Search Results - "Drug Evaluation, Preclinical"

Preclinical Safety.

Authors: Wolff RK Blanchard JD

Source: Journal of aerosol medicine and pulmonary drug delivery [J Aerosol Med Pulm Drug Deliv] 2025 Jun; Vol. 38 (3), pp. 136-144.

Publication Type: Journal Article; Review

Journal Info: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101475057 Publication Model: Print Cited Medium: Internet ISSN: 1941-2703 (Electronic) Linking ISSN: 19412711 NLM ISO Abbreviation: J Aerosol Med Pulm Drug Deliv Subsets: MEDLINE

MeSH Terms: Drug Evaluation, Preclinical* , Deoxyribonuclease I*/pharmacology, Animals ; Dogs ; Humans ; Administration, Inhalation ; Rats ; Haplorhini ; Recombinant Proteins/pharmacology

Advanced Cardiovascular Toxicity Screening: Integrating Human iPSC-Derived Cardiomyocytes with 2D In Silico Models.

Authors: Sinitsyna A Berezhnoy A Semidetnov I et al.

Source: Cardiovascular toxicology [Cardiovasc Toxicol] 2025 May; Vol. 25 (5), pp. 790-804. Date of Electronic Publication: 2025 Mar 28.

Publication Type: Journal Article

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 101135818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0259 (Electronic) Linking ISSN: 15307905 NLM ISO Abbreviation: Cardiovasc Toxicol Subsets: MEDLINE

MeSH Terms: Myocytes, Cardiac*/cytology , Myocytes, Cardiac*/drug effects , Arrhythmias, Cardiac*/chemically induced , Drug Evaluation, Preclinical*/methods, Induced Pluripotent Stem Cells/cytology ; Computer Simulation ; Lidocaine/pharmacology ; Cyclophosphamide/pharmacology ; Anti-Arrhythmia Agents/pharmacology ; Humans ; Cell Line ; Cardiotoxicity

[Application of motor behavior evaluation method of zebrafish model in traditional Chinese medicine research].

Authors: Li X Liang QQ Zhang BY et al.

Source: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2025 May; Vol. 50 (10), pp. 2631-2639.

Publication Type: Journal Article; Review; English Abstract

Journal Info: Publisher: Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Country of Publication: China NLM ID: 8913656 Publication Model: Print Cited Medium: Print ISSN: 1001-5302 (Print) Linking ISSN: 10015302 NLM ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Subsets: MEDLINE

MeSH Terms: Zebrafish*/physiology , Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/therapeutic use , Drug Evaluation, Preclinical*/methods , Behavior, Animal*/drug effects , Behavior, Animal*/physiology , Motor Activity*/drug effects , Motor Activity*/physiology, Medicine, Chinese Traditional ; Disease Models, Animal ; Animals ; Sleep Wake Disorders/drug therapy ; Sleep Wake Disorders/physiopathology ; Epilepsy/drug therapy ; Epilepsy/physiopathology ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/physiopathology ; Fatigue/drug therapy ; Fatigue/physiopathology

Estimating the Strength of Binding Affinity via Delta-Delta-G for Hit Screening After a Deming Regression Calibration.

Authors: Tatikola K Cabrera J

Source: Pharmaceutical statistics [Pharm Stat] 2025 Jan-Feb; Vol. 24 (1), pp. e2460.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 101201192 Publication Model: Print Cited Medium: Internet ISSN: 1539-1612 (Electronic) Linking ISSN: 15391604 NLM ISO Abbreviation: Pharm Stat Subsets: MEDLINE

MeSH Terms: Calibration* , Drug Evaluation, Preclinical*/methods , Drug Evaluation, Preclinical*/statistics & numerical data, Computer Simulation ; Protein Binding ; Regression Analysis

Effect of electrochemical topology on detection sensitivity in MEA assay for drug-induced cardiotoxicity screening.

Authors: Kim B Choi JS Zhu Y et al.

Source: Biosensors & bioelectronics [Biosens Bioelectron] 2025 Mar 15; Vol. 272, pp. 117082. Date of Electronic Publication: 2024 Dec 25.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Advanced Technology Country of Publication: England NLM ID: 9001289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4235 (Electronic) Linking ISSN: 09565663 NLM ISO Abbreviation: Biosens Bioelectron Subsets: MEDLINE

MeSH Terms: Arrhythmias, Cardiac*/chemically induced , Arrhythmias, Cardiac*/diagnosis , Cardiotoxicity*/physiopathology , Cardiovascular Agents*/toxicity , Drug Evaluation, Preclinical* , Inhibitory Concentration 50*, Humans ; Domperidone/toxicity ; Electrochemical Techniques ; Electrodes ; Electrophysiologic Techniques, Cardiac ; Fluorocarbon Polymers ; Induced Pluripotent Stem Cells ; Limit of Detection ; Myocytes, Cardiac/drug effects ; Ranolazine/toxicity ; Sotalol/toxicity ; Nanotechnology

Nano-Collision Electrochemistry for Real-Time Monitoring of Amyloid-β Oligomerization and Rapid Screening of Degrading Drugs.

Authors: Liu J Chen L Zhang ZL et al.

Source: Analytical chemistry [Anal Chem] 2025 Mar 11; Vol. 97 (9), pp. 4898-4905. Date of Electronic Publication: 2025 Feb 24.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE

MeSH Terms: Protein Multimerization* , Amyloid beta-Peptides*/chemistry , Amyloid beta-Peptides*/metabolism , Drug Evaluation, Preclinical*/methods , Electrochemical Techniques*/methods, Metal Nanoparticles/chemistry ; Silver/chemistry ; Proteolysis/drug effects

Development of 3D Muscle Cell Culture-Based Screening System for Metabolic Syndrome Drug Research.

Authors: Na YJ Choi KJ Jung WH et al.

Source: Tissue engineering. Part C, Methods [Tissue Eng Part C Methods] 2025 Feb; Vol. 31 (2), pp. 53-64. Date of Electronic Publication: 2025 Feb 06.

Publication Type: Journal Article

Journal Info: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101466663 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-3392 (Electronic) Linking ISSN: 19373384 NLM ISO Abbreviation: Tissue Eng Part C Methods Subsets: MEDLINE

MeSH Terms: Cell Culture Techniques, Three Dimensional*/methods , Metabolic Syndrome*/drug therapy , Metabolic Syndrome*/genetics , Metabolic Syndrome*/metabolism , Metabolic Syndrome*/pathology , Drug Evaluation, Preclinical*/methods , Muscle, Skeletal*/cytology , Muscle, Skeletal*/metabolism, Animals ; Mice ; Cell Line ; Cell Survival ; Cell Differentiation/drug effects ; Glucose/metabolism ; Insulin Resistance ; Palmitic Acid/pharmacology ; Deoxyglucose/analogs & derivatives ; Deoxyglucose/metabolism ; Deoxyglucose/analogs & derivatives ; 4-Chloro-7-nitrobenzofurazan/analogs & derivatives ; 4-Chloro-7-nitrobenzofurazan/metabolism ; 4-Chloro-7-nitrobenzofurazan/analogs & derivatives

Physiological liver microtissue 384-well microplate system for preclinical hepatotoxicity assessment of therapeutic small molecule drugs.

Authors: Fäs L Chen M Tong W et al.

Source: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2025 Jan 01; Vol. 203 (1), pp. 79-87.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print Cited Medium: Internet ISSN: 1096-0929 (Electronic) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE

MeSH Terms: Chemical and Drug Induced Liver Injury*/etiology , Chemical and Drug Induced Liver Injury*/pathology , Liver*/drug effects , Liver*/pathology , Drug Evaluation, Preclinical*/methods, Humans ; Adenosine Triphosphate/metabolism ; High-Throughput Screening Assays ; Spheroids, Cellular/drug effects ; Toxicity Tests/methods ; Hepatocytes/drug effects ; Hepatocytes/pathology ; Cells, Cultured ; Small Molecule Libraries/toxicity

Construction of a recombinant African swine fever virus with firefly luciferase and eGFP reporter genes and its application in high-throughput antiviral drug screening.

Authors: He X Li P Cao H et al.

Source: Antiviral research [Antiviral Res] 2025 Jan; Vol. 233, pp. 106058. Date of Electronic Publication: 2024 Dec 11.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res Subsets: MEDLINE

MeSH Terms: African Swine Fever Virus*/genetics , African Swine Fever Virus*/drug effects , Green Fluorescent Proteins*/genetics , Antiviral Agents*/pharmacology , Genes, Reporter* , Luciferases, Firefly*/genetics , African Swine Fever*/virology , Drug Evaluation, Preclinical*/methods, Animals ; Chlorocebus aethiops ; Vero Cells ; Swine ; High-Throughput Screening Assays/methods ; Virus Replication/drug effects ; CRISPR-Cas Systems ; Gene Editing/methods ; Macrophages, Alveolar/virology ; Macrophages, Alveolar/drug effects

Engineering organoids-on-chips for drug testing and evaluation.

Authors: Wang H Zhu W Xu C et al.

Source: Metabolism: clinical and experimental [Metabolism] 2025 Jan; Vol. 162, pp. 156065. Date of Electronic Publication: 2024 Nov 09.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE

MeSH Terms: Organoids*/drug effects , Drug Evaluation, Preclinical*/methods , Lab-On-A-Chip Devices*, Humans ; Animals ; Tissue Engineering/methods

In Vitro Cell-Based MTT and Crystal Violet Assays for Drug Toxicity Screening.

Authors: Gambacurta A Tullio V Savini I et al.

Source: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2025; Vol. 2834, pp. 293-301.

Publication Type: Journal Article

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

MeSH Terms: Gentian Violet* , Toxicity Tests*/methods , Cell Survival*/drug effects , Drug Evaluation, Preclinical*/methods , Tetrazolium Salts*/chemistry , High-Throughput Screening Assays*/methods, Humans ; Animals ; Colorimetry/methods ; Thiazoles/toxicity

Optimizing preclinical models of ageing for translation to clinical trials.

Authors: Mitchell SJ MacArthur MR Kane AE

Source: British journal of clinical pharmacology [Br J Clin Pharmacol] 2025 Jan; Vol. 91 (1), pp. 5-7. Date of Electronic Publication: 2023 Sep 21.

Publication Type: Journal Article; Review

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE

MeSH Terms: Aging*/drug effects , Translational Research, Biomedical*/methods , Drug Evaluation, Preclinical*/methods, Animals ; Humans ; Clinical Trials as Topic ; Rats ; Mice ; Male ; Models, Animal ; Female

Reflectometric-based sensor arrays for the screening of kinase-inhibitor interactions and kinetic determination.

Authors: Wurster V Fechner P Proll G et al.

Source: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2025 Dec; Vol. 417 (30), pp. 6811-6822. Date of Electronic Publication: 2025 Feb 10.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101134327 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-2650 (Electronic) Linking ISSN: 16182642 NLM ISO Abbreviation: Anal Bioanal Chem Subsets: MEDLINE

MeSH Terms: Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/pharmacology , Biosensing Techniques*/instrumentation , Biosensing Techniques*/methods , Spectrum Analysis*/methods , Spectrum Analysis*/instrumentation, Kinetics ; Staurosporine/chemistry ; Protein Binding ; Humans ; Drug Evaluation, Preclinical/methods ; Drug Evaluation, Preclinical/instrumentation

HIV Pharmacology Data Repository: Setting the New Information-Sharing Standard for Clinical and Preclinical Pharmacokinetic Studies.

Authors: Tompkins LAR Khoei A Kapeljushnik O et al.

Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2025 Dec; Vol. 118 (6), pp. 1340-1349. Date of Electronic Publication: 2025 May 12.

Publication Type: Journal Article; Review

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

MeSH Terms: Databases, Factual*/standards , HIV Infections*/drug therapy , Information Dissemination*/methods , Anti-HIV Agents*/pharmacokinetics , Anti-HIV Agents*/pharmacology, Humans ; Drug Evaluation, Preclinical/standards ; Drug Evaluation, Preclinical/methods ; Computer Simulation ; Drug Development/methods

Advances in, and prospects of, 3D preclinical models for skin drug discovery.

Authors: Imran M Moyle PM Kamato D et al.

Source: Drug discovery today [Drug Discov Today] 2024 Dec; Vol. 29 (12), pp. 104208. Date of Electronic Publication: 2024 Oct 11.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Ltd. Country of Publication: England NLM ID: 9604391 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5832 (Electronic) Linking ISSN: 13596446 NLM ISO Abbreviation: Drug Discov Today Subsets: MEDLINE

MeSH Terms: Drug Discovery*/methods , Drug Discovery*/trends , Drug Evaluation, Preclinical*/methods , Drug Evaluation, Preclinical*/trends , Skin*/drug effects , Skin*/metabolism, Animals ; Humans ; Models, Biological ; Quantitative Structure-Activity Relationship ; Skin Diseases/drug therapy ; Cell Culture Techniques/methods ; Cell Culture Techniques/trends

Screening for alcohol dehydrogenase inhibitors in natural compounds by electrophoretically mediated microanalysis.

Authors: Su Y Yang R Yu Y et al.

Source: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2025 Dec 15; Vol. 266, pp. 117073. Date of Electronic Publication: 2025 Jul 22.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

MeSH Terms: Alcohol Dehydrogenase*/antagonists & inhibitors , Alcohol Dehydrogenase*/metabolism , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/analysis , Biological Products*/chemistry , Biological Products*/pharmacology, Molecular Docking Simulation/methods ; Electrophoresis, Capillary/methods ; Flavonoids/pharmacology ; Flavonoids/chemistry ; Kaempferols/pharmacology ; Kaempferols/chemistry ; Emodin/pharmacology ; Emodin/chemistry ; Kinetics ; Drug Evaluation, Preclinical/methods

Identification of a novel Aurora B inhibitor using the AI-driven drug screening and docking-based traditional screening.

Authors: Ye J Chen N Zhu Y et al.

Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Dec 15; Vol. 131, pp. 118423. Date of Electronic Publication: 2025 Sep 27.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

MeSH Terms: Aurora Kinase B*/antagonists & inhibitors , Aurora Kinase B*/metabolism , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/chemical synthesis , Molecular Docking Simulation* , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis, Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Drug Evaluation, Preclinical ; Cell Proliferation/drug effects ; Cell Line, Tumor ; Machine Learning

Structure-based virtual screening identifies potent CD28 inhibitors that suppress T cell co-stimulation in cellular and mucosal models.

Authors: Upadhyay S Talagayev V Cho S et al.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118194. Date of Electronic Publication: 2025 Sep 21.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH Terms: CD28 Antigens*/antagonists & inhibitors , CD28 Antigens*/metabolism , T-Lymphocytes*/drug effects , T-Lymphocytes*/immunology, Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical

A virtual screening strategy to repurpose antifolate compounds as W.bancrofti DHFR inhibitors.

Authors: Kwarteng S Wilhelm J Salama M et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Dec 15; Vol. 129, pp. 130370. Date of Electronic Publication: 2025 Aug 12.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

MeSH Terms: Folic Acid Antagonists*/chemistry , Folic Acid Antagonists*/pharmacology , Folic Acid Antagonists*/chemical synthesis , Tetrahydrofolate Dehydrogenase*/metabolism, Structure-Activity Relationship ; Molecular Docking Simulation ; Molecular Structure ; Binding Sites ; Animals ; Methotrexate/chemistry ; Methotrexate/pharmacology ; Drug Evaluation, Preclinical ; Humans ; Dose-Response Relationship, Drug

Development of a liquid overlay-based three-dimensional cell culture panel for drug screening applications.

Authors: Depresle M Daumar P Goisnard A et al.

Source: Scientific reports [Sci Rep] 2025 Dec 02; Vol. 15 (1), pp. 42989. Date of Electronic Publication: 2025 Dec 02.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Cell Culture Techniques, Three Dimensional*/methods , Antineoplastic Agents*/pharmacology , Cell Culture Techniques*/methods, Humans ; Spheroids, Cellular/drug effects ; Drug Screening Assays, Antitumor/methods ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Evaluation, Preclinical/methods ; Cell Survival/drug effects