Suchergebnisse - "Enhancer Elements"

SCOPE-C reveals long-range enhancer networks emerging as key regulators during human cortical neurogenesis.

Autoren: Jia L Hou Y Cui Z et al.

Quelle: Neuron [Neuron] 2025 Dec 03; Vol. 113 (23), pp. 4020-4036.e8. Date of Electronic Publication: 2025 Oct 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE

MeSH-Schlagworte: Neurogenesis*/genetics , Neurogenesis*/physiology , Enhancer Elements, Genetic*/genetics , Cerebral Cortex*/cytology , Cerebral Cortex*/metabolism , Cerebral Cortex*/embryology , Chromatin*/metabolism , Chromatin*/genetics, Humans ; Animals ; Mice ; Neurons/metabolism ; Neurons/physiology ; Matrix Attachment Region Binding Proteins/genetics ; Transcription Factors/genetics ; Gene Regulatory Networks ; Macaca ; Polymorphism, Single Nucleotide

Multiple human enhancer RNAs contain long translated open reading frames.

Autoren: Vlasov PA Ogami K Valenzuela E et al.

Quelle: Genes & development [Genes Dev] 2025 Dec 01; Vol. 39 (23-24), pp. 1468-1489. Date of Electronic Publication: 2025 Dec 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 8711660 Publication Model: Electronic Cited Medium: Internet ISSN: 1549-5477 (Electronic) Linking ISSN: 08909369 NLM ISO Abbreviation: Genes Dev Subsets: MEDLINE

MeSH-Schlagworte: Open Reading Frames*/genetics , Enhancer Elements, Genetic*/genetics , Protein Biosynthesis*, Humans ; Cell Nucleus/metabolism ; Chromatin/metabolism ; Enhancer RNAs

Massively parallel analysis of genotype-dependent enhancer activity among atopic dermatitis genetic risk variants.

Autoren: Shook MS Lu X Chen X et al.

Quelle: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2025 Dec; Vol. 156 (6), pp. 1600-1613. Date of Electronic Publication: 2025 Aug 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Mosby Country of Publication: United States NLM ID: 1275002 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6825 (Electronic) Linking ISSN: 00916749 NLM ISO Abbreviation: J Allergy Clin Immunol Subsets: MEDLINE

MeSH-Schlagworte: Dermatitis, Atopic*/genetics , Enhancer Elements, Genetic*, Humans ; Filaggrin Proteins ; Genetic Predisposition to Disease ; Genotype ; Genome-Wide Association Study ; Genetic Variation ; Jurkat Cells ; Keratinocytes ; Cell Line ; Alleles

SWI/SNF Functions as a Gatekeeper of Enhancer Chromatin Access to Control Progression of Mesenchymal Triple-Negative Breast Cancer.

Autoren: Møldrup RIJ Terp MG Jakobsen ST et al.

Quelle: Cancer research [Cancer Res] 2025 Dec 01; Vol. 85 (23), pp. 4648-4663.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

MeSH-Schlagworte: Triple Negative Breast Neoplasms*/genetics , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/metabolism , Enhancer Elements, Genetic* , Chromatin*/metabolism , Chromatin*/genetics , Transcription Factors*/metabolism , Transcription Factors*/genetics , Chromosomal Proteins, Non-Histone*/metabolism , Chromosomal Proteins, Non-Histone*/genetics, Humans ; Female ; Animals ; Mice ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Chromatin Assembly and Disassembly ; Cell Proliferation ; Disease Progression ; Xenograft Model Antitumor Assays ; Drug Resistance, Neoplasm

Decoding Epigenetic Enhancer-Promoter Interactions in Periodontitis via Transformer-GAN: A Deep Learning Framework for Inflammatory Gene Regulation and Biomarker Discovery.

Autoren: Natarajan PM Yadalam PK

Quelle: International dental journal [Int Dent J] 2025 Dec; Vol. 75 (6), pp. 103879. Date of Electronic Publication: 2025 Sep 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 0374714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-595X (Electronic) Linking ISSN: 00206539 NLM ISO Abbreviation: Int Dent J Subsets: MEDLINE

MeSH-Schlagworte: Deep Learning* , Epigenesis, Genetic* , Periodontitis*/genetics , Promoter Regions, Genetic*/genetics , Enhancer Elements, Genetic*/genetics, Humans ; DNA Methylation ; Biomarkers ; Gene Expression Regulation ; Inflammation/genetics

Mild phenotypes in patients with different deletions in the 3' enhancer region of SHOX.

Autoren: Miranda V Sabeh P Seiltgens C et al.

Quelle: European journal of human genetics : EJHG [Eur J Hum Genet] 2025 Dec; Vol. 33 (12), pp. 1663-1667. Date of Electronic Publication: 2024 Jun 24.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9302235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5438 (Electronic) Linking ISSN: 10184813 NLM ISO Abbreviation: Eur J Hum Genet Subsets: MEDLINE

MeSH-Schlagworte: Enhancer Elements, Genetic* , Growth Disorders*/genetics , Growth Disorders*/pathology , Osteochondrodysplasias*/genetics , Osteochondrodysplasias*/pathology , Phenotype* , Sequence Deletion* , Short Stature Homeobox Protein*/genetics, Child ; Female ; Humans ; Male ; Haploinsufficiency ; Homozygote ; Pedigree ; Adolescent

SCR Disease Name: Langer mesomelic dysplasia; Leri-Weil syndrome; Madelung Deformity

Super-enhancer-associated long noncoding RNA lnc-SPI1U mediates SPI1 feedback regulation by interacting with HNRNPH1 and HNRNPF.

Autoren: Ma X Li Y Sun W et al.

Quelle: Oncogene [Oncogene] 2025 Dec; Vol. 44 (47), pp. 4626-4638. Date of Electronic Publication: 2025 Oct 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE

MeSH-Schlagworte: RNA, Long Noncoding*/genetics , Trans-Activators*/genetics , Trans-Activators*/metabolism , Enhancer Elements, Genetic*/genetics , Proto-Oncogene Proteins*/genetics , Proto-Oncogene Proteins*/metabolism , Leukemia, Promyelocytic, Acute*/genetics , Leukemia, Promyelocytic, Acute*/pathology, Humans ; Feedback, Physiological ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cell Differentiation/genetics ; Gene Expression Regulation, Leukemic

Noncoding function of super enhancer derived Cpox pre-mRNA in modulating neighbouring gene expression and chromatin interactions.

Autoren: Xie B Dean A

Quelle: RNA biology [RNA Biol] 2025 Dec; Vol. 22 (1), pp. 1-17. Date of Electronic Publication: 2025 Mar 12.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101235328 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-8584 (Electronic) Linking ISSN: 15476286 NLM ISO Abbreviation: RNA Biol Subsets: MEDLINE

MeSH-Schlagworte: Enhancer Elements, Genetic* , Chromatin*/metabolism , Chromatin*/genetics , RNA Precursors*/genetics , RNA Precursors*/metabolism , Gene Expression Regulation*, Humans ; Histones/metabolism ; E1A-Associated p300 Protein/metabolism ; Super Enhancers

Genetic knockout suggests Isl1 enhancer redundancy in mouse hindlimb development.

Autoren: Olson S Kawakami H Nichitean AM et al.

Quelle: Developmental biology [Dev Biol] 2025 Dec; Vol. 528, pp. 217-227. Date of Electronic Publication: 2025 Sep 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0372762 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-564X (Electronic) Linking ISSN: 00121606 NLM ISO Abbreviation: Dev Biol Subsets: MEDLINE

MeSH-Schlagworte: LIM-Homeodomain Proteins*/genetics , LIM-Homeodomain Proteins*/metabolism , Transcription Factors*/genetics , Transcription Factors*/metabolism , Hindlimb*/embryology , Hindlimb*/metabolism , Enhancer Elements, Genetic*/genetics, Animals ; Mice ; Gene Expression Regulation, Developmental ; Mice, Knockout ; Chondrogenesis/genetics

Nuclear receptor ESRRA promotes ERα-positive breast cancer through dual action on super enhancers and promoters to regulate gene transcriptional programs.

Autoren: Zheng ZZ Chen L Hu GS et al.

Quelle: Science bulletin [Sci Bull (Beijing)] 2025 Nov 30; Vol. 70 (22), pp. 3822-3839. Date of Electronic Publication: 2025 Sep 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier B.V. Country of Publication: Netherlands NLM ID: 101655530 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2095-9281 (Electronic) Linking ISSN: 20959273 NLM ISO Abbreviation: Sci Bull (Beijing) Subsets: MEDLINE

MeSH-Schlagworte: Breast Neoplasms*/genetics , Breast Neoplasms*/metabolism , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Estrogen Receptor alpha*/metabolism , Estrogen Receptor alpha*/genetics , Promoter Regions, Genetic* , Gene Expression Regulation, Neoplastic*/drug effects , Enhancer Elements, Genetic* , Receptors, Estrogen*/metabolism , Receptors, Estrogen*/genetics, Humans ; Female ; Animals ; Mice ; Cell Line, Tumor ; Interferon-Induced Helicase, IFIH1/genetics ; Interferon-Induced Helicase, IFIH1/metabolism ; DEAD Box Protein 58/genetics ; DEAD Box Protein 58/metabolism ; Signal Transduction ; MCF-7 Cells ; Transcription, Genetic ; Tamoxifen/pharmacology ; ERRalpha Estrogen-Related Receptor ; Receptors, Immunologic ; Super Enhancers ; Nitriles ; Thiazoles

Widespread association of Polycomb complex-deposited histone H2A monoubiquitylation with enhancers and neuronal gene regulation.

Autoren: MacGillivray K Fusca D Tan L et al.

Quelle: Science advances [Sci Adv] 2025 Nov 28; Vol. 11 (48), pp. eadt6316. Date of Electronic Publication: 2025 Nov 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

MeSH-Schlagworte: Histones*/metabolism , Histones*/genetics , Ubiquitination* , Enhancer Elements, Genetic* , Neurons*/metabolism , Polycomb-Group Proteins*/metabolism , Polycomb-Group Proteins*/genetics , Gene Expression Regulation, Developmental*, Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Chromatin/metabolism ; Chromatin/genetics ; Caenorhabditis elegans Proteins/metabolism ; Caenorhabditis elegans Proteins/genetics ; Promoter Regions, Genetic

Motif-based models accurately predict cell type-specific distal regulatory elements.

Autoren: Cornejo-Páramo P Zhang X Louis L et al.

Quelle: Nature communications [Nat Commun] 2025 Nov 24; Vol. 16 (1), pp. 10370. Date of Electronic Publication: 2025 Nov 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Nucleotide Motifs*/genetics , Enhancer Elements, Genetic*/genetics , Computational Biology*/methods , Regulatory Sequences, Nucleic Acid*, Animals ; Mice ; Humans ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Zebrafish/genetics ; Arabidopsis/genetics ; Gene Expression Regulation

MAPK3 modulates enhancer-promoter interactions of SKAP2 in acute myeloid leukemia.

Autoren: Hu Y Chen F Wang T et al.

Quelle: Carcinogenesis [Carcinogenesis] 2025 Nov 21; Vol. 46 (4).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Irl Press At Oxford University Press Country of Publication: England NLM ID: 8008055 Publication Model: Print Cited Medium: Internet ISSN: 1460-2180 (Electronic) Linking ISSN: 01433334 NLM ISO Abbreviation: Carcinogenesis Subsets: MEDLINE

MeSH-Schlagworte: Leukemia, Myeloid, Acute*/genetics , Leukemia, Myeloid, Acute*/pathology , Leukemia, Myeloid, Acute*/metabolism , Enhancer Elements, Genetic*/genetics , Promoter Regions, Genetic*/genetics , Mitogen-Activated Protein Kinase 3*/metabolism , Mitogen-Activated Protein Kinase 3*/genetics, Humans ; CCCTC-Binding Factor/metabolism ; CCCTC-Binding Factor/genetics ; Gene Expression Regulation, Leukemic ; Chromatin/genetics ; Chromatin/metabolism ; Cell Line, Tumor ; Chromatin Immunoprecipitation Sequencing

Myogenic enhancer snatching promotes adipogenic differentiation during epigenetic reprogramming mediated by lineage-specific transcription factors.

Autoren: Hu M Xu Z Sun J et al.

Quelle: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2025 Nov 19; Vol. 82 (1), pp. 412. Date of Electronic Publication: 2025 Nov 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE

MeSH-Schlagworte: Adipogenesis*/genetics , Transcription Factors*/metabolism , Transcription Factors*/genetics , Epigenesis, Genetic* , Muscle Development*/genetics , Enhancer Elements, Genetic*/genetics , Cellular Reprogramming*/genetics, Animals ; Mice ; Myoblasts/metabolism ; Myoblasts/cytology ; Cell Lineage/genetics ; Cell Differentiation/genetics ; Chromatin/metabolism ; Chromatin/genetics ; Cell Line ; Adipocytes/cytology ; Adipocytes/metabolism

Highly Conserved STAT3 Motifs Present in the Neuronal Pomc Enhancer nPE1 are Critical for Maximal Hypothalamic Pomc Expression.

Autoren: Hael CE Low MJ Franchini LF et al.

Quelle: Molecular neurobiology [Mol Neurobiol] 2025 Nov 15; Vol. 63 (1), pp. 51. Date of Electronic Publication: 2025 Nov 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH-Schlagworte: Pro-Opiomelanocortin*/genetics , Pro-Opiomelanocortin*/metabolism , STAT3 Transcription Factor*/metabolism , STAT3 Transcription Factor*/genetics , STAT3 Transcription Factor*/chemistry , Hypothalamus*/metabolism , Neurons*/metabolism , Enhancer Elements, Genetic*/genetics , Conserved Sequence*, Animals ; Male ; Female ; Body Weight/genetics ; Eating/genetics ; Mice ; Mice, Inbred C57BL ; RNA, Messenger/metabolism ; RNA, Messenger/genetics

Generation and characterization of a knockout mouse of an enhancer of EBF3.

Autoren: Cordova Hurtado E Wotton JM Gulka A et al.

Quelle: Biology open [Biol Open] 2025 Nov 15; Vol. 14 (11). Date of Electronic Publication: 2025 Nov 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Company of Biologists Ltd Country of Publication: England NLM ID: 101578018 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2046-6390 (Electronic) Linking ISSN: 20466390 NLM ISO Abbreviation: Biol Open Subsets: MEDLINE

MeSH-Schlagworte: Enhancer Elements, Genetic* , Transcription Factors*/genetics, Animals ; Mice ; Mice, Knockout ; Male ; Phenotype ; Female ; Disease Models, Animal

Prediction of Enhancer RNAs in Chicken Genome.

Autoren: Grushina VA Gagarina VS Prasolov DE et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 13; Vol. 26 (22). Date of Electronic Publication: 2025 Nov 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Chickens*/genetics , Enhancer Elements, Genetic* , Genome*, Animals ; Markov Chains ; Enhancer RNAs

Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4 ⁺ cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype.

Autoren: Arcuschin CD Kahrizi K Sayaman RW et al.

Quelle: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2025 Nov 13; Vol. 82 (1), pp. 397. Date of Electronic Publication: 2025 Nov 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE

MeSH-Schlagworte: Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Transcription Factors*/genetics , Transcription Factors*/metabolism , CD4-Positive T-Lymphocytes*/metabolism , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism , Enhancer Elements, Genetic*/genetics, Humans ; Female ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Epithelial-Mesenchymal Transition/genetics ; Phenotype ; Cell Lineage ; Cell Movement

EnhancerMatcher: comparing cell-type-specific enhancer activity of DNA sequences using deep convolutional neural networks and explainable AI.

Autoren: Solis LM Melendez WL Fuke SH et al.

Quelle: NAR genomics and bioinformatics [NAR Genom Bioinform] 2025 Nov 11; Vol. 7 (4), pp. lqaf151. Date of Electronic Publication: 2025 Nov 11 (Print Publication: 2025).

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 101756213 Publication Model: eCollection Cited Medium: Internet ISSN: 2631-9268 (Electronic) Linking ISSN: 26319268 NLM ISO Abbreviation: NAR Genom Bioinform Subsets: MEDLINE

MeSH-Schlagworte: Enhancer Elements, Genetic* , Neural Networks, Computer* , Software* , Sequence Analysis, DNA*/methods, Humans ; Animals ; Mice ; Deep Learning ; Machine Learning ; Convolutional Neural Networks

Transcriptional pause release at enhancers mediates cell identity.

Autoren: Ekstrom TL Johnsen SA

Quelle: NAR cancer [NAR Cancer] 2025 Nov 11; Vol. 7 (4), pp. zcaf039. Date of Electronic Publication: 2025 Nov 11 (Print Publication: 2025).

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 101769553 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-8674 (Electronic) Linking ISSN: 26328674 NLM ISO Abbreviation: NAR Cancer Subsets: MEDLINE

MeSH-Schlagworte: Enhancer Elements, Genetic*/genetics , RNA Polymerase II*/metabolism , RNA Polymerase II*/genetics , Transcription, Genetic* , Neoplasms*/genetics , Neoplasms*/pathology, Humans ; Promoter Regions, Genetic ; Animals ; Transcription Factors/metabolism