure

Novel ternary deep eutectic solvent coupled with in-situ-ultrasound synergistic extraction of flavonoids from Epimedium wushanense: machine learning, mechanistic investigation, and antioxidant activity.

Authors: Liu C Lei J Liu X et al.

Source: Ultrasonics sonochemistry [Ultrason Sonochem] 2025 Oct; Vol. 121, pp. 107547. Date of Electronic Publication: 2025 Sep 02.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9433356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2828 (Electronic) Linking ISSN: 13504177 NLM ISO Abbreviation: Ultrason Sonochem Subsets: MEDLINE

MeSH Terms: Flavonoids*/isolation & purification , Flavonoids*/pharmacology , Flavonoids*/chemistry , Antioxidants*/pharmacology , Antioxidants*/isolation & purification , Antioxidants*/chemistry , Ultrasonic Waves* , Machine Learning* , Epimedium*/chemistry , Deep Eutectic Solvents*/chemistry , Chemical Fractionation*/methods

Fufang epimedium formula alleviates acute liver injury through dual modulation of PI3K/AKT/Bcl-2 anti-apoptotic signaling pathway and cGAS-STING-IRF3 anti-inflammatory signaling pathway.

Authors: Feng Y Yusufu R Chen T et al.

Source: Journal of ethnopharmacology [J Ethnopharmacol] 2025 Sep 25; Vol. 353 (Pt B), pp. 120415. Date of Electronic Publication: 2025 Aug 12.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE

MeSH Terms: Chemical and Drug Induced Liver Injury*/drug therapy , Chemical and Drug Induced Liver Injury*/pathology , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/therapeutic use , Epimedium*/chemistry , Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/therapeutic use, Animals ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Apoptosis/drug effects ; Mice ; Membrane Proteins/metabolism ; Male ; Interferon Regulatory Factor-3/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Nucleotidyltransferases/metabolism ; Liver/drug effects ; Liver/pathology ; Lipopolysaccharides ; Galactosamine

2″-O-rhamnosyl icariside Ⅱ from Epimedium sagittatum maxim ameliorates pulmonary fibrosis by modulating the E-cadherin-mediated oxidative-epithelial mesenchymal transition axis.

Authors: Tie Q Wang R Zeng M et al.

Source: Journal of ethnopharmacology [J Ethnopharmacol] 2025 Sep 25; Vol. 353 (Pt B), pp. 120403. Date of Electronic Publication: 2025 Aug 12.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE

MeSH Terms: Epithelial-Mesenchymal Transition*/drug effects , Epimedium*/chemistry , Pulmonary Fibrosis*/drug therapy , Pulmonary Fibrosis*/chemically induced , Pulmonary Fibrosis*/pathology , Pulmonary Fibrosis*/metabolism , Flavonoids*/pharmacology , Flavonoids*/isolation & purification , Flavonoids*/therapeutic use , Cadherins*/metabolism, Animals ; Mice ; Male ; Oxidative Stress/drug effects ; Bleomycin ; Antigens, CD/metabolism ; Mice, Inbred C57BL ; Lung/drug effects ; Lung/pathology ; Lung/metabolism ; Molecular Docking Simulation ; Humans ; Disease Models, Animal

Exploration of the active components and mechanisms of Epimedium for the treatment of Undescended Testis.

Authors: Deng Z Zhang S Zhao H et al.

Source: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2025 Aug 27; Vol. 16, pp. 1642197. Date of Electronic Publication: 2025 Aug 27 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE

MeSH Terms: Epimedium*/chemistry , Cryptorchidism*/drug therapy , Cryptorchidism*/pathology , Cryptorchidism*/metabolism , Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/therapeutic use , Drugs, Chinese Herbal*/chemistry, Male ; Animals ; Humans ; Molecular Docking Simulation ; Medicine, Chinese Traditional/methods ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Mice

Identification of chemical components and metabolites in rats after oral administration of Epimedium-Astragalus granule pair by liquid chromatography-high resolution mass spectrometry combined with diagnostic fragment ions and mass defect filtering.

Authors: Wang S Chang X Li J et al.

Source: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2025 Jul 15; Vol. 259, pp. 116768. Date of Electronic Publication: 2025 Feb 24.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

MeSH Terms: Epimedium*/chemistry , Drugs, Chinese Herbal*/administration & dosage , Drugs, Chinese Herbal*/chemistry , Drugs, Chinese Herbal*/metabolism , Drugs, Chinese Herbal*/pharmacokinetics , Astragalus Plant*/chemistry, Animals ; Rats ; Chromatography, High Pressure Liquid/methods ; Administration, Oral ; Male ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry/methods ; Drug Combinations

Epimedium Brevicornu and Curculigo orchioides inhibit osteoclast autophagy by degrading the level of miRNA-199 to regulate the mTOR signaling pathway.

Authors: Shi M Sun P Chai F

Source: Journal of orthopaedic surgery and research [J Orthop Surg Res] 2025 Jul 09; Vol. 20 (1), pp. 631. Date of Electronic Publication: 2025 Jul 09.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101265112 Publication Model: Electronic Cited Medium: Internet ISSN: 1749-799X (Electronic) Linking ISSN: 1749799X NLM ISO Abbreviation: J Orthop Surg Res Subsets: MEDLINE

MeSH Terms: TOR Serine-Threonine Kinases*/metabolism , MicroRNAs*/metabolism , MicroRNAs*/genetics , Signal Transduction*/drug effects , Signal Transduction*/physiology , Autophagy*/drug effects , Osteoclasts*/drug effects , Osteoclasts*/metabolism , Epimedium*/chemistry , Curculigo*/chemistry , Plant Extracts*/pharmacology, Animals ; Mice ; Rats, Wistar ; Rats ; Male ; RAW 264.7 Cells

Genome-wide identification and expression patterns of the aspartic protease gene family in Epimedium pubescens.

Authors: Zheng H Zheng L Song H et al.

Source: BMC genomics [BMC Genomics] 2025 May 02; Vol. 26 (1), pp. 436. Date of Electronic Publication: 2025 May 02.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100965258 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2164 (Electronic) Linking ISSN: 14712164 NLM ISO Abbreviation: BMC Genomics Subsets: MEDLINE

MeSH Terms: Epimedium*/genetics , Epimedium*/enzymology , Epimedium*/radiation effects , Gene Expression Regulation, Plant* , Aspartic Acid Proteases*/genetics , Aspartic Acid Proteases*/metabolism , Aspartic Acid Proteases*/chemistry , Plant Proteins*/genetics , Plant Proteins*/metabolism , Plant Proteins*/chemistry , Multigene Family*, Phylogeny ; Stress, Physiological/genetics ; Gene Expression Profiling ; Light ; Promoter Regions, Genetic ; Genome, Plant

Efficient Biosynthesis of 8-Prenylkaempferol from Kaempferol by Using Flavonoid 8-Dimethylallyltransferase Derived from Epimedium koreanum .

Authors: Gao S Zeng W Li D et al.

Source: Journal of agricultural and food chemistry [J Agric Food Chem] 2025 Apr 30; Vol. 73 (17), pp. 10449-10455. Date of Electronic Publication: 2025 Apr 17.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

MeSH Terms: Epimedium*/enzymology , Epimedium*/genetics , Epimedium*/chemistry , Kaempferols*/metabolism , Kaempferols*/chemistry , Plant Proteins*/genetics , Plant Proteins*/metabolism , Plant Proteins*/chemistry , Dimethylallyltranstransferase*/metabolism , Dimethylallyltranstransferase*/genetics , Dimethylallyltranstransferase*/chemistry, Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Flavonoids/biosynthesis

Temporal dynamics of medium and micronutrient requirements in Epimedium pubescens: key elements regulating growth and Icariin-Flavonoids biosynthesis.

Authors: An X Wang Y Liu S et al.

Source: BMC plant biology [BMC Plant Biol] 2025 Apr 28; Vol. 25 (1), pp. 551. Date of Electronic Publication: 2025 Apr 28.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100967807 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2229 (Electronic) Linking ISSN: 14712229 NLM ISO Abbreviation: BMC Plant Biol Subsets: MEDLINE

MeSH Terms: Flavonoids*/biosynthesis , Flavonoids*/metabolism , Epimedium*/metabolism , Epimedium*/growth & development , Micronutrients*/metabolism, Plant Leaves/metabolism ; Plant Leaves/growth & development ; Biomass

Diversity and epimedium biotransformation potential of cultivable endophytic fungi associated with Epimedium brevicornum Maxim in the Qinling Mountains, China.

Authors: Ma S An C Xue W et al.

Source: Microbial cell factories [Microb Cell Fact] 2025 Apr 03; Vol. 24 (1), pp. 80. Date of Electronic Publication: 2025 Apr 03.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101139812 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2859 (Electronic) Linking ISSN: 14752859 NLM ISO Abbreviation: Microb Cell Fact Subsets: MEDLINE

MeSH Terms: Epimedium*/microbiology , Epimedium*/metabolism , Epimedium*/chemistry , Endophytes*/metabolism , Endophytes*/isolation & purification , Endophytes*/genetics , Endophytes*/classification , Fungi*/metabolism , Fungi*/isolation & purification , Fungi*/classification , Fungi*/genetics, Biotransformation ; China ; Flavonoids/metabolism ; Phylogeny

A regio-specific 4 ' - O -methyltransferase from Epimedium pseudowushanense  regiospecifically catalyzing 8-prenylkeampferol to icaritin.

Authors: Feng KP Liu JM Chen RD et al.

Source: Journal of Asian natural products research [J Asian Nat Prod Res] 2025 Apr; Vol. 27 (4), pp. 568-576. Date of Electronic Publication: 2024 Oct 07.

Publication Type: Journal Article

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 100888334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-2213 (Electronic) Linking ISSN: 10286020 NLM ISO Abbreviation: J Asian Nat Prod Res Subsets: MEDLINE

MeSH Terms: Epimedium*/enzymology , Epimedium*/chemistry , Flavonoids*/chemistry , Flavonoids*/metabolism , Methyltransferases*/metabolism , Methyltransferases*/isolation & purification , Methyltransferases*/chemistry , Kaempferols*/chemistry , Kaempferols*/metabolism , Drugs, Chinese Herbal*/chemistry, Molecular Structure ; Stereoisomerism ; Methylation

Qualitative and Comparative Analysis of Chemical Constituents in Epimedii Folium From Four Species Based on UPLC-ZenoTOF-MS/MS.

Authors: Xue J Cai Z Yi D et al.

Source: Journal of mass spectrometry : JMS [J Mass Spectrom] 2025 Jun; Vol. 60 (6), pp. e5146.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 9504818 Publication Model: Print Cited Medium: Internet ISSN: 1096-9888 (Electronic) Linking ISSN: 10765174 NLM ISO Abbreviation: J Mass Spectrom Subsets: MEDLINE

MeSH Terms: Tandem Mass Spectrometry*/methods , Epimedium*/chemistry , Epimedium*/classification , Drugs, Chinese Herbal*/chemistry , Drugs, Chinese Herbal*/analysis, Chromatography, High Pressure Liquid/methods ; Plant Leaves/chemistry