Suchergebnisse - "Endothelial Cells metabolism"

SECS, drugs, and Rac1&Rho: regulation of EnNaC in vascular endothelial cells

Autoren: Fels, B. Fischer, F. Herrnboeck, L. et al.

Quelle: Pflugers Arch
Pflugers Archiv, vol. 477, no. 7, pp. 977-992

Schlagwörter: Research, rac1 GTP-Binding Protein/metabolism, Humans, Endothelial Cells/metabolism, Endothelial Cells/drug effects, Epithelial Sodium Channels/metabolism, Animals, rhoA GTP-Binding Protein/metabolism, Protein Serine-Threonine Kinases/metabolism, Actin-Related Protein 2-3 Complex/metabolism, Amiloride/pharmacology, Amiloride/analogs & derivatives, Signal Transduction, Human Umbilical Vein Endothelial Cells/metabolism, Cells, Cultured, Immediate-Early Proteins, AFM, EnNaC, Endothelial nanomechanics, Non-genomic aldosterone effects

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/40402207
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_44DF8BFA1AF06
https://serval.unil.ch/resource/serval:BIB_44DF8BFA1AF0.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_44DF8BFA1AF0

Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging

Autoren: Seyed Soheil Saeedi Saravi Benoit Pugin Florentin Constancias et al.

Quelle: Nat Aging
Nature aging, vol. 5, no. 6, pp. 1025-1045
Saeedi Saravi, S S, Pugin, B, Constancias, F, Shabanian, K, Spalinger, M, Thomas, A, Le Gludic, S, Shabanian, T, Karsai, G, Colucci, M, Menni, C, Attaye, I, Zhang, X, Allemann, M S, Lee, P, Visconti, A, Falchi, M, Alimonti, A, Ruschitzka, F, Paneni, F & Beer, J H 2025, ' Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging ', Nature Aging, vol. 5, no. 6, pp. 1025-1045 . https://doi.org/10.1038/s43587-025-00864-8
Nature Aging, 5 (6)

Schlagwörter: Male, Gastrointestinal Microbiome/physiology, Animals, Phenylacetates/metabolism, Phenylacetates/blood, Cellular Senescence/physiology, Cellular Senescence/drug effects, Aging/metabolism, Humans, Mice, Endothelial Cells/metabolism, Clostridium/metabolism, Mice, Inbred C57BL, Hydrogen Peroxide/metabolism, Female, Glutamine/analogs & derivatives, Glutamine/metabolism, Feces/microbiology, Feces/chemistry, Aged, Mitochondria/metabolism, Sirtuin 1/metabolism, Article

Dateibeschreibung: application/pdf; application/application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/40355758
https://serval.unil.ch/notice/serval:BIB_BF2F3CCC4022
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_BF2F3CCC40228
https://serval.unil.ch/resource/serval:BIB_BF2F3CCC4022.P001/REF.pdf
https://kclpure.kcl.ac.uk/ws/files/340199243/s43587-025-00864-8.pdf
http://hdl.handle.net/20.500.11850/736072

Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques

Autoren: Katyayani Sukhavasi Giuseppe Mocci Lijiang Ma et al.

Weitere Verfasser: Katyayani Sukhavasi Giuseppe Mocci Lijiang Ma et al.

Quelle: Nat Cardiovasc Res

Schlagwörter: Male, Myocytes, Smooth Muscle, Endothelial Cells/metabolism, Article, Sex Factors, Macrophages/metabolism, Journal Article, Humans, Comparative Study, Gene Regulatory Networks, Carotid Stenosis, RNA-Seq, Aged, Cell Proliferation, Neovascularization, Pathologic, Myocytes, Smooth Muscle/metabolism, Macrophages, Endothelial Cells, Carotid Stenosis/genetics, Middle Aged, Carotid Arteries/pathology, Plaque, Atherosclerotic, Phenotype, Carotid Arteries, Female, Single-Cell Analysis, Transcriptome

Dateibeschreibung: application/pdf; application/zip; text/xml

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/40211055
https://dspace.library.uu.nl/handle/1874/461109
https://erepo.uef.fi/handle/123456789/34301
https://www.repository.cam.ac.uk/handle/1810/389468
https://doi.org/10.1038/s44161-025-00628-y
https://www.repository.cam.ac.uk/handle/1810/382786
https://doi.org/10.1038/s44161-025-00628-y

Sepsis-associated acute kidney injury in mice and humans elicits heterogeneous renal microvascular microRNA responses

Autoren: Luxen, Matthijs van der Aart, Tamar J Jongman, Rianne M et al.

Quelle: Scientific Reports. 15(1)

Schlagwörter: Male, Acute Kidney Injury/etiology, Kidney/blood supply, Endothelial Cells/metabolism, Middle Aged, Inbred C57BL, MicroRNAs/genetics, Mice, Sepsis/complications, Microvessels/metabolism, Humans, Animals, Female, Biomarkers

Zugangs-URL: https://research.rug.nl/en/publications/25cdd50c-b58a-4ba9-999e-6c676bfd42c4
https://hdl.handle.net/11370/25cdd50c-b58a-4ba9-999e-6c676bfd42c4

Pharmacological blocking of microfibrillar-associated protein 4 reduces retinal neoangiogenesis and vascular leakage

Autoren: Anders Schlosser Bartosz Pilecki Claire Allen et al.

Quelle: Mol Ther
Schlosser, A, Pilecki, B, Allen, C, Benest, A V, Lynch, A P, Hua, J, Ved, N, Blackley, Z, Andersen, T L, Hennig, D, Graversen, J H, Möller, S, Skallerup, S, Ormhøj, M, Lange, C, Agostini, H T, Grauslund, J, Heegaard, S, Dacheva, I, Koss, M, Hu, W, Iglesias, B, Lawrence, M S, Beck, H C, Steffensen, L B, Laursen, N S, Andersen, G R, Holmskov, U, Bates, D O & Sorensen, G L 2025, 'Pharmacological blocking of microfibrillar-associated protein 4 reduces retinal neoangiogenesis and vascular leakage', Molecular Therapy, vol. 33, no. 3, pp. 1048-1072. https://doi.org/10.1016/j.ymthe.2025.01.038

Schlagwörter: glycoprotein, integrin, extracellular matrix, Cell Movement/drug effects, neovascular age-related macular degeneration, Endothelial Cells/metabolism, Retinal Neovascularization, vascular leakage, MFAP4, Extracellular Matrix Proteins/metabolism, Capillary Permeability, Mice, Cell Movement, microfibrillar-associated protein 4, DME, Animals, Humans, Capillary Permeability/drug effects, x-ray crystallography, Retinal Neovascularization/drug therapy, Extracellular Matrix Proteins, Diabetic Retinopathy, Animal, Choroidal Neovascularization/drug therapy, Endothelial Cells, Choroidal Neovascularization, Disease Models, Animal, therapeutic antibody, Disease Models, nAMD, Diabetic Retinopathy/drug therapy, Original Article, RNA Splicing Factors, diabetic macular edema

Dateibeschreibung: pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39863929
https://portal.findresearcher.sdu.dk/da/publications/517051ca-ba94-45f6-b470-5d3567790eed
https://doi.org/10.1016/j.ymthe.2025.01.038
https://pure.au.dk/portal/en/publications/d7778dee-8a01-4818-a4f5-14ab89f98c1c
http://www.scopus.com/inward/record.url?scp=85217266244&partnerID=8YFLogxK
https://doi.org/10.1016/j.ymthe.2025.01.038

Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype

Autoren: Rademakers, Timo Manca, Marco Jin, Han et al.

Weitere Verfasser: Rademakers, Timo Manca, Marco Jin, Han et al.

Quelle: Angiogenesis
Angiogenesis 27(3), 461-474 (2024). doi:10.1007/s10456-024-09921-z

Schlagwörter: 0301 basic medicine, Spectrin/metabolism, Cancer Research, Physiology, Clinical Biochemistry, Biochimie, biophysique & biologie moléculaire, Vascular biology, Zebrafish/genetics, Stiffness, Capillary Permeability, 03 medical and health sciences, Human Umbilical Vein Endothelial Cells, Animals, Humans, Plaque, Atherosclerotic/pathology, Plaque, Atherosclerotic/metabolism, Human Umbilical Vein Endothelial Cells/metabolism, Plaque microvessels, Zebrafish, Plaque, Leaky vessels, Original Paper, 0303 health sciences, Spectrin, Plaque, Atherosclerotic/genetics, Atherosclerosis, Life sciences, Plaque, Atherosclerotic, Phenotype, Microvessels, Microvessels/metabolism, Sciences du vivant, Microvessels/pathology, Atherosclerotic/pathology, Capillary Permeability [MeSH], Spectrin/metabolism [MeSH], Spectrin/genetics [MeSH], Humans [MeSH], Plaque, Atherosclerotic/genetics [MeSH], Human Umbilical Vein Endothelial Cells/metabolism [MeSH], Plaque, Atherosclerotic/metabolism [MeSH], Animals [MeSH], Microvessels/pathology [MeSH], Microvessels/metabolism [MeSH], Transcriptome [MeSH], Phenotype [MeSH], Plaque, Atherosclerotic/pathology [MeSH], Zebrafish/genetics [MeSH], Spectrin/genetics, Transcriptome, SPTBN1 protein, human, Biochemistry, biophysics & molecular biology

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38780883
https://dspace.library.uu.nl/handle/1874/455311
https://pure.amsterdamumc.nl/en/publications/c3c145c1-42bf-4d69-b081-874b702b1433
https://doi.org/10.1007/s10456-024-09921-z
https://hdl.handle.net/2268/323674
https://doi.org/10.1007/s10456-024-09921-z
https://repository.publisso.de/resource/frl:6509507
https://publications.rwth-aachen.de/record/1007213

FLT4 causes developmental disorders of the cardiovascular and lymphovascular systems via pleiotropic molecular mechanisms

Autoren: Richard M Monaghan Richard W Naylor Daisy Flatman et al.

Quelle: Cardiovasc Res
Monaghan, R M, Naylor, R W, Flatman, D, Kasher, P R, Williams, S G & Keavney, B D 2024, 'FLT4 causes developmental disorders of the cardiovascular and lymphovascular systems via pleiotropic molecular mechanisms', Cardiovascular research, vol. 120, no. 10, cvae104, pp. 1164-1176. https://doi.org/10.1093/cvr/cvae104

Schlagwörter: 0301 basic medicine, Cells, Endothelial Cells/metabolism, Endoplasmic Reticulum, Zebrafish/genetics, 03 medical and health sciences, Primary lymphoedema, Zebrafish Proteins/genetics, Human Umbilical Vein Endothelial Cells, Animals, Humans, Developmental, Genetic Predisposition to Disease, Vascular Endothelial Growth Factor Receptor-3/metabolism, Lymphedema, FLT4, Human Umbilical Vein Endothelial Cells/metabolism, Endoplasmic Reticulum/metabolism, Cells, Cultured, Zebrafish, Congenital heart disease, 0303 health sciences, Cultured, Endothelial Cells, Gene Expression Regulation, Developmental, Tetralogy of Fallot/genetics, Zebrafish Proteins, Vascular Endothelial Growth Factor Receptor-3, 3. Good health, Phenotype, Gene Expression Regulation, Mutation, Proteostasis, Tetralogy of Fallot, Original Article, Developmental pleiotropy, VEGFR3, Lymphedema/genetics, Signal Transduction

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38713105
https://research.manchester.ac.uk/en/publications/8c40ed3a-6c44-44cc-856f-46aef161c8b3
https://doi.org/10.1093/cvr/cvae104
https://research.manchester.ac.uk/en/publications/8c40ed3a-6c44-44cc-856f-46aef161c8b3
http://www.scopus.com/inward/record.url?scp=85200464249&partnerID=8YFLogxK
https://doi.org/10.1093/cvr/cvae104

A Novel Stem Cell Model to Study Preeclampsia Endothelial Dysfunction

Autoren: Yanming Wu Tianyanxin Sun Pedro Medina et al.

Quelle: Reprod Sci

Schlagwörter: Adult, 0301 basic medicine, 0303 health sciences, Induced Pluripotent Stem Cells, Endothelial Cells, Original Article, Nitric Oxide/metabolism [MeSH], Pre-Eclampsia/blood [MeSH], Pre-Eclampsia/metabolism [MeSH], Induced Pluripotent Stem Cells/metabolism [MeSH], Induced pluripotent stem cells (iPSCs), Endothelium, Vascular/metabolism [MeSH], Cells, Cultured [MeSH], Pregnancy [MeSH], Hypertension [Endothelial Cells/metabolism [MeSH], Female [MeSH], Pre-Eclampsia/physiopathology [MeSH], Preeclampsia, Endothelial dysfunction, Cell Differentiation/physiology [MeSH], Cell Movement/physiology [MeSH], Pregnancy, Adult [MeSH], Humans [MeSH], Endothelium, Vascular/physiopathology [MeSH], Maternal Fetal Medicine/Biology], Cell Differentiation, Nitric Oxide, Maternal Fetal Medicine/Biology: Original Article, 03 medical and health sciences, Pre-Eclampsia, Cell Movement, Humans, Female, Endothelium, Vascular, Cells, Cultured

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39179924
https://repository.publisso.de/resource/frl:6499977

Normalization of Snai1-mediated vessel dysfunction increases drug response in cancer

Autoren: Helene Hoffmann Martin Wartenberg Sandra Vorlova et al.

Quelle: Oncogene

Schlagwörter: 0301 basic medicine, 0303 health sciences, Epithelial-Mesenchymal Transition, Neovascularization, Pathologic, Endothelial Cells, Angiogenesis Inhibitors, Article, Mice, 03 medical and health sciences, Neoplasms, Cell Line, Tumor, 14/19, Angiogenesis Inhibitors/pharmacology [MeSH], Endothelial Cells/pathology [MeSH], Neovascularization, Pathologic/pathology [MeSH], Cell Line, Tumor [MeSH], 631/67/1059/2326, Tumor Microenvironment/drug effects [MeSH], Endothelial Cells/drug effects [MeSH], Neovascularization, Pathologic/metabolism [MeSH], Neoplasms/metabolism [MeSH], 13/51, 631/67/327, 38/109, Neoplasms/pathology [MeSH], Human Umbilical Vein Endothelial Cells [MeSH], 631/67/322, Snail Family Transcription Factors/metabolism [MeSH], 14/63, 13/2, Endothelial Cells/metabolism [MeSH], Female [MeSH], Neoplasms/blood supply [MeSH], 82/80, Epithelial-Mesenchymal Transition/drug effects [MeSH], Humans [MeSH], 631/67/2328, Neoplasms/genetics [MeSH], Animals [MeSH], 64/60, Epithelial-Mesenchymal Transition/genetics [MeSH], Neovascularization, Pathologic/drug therapy [MeSH], Mice [MeSH], Neovascularization, Pathologic/genetics [MeSH], 82, Neoplasms/drug therapy [MeSH], 38/89, 64, article, Snail Family Transcription Factors/genetics [MeSH], Tumor Microenvironment, Human Umbilical Vein Endothelial Cells, Animals, Humans, Female, Snail Family Transcription Factors

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39095583
https://repository.publisso.de/resource/frl:6503989

Site-specific genetic and functional signatures of aortic endothelial cells at aneurysm predilection sites in healthy and AngII ApoE−/− mice

Autoren: Brückner, Alexander Brandtner, Adrian Rieck, Sarah et al.

Quelle: Angiogenesis

Schlagwörter: Male, Mice, Knockout, 0301 basic medicine, Angiotensin II/metabolism [MeSH], Aorta/metabolism [MeSH], Aorta/pathology [MeSH], Endothelial Cells/pathology [MeSH], Endothelial Cells/metabolism [MeSH], Mice, Inbred C57BL [MeSH], Site-specificity, Aortic Aneurysm/pathology [MeSH], Aortic aneurysm, Apolipoproteins E/metabolism [MeSH], Animals [MeSH], Mice, Knockout [MeSH], Aortic Aneurysm/metabolism [MeSH], Mice [MeSH], RNA-seq, Endothelial cells, Male [MeSH], Aortic Aneurysm/genetics [MeSH], Apolipoproteins E/deficiency [MeSH], Original Paper, Apolipoproteins E/genetics [MeSH], Heterogeneity, Disease Models, Animal [MeSH], 0303 health sciences, Angiotensin II, Endothelial Cells, Aortic Aneurysm, Mice, Inbred C57BL, Mice, Disease Models, Animal, 03 medical and health sciences, Apolipoproteins E, Animals, Aorta

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38965173
https://repository.publisso.de/resource/frl:6519591

Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity

Autoren: Sarah E. J. Chambers Jasenka Guduric-Fuchs Edoardo Pedrini et al.

Quelle: Angiogenesis
Chambers, S E J, Guduric-Fuchs, J, Pedrini, E, Bertelli, P M, Charoensuk, C, Peixoto, E, Pathak, V, Alhamdan, H I, Xie, R, Krasnodembskaya, A, Lechner, J, Stitt, A W & Medina, R J 2025, 'Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity', Angiogenesis, vol. 28, no. 3, 30. https://doi.org/10.1007/s10456-025-09982-8

Schlagwörter: Original Paper, Endothelial Protein C Receptor/metabolism, Cell Movement, Cell Cycle, Humans, Endothelial Protein C Receptor, Neovascularization, Physiologic, Endothelial Cells, Endothelial Cells/metabolism, Endothelial Progenitor Cells/metabolism, Endothelial Progenitor Cells, Cell Proliferation

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/40407837
https://pure.qub.ac.uk/en/publications/a64c76a3-a410-4f13-9388-9e52912001cb

Calciprotein particle-activated endothelial cells aggravate smooth muscle cell calcification via paracrine signalling

Autoren: Lian Feenstra Lara W. Zeper Brenda van de Langenberg et al.

Quelle: Cell Mol Life Sci
Cellular and Molecular Life Sciences, 82, 1

Schlagwörter: Cells, Vascular Cell Adhesion Molecule-1/metabolism, Myocytes, Smooth Muscle, Vascular Cell Adhesion Molecule-1, Endothelial Cells/metabolism, Chronic/metabolism, Medical Biosciences - Radboud University Medical Center, Vascular Calcification/metabolism, Muscle, Smooth, Vascular, Conditioned/pharmacology, Paracrine Communication, E-Selectin/metabolism, Humans, Animals, Renal Insufficiency, Renal Insufficiency, Chronic, Vascular Calcification, Smooth Muscle/metabolism, Cells, Cultured, Myocytes, Cultured, Paracrine Communication/drug effects, Endothelial Cells, Vascular/metabolism, Intercellular Adhesion Molecule-1/metabolism, Intercellular Adhesion Molecule-1, Culture Media, Culture Media, Conditioned, Muscle, Original Article, Smooth, E-Selectin

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/40287595
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/318711
https://research.rug.nl/en/publications/1d95d3d7-8844-497f-8670-4f91cfb4aa9a
https://hdl.handle.net/11370/1d95d3d7-8844-497f-8670-4f91cfb4aa9a
https://doi.org/10.1007/s00018-025-05702-z
https://repository.ubn.ru.nl//bitstream/handle/2066/318711/318711.pdf
https://hdl.handle.net/2066/318711

Simultaneous isolation and culture of endothelial colony-forming cells, endothelial cells and vascular smooth muscle cells from human umbilical cords

Autoren: Marie-Lotus Burger Steeve Menétrey Catherine Ponti et al.

Quelle: Mol Biol Rep
Molecular biology reports, vol. 52, no. 1, pp. 302

Schlagwörter: Male, Umbilical Veins, Myocytes, Smooth Muscle, Methodology, Cell Culture Techniques, Endothelial Cells, Cell Separation, Fetal Blood, Flow Cytometry, Humans, Umbilical Cord/cytology, Myocytes, Smooth Muscle/metabolism, Myocytes, Smooth Muscle/cytology, Muscle, Smooth, Vascular/cytology, Muscle, Smooth, Vascular/metabolism, Cell Separation/methods, Cells, Cultured, Fetal Blood/cytology, Human Umbilical Vein Endothelial Cells/metabolism, Endothelial Cells/metabolism, Endothelial Cells/cytology, Female, Cell Culture Techniques/methods, Flow Cytometry/methods, Umbilical Arteries/cytology, Pregnancy, Endothelial cell, Endothelial colony-forming cell, Human umbilical artery, Human umbilical cord blood, Human umbilical vein, Vascular smooth muscle cell, Muscle, Smooth, Vascular, Umbilical Arteries, Umbilical Cord, Human Umbilical Vein Endothelial Cells

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/40080230
https://serval.unil.ch/resource/serval:BIB_29AE573B4C2C.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_29AE573B4C2C3
https://serval.unil.ch/notice/serval:BIB_29AE573B4C2C

Establishment of the deuterium oxide dilution method as a new possibility for determining the transendothelial water permeability

Autoren: Hannes Müller Janina Hahn Angelina Gierke et al.

Quelle: Pflugers Arch

Schlagwörter: 0301 basic medicine, 0303 health sciences, Signaling and Cell Physiology, Water, Endothelial Cells, Permeability, Capillary Permeability, 03 medical and health sciences, Electric Impedance, Human Umbilical Vein Endothelial Cells, Humans, Animals, Transendothelial water permeability, Endothelial Cells/metabolism [MeSH], Permeability [MeSH], Humans [MeSH], D, Endothelial barrier function, Endothelial Cells/drug effects [MeSH], Human Umbilical Vein Endothelial Cells/metabolism [MeSH], Animals [MeSH], Endothelium, Vascular/drug effects [MeSH], Deuterium Oxide/metabolism [MeSH], Capillary Permeability/drug effects [MeSH], Edema, Human Umbilical Vein Endothelial Cells/drug effects [MeSH], Water/metabolism [MeSH], Electric Impedance [MeSH], Endothelium, Vascular/metabolism [MeSH], Endothelium, Vascular, Deuterium Oxide

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38438679
https://repository.publisso.de/resource/frl:6506640

2-Desaza-annomontine (C81) impedes angiogenesis through reduced VEGFR2 expression derived from inhibition of CDC2-like kinases

Autoren: T. J. Zech A. Wolf M. Hector et al.

Quelle: Angiogenesis

Schlagwörter: Inflammation, Vascular Endothelial Growth Factor A, 0301 basic medicine, Original Paper, 0303 health sciences, Angiogenesis Inhibitors/pharmacology [MeSH], Endothelial Cells/metabolism [MeSH], beta Catenin/metabolism [MeSH], Kinase inhibitor, CDC-2-like-kinases, Carbolines [MeSH], Humans [MeSH], Inflammation [MeSH], Human Umbilical Vein Endothelial Cells/metabolism [MeSH], Splicing, Animals [MeSH], Angiogenesis [MeSH], Neovascularization, Pathologic/drug therapy [MeSH], WNT-signaling, Wnt Signaling Pathway [MeSH], Mice [MeSH], Vascular Endothelial Growth Factor A/metabolism [MeSH], Natural product, Pyrimidines [MeSH], Angiogenesis, Vascular Endothelial Growth Factor Receptor-2/metabolism [MeSH], Neovascularization, Pathologic, Endothelial Cells, Angiogenesis Inhibitors, Vascular Endothelial Growth Factor Receptor-2, Mice, 03 medical and health sciences, Pyrimidines, Human Umbilical Vein Endothelial Cells, Animals, Humans, Wnt Signaling Pathway, beta Catenin, Carbolines

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38403816
https://repository.publisso.de/resource/frl:6518611

Peptidylarginine Deiminases Inhibitors Decrease Endothelial Cells Angiogenic Potential by Affecting Akt Signaling and the Expression and Secretion of Angiogenic Factors

Autoren: Ciesielski, O. Pirola, L. Balcerczyk, A. et al.

Weitere Verfasser: Ciesielski, O. Pirola, L. Balcerczyk, A. et al.

Quelle: Cellular Physiology and Biochemistry. 58:63-82

Schlagwörter: Vascular Endothelial Growth Factor A, 0301 basic medicine, Angiogenesis Inhibitors/chemistry/pharmacology, Endothelial cells, [SDV]Life Sciences [q-bio], Histones/metabolism, Amidines, Angiogenesis Inhibitors, Histones, 03 medical and health sciences, Endothelial Cells/metabolism, Vascular Endothelial Growth Factor A/genetics/metabolism, Humans, 0303 health sciences, Akt, Protein-Arginine Deiminases/antagonists & inhibitors, Endothelial Cells, PADs inhibitors, Amidines/chemistry/pharmacology, 3. Good health, [SDV] Life Sciences [q-bio], Proto-Oncogene Proteins c-akt/metabolism, Protein-Arginine Deiminases, Citrullination, Angiogenesis, signaling, Humans, Signal Transduction, Angiogenesis, *Endothelial Cells/metabolism, *Protein-Arginine Deiminases/antagonists & inhibitors, *Proto-Oncogene Proteins c-akt/metabolism, Akt, Amidines/chemistry/pharmacology, Angiogenesis Inhibitors/chemistry/pharmacology, Citrullination, Endothelial cells, Histones/metabolism, PADs inhibitors, signaling, Vascular Endothelial Growth Factor A/genetics/metabolism, Proto-Oncogene Proteins c-akt, Signal Transduction

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38374715
https://hal.science/hal-04661057v1
https://doi.org/10.33594/000000683

Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis

Autoren: Drost, Carolin Christina Rovas, Alexandros Osiaevi, Irina et al.

Quelle: Angiogenesis

Schlagwörter: Male, 0301 basic medicine, Original Paper, 0303 health sciences, Interleukin-6, SARS-CoV-2, Endothelial Cells/pathology [MeSH], COVID-19, Heparanase, Aged [MeSH], Glycocalyx/pathology [MeSH], COVID-19/complications [MeSH], COVID-19/pathology [MeSH], Sepsis/pathology [MeSH], Antibodies, Monoclonal, Humanized [MeSH], Glycocalyx/metabolism [MeSH], Male [MeSH], Sepsis, SARS-CoV-2/metabolism [MeSH], Sepsis/metabolism [MeSH], Interleukin-6/metabolism [MeSH], Endothelial Cells/metabolism [MeSH], Female [MeSH], Humans [MeSH], Prospective Studies [MeSH], Middle Aged [MeSH], Endothelial glycocalyx, Sepsis/complications [MeSH], COVID-19/metabolism [MeSH], Sublingual microscopy, Interleukin-6/blood [MeSH], Endothelial Cells, Middle Aged, Glycocalyx, Antibodies, Monoclonal, Humanized, 03 medical and health sciences, Humans, Female, Prospective Studies, Aged

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38598083
https://repository.publisso.de/resource/frl:6504681

A brain-specific angiogenic mechanism enabled by tip cell specialization

Autoren: Giel Schevenels Pauline Cabochette Michelle America et al.

Quelle: Nature

Schlagwörter: Collagen Type IV, 0301 basic medicine, CRISPR-Cas Systems -- genetics, Cell- och molekylärbiologi, Brain -- cytology -- blood supply -- metabolism, Neovascularization, Physiologic, Wnt Proteins -- metabolism, Article, Basement Membrane, 03 medical and health sciences, Meninges -- cytology -- blood supply -- metabolism, Meninges, Cell Movement, Basement Membrane -- metabolism, Animals, Physiologic, Wnt Signaling Pathway, Neovascularization, Zebrafish, 0303 health sciences, Blood-Brain Barrier -- metabolism -- cytology, Zebrafish -- genetics -- metabolism, Brain, Endothelial Cells, Sciences bio-médicales et agricoles, Zebrafish Proteins, Endothelial Cells -- metabolism -- cytology, Wnt Proteins, Blood-Brain Barrier, Organ Specificity, Zebrafish Proteins -- metabolism -- genetics, CRISPR-Cas Systems, Collagen Type IV -- metabolism, Cell and Molecular Biology

Dateibeschreibung: application/pdf; 1 full-text file(s): application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38570687
https://researchportal.unamur.be/en/publications/aa2779b6-7970-4970-a750-0fe97f0eb57d
https://doi.org/10.1038/s41586-024-07283-6
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-532264

AXL promotes lymphangiogenesis by amplifying VEGF-C-mediated AKT pathway

Autoren: Pirson, Sébastien Gautier-Isola, Marine Baudin, Louis et al.

Weitere Verfasser: Pirson, Sébastien Gautier-Isola, Marine Baudin, Louis et al.

Quelle: Cell Mol Life Sci
Cellular and Molecular Life Sciences

Schlagwörter: Vascular Endothelial Growth Factor C/metabolism, Vascular Endothelial Growth Factor C, Endothelial Cells/metabolism, R428/Bemcentinib, Biochimie, biophysique & biologie moléculaire, Mice, Cell Movement, bemcentinib, Proto-Oncogene Proteins, Humans, Animals, Lymphangiogenesis, Molecular Biology, Lymphatic Vessels, Lymphatic Vessels/metabolism, AXL, Receptor Protein-Tyrosine Kinases, Endothelial Cells, VEGF-C pathway, Triazoles, Proto-Oncogene Proteins/metabolism, Life sciences, Axl Receptor Tyrosine Kinase, Benzocycloheptenes, AKT pathway, Lymphatic Metastasis, Lymph Nodes/metabolism, Lymph Nodes/pathology, Sciences du vivant, Molecular Medicine, Lymph node, Original Article, Lymph Nodes, AXL protein, human, Proto-Oncogene Proteins c-akt, Biochemistry, biophysics & molecular biology, Signal Transduction

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/40011241
https://hdl.handle.net/2268/330543
https://doi.org/10.1007/s00018-024-05542-3

Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling

Autoren: Grootaert, Mandy O.J. Pasut, Alessandra Raman, Jana et al.

Quelle: Cardiovasc Diabetol
Cardiovascular Diabetology, Vol 24, Iss 1, Pp 1-16 (2025)
Cardiovascular Diabetology

Schlagwörter: Male, Cardiac & Cardiovascular Systems, Endothelial cells, PERICYTES, Left, Sodium Chloride, MOUSE, Inbred C57BL, Ventricular Function, Left, Mice, Ventricular Function, Pericytes/metabolism pathology, 1102 Cardiorespiratory Medicine and Haematology, Coronary Vessels/physiopathology metabolism pathology, Dietary/adverse effects, Coronary Vessels, Diastolic/physiopathology metabolism pathology etiology genetics, PRESERVED EJECTION FRACTION, Smooth muscle cells, Diastolic dysfunction, Single-Cell Analysis, 3201 Cardiovascular medicine and haematology, Life Sciences & Biomedicine, Receptor, Signal Transduction, PATHOPHYSIOLOGY, Mice, Transgenic, Platelet-Derived Growth Factor beta/metabolism genetics, Vascular Remodeling, Receptor, Platelet-Derived Growth Factor beta, Endocrinology & Metabolism, Paracrine Communication, Diseases of the circulatory (Cardiovascular) system, Animals, Heart Failure, Heart Failure, Diastolic, Science & Technology, Animal, Research, Endothelial Cells, Stroke Volume, HFpEF, Actins, Mice, Inbred C57BL, MICE, Endothelial Cells/metabolism pathology, Disease Models, Animal, Cardiovascular System & Hematology, RC666-701, Disease Models, STAT1 Transcription Factor/metabolism genetics, Cardiovascular System & Cardiology, Pericytes

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39920783
https://doaj.org/article/c8090c6f2cf9442c8a6b36581e9baeb7
https://cris.maastrichtuniversity.nl/en/publications/a8dd9bbd-323a-4f71-94f1-6ae0f09a713e
https://doi.org/10.1186/s12933-025-02623-w
https://lirias.kuleuven.be/handle/20.500.12942/760210
https://doi.org/10.1186/s12933-025-02623-w