Search Results - "Drug Repositioning methods"

Repurposing of H1-receptor antagonists (levo)cetirizine, (des)loratadine, and fexofenadine as a case study for systematic analysis of trials on clinicaltrials.gov using semi-automated processes with custom-coded software

Authors: Specht, Tim Seifert, Roland

Source: Naunyn Schmiedebergs Arch Pharmacol

Subject Terms: 0301 basic medicine, 0303 health sciences, Clinical Trials as Topic, Histamine H1 Antagonists, Non-Sedating, Research, Drug Repositioning, COVID-19, Loratadine, Cetirizine, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Histamine H1 Antagonists/therapeutic use [MeSH], Drug repurposing, H, Humans [MeSH], Software [MeSH], Drug Repositioning/methods [MeSH], Terfenadine/therapeutic use [MeSH], Clinical Trials as Topic/methods [MeSH], Terfenadine/analogs, Information storage and retrieval, COVID-19 [MeSH], Loratadine/analogs, Cetirizine/therapeutic use [MeSH], Clinical trials as topic, Loratadine/therapeutic use [MeSH], Histamine H1 Antagonists, Non-Sedating/therapeutic use [MeSH], Histamine H1 Antagonists, Humans, Terfenadine, Software

Access URL: https://pubmed.ncbi.nlm.nih.gov/37870580
https://repository.publisso.de/resource/frl:6520123

Drug Repositioning Using Temporal Trajectories of Accompanying Comorbidities in Diabetes Mellitus

Authors: Namgi Park Ja Young Jeon Eugene Jeong et al.

Contributors: Namgi Park Ja Young Jeon Eugene Jeong et al.

Source: Endocrinol Metab (Seoul)
Endocrinology and Metabolism, Vol 37, Iss 1, Pp 65-73 (2022)

Subject Terms: Adult, 0301 basic medicine, drug repositioning, Comorbidity, Diseases of the endocrine glands. Clinical endocrinology, Diabetes Complications, 03 medical and health sciences, Diabetes Mellitus, Type 2* / drug therapy, Humans, 0303 health sciences, Type 2* / complications, Drug repositioning, Drug Repositioning, RC648-665, 3. Good health, Retrospective studies, retrospective studies, type 2, Diabetes Mellitus, Type 2, Case-Control Studies, diabetes mellitus, Drug Repositioning / methods, Original Article

Access URL: https://www.e-enm.org/upload/pdf/enm-2021-1275.pdf
https://pubmed.ncbi.nlm.nih.gov/35144331
https://doaj.org/article/aa7457a1346540aa8d52032ea6e1cf5f

Use of repurposed and adjuvant drugs in hospital patients with covid-19:Multinational network cohort study

Authors: Prats-Uribe, Albert Sena, Anthony G. Lai, Lana Yin Hui et al.

Source: Prats-Uribe, A, Sena, A G, Lai, L Y H, Ahmed, W U R, Alghoul, H, Alser, O, Alshammari, T M, Areia, C, Carter, W, Casajust, P, Dawoud, D, Golozar, A, Jonnagaddala, J, Mehta, P P, Gong, M, Morales, D R, Nyberg, F, Posada, J D, Recalde, M, Roel, E, Shah, K, Shah, N H, Schilling, L M, Subbian, V, Vizcaya, D, Zhang, L, Zhang, Y, Zhu, H, Liu, L, Cho, J, Lynch, K E, Matheny, M E, You, S C, Rijnbeek, P R, Hripcsak, G, Lane, J C E, Burn, E, Reich, C, Suchard, M A, Duarte-Salles, T, Kostka, ....

Subject Terms: Administrative Claims, Healthcare/statistics & numerical data, Adolescent, Adrenal Cortex Hormones/therapeutic use, Adult, Aged, 80 and over, Azithromycin/therapeutic use, COVID-19/diagnosis, Ceftriaxone/therapeutic use, Chemotherapy, Adjuvant/methods, Child, Preschool, China/epidemiology, Cohort Studies, Drug Combinations, Drug Repositioning/methods, Electronic Health Records/statistics & numerical data, Enoxaparin/therapeutic use, Female, Fluoroquinolones/therapeutic use, Humans, Hydroxychloroquine/therapeutic use, Infant, Newborn, Inpatients, Lopinavir/therapeutic use, Male, Middle Aged

File Description: application/pdf

Availability: https://portal.findresearcher.sdu.dk/da/publications/c0b4c38a-de1a-4e41-a55c-558e7d8fbb4e
https://doi.org/10.1136/bmj.n1038
https://findresearcher.sdu.dk/ws/files/182690792/Prats_uribe_2021_Use_of_repurposed_and_adjuvant_drug.pdf

Recycling the purpose of old drugs to treat ovarian cancer

Authors: Nunes, M Abreu, MH Bartosch, C et al.

Contributors: Nunes, M Abreu, MH Bartosch, C et al.

Subject Terms: Chemoresistance, Drug repurposing, Ex vivo cultures, Ovarian cancer, Diphosphonates / therapeutic use, Drug Repositioning / methods, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use, Itraconazole / therapeutic use, Ivermectin / therapeutic use, Metformin / therapeutic use, Neoplasm Recurrence, Local / prevention & control, Ovarian Neoplasms / drug therapy, Ovarian Neoplasms / pathology, Ritonavir / therapeutic use

File Description: application/pdf

Relation: info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FMEC-ONC%2F29503%2F2017/PT; International Journal of Molecular Sciences, vol.21(20):7768; https://www.mdpi.com/1422-0067/21/20/7768; https://hdl.handle.net/10216/145250

Availability: https://hdl.handle.net/10216/145250
https://doi.org/10.3390/ijms21207768

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

Authors: Sadegh, Sepideh Matschinske, Julian Blumenthal, David B. et al.

Source: Sadegh, S, Matschinske, J, Blumenthal, D B, Galindez, G, Kacprowski, T, List, M, Nasirigerdeh, R, Oubounyt, M, Pichlmair, A, Rose, T D, Salgado-Albarrán, M, Späth, J, Stukalov, A, Wenke, N K, Yuan, K, Pauling, J K & Baumbach, J 2020, 'Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing', Nature Communications, vol. 11, 3518. https://doi.org/10.1038/s41467-020-17189-2

Subject Terms: Algorithms, Antiviral Agents/therapeutic use, Betacoronavirus/drug effects, COVID-19, Computer Simulation, Coronavirus Infections/drug therapy, Drug Repositioning/methods, Host Microbial Interactions/physiology, Humans, Internet, Pandemics, Pneumonia, Viral/drug therapy, Protein Interaction Maps, SARS-CoV-2, Virus Attachment/drug effects

File Description: application/pdf

Availability: https://portal.findresearcher.sdu.dk/da/publications/6621fc1a-64fb-4eaa-a50b-acb87d7aef3e
https://doi.org/10.1038/s41467-020-17189-2
https://findresearcher.sdu.dk/ws/files/171457237/s41467_020_17189_2.pdf

Systems pharmacology-based integration of human and mouse data for drug repurposing to treat thoracic aneurysms

Authors: Hansen, Jens Galatioto, Josephine Caescu, Cristina I et al.

Source: Hansen, J, Galatioto, J, Caescu, C I, Arnaud, P, Calizo, R C, Spronck, B, Murtada, S-I, Borkar, R, Weinberg, A, Azeloglu, E U, Bintanel-Morcillo, M, Gallo, J M, Humphrey, J D, Jondeau, G, Boileau, C, Ramirez, F & Iyengar, R 2019, 'Systems pharmacology-based integration of human and mouse data for drug repurposing to treat thoracic aneurysms', JCI INSIGHT, vol. 4, no. 11, 027652. https://doi.org/10.1172/jci.insight.127652

Subject Terms: Animals, Aortic Aneurysm, Thoracic/drug therapy, Cardiovascular Agents/pharmacology, Disease Models, Animal, Drug Repositioning/methods, Gene Expression Profiling, Humans, Marfan Syndrome/complications, Mice, Transgenic, Transcriptome/drug effects, IDENTIFY, AORTIC-ANEURYSM, RECEPTOR, MARFAN, EXPRESSION SIGNATURES, INHIBITION, DISEASE, GENES, PROGRESSION

Relation: info:eu-repo/semantics/altIdentifier/pmid/31167969; info:eu-repo/semantics/altIdentifier/wos/000470657800016; info:eu-repo/semantics/altIdentifier/pissn/2379-3708

Availability: https://cris.maastrichtuniversity.nl/en/publications/5bb48844-d5dc-4bc6-9fe9-a20fe1efecac
https://doi.org/10.1172/jci.insight.127652
https://www.scopus.com/pages/publications/85070661366

A combined systems and structural modeling approach repositions antibiotics for Mycoplasma genitalium

Authors: Kazakiewicz, Denis Karr, Jonathan Langner, Karol et al.

Source: Computational Biology and Chemistry. 59:91-97

Subject Terms: Mycoplasma genitalium - enzymology, 0301 basic medicine, Mycoplasma genitalium - drug effects, Mycoplasma genitalium, Microbial Sensitivity Tests, Microbial sensitivity tests, Nucleoside-phosphate kinase - metabolism, Models, Biological, 03 medical and health sciences, Piperidines, Models, Humans, Piperidines - chemistry, Thymine - analogs & derivatives, 0303 health sciences, Binding Sites, Anti-bacterial agents - chemistry, Systems Biology, Piperidines - pharmacology, Drug Repositioning, Thymine - chemistry, Nucleoside-phosphate kinase - antagonists & inhibitors, Binding sites - drug effects, Anti-bacterial agents - pharmacology, Anti-Bacterial Agents, 3. Good health, Drug repositioning - methods, Thymine - pharmacology, Systems biology, Nucleoside-Phosphate Kinase, biological, Algorithms, Thymine

Access URL: https://pubmed.ncbi.nlm.nih.gov/26271684
http://www.ncbi.nlm.nih.gov/pubmed/26271684
https://doi.org/10.1016/j.compbiolchem.2015.07.007
https://dblp.uni-trier.de/db/journals/candc/candc59.html#KazakiewiczKLP15
https://www.sciencedirect.com/science/article/pii/S147692711530089X
http://www.karrlab.org/static/doc/papers/Kazakiewicz2015.pdf
http://www.sciencedirect.com/science/article/pii/S147692711530089X

Recommendations for Dosing of Repurposed COVID-19 Medications in Patients with Renal and Hepatic Impairment

Authors: Fiona Marra Saye Khoo Marco Siccardi et al.

Source: Drugs R D
DRUGS IN R&D
Drugs in R&D, 21, 1, pp. 9-27
Drugs in R&D, vol. 21, no. 1, pp. 9-27
Drugs in R&D

Subject Terms: Pharmacology, 0301 basic medicine, Clinical Trials as Topic, 0303 health sciences, Alanine, Dose-Response Relationship, Drug, Liver Diseases, Adenosine Monophosphate/administration & dosage, Adenosine Monophosphate/analogs & derivatives, Alanine/administration & dosage, Alanine/analogs & derivatives, Antiviral Agents/administration & dosage, COVID-19/diagnosis, COVID-19/epidemiology, Clinical Trials as Topic/methods, Dexamethasone/administration & dosage, Drug Repositioning/methods, Humans, Hydroxychloroquine/administration & dosage, Kidney Diseases/diagnosis, Kidney Diseases/drug therapy, Kidney Diseases/epidemiology, Liver Diseases/diagnosis, Liver Diseases/drug therapy, Liver Diseases/epidemiology, COVID-19 Drug Treatment, Drug Repositioning, COVID-19, Clinical Pharmacy - Radboud University Medical Center, Review Article, Antiviral Agents, Adenosine Monophosphate, Dexamethasone, 3. Good health, 03 medical and health sciences, Kidney Diseases, Radboudumc 4: lnfectious Diseases and Global Health RIHS: Radboud Institute for Health Sciences, Hydroxychloroquine

File Description: application/pdf

Access URL: https://link.springer.com/content/pdf/10.1007/s40268-020-00333-0.pdf
https://pubmed.ncbi.nlm.nih.gov/33336316
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/232502
https://repository.ubn.ru.nl//bitstream/handle/2066/232502/232502.pdf
https://repository.ubn.ru.nl/handle/2066/232502
https://serval.unil.ch/notice/serval:BIB_3B376E366BC1
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_3B376E366BC12
https://serval.unil.ch/resource/serval:BIB_3B376E366BC1.P001/REF.pdf

DMAP: a connectivity map database to enable identification of novel drug repositioning candidates

Authors: Huang, Hui Nguyen, Thanh Ibrahim, Sara et al.

Contributors: Huang, Hui Nguyen, Thanh Ibrahim, Sara et al.

Source: PMC

Subject Terms: Databases, Factual -- Utilization, Drug Repositioning -- Methods, Proteins -- Chemistry

File Description: application/pdf

Relation: BMC Bioinformatics; https://hdl.handle.net/1805/11089

Availability: https://hdl.handle.net/1805/11089

Future avenues for Alzheimer's disease detection and therapy: liquid biopsy, intracellular signaling modulation, systems pharmacology drug discovery.

Authors: Vergallo, Andrea Caraci, Filippo Broich, Karl et al.

Source: Neuropharmacology 185, 108081 - (2021). doi:10.1016/j.neuropharm.2020.108081

Subject Terms: info:eu-repo/classification/ddc/610, Alzheimer Disease: diagnosis, Alzheimer Disease: drug therapy, Alzheimer Disease: metabolism, Animals, Anti-Inflammatory Agents: administration & dosage, Anti-Inflammatory Agents: metabolism, Drug Discovery: methods, Drug Discovery: trends, Drug Repositioning: methods, Drug Repositioning: trends, Forecasting, Humans, Intracellular Fluid: drug effects, Intracellular Fluid: metabolism, Liquid Biopsy: methods, Liquid Biopsy: trends, Membrane Glycoproteins: metabolism, Pharmacology, Clinical: methods, Clinical: trends, Receptors, Immunologic: metabolism, Signal Transduction: drug effects, Signal Transduction: physiology, Systems Biology: methods, Systems Biology: trends, Alzheimer's disease, Blood biomarkers, Disease-modifying therapies

Subject Geographic: DE

Relation: info:eu-repo/semantics/altIdentifier/pmid/pmid:32407924; info:eu-repo/semantics/altIdentifier/issn/1873-7064; info:eu-repo/semantics/altIdentifier/issn/0028-3908; https://pub.dzne.de/record/155926

Availability: https://pub.dzne.de/record/155926
https://pub.dzne.de/search?p=id:%22DZNE-2021-01080%22

Drug Repurposing and Computational Drug Discovery : Strategies and Advances

Authors: Mithun Rudrapal

Resource Type: eBook.

Subjects: Drug Repositioning--methods, Drug Discovery--methods, Medical Informatics Computing

Categories: MEDICAL / Pharmacology, MEDICAL / Pharmacy, SCIENCE / Biotechnology, SCIENCE / Life Sciences / General

DMAP: a connectivity map database to enable identification of novel drug repositioning candidates

Authors: Thanh Nguyen Sara Ibrahim Hui Huang et al.

Contributors: Thanh Nguyen Sara Ibrahim Hui Huang et al.

Source: BMC Bioinformatics

Subject Terms: 0301 basic medicine, 0303 health sciences, Databases, Factual, Factual -- Utilization, Drug Repositioning, Proteins, Biochemistry, Computer Science Applications, 3. Good health, Databases, 03 medical and health sciences, Proceedings, Proteins -- Chemistry, Drug Repositioning -- Methods, Molecular Biology

File Description: application/pdf

Access URL: https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/1471-2105-16-S13-S4
https://pubmed.ncbi.nlm.nih.gov/26423722
https://0-bmcbioinformatics-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2105-16-S13-S4
https://paperity.org/p/73969457/dmap-a-connectivity-map-database-to-enable-identification-of-novel-drug-repositioning
https://link.springer.com/content/pdf/10.1186/1471-2105-16-S13-S4.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597058/
https://link.springer.com/article/10.1186/1471-2105-16-S13-S4
https://europepmc.org/article/PMC/PMC4597058

Drug repurposing studies of PARP inhibitors as a new therapy for inherited retinal degeneration.

Authors: Sahaboglu, Ayse Miranda, Maria Canjuga, Denis et al.

Source: Cellular and molecular life sciences 77(11), 2199-2216 (2019). doi:10.1007/s00018-019-03283-2

Subject Terms: info:eu-repo/classification/ddc/610, Animals, Benzamides: therapeutic use, Drug Repositioning: methods, Humans, Mice, Phthalazines: therapeutic use, Poly(ADP-ribose) Polymerase Inhibitors: therapeutic use, Poly(ADP-ribose) Polymerases: metabolism, Retina: drug effects, Retina: metabolism, Retina: pathology, Retinal Degeneration: drug therapy, Retinal Degeneration: metabolism, Retinal Degeneration: pathology, Retinitis Pigmentosa: drug therapy, Retinitis Pigmentosa: metabolism, Retinitis Pigmentosa: pathology, Benzamides, Phthalazines, Poly(ADP-ribose) Polymerase Inhibitors, 3-aminobenzamide, talazoparib, Poly(ADP-ribose) Polymerases

Subject Geographic: DE

Relation: info:eu-repo/semantics/altIdentifier/pmid/pmid:31451894; info:eu-repo/semantics/altIdentifier/issn/0014-4754; info:eu-repo/semantics/altIdentifier/issn/1420-682X; info:eu-repo/semantics/altIdentifier/issn/1420-9071; https://pub.dzne.de/record/145040

Availability: https://pub.dzne.de/record/145040
https://pub.dzne.de/search?p=id:%22DZNE-2020-00400%22

Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition

Authors: Patel, Kush Ahmed, Zainab So Huang, Xuemei et al.

Source: Public Health Sciences Articles

Subject Terms: Animals, Antineoplastic Agents/chemistry/pharmacology/therapeutic use, Deubiquitinating Enzymes/antagonists & inhibitors/metabolism, Drug Design, Drug Discovery/methods, Drug Repositioning/methods, Humans, Neoplasms/drug therapy/metabolism, Proteasome Endopeptidase Complex/metabolism, Proteasome Inhibitors/chemistry/pharmacology/therapeutic use, Ubiquitin/metabolism, Ubiquitination/drug effects, 19s, 26s, DUB inhibitors, cancer, deubiquitinating enzymes, drug reposition, molecular targeting, rational design, ubiquitin proteasome system

Relation: https://scholarlycommons.henryford.com/publichealthsciences_articles/145; https://libkey.io/libraries/106/gotofulltext/pmid/30066579

Availability: https://scholarlycommons.henryford.com/publichealthsciences_articles/145
https://libkey.io/libraries/106/gotofulltext/pmid/30066579