Suchergebnisse - "ESTRADIOL"

Female Mice with HSD17B1 Inactivation Show Mild Hyperandrogenism without Notable Impact on Reproductive Function or Bone.

Autoren: Junnila A Petruk N Heikelä H et al.

Quelle: Endocrinology [Endocrinology] 2025 Dec 05; Vol. 167 (1).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE

MeSH-Schlagworte: Reproduction*/genetics , Reproduction*/physiology , Hyperandrogenism*/genetics , Hyperandrogenism*/metabolism , Estradiol Dehydrogenases*/genetics , Bone and Bones*/metabolism, Animals ; Female ; Mice ; Ovary/metabolism ; Estradiol/metabolism ; Humans ; Estrone/metabolism ; 17-Hydroxysteroid Dehydrogenases/genetics

Estradiol Promotes Habituation Learning via an Unidentified Target, Bypassing the Suppressive Effects of Established ERs.

Autoren: Hsiao A Darvaux-Hubert I Hicks D et al.

Quelle: Endocrinology [Endocrinology] 2025 Jun 10; Vol. 166 (8).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE

MeSH-Schlagworte: Estradiol*/pharmacology , Habituation, Psychophysiologic*/drug effects , Learning*/drug effects , Learning*/physiology , Receptors, Estrogen*/genetics , Receptors, Estrogen*/metabolism, Animals ; Zebrafish ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism ; Female ; Receptors, Estradiol/genetics ; Receptors, Estradiol/metabolism

The clinical relevance of having more than one estrogen in combined hormonal contraception to address the needs of women.

Autoren: Frisendahl C Kallner HK Gemzell-Danielsson K

Quelle: Best practice & research. Clinical obstetrics & gynaecology [Best Pract Res Clin Obstet Gynaecol] 2025 Feb; Vol. 98, pp. 102571. Date of Electronic Publication: 2024 Nov 30.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101121582 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1932 (Electronic) Linking ISSN: 15216934 NLM ISO Abbreviation: Best Pract Res Clin Obstet Gynaecol Subsets: MEDLINE

MeSH-Schlagworte: Contraceptives, Oral, Combined*/adverse effects , Contraceptives, Oral, Combined*/administration & dosage , Estrogens*/adverse effects , Estrogens*/administration & dosage , Estetrol*/adverse effects , Estetrol*/administration & dosage , Estetrol*/therapeutic use , Estradiol*/adverse effects , Estradiol*/administration & dosage , Hormonal Contraception*/methods, Humans ; Female ; Ethinyl Estradiol/adverse effects ; Ethinyl Estradiol/administration & dosage ; Venous Thromboembolism/prevention & control ; Venous Thromboembolism/chemically induced ; Androstenes ; Clinical Relevance

Lower reporting of venous thromboembolisms events with natural estrogen-based combined oral contraceptives compared to ethinylestradiol-containing pills: A disproportionality analysis of the Eudravigilance database.

Autoren: Didembourg M Locquet M Raskin L et al.

Quelle: Contraception [Contraception] 2025 Feb; Vol. 142, pp. 110727. Date of Electronic Publication: 2024 Oct 17.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0234361 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0518 (Electronic) Linking ISSN: 00107824 NLM ISO Abbreviation: Contraception Subsets: MEDLINE

MeSH-Schlagworte: Venous Thromboembolism*/chemically induced , Venous Thromboembolism*/epidemiology , Ethinyl Estradiol*/adverse effects , Contraceptives, Oral, Combined*/adverse effects , Estrogens*/adverse effects, Humans ; Female ; Databases, Factual ; Estetrol/adverse effects ; Pharmacovigilance ; Estradiol/adverse effects ; Levonorgestrel/adverse effects ; Adult ; Drug Combinations

Simultaneous removal of E1, E2, EE2 and levonorgestrel from water using TiO 2 catalyst anchored on activated carbon: Processes optimization, materials characterization, and assessment of the estrogenicity reduction.

Autoren: Pastre MMG Coutinho R Renno M et al.

Quelle: Environmental research [Environ Res] 2024 Dec 15; Vol. 263 (Pt 3), pp. 120173. Date of Electronic Publication: 2024 Oct 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0147621 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0953 (Electronic) Linking ISSN: 00139351 NLM ISO Abbreviation: Environ Res Subsets: MEDLINE

MeSH-Schlagworte: Titanium*/chemistry , Levonorgestrel*/chemistry , Water Pollutants, Chemical*/chemistry , Ethinyl Estradiol*/chemistry , Charcoal*/chemistry, Estradiol/chemistry ; Estrone/chemistry ; Adsorption ; Estrogens/chemistry ; Catalysis ; Water Purification/methods

Injectable Estradiol Monotherapy Effectively Suppresses Testosterone in Gender-Affirming Hormone Therapy.

Autoren: Misakian AL Ariel D Sullivan EA et al.

Quelle: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists [Endocr Pract] 2025 Nov; Vol. 31 (11), pp. 1462-1469. Date of Electronic Publication: 2025 Jul 08.

Publikationsart: Journal Article; Multicenter Study

Info zur Zeitschrift: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9607439 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1530-891X (Print) Linking ISSN: 1530891X NLM ISO Abbreviation: Endocr Pract Subsets: MEDLINE

MeSH-Schlagworte: Testosterone*/blood , Testosterone*/antagonists & inhibitors , Estradiol*/administration & dosage , Estradiol*/therapeutic use , Gender-Affirming Procedures*, Humans ; Retrospective Studies ; Male ; Adult ; Female ; Cross-Sectional Studies ; Middle Aged ; Transgender Persons ; Injections, Intramuscular ; Injections, Subcutaneous

Synthesis of novel estradiol bisselenocyanate with unique 2-selenocyano-17-selenocyanoesteryl structure and evaluation of antitumor activity.

Autoren: Gan T Cheng Y Tian W et al.

Quelle: Molecular diversity [Mol Divers] 2025 Oct; Vol. 29 (5), pp. 4387-4401. Date of Electronic Publication: 2024 Nov 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

MeSH-Schlagworte: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Estradiol*/chemistry , Estradiol*/pharmacology , Estradiol*/chemical synthesis , Estradiol*/analogs & derivatives , Organoselenium Compounds*/chemistry , Organoselenium Compounds*/pharmacology , Organoselenium Compounds*/chemical synthesis , Isothiocyanates*/chemistry , Isothiocyanates*/pharmacology , Isothiocyanates*/chemical synthesis, Humans ; Animals ; HeLa Cells ; Zebrafish ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Cell Movement/drug effects ; Xenograft Model Antitumor Assays ; Cyanates/chemistry ; Cell Cycle/drug effects

Inhibitory effects of parabens on human and rat 17β-hydroxysteroid dehydrogenase 1: Mechanisms of action and impact on hormone synthesis.

Autoren: Chen Z Gong C Tang Y et al.

Quelle: Toxicology [Toxicology] 2024 Aug; Vol. 506, pp. 153873. Date of Electronic Publication: 2024 Jul 08.

Publikationsart: Journal Article; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3185 (Electronic) Linking ISSN: 0300483X NLM ISO Abbreviation: Toxicology Subsets: MEDLINE

MeSH-Schlagworte: Parabens*/toxicity , Molecular Docking Simulation* , Estradiol* , Placenta*/drug effects , Placenta*/metabolism , Placenta*/enzymology, Animals ; Humans ; Rats ; Female ; 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors ; 17-Hydroxysteroid Dehydrogenases/metabolism ; Pregnancy ; Preservatives, Pharmaceutical ; Ovary/drug effects ; Ovary/metabolism ; Ovary/enzymology ; Cell Line, Tumor ; Enzyme Inhibitors/pharmacology ; Binding Sites ; Estradiol Dehydrogenases/antagonists & inhibitors ; Estradiol Dehydrogenases/metabolism

MicroRNA mediated downregulation of HSD17B1 impairs estrone-to-estradiol conversion in polycystic ovarian syndrome.

Autoren: Bhandary P Shetty PK Shetty P et al.

Quelle: Reproductive biology [Reprod Biol] 2025 Dec; Vol. 25 (4), pp. 101085. Date of Electronic Publication: 2025 Sep 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Urban & Partner Country of Publication: Poland NLM ID: 101160559 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2300-732X (Electronic) Linking ISSN: 1642431X NLM ISO Abbreviation: Reprod Biol Subsets: MEDLINE

MeSH-Schlagworte: Polycystic Ovary Syndrome*/metabolism , Polycystic Ovary Syndrome*/genetics , Polycystic Ovary Syndrome*/blood , MicroRNAs*/metabolism , MicroRNAs*/genetics , Estradiol*/metabolism , Estradiol*/blood , Estrone*/metabolism , Estrone*/blood , Estradiol Dehydrogenases*/metabolism , Estradiol Dehydrogenases*/genetics, Female ; Humans ; Down-Regulation ; Adult

Effects of estetrol/drospirenone versus ethinyl estradiol/drospirenone on glucose tolerance in women with polycystic ovary syndrome: A randomised controlled trial.

Autoren: Bunyapipat P Klangsin S Peeyananjarassri K et al.

Quelle: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2025 Dec; Vol. 27 (12), pp. 7244-7257. Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article; Randomized Controlled Trial; Comparative Study

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1463-1326 (Electronic) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE

MeSH-Schlagworte: Polycystic Ovary Syndrome*/drug therapy , Ethinyl Estradiol*/therapeutic use , Ethinyl Estradiol*/administration & dosage , Androstenes*/therapeutic use , Estetrol*/therapeutic use , Estetrol*/administration & dosage , Glucose Intolerance*, Humans ; Female ; Adult ; Glucose Tolerance Test ; Insulin Resistance ; Cross-Over Studies ; Blood Glucose/drug effects ; Blood Glucose/analysis ; Young Adult ; Insulin/blood ; Drug Combinations

Significance of Exogenous Estradiol on Plasma Cortisol and Salivary Cortisol During Adrenocorticotropic Hormone Stimulation in Women With Pituitary Insufficiency.

Autoren: Aagaard LS Krogh J Perlman S et al.

Quelle: Clinical endocrinology [Clin Endocrinol (Oxf)] 2025 Dec; Vol. 103 (6), pp. 852-862. Date of Electronic Publication: 2025 Aug 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Blackwell Publishing Country of Publication: England NLM ID: 0346653 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2265 (Electronic) Linking ISSN: 03000664 NLM ISO Abbreviation: Clin Endocrinol (Oxf) Subsets: MEDLINE

MeSH-Schlagworte: Hydrocortisone*/blood , Hydrocortisone*/metabolism , Estradiol*/administration & dosage , Estradiol*/therapeutic use , Estradiol*/pharmacology , Saliva*/metabolism , Saliva*/chemistry , Adrenocorticotropic Hormone*/pharmacology , Hypopituitarism*/blood , Hypopituitarism*/drug therapy , Hypopituitarism*/metabolism, Humans ; Female ; Adult ; Cross-Over Studies ; Middle Aged ; Adrenal Insufficiency/blood ; Adrenal Insufficiency/diagnosis ; Adrenal Insufficiency/drug therapy ; Administration, Oral ; Administration, Cutaneous

An integrated drug delivery device for the localized treatment of the genitourinary syndrome of menopause.

Autoren: Abdelgader A Govender M Kumar P et al.

Quelle: International journal of pharmaceutics [Int J Pharm] 2025 Nov 30; Vol. 685, pp. 126195. Date of Electronic Publication: 2025 Sep 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE

MeSH-Schlagworte: Drug Delivery Systems*/methods , Menopause*/drug effects , Estradiol*/administration & dosage , Estradiol*/chemistry , Female Urogenital Diseases*/drug therapy , Norethindrone*/administration & dosage , Norethindrone*/analogs & derivatives , Norethindrone*/chemistry, Female ; Animals ; Mice ; Administration, Intravaginal ; Drug Liberation ; NIH 3T3 Cells ; Humans ; Syndrome ; Polymers/chemistry

A transdermal drug delivery system based on estradiol liposomes enhances the alleviation of psoriatic skin inflammation.

Autoren: Guo J Zhang L Li Z et al.

Quelle: International journal of pharmaceutics [Int J Pharm] 2025 Nov 30; Vol. 685, pp. 126234. Date of Electronic Publication: 2025 Sep 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE

MeSH-Schlagworte: Psoriasis*/drug therapy , Psoriasis*/pathology , Psoriasis*/metabolism , Estradiol*/administration & dosage , Estradiol*/pharmacokinetics , Drug Delivery Systems* , Anti-Inflammatory Agents*/administration & dosage, Liposomes ; Administration, Cutaneous ; Animals ; Humans ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Skin Absorption ; Skin/drug effects ; Skin/metabolism ; Skin/pathology ; Mice ; Cell Proliferation/drug effects ; Inflammation/drug therapy ; Male ; Female ; Gels

A Metal-Phenolic Network-Coated Coacervate System Mediates Mitochondrial Modulation and Bone Homeostasis Restoration for Postmenopausal Osteoporosis Therapy.

Autoren: Zhang S Zeng Y Zhou J et al.

Quelle: Nano letters [Nano Lett] 2025 Nov 05; Vol. 25 (44), pp. 15854-15863. Date of Electronic Publication: 2025 Oct 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101088070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6992 (Electronic) Linking ISSN: 15306984 NLM ISO Abbreviation: Nano Lett Subsets: MEDLINE

MeSH-Schlagworte: Osteoporosis, Postmenopausal*/drug therapy , Osteoporosis, Postmenopausal*/pathology , Osteoporosis, Postmenopausal*/metabolism , Mitochondria*/drug effects , Mitochondria*/metabolism , Estradiol*/chemistry , Estradiol*/pharmacology , Estradiol*/administration & dosage , Phenols*/chemistry, Female ; Animals ; Mice ; Homeostasis/drug effects ; Humans ; Bone Density/drug effects ; Ovariectomy ; Peptides/chemistry

Estradiol is not protective against angiotensin II-induced hypertension in middle-aged ovariectomized rats.

Autoren: Leite APO Pires Dos Santos I Zha Y et al.

Quelle: Physiological reports [Physiol Rep] 2025 Nov; Vol. 13 (21), pp. e70646.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM ID: 101607800 Publication Model: Print Cited Medium: Internet ISSN: 2051-817X (Electronic) Linking ISSN: 2051817X NLM ISO Abbreviation: Physiol Rep Subsets: MEDLINE

MeSH-Schlagworte: Estradiol*/pharmacology , Estradiol*/therapeutic use , Hypertension*/chemically induced , Hypertension*/prevention & control , Hypertension*/metabolism , Hypertension*/physiopathology , Angiotensin II*/toxicity, Animals ; Female ; Ovariectomy ; Rats, Long-Evans ; Rats ; Blood Pressure/drug effects ; NADPH Oxidase 4/metabolism ; NADPH Oxidase 4/genetics ; Kidney/drug effects ; Kidney/metabolism ; Oxidative Stress/drug effects ; Menopause ; Aorta/metabolism ; Aorta/drug effects ; Receptors, G-Protein-Coupled/metabolism

Transcriptome landscapes induced by estetrol, estradiol, and ethinylestradiol in primary human endometriotic stromal cells.

Autoren: Nakajima M Izumi G Koga K et al.

Quelle: F&S science [F S Sci] 2025 Nov; Vol. 6 (4), pp. 387-396. Date of Electronic Publication: 2025 Jun 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101765857 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-335X (Electronic) Linking ISSN: 2666335X NLM ISO Abbreviation: F S Sci Subsets: MEDLINE

MeSH-Schlagworte: Ethinyl Estradiol*/pharmacology , Stromal Cells*/drug effects , Stromal Cells*/metabolism , Estradiol*/pharmacology , Transcriptome*/drug effects , Estetrol*/pharmacology , Endometrium*/drug effects , Endometrium*/metabolism , Endometrium*/cytology, Humans ; Female ; Endometriosis/genetics ; Cells, Cultured ; Adult

Endometrial thickness and pathology in postmenopausal women with bleeding on transdermal 17β-estradiol plus body-identical progesterone.

Autoren: Glynne S Kamal A Neville A et al.

Quelle: Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2025 Nov; Vol. 312 (5), pp. 1705-1717. Date of Electronic Publication: 2025 Sep 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8710213 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0711 (Electronic) Linking ISSN: 09320067 NLM ISO Abbreviation: Arch Gynecol Obstet Subsets: MEDLINE

MeSH-Schlagworte: Estradiol*/administration & dosage , Estradiol*/adverse effects , Progesterone*/administration & dosage , Progesterone*/adverse effects , Endometrium*/pathology , Endometrium*/diagnostic imaging , Endometrium*/drug effects , Postmenopause* , Estrogen Replacement Therapy*/adverse effects , Estrogen Replacement Therapy*/methods , Uterine Hemorrhage*/chemically induced , Uterine Hemorrhage*/pathology, Humans ; Female ; Middle Aged ; Retrospective Studies ; Administration, Cutaneous ; Ultrasonography ; Aged ; Obesity

Combination of Si@UiO-66-NH 2 paper-based thin film microextraction with direct solid-state spectrofluorimetry for extraction and determination of estradiol in urine.

Autoren: Ghamat SN Noori M Talebpour Z

Quelle: Analytica chimica acta [Anal Chim Acta] 2025 Nov 01; Vol. 1373, pp. 344499. Date of Electronic Publication: 2025 Aug 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4324 (Electronic) Linking ISSN: 00032670 NLM ISO Abbreviation: Anal Chim Acta Subsets: MEDLINE

MeSH-Schlagworte: Estradiol*/urine , Estradiol*/isolation & purification , Paper* , Silicon*/chemistry , Solid Phase Microextraction*/methods, Humans ; Spectrometry, Fluorescence/methods ; Female ; Limit of Detection

Estradiol Concentrations for Adequate Gender-Affirming Feminizing Therapy: A Systematic Review.

Autoren: Winston-McPherson GN Thomas TA Krasowski MD et al.

Quelle: LGBT health [LGBT Health] 2025 Oct; Vol. 12 (7), pp. 477-489. Date of Electronic Publication: 2025 Jun 24.

Publikationsart: Journal Article; Systematic Review; Review

Info zur Zeitschrift: Publisher: Mary Ann Liebert, Inc. publishers Country of Publication: United States NLM ID: 101616707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2325-8306 (Electronic) Linking ISSN: 23258292 NLM ISO Abbreviation: LGBT Health Subsets: MEDLINE

MeSH-Schlagworte: Estradiol*/blood , Estradiol*/therapeutic use , Estradiol*/administration & dosage , Transgender Persons*, Humans ; Female ; Male

The thrombin generation potential increases after feminizing gender-affirming hormone treatment, decreases after masculinizing gender-affirming hormone treatment, and is determined by the hormone treatment regimen.

Autoren: Bøgehave M Glintborg D Christensen LL et al.

Quelle: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2025 Oct; Vol. 23 (10), pp. 3084-3097. Date of Electronic Publication: 2025 Mar 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836 (Electronic) Linking ISSN: 15387836 NLM ISO Abbreviation: J Thromb Haemost Subsets: MEDLINE

MeSH-Schlagworte: Thrombin*/metabolism , Estradiol*/administration & dosage , Estradiol*/adverse effects , Testosterone*/administration & dosage , Testosterone*/adverse effects , Cyproterone Acetate*/administration & dosage , Cyproterone Acetate*/adverse effects , Blood Coagulation*/drug effects , Transsexualism*/blood , Transsexualism*/drug therapy , Hormone Replacement Therapy*/adverse effects , Hormone Replacement Therapy*/methods , Gender-Affirming Procedures*/adverse effects, Humans ; Male ; Female ; Transgender Persons ; Adult ; Administration, Cutaneous ; Middle Aged ; Young Adult ; Injections, Intramuscular ; Administration, Oral ; Time Factors ; Adolescent ; Treatment Outcome