Suchergebnisse - "ENZYME inhibitors"

Cellular Potency Optimization of Novel Heme-Binding Imidazo[5,1- b ]thiazoles, Imidazo[1,5- a ]pyridines and Pyrazines as Potent IDO1 Inhibitors Devoid of Cytochrome P450 Inhibition.

Autoren: Cren S Lotz-Jenne C Kimmerlin T et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Oct 09; Vol. 68 (19), pp. 20130-20153. Date of Electronic Publication: 2025 Sep 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Indoleamine-Pyrrole 2,3,-Dioxygenase*/antagonists & inhibitors , Indoleamine-Pyrrole 2,3,-Dioxygenase*/metabolism , Pyridines*/pharmacology , Pyridines*/chemistry , Pyridines*/chemical synthesis , Thiazoles*/pharmacology , Thiazoles*/chemistry , Thiazoles*/chemical synthesis , Thiazoles*/metabolism , Imidazoles*/pharmacology , Imidazoles*/chemistry , Imidazoles*/chemical synthesis , Pyrazines*/pharmacology , Pyrazines*/chemistry , Pyrazines*/metabolism , Pyrazines*/chemical synthesis , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/metabolism , Heme*/metabolism, Humans ; Structure-Activity Relationship ; Cytochrome P-450 Enzyme Inhibitors/pharmacology ; Cytochrome P-450 Enzyme System/metabolism ; Animals

In silico identification and experimental validation of two types of angiotensin-converting enzyme (ACE) and xanthine oxidase (XO) milk inhibitory peptides.

Autoren: Li Z Zhang W Abubaker MA et al.

Quelle: Food chemistry [Food Chem] 2025 Feb 01; Vol. 464 (Pt 3), pp. 141864. Date of Electronic Publication: 2024 Nov 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Angiotensin-Converting Enzyme Inhibitors*/chemistry , Angiotensin-Converting Enzyme Inhibitors*/pharmacology , Peptides*/chemistry , Molecular Docking Simulation* , Xanthine Oxidase*/chemistry , Xanthine Oxidase*/metabolism, Animals ; Milk/chemistry ; Milk/enzymology ; Peptidyl-Dipeptidase A/chemistry ; Peptidyl-Dipeptidase A/metabolism ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Molecular Dynamics Simulation ; Computer Simulation ; Cattle ; Milk Proteins/chemistry ; Milk Proteins/metabolism

Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors Versus Angiotensin Receptor Blockers: Multidatabase Target Trial Emulation Studies.

Autoren: Xie C Chen R Zhou S et al.

Quelle: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2025 Dec; Vol. 82 (12), pp. 2072-2081. Date of Electronic Publication: 2025 Sep 04.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4563 (Electronic) Linking ISSN: 0194911X NLM ISO Abbreviation: Hypertension Subsets: MEDLINE

MeSH-Schlagworte: Angiotensin-Converting Enzyme Inhibitors*/therapeutic use , Angiotensin-Converting Enzyme Inhibitors*/adverse effects , Angiotensin Receptor Antagonists*/therapeutic use , Angiotensin Receptor Antagonists*/adverse effects , Hypertension*/drug therapy , Hypertension*/mortality , Hypertension*/physiopathology , Cardiovascular Diseases*/mortality, Humans ; Female ; Male ; Middle Aged ; Aged ; United Kingdom/epidemiology ; China/epidemiology ; Treatment Outcome ; Databases, Factual ; Propensity Score ; Cohort Studies

Withholding vs. continuing angiotensin-converting enzyme inhibitors or angiotensin receptor blockers before surgery: a systematic review and meta-analysis of randomized controlled trials.

Autoren: Dou W Hu JH Long YQ et al.

Quelle: Annals of medicine [Ann Med] 2025 Dec; Vol. 57 (1), pp. 2566873. Date of Electronic Publication: 2025 Sep 29.

Publikationsart: Journal Article; Systematic Review; Meta-Analysis

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8906388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2060 (Electronic) Linking ISSN: 07853890 NLM ISO Abbreviation: Ann Med Subsets: MEDLINE

MeSH-Schlagworte: Angiotensin-Converting Enzyme Inhibitors*/administration & dosage , Angiotensin-Converting Enzyme Inhibitors*/therapeutic use , Angiotensin Receptor Antagonists*/administration & dosage , Angiotensin Receptor Antagonists*/therapeutic use , Hypotension*/prevention & control , Hypotension*/epidemiology , Preoperative Care*/methods , Postoperative Complications*/prevention & control , Postoperative Complications*/epidemiology , Withholding Treatment* , Intraoperative Complications*/prevention & control , Intraoperative Complications*/epidemiology, Humans ; Randomized Controlled Trials as Topic ; Hypertension

Discovery and development of steroidal enzyme inhibitors as anti-cancer drugs: state-of-the-art and future perspectives.

Autoren: Cerra B Gioiello A

Quelle: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2483818. Date of Electronic Publication: 2025 Apr 02.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Steroids*/pharmacology , Steroids*/chemistry , Steroids*/chemical synthesis , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Drug Discovery* , Drug Development* , Neoplasms*/drug therapy, Humans ; Cell Proliferation/drug effects ; Molecular Structure ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Animals

Small Molecule Inhibitors of Nicotinamide N-Methyltransferase Enzyme for the Treatment of Osteosarcoma and Merkel Cell Carcinoma: Potential for the Development of a Targeted Therapeutic Strategy.

Autoren: Pompei V Cecati M Serritelli EN et al.

Quelle: Biomolecules [Biomolecules] 2025 Nov 05; Vol. 15 (11). Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE

MeSH-Schlagworte: Osteosarcoma*/drug therapy , Osteosarcoma*/metabolism , Osteosarcoma*/pathology , Osteosarcoma*/enzymology , Nicotinamide N-Methyltransferase*/antagonists & inhibitors , Nicotinamide N-Methyltransferase*/metabolism , Carcinoma, Merkel Cell*/drug therapy , Carcinoma, Merkel Cell*/metabolism , Carcinoma, Merkel Cell*/pathology , Carcinoma, Merkel Cell*/enzymology , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Bone Neoplasms*/drug therapy , Small Molecule Libraries*/pharmacology , Small Molecule Libraries*/chemistry, Humans ; Cell Line, Tumor ; Apoptosis/drug effects ; Reactive Oxygen Species/metabolism ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cisplatin/pharmacology

Neurohormonal therapies at baseline and follow-up and survival in wild-type transthyretin cardiac amyloidosis.

Autoren: Aimo A Milani P Tini G et al.

Quelle: Journal of cardiovascular medicine (Hagerstown, Md.) [J Cardiovasc Med (Hagerstown)] 2025 Nov 01; Vol. 26 (11), pp. 656-665. Date of Electronic Publication: 2025 Sep 26.

Publikationsart: Journal Article; Multicenter Study

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101259752 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-2035 (Electronic) Linking ISSN: 15582027 NLM ISO Abbreviation: J Cardiovasc Med (Hagerstown) Subsets: MEDLINE

MeSH-Schlagworte: Amyloid Neuropathies, Familial*/drug therapy , Amyloid Neuropathies, Familial*/mortality , Amyloid Neuropathies, Familial*/physiopathology , Amyloid Neuropathies, Familial*/diagnosis , Adrenergic beta-Antagonists*/therapeutic use , Adrenergic beta-Antagonists*/adverse effects , Angiotensin-Converting Enzyme Inhibitors*/therapeutic use , Angiotensin-Converting Enzyme Inhibitors*/adverse effects , Angiotensin Receptor Antagonists*/therapeutic use , Cardiomyopathies*/drug therapy , Cardiomyopathies*/mortality , Cardiomyopathies*/physiopathology , Cardiomyopathies*/diagnosis , Heart Failure*/drug therapy , Heart Failure*/mortality , Heart Failure*/physiopathology , Heart Failure*/etiology , Heart Failure*/diagnosis , Mineralocorticoid Receptor Antagonists*/therapeutic use, Humans ; Male ; Female ; Aged ; Aged, 80 and over ; Treatment Outcome ; Stroke Volume ; Time Factors ; Risk Factors ; Ventricular Function, Left/drug effects ; Retrospective Studies

SCR Disease Name: Amyloidosis, Hereditary, Transthyretin-Related

Optimizing renin-angiotensin-aldosterone inhibition in advanced chronic kidney disease: balancing benefits and risks.

Autoren: Spencer S Bhandari S

Quelle: Current opinion in nephrology and hypertension [Curr Opin Nephrol Hypertens] 2025 Nov 01; Vol. 34 (6), pp. 469-476. Date of Electronic Publication: 2025 Apr 10.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9303753 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-6543 (Electronic) Linking ISSN: 10624821 NLM ISO Abbreviation: Curr Opin Nephrol Hypertens Subsets: MEDLINE

MeSH-Schlagworte: Angiotensin-Converting Enzyme Inhibitors*/therapeutic use , Angiotensin-Converting Enzyme Inhibitors*/adverse effects , Renal Insufficiency, Chronic*/drug therapy , Renal Insufficiency, Chronic*/physiopathology , Renal Insufficiency, Chronic*/diagnosis , Renal Insufficiency, Chronic*/mortality , Renin-Angiotensin System*/drug effects , Angiotensin Receptor Antagonists*/therapeutic use , Angiotensin Receptor Antagonists*/adverse effects , Kidney*/physiopathology , Kidney*/drug effects , Angiotensin II Type 1 Receptor Blockers*/adverse effects , Angiotensin II Type 1 Receptor Blockers*/therapeutic use, Humans ; Risk Assessment ; Risk Factors ; Treatment Outcome ; Hyperkalemia/chemically induced ; Glomerular Filtration Rate/drug effects

Structure-based design of a novel series of cholesterol 24-hydroxylase (CH24H) inhibitors bearing 1,3-oxazole as a heme-iron binding group.

Autoren: Ito Y Hasui T Kimura E et al.

Quelle: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Oct 01; Vol. 128, pp. 118280. Date of Electronic Publication: 2025 Jun 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Oxazoles*/chemistry , Oxazoles*/pharmacology , Oxazoles*/chemical synthesis , Drug Design* , Cholesterol 24-Hydroxylase*/antagonists & inhibitors , Cholesterol 24-Hydroxylase*/metabolism , Heme*/chemistry , Heme*/metabolism , Iron*/chemistry , Iron*/metabolism , Cytochrome P-450 Enzyme Inhibitors*/chemistry , Cytochrome P-450 Enzyme Inhibitors*/pharmacology , Cytochrome P-450 Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology, Animals ; Structure-Activity Relationship ; Mice ; Molecular Structure ; Humans ; Brain/metabolism ; Dose-Response Relationship, Drug ; Male

Bioactivity-guided isolation of pancreatic lipase inhibitors from Lycium ruthenicum using a novel HPLC-FLD/pancreatic lipase online recognition system.

Autoren: Li Y Zhang Y Zhang L et al.

Quelle: Food chemistry [Food Chem] 2025 Dec 30; Vol. 497, pp. 147031. Date of Electronic Publication: 2025 Nov 08.

Publikationsart: Journal Article; Evaluation Study

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Lipase*/antagonists & inhibitors , Lipase*/chemistry , Enzyme Inhibitors*/isolation & purification , Enzyme Inhibitors*/chemistry , Lycium*/chemistry , Plant Extracts*/chemistry , Plant Extracts*/isolation & purification, Chromatography, High Pressure Liquid/methods ; Chromatography, High Pressure Liquid/instrumentation ; Molecular Docking Simulation ; Pancreas/enzymology ; Humans

Nicotinamide delays browning in fresh-cut apples through reducing Chlorogenic acid and inhibiting PPO activity.

Autoren: Wang C Dai LP Bai XR et al.

Quelle: Food chemistry [Food Chem] 2025 Dec 25; Vol. 496 (Pt 2), pp. 146738. Date of Electronic Publication: 2025 Oct 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Chlorogenic Acid*/metabolism , Chlorogenic Acid*/chemistry , Chlorogenic Acid*/analysis , Niacinamide*/pharmacology , Niacinamide*/chemistry , Malus*/chemistry , Malus*/enzymology , Malus*/drug effects , Malus*/metabolism , Catechol Oxidase*/chemistry , Catechol Oxidase*/metabolism , Catechol Oxidase*/antagonists & inhibitors , Catechol Oxidase*/genetics , Fruit*/chemistry , Fruit*/drug effects , Fruit*/enzymology , Fruit*/metabolism , Plant Proteins*/metabolism , Plant Proteins*/chemistry , Plant Proteins*/antagonists & inhibitors , Plant Proteins*/genetics , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry, Maillard Reaction/drug effects

Microwave-assisted deep eutectic solvent extraction of star anise polysaccharides: Role of hydroxyl (OH) group density in the extraction media on the properties and bioactivities of polysaccharides.

Autoren: Alias AHD Shafie MH

Quelle: Food chemistry [Food Chem] 2025 Dec 25; Vol. 496 (Pt 1), pp. 146686. Date of Electronic Publication: 2025 Oct 09.

Publikationsart: Journal Article; Evaluation Study

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Polysaccharides*/chemistry , Polysaccharides*/isolation & purification , Plant Extracts*/isolation & purification , Plant Extracts*/chemistry , Chemical Fractionation*/methods , Chemical Fractionation*/instrumentation , Enzyme Inhibitors*/isolation & purification , Enzyme Inhibitors*/chemistry, Microwaves ; Antioxidants/isolation & purification ; Antioxidants/chemistry ; Deep Eutectic Solvents/chemistry ; Molecular Weight ; Viscosity

Development of novel analogs of the TRi-1 and TRi-2 selenoprotein thioredoxin reductase inhibitors with initial assessment of their cytotoxicity profiles.

Autoren: Jović M Gencheva R Scholzen KC et al.

Quelle: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 16; Vol. 241, pp. 689-706. Date of Electronic Publication: 2025 Sep 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH-Schlagworte: Thioredoxin Reductase 1*/antagonists & inhibitors , Thioredoxin Reductase 1*/metabolism , Thioredoxin Reductase 1*/genetics , Thioredoxin Reductase 2*/antagonists & inhibitors , Thioredoxin Reductase 2*/metabolism , Thioredoxin Reductase 2*/genetics , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/chemistry , Organophosphorus Compounds*/pharmacology , Organophosphorus Compounds*/chemical synthesis , Organophosphorus Compounds*/chemistry , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology, Humans ; A549 Cells ; Mitochondria/drug effects ; Mitochondria/metabolism ; Cell Line, Tumor ; NF-E2-Related Factor 2/metabolism ; NF-E2-Related Factor 2/genetics

Discovery of selective mPGES-1 inhibitors through pharmacophore modeling, molecular docking, and quantum chemical analysis.

Autoren: Saravanan V Mohan Maruga Raja M Muthukumaradoss K

Quelle: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Dec 15; Vol. 792, pp. 152956. Date of Electronic Publication: 2025 Nov 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH-Schlagworte: Prostaglandin-E Synthases*/antagonists & inhibitors , Prostaglandin-E Synthases*/chemistry , Prostaglandin-E Synthases*/metabolism , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Drug Discovery* , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology, Molecular Docking Simulation ; Humans ; Quantum Theory ; Ligands ; Drug Design ; Pharmacophore

Lactiplantibacillus plantarum-mediated bioconversion of blue honeysuckle juice amplifies phenolics to inhibit xanthine oxidase and reshapes volatile metabolome.

Autoren: Liu JY Ruan W Yu H et al.

Quelle: Food chemistry [Food Chem] 2025 Dec 15; Vol. 495 (Pt 2), pp. 146350. Date of Electronic Publication: 2025 Sep 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Lonicera*/microbiology , Lonicera*/chemistry , Lonicera*/metabolism , Xanthine Oxidase*/antagonists & inhibitors , Xanthine Oxidase*/metabolism , Xanthine Oxidase*/chemistry , Fruit and Vegetable Juices*/analysis , Fruit and Vegetable Juices*/microbiology , Phenols*/metabolism , Phenols*/chemistry , Phenols*/pharmacology , Volatile Organic Compounds*/metabolism , Volatile Organic Compounds*/chemistry , Lactobacillus plantarum*/metabolism , Enzyme Inhibitors*/metabolism , Enzyme Inhibitors*/chemistry , Lactobacillaceae*/metabolism, Fermentation ; Metabolome

Boosting health: Candida phyllophila J14-4 fermentation enhances angiotensin-converting enzyme inhibition and antihypertensive properties in wheat wort.

Autoren: Guo X Wang M Cheng Y et al.

Quelle: Food chemistry [Food Chem] 2025 Dec 15; Vol. 495 (Pt 3), pp. 146533. Date of Electronic Publication: 2025 Sep 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Triticum*/microbiology , Triticum*/metabolism , Triticum*/chemistry , Angiotensin-Converting Enzyme Inhibitors*/metabolism , Angiotensin-Converting Enzyme Inhibitors*/chemistry , Angiotensin-Converting Enzyme Inhibitors*/administration & dosage , Antihypertensive Agents*/metabolism , Antihypertensive Agents*/chemistry , Antihypertensive Agents*/administration & dosage , Hypertension*/drug therapy , Hypertension*/physiopathology , Hypertension*/enzymology , Candida*/metabolism, Fermentation ; Animals ; Rats ; Rats, Inbred SHR ; Male ; Humans ; Fermented Foods/microbiology ; Fermented Foods/analysis ; Peptidyl-Dipeptidase A/metabolism

Discovery of inhibitors of the cancer-promoting phosphatase PRL-3 and their evaluation in intestinal organoids.

Autoren: Hoffmann A Weyershaeuser J Chand Y et al.

Quelle: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Dec 15; Vol. 131, pp. 118412. Date of Electronic Publication: 2025 Sep 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Protein Tyrosine Phosphatases*/antagonists & inhibitors , Protein Tyrosine Phosphatases*/metabolism , Organoids*/drug effects , Organoids*/metabolism , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Drug Discovery* , Neoplasm Proteins*/antagonists & inhibitors , Neoplasm Proteins*/metabolism , Intestines*/drug effects , Intestines*/cytology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis, Animals ; Humans ; Mice ; Structure-Activity Relationship ; Molecular Structure ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology

Targeting virulence to disarm the pathogen: Enzyme-activated-substrate inhibition of Anthrax edema factor.

Autoren: Kim S Cregar-Hernandez L Moayeri M et al.

Quelle: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Dec 15; Vol. 129, pp. 130393. Date of Electronic Publication: 2025 Sep 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

MeSH-Schlagworte: Bacillus anthracis*/drug effects , Bacillus anthracis*/enzymology , Bacillus anthracis*/pathogenicity , Bacterial Toxins*/antagonists & inhibitors , Bacterial Toxins*/metabolism , Antigens, Bacterial*/metabolism , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Adenylyl Cyclases*/metabolism, Structure-Activity Relationship ; Anthrax/drug therapy ; Molecular Structure ; Humans

Targeted degradation of Werner syndrome helicase (WRN) via ligand-directed covalent hydrophobic tagging.

Autoren: Tao W Zhu J Fu Z et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118121. Date of Electronic Publication: 2025 Sep 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Werner Syndrome Helicase*/metabolism , Werner Syndrome Helicase*/antagonists & inhibitors , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis, Humans ; Hydrophobic and Hydrophilic Interactions ; Ligands ; Structure-Activity Relationship ; Molecular Structure ; Cell Proliferation/drug effects ; Proteolysis/drug effects ; Dose-Response Relationship, Drug

Screening for alcohol dehydrogenase inhibitors in natural compounds by electrophoretically mediated microanalysis.

Autoren: Su Y Yang R Yu Y et al.

Quelle: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2025 Dec 15; Vol. 266, pp. 117073. Date of Electronic Publication: 2025 Jul 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

MeSH-Schlagworte: Alcohol Dehydrogenase*/antagonists & inhibitors , Alcohol Dehydrogenase*/metabolism , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/analysis , Biological Products*/chemistry , Biological Products*/pharmacology, Molecular Docking Simulation/methods ; Electrophoresis, Capillary/methods ; Flavonoids/pharmacology ; Flavonoids/chemistry ; Kaempferols/pharmacology ; Kaempferols/chemistry ; Emodin/pharmacology ; Emodin/chemistry ; Kinetics ; Drug Evaluation, Preclinical/methods