Suchergebnisse - "Drug Synergism"

Dual β-lactam synergy in Enterococcus faecalis and its relationship with penicillin-ceftriaxone infective endocarditis treatment outcomes.

Autoren: Gregson A Mowlaboccus S Sudeep SM et al.

Quelle: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2025 Dec 02; Vol. 80 (12), pp. 3357-3366.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE

MeSH-Schlagworte: Ceftriaxone*/pharmacology , Ceftriaxone*/therapeutic use , Enterococcus faecalis*/drug effects , Enterococcus faecalis*/isolation & purification , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Gram-Positive Bacterial Infections*/drug therapy , Gram-Positive Bacterial Infections*/microbiology , Drug Synergism* , Endocarditis, Bacterial*/drug therapy , Endocarditis, Bacterial*/microbiology , beta-Lactams*/pharmacology , beta-Lactams*/therapeutic use, Humans ; Male ; Female ; Retrospective Studies ; Microbial Sensitivity Tests ; Treatment Outcome ; Middle Aged ; Aged ; Adult ; Sensitivity and Specificity ; Aged, 80 and over

The synergistic activity of tigecycline-based combinations against multidrug-resistant Acinetobacter baumannii-caused bloodstream infections.

Autoren: Zhang H Liang B Tan Z et al.

Quelle: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2025 Dec 02; Vol. 80 (12), pp. 3407-3418.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE

MeSH-Schlagworte: Tigecycline*/pharmacology , Tigecycline*/therapeutic use , Tigecycline*/pharmacokinetics , Tigecycline*/administration & dosage , Acinetobacter baumannii*/drug effects , Acinetobacter baumannii*/isolation & purification , Acinetobacter Infections*/drug therapy , Acinetobacter Infections*/microbiology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/pharmacokinetics , Anti-Bacterial Agents*/therapeutic use , Anti-Bacterial Agents*/administration & dosage , Drug Synergism* , Drug Resistance, Multiple, Bacterial* , Bacteremia*/drug therapy , Bacteremia*/microbiology , Minocycline*/analogs & derivatives , Minocycline*/pharmacology, Animals ; Humans ; Microbial Sensitivity Tests ; Mice ; Disease Models, Animal ; Meropenem/pharmacology ; Meropenem/therapeutic use ; Meropenem/pharmacokinetics ; Meropenem/administration & dosage ; Drug Therapy, Combination/methods ; Female ; Male

Isoniazid potentiates tigecycline to kill methicillin-resistant Staphylococcus aureus .

Autoren: Chen XW Chen HQ Wu JH et al.

Quelle: Emerging microbes & infections [Emerg Microbes Infect] 2025 Dec; Vol. 14 (1), pp. 2434587. Date of Electronic Publication: 2024 Dec 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE

MeSH-Schlagworte: Tigecycline*/pharmacology , Methicillin-Resistant Staphylococcus aureus*/drug effects , Isoniazid*/pharmacology , Drug Synergism* , Microbial Sensitivity Tests* , Anti-Bacterial Agents*/pharmacology , Staphylococcal Infections*/drug therapy , Staphylococcal Infections*/microbiology, Animals ; Mice ; Humans

Physiologically informed in vitro framework reveals context-dependent combinatory activity of niclosamide-colistin against Gram-negative bacteria.

Autoren: Romero-Gonzalez M Park M Lin W et al.

Quelle: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2025 Nov 04; Vol. 80 (11), pp. 2958-2969.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE

MeSH-Schlagworte: Niclosamide*/pharmacology , Niclosamide*/pharmacokinetics , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/pharmacokinetics , Drug Synergism* , Gram-Negative Bacteria*/drug effects , Colistin*/pharmacology , Colistin*/pharmacokinetics, Microbial Sensitivity Tests ; Humans ; Hydrogen-Ion Concentration

BridgeSyn: a bridging fusion framework for drug combination synergy prediction.

Autoren: Wang Q Mao S Liu X et al.

Quelle: Briefings in bioinformatics [Brief Bioinform] 2025 Nov 01; Vol. 26 (6).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 100912837 Publication Model: Print Cited Medium: Internet ISSN: 1477-4054 (Electronic) Linking ISSN: 14675463 NLM ISO Abbreviation: Brief Bioinform Subsets: MEDLINE

MeSH-Schlagworte: Drug Synergism* , Computational Biology*/methods , Software*, Humans ; Drug Combinations ; Algorithms

Synergistic Drug Combination Prediction via Dual-Level Feature Aggregation and Knowledge Graph-Based Deep Neural Network.

Autoren: Zuo Y Zhang Y Wang L et al.

Quelle: IEEE journal of biomedical and health informatics [IEEE J Biomed Health Inform] 2025 Nov; Vol. 29 (11), pp. 7945-7954.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Institute of Electrical and Electronics Engineers Country of Publication: United States NLM ID: 101604520 Publication Model: Print Cited Medium: Internet ISSN: 2168-2208 (Electronic) Linking ISSN: 21682194 NLM ISO Abbreviation: IEEE J Biomed Health Inform Subsets: MEDLINE

MeSH-Schlagworte: Neural Networks, Computer* , Drug Synergism* , Computational Biology*/methods , Deep Learning*, Humans ; Drug Combinations

Enhancing Drug Synergy Combination: Integrating Graph Transformers and BiLSTM for Accurate Drug Synergy Prediction.

Autoren: Sun B Du H Hou S et al.

Quelle: IEEE journal of biomedical and health informatics [IEEE J Biomed Health Inform] 2025 Nov; Vol. 29 (11), pp. 7922-7931.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Institute of Electrical and Electronics Engineers Country of Publication: United States NLM ID: 101604520 Publication Model: Print Cited Medium: Internet ISSN: 2168-2208 (Electronic) Linking ISSN: 21682194 NLM ISO Abbreviation: IEEE J Biomed Health Inform Subsets: MEDLINE

MeSH-Schlagworte: Drug Synergism* , Computational Biology*/methods, Humans ; Neural Networks, Computer ; Algorithms

GraphFusion: Integrative prediction of drug synergy using multi-scale graph representations and cell line contexts.

Autoren: Zeng B Tu S Xu L

Quelle: Journal of biomedical informatics [J Biomed Inform] 2025 Nov; Vol. 171, pp. 104921. Date of Electronic Publication: 2025 Sep 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 100970413 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-0480 (Electronic) Linking ISSN: 15320464 NLM ISO Abbreviation: J Biomed Inform Subsets: MEDLINE

MeSH-Schlagworte: Drug Synergism* , Computational Biology*/methods , Antineoplastic Agents*/pharmacology, Humans ; Cell Line, Tumor ; Machine Learning ; Neoplasms/drug therapy ; Algorithms

GLA-Synergy: An Interpretable Global-Local Adaptive Framework for Drug Synergy Prediction in Cancer Treatment.

Autoren: Deng L Yan S Yang J et al.

Quelle: Journal of chemical information and modeling [J Chem Inf Model] 2025 Oct 27; Vol. 65 (20), pp. 11385-11399. Date of Electronic Publication: 2025 Oct 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101230060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-960X (Electronic) Linking ISSN: 15499596 NLM ISO Abbreviation: J Chem Inf Model Subsets: MEDLINE

MeSH-Schlagworte: Neoplasms*/drug therapy , Neoplasms*/pathology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/chemistry , Drug Synergism*, Humans ; Deep Learning ; Neural Networks, Computer ; Cell Line, Tumor

CASynergy: A causal attention model for interpretable prediction of cancer drug synergy.

Autoren: Li H Zheng L Li L et al.

Quelle: PLoS computational biology [PLoS Comput Biol] 2025 Oct 15; Vol. 21 (10), pp. e1013567. Date of Electronic Publication: 2025 Oct 15 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7358 (Electronic) Linking ISSN: 1553734X NLM ISO Abbreviation: PLoS Comput Biol Subsets: MEDLINE

MeSH-Schlagworte: Neoplasms*/drug therapy , Neoplasms*/genetics , Drug Synergism* , Antineoplastic Agents*/pharmacology, Humans ; Computational Biology/methods ; Algorithms ; Cell Line, Tumor ; Deep Learning ; Gene Regulatory Networks/drug effects

DGSS: A Dynamic Interaction Graph Neural Network with Specific Substructure Awareness for Drug Synergy Prediction.

Autoren: Ge J Han P Xu R et al.

Quelle: Journal of chemical information and modeling [J Chem Inf Model] 2025 Oct 13; Vol. 65 (19), pp. 10549-10560. Date of Electronic Publication: 2025 Sep 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101230060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-960X (Electronic) Linking ISSN: 15499596 NLM ISO Abbreviation: J Chem Inf Model Subsets: MEDLINE

MeSH-Schlagworte: Neural Networks, Computer* , Drug Synergism* , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry, Humans ; Graph Neural Networks

Synergistic cefiderocol-containing antibiotic combinations active against highly drug-resistant Acinetobacter baumannii patient isolates with diverse resistance mechanisms.

Autoren: Halim J Keane AP Bouzo J et al.

Quelle: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2025 Oct 03; Vol. 80 (10), pp. 2814-2824.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE

MeSH-Schlagworte: Acinetobacter baumannii*/drug effects , Acinetobacter baumannii*/genetics , Acinetobacter baumannii*/isolation & purification , Anti-Bacterial Agents*/pharmacology , Cephalosporins*/pharmacology , Drug Synergism* , Drug Resistance, Multiple, Bacterial*/genetics, Humans ; Microbial Sensitivity Tests ; Acinetobacter Infections/microbiology ; Acinetobacter Infections/drug therapy ; Cefiderocol/pharmacology ; Drug Combinations ; Ceftazidime/pharmacology ; Azabicyclo Compounds/pharmacology ; beta-Lactamases/genetics

Synergistic drug strategy against mastitis-associated MRSA strains.

Autoren: Li X Yao L Qian L

Quelle: Future microbiology [Future Microbiol] 2025 Oct; Vol. 20 (15), pp. 1007-1016. Date of Electronic Publication: 2025 Oct 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101278120 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1746-0921 (Electronic) Linking ISSN: 17460913 NLM ISO Abbreviation: Future Microbiol Subsets: MEDLINE

MeSH-Schlagworte: Methicillin-Resistant Staphylococcus aureus*/drug effects , Methicillin-Resistant Staphylococcus aureus*/isolation & purification , Staphylococcal Infections*/microbiology , Staphylococcal Infections*/drug therapy , Drug Synergism* , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Mastitis*/microbiology , Mastitis*/drug therapy, Animals ; Female ; Microbial Sensitivity Tests ; Humans ; Disease Models, Animal ; Drug Therapy, Combination ; Drug Resistance, Multiple, Bacterial ; Moths/microbiology ; Rifampin/pharmacology ; Oxacillin/pharmacology ; Microbial Viability/drug effects ; Larva/microbiology

FRSynergy: A Feature Refinement Network for Synergistic Drug Combination Prediction.

Autoren: Li L Li H Zheng C et al.

Quelle: IEEE journal of biomedical and health informatics [IEEE J Biomed Health Inform] 2025 Oct; Vol. 29 (10), pp. 7682-7693.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Institute of Electrical and Electronics Engineers Country of Publication: United States NLM ID: 101604520 Publication Model: Print Cited Medium: Internet ISSN: 2168-2208 (Electronic) Linking ISSN: 21682194 NLM ISO Abbreviation: IEEE J Biomed Health Inform Subsets: MEDLINE

MeSH-Schlagworte: Drug Synergism* , Deep Learning*, Humans ; Cell Line, Tumor ; Drug Combinations

Predicting synergistic drug combinations via hierarchical molecular representation and cell line latent space fusion.

Autoren: Bai C Han X Li S et al.

Quelle: Computer methods and programs in biomedicine [Comput Methods Programs Biomed] 2025 Oct; Vol. 270, pp. 108933. Date of Electronic Publication: 2025 Jul 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8506513 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7565 (Electronic) Linking ISSN: 01692607 NLM ISO Abbreviation: Comput Methods Programs Biomed Subsets: MEDLINE

MeSH-Schlagworte: Drug Synergism* , Antineoplastic Agents*/pharmacology, Humans ; Cell Line, Tumor ; Deep Learning ; Neoplasms/drug therapy ; Algorithms ; Drug Combinations ; Computational Biology

Synergistic antifungal effect of naturally-derived antimicrobials with penetration enhancer against Candida albicans biofilm at 5 °C and 22 °C.

Autoren: Ko BS Park SG Rhee MS

Quelle: Journal of infection and public health [J Infect Public Health] 2025 Oct; Vol. 18 (10), pp. 102882. Date of Electronic Publication: 2025 Jun 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 101487384 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-035X (Electronic) Linking ISSN: 18760341 NLM ISO Abbreviation: J Infect Public Health Subsets: MEDLINE

MeSH-Schlagworte: Biofilms*/drug effects , Candida albicans*/drug effects , Candida albicans*/physiology , Antifungal Agents*/pharmacology , Drug Synergism* , Propylene Glycol*/pharmacology , Caprylates*/pharmacology, Cymenes ; Monoterpenes/pharmacology ; Microscopy, Electron, Scanning ; Cold Temperature ; Microscopy, Confocal ; Microbial Sensitivity Tests

Investigation of synergic activity of ceftazidime and colistin, and the effect of baicalin on biofilms.

Autoren: Biyik İ Tanriverdi Çayci Y Birinci A

Quelle: Journal of infection in developing countries [J Infect Dev Ctries] 2025 Sep 30; Vol. 19 (9), pp. 1384-1390. Date of Electronic Publication: 2025 Sep 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Open Learning on Enteric Pathogens Country of Publication: Italy NLM ID: 101305410 Publication Model: Electronic Cited Medium: Internet ISSN: 1972-2680 (Electronic) Linking ISSN: 19722680 NLM ISO Abbreviation: J Infect Dev Ctries Subsets: MEDLINE

MeSH-Schlagworte: Biofilms*/drug effects , Biofilms*/growth & development , Colistin*/pharmacology , Ceftazidime*/pharmacology , Flavonoids*/pharmacology , Pseudomonas aeruginosa*/drug effects , Pseudomonas aeruginosa*/isolation & purification , Pseudomonas aeruginosa*/physiology , Drug Synergism* , Anti-Bacterial Agents*/pharmacology, Humans ; Microbial Sensitivity Tests ; Pseudomonas Infections/microbiology

Paradoxical interaction between dalbavancin and β-lactams against endocarditis-associated Enterococcus faecalis clinical isolates.

Autoren: Luque Paz D Turban A Guérin F et al.

Quelle: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2025 Sep 03; Vol. 80 (9), pp. 2524-2529.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE

MeSH-Schlagworte: Enterococcus faecalis*/drug effects , Enterococcus faecalis*/isolation & purification , Teicoplanin*/analogs & derivatives , Teicoplanin*/pharmacology , beta-Lactams*/pharmacology , Anti-Bacterial Agents*/pharmacology , Gram-Positive Bacterial Infections*/microbiology , Drug Synergism* , Endocarditis, Bacterial*/microbiology, Microbial Sensitivity Tests ; Humans ; Drug Interactions ; Microbial Viability/drug effects

Synergistic effects of DHA27 combined with gentamicin against methicillin-resistant Staphylococcus aureus in vitro and in vivo.

Autoren: Chen X Ouyang F Wang N et al.

Quelle: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2025 Sep 03; Vol. 80 (9), pp. 2447-2458.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE

MeSH-Schlagworte: Methicillin-Resistant Staphylococcus aureus*/drug effects , Methicillin-Resistant Staphylococcus aureus*/ultrastructure , Gentamicins*/pharmacology , Gentamicins*/administration & dosage , Gentamicins*/therapeutic use , Staphylococcal Infections*/drug therapy , Staphylococcal Infections*/microbiology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/administration & dosage , Anti-Bacterial Agents*/therapeutic use , Drug Synergism*, Animals ; Microbial Sensitivity Tests ; Mice ; Disease Models, Animal ; Sepsis/drug therapy ; Sepsis/microbiology ; Microscopy, Electron, Transmission ; Microscopy, Electron, Scanning ; Gene Expression Profiling ; Bacterial Proteins/genetics ; Mice, Inbred BALB C ; Chromatography, Liquid ; Real-Time Polymerase Chain Reaction

Protein Spatial Structure Meets Artificial Intelligence: Revolutionizing Drug Synergy-Antagonism in Precision Medicine.

Autoren: Lin A Che C Jiang A et al.

Quelle: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Sep; Vol. 12 (33), pp. e07764. Date of Electronic Publication: 2025 Aug 07.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH-Schlagworte: Precision Medicine*/methods , Artificial Intelligence* , Drug Synergism* , Drug Design* , Proteins*/chemistry, Humans ; Molecular Docking Simulation