Search Results - "Endothelial-Mesenchymal Transition"

NanoCRISPR-assisted biomimetic tissue-equivalent patch regenerates the intervertebral disc by inhibiting endothelial-to-mesenchymal transition.

Authors: Huang Y Li H Qi L et al.

Source: Biomaterials [Biomaterials] 2025 Nov; Vol. 322, pp. 123404. Date of Electronic Publication: 2025 May 14.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE

MeSH Terms: Endothelial-Mesenchymal Transition*/genetics , Biomimetic Materials*/therapeutic use , Regeneration*/genetics , Intervertebral Disc Degeneration*/therapy , Nanofibers*/therapeutic use , Annulus Fibrosus*/blood supply , Annulus Fibrosus*/injuries , Annulus Fibrosus*/physiology , Neovascularization, Pathologic*/genetics , Neovascularization, Pathologic*/therapy , Gene Editing*, CRISPR-Cas Systems ; Vascular Endothelial Growth Factor A/genetics ; Sequence Analysis, RNA ; Imidazoles/chemistry ; Zeolites/chemistry ; Male ; Animals ; Rats ; Rats, Sprague-Dawley ; Disease Models, Animal ; CRISPR-Associated Protein 9/genetics

Regulation of partial endothelial-to-mesenchymal transition by circATXN1 in ischemic diseases.

Authors: Li Y Zheng Z Fan S et al.

Source: Nature communications [Nat Commun] 2025 Jul 10; Vol. 16 (1), pp. 6357. Date of Electronic Publication: 2025 Jul 10.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Endothelial-Mesenchymal Transition* , RNA, Circular*/genetics , RNA, Circular*/metabolism , Ataxin-1*/genetics , Ataxin-1*/metabolism , Vascular Diseases*/genetics , Vascular Diseases*/metabolism, Humans ; Male ; Animals ; Mice ; Mice, Inbred C57BL ; Cells, Cultured ; RNA Methylation ; Disease Models, Animal ; Hypoxia/genetics ; Hypoxia/metabolism ; AlkB Homolog 5, RNA Demethylase/metabolism ; Snail Family Transcription Factors

Chitosan and hyaluronic acid in colorectal cancer therapy: A review on EMT regulation, metastasis, and overcoming drug resistance.

Authors: Han M Zhou X Cheng H et al.

Source: International journal of biological macromolecules [Int J Biol Macromol] 2025 Feb; Vol. 289, pp. 138800. Date of Electronic Publication: 2024 Dec 16.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH Terms: Drug Resistance, Neoplasm* , Colorectal Neoplasms*/diet therapy , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/pathology , Endothelial-Mesenchymal Transition* , Neoplasm Metastasis* , Chitosan*/chemistry , Hyaluronic Acid*/chemistry, Humans ; Animals ; Drug Carriers ; RNA, Untranslated/genetics ; Antineoplastic Agents/therapeutic use

Heparanase and MMP-9 synergistically induce endothelial-mesenchymal transition in portal vein microvessels to promote hepatocellular carcinoma metastasis.

Authors: Pan M Chen P Peng J et al.

Source: Pathology, research and practice [Pathol Res Pract] 2025 Nov; Vol. 275, pp. 156229. Date of Electronic Publication: 2025 Sep 11.

Publication Type: Journal Article

Journal Info: Publisher: Gustav Fischer Verlag Country of Publication: Germany NLM ID: 7806109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0631 (Electronic) Linking ISSN: 03440338 NLM ISO Abbreviation: Pathol Res Pract Subsets: MEDLINE

MeSH Terms: Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , Liver Neoplasms*/enzymology , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/enzymology , Matrix Metalloproteinase 9*/metabolism , Matrix Metalloproteinase 9*/genetics , Epithelial-Mesenchymal Transition*/physiology , Glucuronidase*/metabolism , Glucuronidase*/genetics , Portal Vein*/pathology , Portal Vein*/metabolism, Humans ; Animals ; Mice ; Human Umbilical Vein Endothelial Cells/pathology ; Microvessels/pathology ; Microvessels/metabolism ; Mice, Nude ; Male ; Coculture Techniques ; Neoplasm Metastasis ; Mice, Inbred BALB C ; Endothelial-Mesenchymal Transition

SIRT3 attenuates sepsis-induced EndMT and cardiac remodeling by facilitating mitophagy process via PINK1/Parkin signaling.

Authors: Liu P Xu T Luo Y et al.

Source: International immunopharmacology [Int Immunopharmacol] 2025 Oct 30; Vol. 164, pp. 115377. Date of Electronic Publication: 2025 Aug 20.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH Terms: Sirtuin 3*/genetics , Sirtuin 3*/metabolism , Protein Kinases*/metabolism , Sepsis*/metabolism , Sepsis*/complications , Sepsis*/pathology , Ubiquitin-Protein Ligases*/metabolism, Animals ; Mitophagy ; Mice, Knockout ; Signal Transduction ; Humans ; Mice ; Male ; Mice, Inbred C57BL ; Ventricular Remodeling ; Endothelial Cells/metabolism ; Lipopolysaccharides ; Oxidative Stress ; Myocardium/pathology ; Endothelial-Mesenchymal Transition

Integrative transcriptomic analysis identifies shared EndMT-related gene signatures in endometriosis and recurrent miscarriage.

Authors: Liang Y Yu L Zhou Q et al.

Source: Scientific reports [Sci Rep] 2025 Oct 21; Vol. 15 (1), pp. 36654. Date of Electronic Publication: 2025 Oct 21.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Endometriosis*/genetics , Endometriosis*/pathology , Abortion, Habitual*/genetics , Abortion, Habitual*/pathology , Gene Expression Profiling* , Transcriptome* , Epithelial-Mesenchymal Transition*/genetics, Humans ; Female ; Protein Interaction Maps/genetics ; Computational Biology/methods ; Gene Regulatory Networks ; Gene Ontology ; Pregnancy ; Endothelial-Mesenchymal Transition

Unveiling the secret of cellular metamorphosis: the crucial role of EndMT mechanisms in COVID-19-induced pulmonary fibrosis.

Authors: Zhang X Tong X Hou R et al.

Source: Inflammopharmacology [Inflammopharmacology] 2025 Oct; Vol. 33 (10), pp. 6251-6260. Date of Electronic Publication: 2025 Sep 24.

Publication Type: Journal Article; Review

Journal Info: Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9112626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5608 (Electronic) Linking ISSN: 09254692 NLM ISO Abbreviation: Inflammopharmacology Subsets: MEDLINE

MeSH Terms: COVID-19*/complications , COVID-19*/pathology , Pulmonary Fibrosis*/virology , Pulmonary Fibrosis*/pathology , Pulmonary Fibrosis*/etiology , Pulmonary Fibrosis*/metabolism , Epithelial-Mesenchymal Transition*/physiology, Humans ; Animals ; Endothelial Cells/pathology ; Endothelial Cells/metabolism ; SARS-CoV-2 ; Endothelial-Mesenchymal Transition

ANGPTL4 Prevents Atherosclerosis by Preserving KLF2 to Suppress EndMT and Mitigates Endothelial Dysfunction.

Authors: Cho DI Ahn JH Kang BG et al.

Source: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2025 Oct; Vol. 45 (10), pp. 1742-1761. Date of Electronic Publication: 2025 Aug 14.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505803 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4636 (Electronic) Linking ISSN: 10795642 NLM ISO Abbreviation: Arterioscler Thromb Vasc Biol Subsets: MEDLINE

MeSH Terms: Angiopoietin-Like Protein 4*/genetics , Angiopoietin-Like Protein 4*/metabolism , Angiopoietin-Like Protein 4*/blood , Kruppel-Like Transcription Factors*/metabolism , Kruppel-Like Transcription Factors*/genetics , Atherosclerosis*/prevention & control , Atherosclerosis*/metabolism , Atherosclerosis*/pathology , Atherosclerosis*/genetics , Atherosclerosis*/physiopathology , Epithelial-Mesenchymal Transition* , Endothelium, Vascular*/metabolism , Endothelium, Vascular*/physiopathology , Endothelium, Vascular*/pathology , Coronary Artery Disease*/prevention & control , Coronary Artery Disease*/metabolism , Coronary Artery Disease*/pathology , Coronary Artery Disease*/physiopathology , Coronary Artery Disease*/genetics, Humans ; Animals ; Mice, Knockout, ApoE ; Disease Models, Animal ; Plaque, Atherosclerotic ; Male ; Human Umbilical Vein Endothelial Cells/metabolism ; Human Umbilical Vein Endothelial Cells/pathology ; Signal Transduction ; Mice, Inbred C57BL ; Female ; Cells, Cultured ; Mice ; Smad2 Protein/metabolism ; Middle Aged ; Endothelial-Mesenchymal Transition

Endothelial-Mesenchymal Transition in Tumor Microenvironment Promotes Neuroendocrine Differentiation of Prostate Cancer.

Authors: Kageyama T Kato M Miyachi S et al.

Source: Cancer science [Cancer Sci] 2025 Oct; Vol. 116 (10), pp. 2712-2722. Date of Electronic Publication: 2025 Jul 24.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Publishing on behalf of the Japanese Cancer Association Country of Publication: England NLM ID: 101168776 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7006 (Electronic) Linking ISSN: 13479032 NLM ISO Abbreviation: Cancer Sci Subsets: MEDLINE

MeSH Terms: Tumor Microenvironment*/drug effects , Prostatic Neoplasms, Castration-Resistant*/pathology , Prostatic Neoplasms, Castration-Resistant*/metabolism , Prostatic Neoplasms, Castration-Resistant*/genetics , Prostatic Neoplasms*/pathology , Prostatic Neoplasms*/metabolism , Prostatic Neoplasms*/genetics, Humans ; Male ; Human Umbilical Vein Endothelial Cells ; Cell Line, Tumor ; Cell Differentiation ; Interleukin-1beta/metabolism ; Interleukin-1beta/pharmacology ; Signal Transduction/drug effects ; Epithelial-Mesenchymal Transition ; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Benzamides ; Transforming Growth Factor beta2/metabolism ; Transforming Growth Factor beta2/pharmacology ; Nitriles ; STAT3 Transcription Factor/metabolism ; Phenylthiohydantoin/analogs & derivatives ; Phenylthiohydantoin/pharmacology ; Gene Expression Regulation, Neoplastic ; Endothelial-Mesenchymal Transition

PM 2.5 Induce Endothelial-Mesenchymal Transition and Cardiac Fibrosis via the NCOA4-Mediated Ferritinophagy.

Authors: Sun Q Wang M Liu L et al.

Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Dec; Vol. 12 (45), pp. e07536. Date of Electronic Publication: 2025 Sep 15.

Publication Type: Journal Article

Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH Terms: Particulate Matter*/adverse effects , Particulate Matter*/toxicity , Nuclear Receptor Coactivators*/metabolism , Nuclear Receptor Coactivators*/genetics , Ferritins*/metabolism , Myocardium*/pathology , Myocardium*/metabolism , Epithelial-Mesenchymal Transition*/drug effects, Fibrosis/metabolism ; Animals ; Mice ; Humans ; Mice, Inbred C57BL ; Endothelial Cells/metabolism ; Endothelial Cells/drug effects ; Male ; Endothelial-Mesenchymal Transition

Fei Wei formula attenuates pulmonary fibrosis by inhibiting lactate-driven endothelial mesenchymal transition via its target of HSP90ab1.

Authors: Gu JM Wang SL Zhang SN et al.

Source: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Nov 25; Vol. 148, pp. 157501. Date of Electronic Publication: 2025 Oct 30.

Publication Type: Journal Article

Journal Info: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

MeSH Terms: HSP90 Heat-Shock Proteins*/metabolism , Idiopathic Pulmonary Fibrosis*/drug therapy , Idiopathic Pulmonary Fibrosis*/metabolism , Drugs, Chinese Herbal*/pharmacology , Epithelial-Mesenchymal Transition*/drug effects , Pulmonary Fibrosis*/drug therapy , Lactic Acid*/metabolism, Animals ; Humans ; Mice ; Bleomycin ; Male ; Mice, Inbred C57BL ; Endothelial Cells/drug effects ; Disease Models, Animal ; Female ; Endothelial-Mesenchymal Transition

Betulinic acid as a novel AT1R inhibitor: attenuation of liver fibrosis via modulation of endothelial-mesenchymal transition in chronic hepatic injury.

Authors: Zhu B Dai X Liu C et al.

Source: Journal of translational medicine [J Transl Med] 2025 Nov 13; Vol. 23 (1), pp. 1282. Date of Electronic Publication: 2025 Nov 13.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

MeSH Terms: Liver Cirrhosis*/drug therapy , Liver Cirrhosis*/pathology , Receptor, Angiotensin, Type 1*/metabolism , Receptor, Angiotensin, Type 1*/chemistry , Epithelial-Mesenchymal Transition*/drug effects , Triterpenes*/pharmacology , Triterpenes*/therapeutic use, Betulinic Acid ; Animals ; Pentacyclic Triterpenes/pharmacology ; Humans ; Human Umbilical Vein Endothelial Cells/drug effects ; Male ; Molecular Dynamics Simulation ; Mice, Inbred C57BL ; Mice ; Liver/pathology ; Liver/drug effects ; Endothelial-Mesenchymal Transition

Activin A-Activated ALK4 Induces Pathogenic Th17-Involved Endothelial-Mesenchymal Transition in Systemic Lupus Erythematosus-Associated Pulmonary Arterial Hypertension.

Authors: Jing S Qian J Ying H et al.

Source: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2025 Nov; Vol. 77 (11), pp. 1533-1547. Date of Electronic Publication: 2025 Jul 16.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101623795 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2326-5205 (Electronic) Linking ISSN: 23265191 NLM ISO Abbreviation: Arthritis Rheumatol Subsets: MEDLINE

MeSH Terms: Lupus Erythematosus, Systemic*/complications , Lupus Erythematosus, Systemic*/immunology , Activins*/immunology , Activins*/metabolism , Activins*/blood , Th17 Cells*/immunology , Th17 Cells*/metabolism , Pulmonary Arterial Hypertension*/immunology , Pulmonary Arterial Hypertension*/etiology , Activin Receptors, Type I*/metabolism , Activin Receptors, Type I*/immunology , Epithelial-Mesenchymal Transition*/immunology , Hypertension, Pulmonary*/immunology, Humans ; Animals ; Mice ; Interleukin-17/immunology ; Interleukin-17/blood ; Female ; Endothelial Cells/metabolism ; Adult ; Male ; Signal Transduction ; Middle Aged ; Coculture Techniques ; Endothelial-Mesenchymal Transition ; Activin Receptors, Type II

Endothelial adenosine receptor 2A loss alleviates diabetic vascular calcification by blocking CREB1-SNAI1-driven EndMT.

Authors: Zhou Y Zhao D Ma Q et al.

Source: Pharmacological research [Pharmacol Res] 2025 Nov; Vol. 221, pp. 107981. Date of Electronic Publication: 2025 Oct 09.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE

MeSH Terms: Receptor, Adenosine A2A*/genetics , Receptor, Adenosine A2A*/metabolism , Vascular Calcification*/metabolism , Vascular Calcification*/pathology , Vascular Calcification*/etiology , Cyclic AMP Response Element-Binding Protein*/metabolism , Diabetes Mellitus, Experimental*/metabolism , Diabetes Mellitus, Experimental*/complications , Diabetes Mellitus, Experimental*/pathology , Endothelial Cells*/metabolism , Endothelial Cells*/drug effects , Endothelial Cells*/pathology , Snail Family Transcription Factors*/metabolism , Epithelial-Mesenchymal Transition* , Diabetic Angiopathies*/metabolism , Diabetic Angiopathies*/pathology , Diabetic Angiopathies*/genetics, Animals ; Humans ; Male ; Mice, Inbred C57BL ; Mice ; Cells, Cultured ; Osteogenesis/drug effects ; Mice, Knockout ; Endothelial-Mesenchymal Transition

Catalpol inhibits HHcy-induced EndMT in endothelial cells by modulating ROS/NF-κB signaling.

Authors: Wu C Li Y Liu S et al.

Source: BMC cardiovascular disorders [BMC Cardiovasc Disord] 2024 Aug 16; Vol. 24 (1), pp. 431. Date of Electronic Publication: 2024 Aug 16.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100968539 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2261 (Electronic) Linking ISSN: 14712261 NLM ISO Abbreviation: BMC Cardiovasc Disord Subsets: MEDLINE

MeSH Terms: Atherosclerosis*/drug therapy , Atherosclerosis*/etiology , Atherosclerosis*/pathology , Endothelial-Mesenchymal Transition*/drug effects , Hyperhomocysteinemia*/drug therapy , Hyperhomocysteinemia*/metabolism , Hyperhomocysteinemia*/complications , Iridoid Glucosides*/pharmacology , Iridoid Glucosides*/therapeutic use , NF-kappa B*/metabolism , Reactive Oxygen Species*/metabolism, Animals ; Humans ; Antigens, CD/metabolism ; Antioxidants/pharmacology ; Cadherins/metabolism ; Cells, Cultured ; Disease Models, Animal ; Human Umbilical Vein Endothelial Cells/metabolism ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/pathology ; Mice, Inbred C57BL ; Oxidative Stress/drug effects ; Signal Transduction/drug effects ; Transcription Factor RelA/metabolism ; Mice

Frataxin Loss Promotes Angiotensin II-Induced Endothelial-to-Mesenchymal Transition.

Authors: Guo Y Cheng X Huang C et al.

Source: Journal of the American Heart Association [J Am Heart Assoc] 2024 Aug 06; Vol. 13 (15), pp. e034316. Date of Electronic Publication: 2024 Jul 18.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE

MeSH Terms: Frataxin*/genetics , Frataxin*/metabolism , Angiotensin II*/pharmacology , Endothelial-Mesenchymal Transition*/drug effects , Endothelial-Mesenchymal Transition*/genetics, Humans ; Animals ; HEK293 Cells ; Mice, Inbred C57BL ; Mutation ; Sirtuin 3/metabolism ; Silymarin/pharmacology ; Acetylation ; Mice, Knockout ; Gene Expression Regulation/drug effects

Induced pluripotent stem cell-derived conditioned medium, as well as nintedanib, ameliorates bleomycin-induced pulmonary fibrosis via suppressing endothelial-mesenchymal transition.

Authors: Yu WK Yang YP Chen WC et al.

Source: Respiratory investigation [Respir Investig] 2025 Sep; Vol. 63 (5), pp. 904-914. Date of Electronic Publication: 2025 Jul 18.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101581124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-5353 (Electronic) Linking ISSN: 22125345 NLM ISO Abbreviation: Respir Investig Subsets: MEDLINE

MeSH Terms: Bleomycin*/adverse effects , Indoles*/pharmacology , Indoles*/therapeutic use , Induced Pluripotent Stem Cells* , Pulmonary Fibrosis*/chemically induced , Pulmonary Fibrosis*/drug therapy , Pulmonary Fibrosis*/pathology , Pulmonary Fibrosis*/metabolism , Epithelial-Mesenchymal Transition*/drug effects , Endothelial Cells*, Animals ; Mice, Inbred C57BL ; Humans ; Culture Media, Conditioned/pharmacology ; Cadherins/metabolism ; Cells, Cultured ; Mice ; Focal Adhesion Kinase 1/metabolism ; Disease Models, Animal ; Male ; Vimentin/metabolism ; Endothelial-Mesenchymal Transition ; Antigens, CD

Ginsenoside Rb1 inhibits M1 macrophages-induced IGFBP2-mediated endothelial-mesenchymal transition to alleviate myocardial fibrosis in mice with chronic heart failure.

Authors: Jiang Y Zhao Q Zhang T et al.

Source: In vitro cellular & developmental biology. Animal [In Vitro Cell Dev Biol Anim] 2025 Aug; Vol. 61 (7), pp. 848-861. Date of Electronic Publication: 2025 Jul 02.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 9418515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-706X (Electronic) Linking ISSN: 10712690 NLM ISO Abbreviation: In Vitro Cell Dev Biol Anim Subsets: MEDLINE

MeSH Terms: Ginsenosides*/pharmacology , Ginsenosides*/therapeutic use , Macrophages*/drug effects , Macrophages*/metabolism , Macrophages*/pathology , Myocardium*/pathology , Insulin-Like Growth Factor Binding Protein 2*/metabolism , Heart Failure*/drug therapy , Heart Failure*/pathology , Heart Failure*/complications , Epithelial-Mesenchymal Transition*/drug effects, Animals ; Mice ; Fibrosis ; Male ; Endothelial Cells/drug effects ; Endothelial Cells/pathology ; Endothelial Cells/metabolism ; Chronic Disease ; Mice, Inbred C57BL ; Disease Models, Animal ; Coculture Techniques ; Endothelial-Mesenchymal Transition

Endothelial histone deacetylase 9 promotes diabetic retinopathy in mice by regulating endothelial-mesenchymal transition.

Authors: Bei Y Shen ZX Lin HR et al.

Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2025 Aug; Vol. 46 (8), pp. 2213-2224. Date of Electronic Publication: 2025 Mar 31.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE

MeSH Terms: Diabetic Retinopathy*/metabolism , Diabetic Retinopathy*/pathology , Histone Deacetylases*/metabolism , Histone Deacetylases*/genetics , Diabetes Mellitus, Experimental*/metabolism , Diabetes Mellitus, Experimental*/pathology , Repressor Proteins*/metabolism , Repressor Proteins*/genetics , Endothelial Cells*/metabolism , Epithelial-Mesenchymal Transition*, Animals ; Humans ; Mice ; Mice, Inbred C57BL ; Male ; Streptozocin ; Retina/pathology ; Retina/metabolism ; Endothelial-Mesenchymal Transition

CLCF1 contributes to high-glucose-induced EndMT by modulating JAK2/STAT3 signaling.

Authors: Deng R He K You Q et al.

Source: European journal of medical research [Eur J Med Res] 2025 Jul 29; Vol. 30 (1), pp. 682. Date of Electronic Publication: 2025 Jul 29.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9517857 Publication Model: Electronic Cited Medium: Internet ISSN: 2047-783X (Electronic) Linking ISSN: 09492321 NLM ISO Abbreviation: Eur J Med Res Subsets: MEDLINE

MeSH Terms: STAT3 Transcription Factor*/metabolism , Janus Kinase 2*/metabolism , Glucose*/metabolism , Glucose*/pharmacology , Epithelial-Mesenchymal Transition* , Diabetic Nephropathies*/metabolism , Diabetic Nephropathies*/pathology , Diabetic Nephropathies*/genetics , Cytokines*/metabolism , Cytokines*/genetics, Humans ; Signal Transduction ; Male ; Female ; Middle Aged ; Kidney Glomerulus/metabolism ; Kidney Glomerulus/pathology ; Endothelial Cells/metabolism ; Endothelial-Mesenchymal Transition