Suchergebnisse - "Drug Eruptions"

Severe cutaneous adverse reactions associated with novel antiandrogens: A disproportionality analysis of three databases.

Autoren: Zhu J Huo X Li X et al.

Quelle: International journal of cancer [Int J Cancer] 2025 Dec 15; Vol. 157 (12), pp. 2589-2602. Date of Electronic Publication: 2025 Jul 30.

Publikationsart: Journal Article; Observational Study

Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE

MeSH-Schlagworte: Androgen Antagonists*/adverse effects , Drug Eruptions*/etiology , Drug Eruptions*/epidemiology, Humans ; Male ; Female ; Retrospective Studies ; Middle Aged ; Pharmacovigilance ; Databases, Factual ; Adult ; Aged ; Adverse Drug Reaction Reporting Systems ; Stevens-Johnson Syndrome/etiology ; Stevens-Johnson Syndrome/epidemiology ; Drug Hypersensitivity Syndrome/etiology ; Drug Hypersensitivity Syndrome/epidemiology ; Acute Generalized Exanthematous Pustulosis/etiology ; Acute Generalized Exanthematous Pustulosis/epidemiology

Cutaneous Adverse Effects of EGFR Therapy in Breast Cancer Treatment.

Autoren: Devireddy T Lim C Patel J et al.

Quelle: Clinical and translational science [Clin Transl Sci] 2025 Dec; Vol. 18 (12), pp. e70432.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

MeSH-Schlagworte: Breast Neoplasms*/drug therapy , Protein Kinase Inhibitors*/adverse effects , Protein Kinase Inhibitors*/administration & dosage , Drug Eruptions*/etiology , Drug Eruptions*/therapy , Drug Eruptions*/diagnosis , Antineoplastic Agents*/adverse effects, Humans ; Female ; ErbB Receptors/antagonists & inhibitors ; Quality of Life

Histopathologic and Clinical Characteristics of Cutaneous Toxicities of Tyrosine Kinase Inhibitors: Insights Into Pathologic Mechanisms From a Retrospective Cohort.

Autoren: Nykaza I Platero-Portillo T Berman E et al.

Quelle: The American Journal of dermatopathology [Am J Dermatopathol] 2025 Dec 01; Vol. 47 (12), pp. 920-929. Date of Electronic Publication: 2025 Sep 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7911005 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-0311 (Electronic) Linking ISSN: 01931091 NLM ISO Abbreviation: Am J Dermatopathol Subsets: MEDLINE

MeSH-Schlagworte: Protein Kinase Inhibitors*/adverse effects , Drug Eruptions*/pathology , Drug Eruptions*/etiology , Antineoplastic Agents*/adverse effects, Humans ; Retrospective Studies ; Male ; Female ; Middle Aged ; Aged ; Adult ; Aged, 80 and over ; Imidazoles/adverse effects ; Tyrosine Kinase Inhibitors

Acute cutaneous adverse drug reactions in hepatocellular carcinoma patients undergoing combined targeted and immunotherapy: unraveling the impact of dosage and interval.

Autoren: Li T Li L Li X et al.

Quelle: Cutaneous and ocular toxicology [Cutan Ocul Toxicol] 2025 Dec; Vol. 44 (4), pp. 413-422. Date of Electronic Publication: 2025 Sep 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 101266892 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-9535 (Electronic) Linking ISSN: 15569527 NLM ISO Abbreviation: Cutan Ocul Toxicol Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/drug therapy , Liver Neoplasms*/drug therapy , Drug Eruptions*/etiology , Drug Eruptions*/epidemiology , Drug Eruptions*/pathology , Immune Checkpoint Inhibitors*/adverse effects , Immune Checkpoint Inhibitors*/administration & dosage , Immune Checkpoint Inhibitors*/therapeutic use , Antineoplastic Agents*/adverse effects , Antineoplastic Agents*/therapeutic use, Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Aged ; Immunotherapy/adverse effects ; Adult ; Molecular Targeted Therapy/adverse effects

Type 2 immunity links eczematous and lichenoid eruptions caused by immune checkpoint inhibitors.

Autoren: Azin M Farokh P McGarry A et al.

Quelle: Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2025 Dec; Vol. 93 (6), pp. 1456-1463. Date of Electronic Publication: 2025 Aug 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Mosby Country of Publication: United States NLM ID: 7907132 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6787 (Electronic) Linking ISSN: 01909622 NLM ISO Abbreviation: J Am Acad Dermatol Subsets: MEDLINE

MeSH-Schlagworte: Immune Checkpoint Inhibitors*/adverse effects , Lichenoid Eruptions*/immunology , Lichenoid Eruptions*/chemically induced , Lichenoid Eruptions*/pathology , Drug Eruptions*/immunology , Drug Eruptions*/pathology , Drug Eruptions*/etiology , Eczema*/immunology , Eczema*/chemically induced , Eczema*/pathology , Neoplasms*/drug therapy , Neoplasms*/immunology, Humans ; Female ; Male ; Middle Aged ; Prospective Studies ; Aged ; Th2 Cells/immunology ; Adult ; Biopsy ; Th1 Cells/immunology ; Skin/pathology ; Skin/immunology

Histopathological and immunohistochemical features of cutaneous and oral immune-related adverse events associated with programmed cell death protein 1 inhibitor therapy.

Autoren: Medeiros YL Heguedusch D Oliveira Filho OV et al.

Quelle: Clinical and experimental dermatology [Clin Exp Dermatol] 2025 Nov 25; Vol. 50 (12), pp. 2466-2472.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 7606847 Publication Model: Print Cited Medium: Internet ISSN: 1365-2230 (Electronic) Linking ISSN: 03076938 NLM ISO Abbreviation: Clin Exp Dermatol Subsets: MEDLINE

MeSH-Schlagworte: Antibodies, Monoclonal, Humanized*/adverse effects , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Nivolumab*/adverse effects , Immune Checkpoint Inhibitors*/adverse effects , Drug Eruptions*/pathology , Drug Eruptions*/etiology, Humans ; Male ; Female ; Middle Aged ; Aged ; Immunohistochemistry ; Lichenoid Eruptions/chemically induced ; Lichenoid Eruptions/pathology ; Stevens-Johnson Syndrome/pathology ; Stevens-Johnson Syndrome/etiology ; Aged, 80 and over ; Adult

Apalutamide-induced life-threatening dermatologic toxicity: Clinical histopathological correlations and salvage therapies in four cases: Case report series.

Autoren: Li Y Cao Y Wei L et al.

Quelle: Medicine [Medicine (Baltimore)] 2025 Nov 14; Vol. 104 (46), pp. e45425.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

MeSH-Schlagworte: Androgen Receptor Antagonists*/adverse effects , Drug Eruptions*/etiology , Drug Eruptions*/pathology , Prostatic Neoplasms, Castration-Resistant*/drug therapy , Thiohydantoins*/adverse effects , Thiohydantoins*/therapeutic use , Thiohydantoins*/administration & dosage, Aged ; Humans ; Male ; Quality of Life ; Salvage Therapy/methods

Late-onset warfarin-induced skin necrosis in a long-term anticoagulated patient.

Autoren: P R G R V M et al.

Quelle: BMJ case reports [BMJ Case Rep] 2025 Nov 10; Vol. 18 (11). Date of Electronic Publication: 2025 Nov 10.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 101526291 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-790X (Electronic) Linking ISSN: 1757790X NLM ISO Abbreviation: BMJ Case Rep Subsets: MEDLINE

MeSH-Schlagworte: Warfarin*/adverse effects , Anticoagulants*/adverse effects , Skin*/pathology , Drug Eruptions*/etiology , Drug Eruptions*/pathology, Humans ; Necrosis/chemically induced ; Male ; Aged ; Female

Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) following first administration of immunoglobulin replacement.

Autoren: Legakis L Liao J Zidan E et al.

Quelle: BMJ case reports [BMJ Case Rep] 2025 Nov 05; Vol. 18 (11). Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 101526291 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-790X (Electronic) Linking ISSN: 1757790X NLM ISO Abbreviation: BMJ Case Rep Subsets: MEDLINE

MeSH-Schlagworte: Immunoglobulins, Intravenous*/adverse effects , Immunoglobulins, Intravenous*/administration & dosage , Exanthema*/chemically induced , Exanthema*/drug therapy , Drug Eruptions*/etiology , Drug Eruptions*/drug therapy, Humans ; Female ; Adult ; Rituximab/adverse effects ; Multiple Sclerosis/drug therapy ; Immunologic Factors/adverse effects

Dermatological adverse effects of doxycycline as post-exposure prophylaxis for sexually transmitted infections among men who have sex with men: real-world findings from a multicentre study.

Autoren: Chen LY Lin WT Chen YT et al.

Quelle: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2025 Nov 04; Vol. 80 (11), pp. 3118-3122.

Publikationsart: Journal Article; Multicenter Study

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE

MeSH-Schlagworte: Doxycycline*/adverse effects , Doxycycline*/administration & dosage , Sexually Transmitted Diseases*/prevention & control , Sexually Transmitted Diseases*/drug therapy , Homosexuality, Male* , Post-Exposure Prophylaxis* , Anti-Bacterial Agents*/adverse effects , Drug Eruptions*/epidemiology , Drug Eruptions*/etiology, Humans ; Male ; Retrospective Studies ; Adult ; Middle Aged ; Incidence ; Young Adult ; HIV Infections/prevention & control

Incidence and clinical patterns, severity and preventability of cutaneous adverse drug reactions among hospitalized patients in a tertiary centre.

Autoren: Ramnan MM Jamil A Preamala G

Quelle: The Medical journal of Malaysia [Med J Malaysia] 2025 Nov; Vol. 80 (6), pp. 878-885.

Publikationsart: Journal Article; Observational Study

Info zur Zeitschrift: Publisher: Malaysian Medical Association Country of Publication: Malaysia NLM ID: 0361547 Publication Model: Print Cited Medium: Internet ISSN: 0300-5283 (Print) Linking ISSN: 03005283 NLM ISO Abbreviation: Med J Malaysia Subsets: MEDLINE

MeSH-Schlagworte: Drug Eruptions*/epidemiology , Drug Eruptions*/prevention & control , Drug-Related Side Effects and Adverse Reactions*/epidemiology , Drug-Related Side Effects and Adverse Reactions*/prevention & control, Humans ; Female ; Male ; Middle Aged ; Malaysia/epidemiology ; Incidence ; Prospective Studies ; Cross-Sectional Studies ; Adult ; Tertiary Care Centers/statistics & numerical data ; Hospitalization ; Severity of Illness Index ; Aged ; Stevens-Johnson Syndrome/epidemiology

Drug-induced fixed urticaria because of hypersensitivity to non steroidal anti-inflammatory drugs.

Autoren: Gómez-Aguado JJ Muñoz AM Gómez BC et al.

Quelle: Allergologia et immunopathologia [Allergol Immunopathol (Madr)] 2025 Nov 01; Vol. 53 (6), pp. 157-161. Date of Electronic Publication: 2025 Nov 01 (Print Publication: 2025).

Publikationsart: Case Reports; Journal Article

Info zur Zeitschrift: Publisher: Codon Publications Country of Publication: Singapore NLM ID: 0370073 Publication Model: eCollection Cited Medium: Internet ISSN: 1578-1267 (Electronic) Linking ISSN: 03010546 NLM ISO Abbreviation: Allergol Immunopathol (Madr) Subsets: MEDLINE

MeSH-Schlagworte: Urticaria*/chemically induced , Urticaria*/diagnosis , Anti-Inflammatory Agents, Non-Steroidal*/adverse effects , Drug Eruptions*/diagnosis , Drug Eruptions*/etiology , Drug Hypersensitivity*/diagnosis, Humans ; Female ; Child ; Ibuprofen/adverse effects ; Dipyrone/adverse effects ; Aspirin/adverse effects

Soluble IL-2 receptor levels support diagnosis of sarcoidosis-like reaction in melanoma patients on immunotherapy - a diagnostic algorithm based on a single center retrospective study.

Autoren: Gussek P Mentzel J Ablefoni M et al.

Quelle: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG [J Dtsch Dermatol Ges] 2025 Nov; Vol. 23 (11), pp. 1404-1412. Date of Electronic Publication: 2025 Aug 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Blackwell Country of Publication: Germany NLM ID: 101164708 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1610-0387 (Electronic) Linking ISSN: 16100379 NLM ISO Abbreviation: J Dtsch Dermatol Ges Subsets: MEDLINE

MeSH-Schlagworte: Melanoma*/drug therapy , Melanoma*/blood , Melanoma*/secondary , Receptors, Interleukin-2*/blood , Sarcoidosis*/diagnosis , Sarcoidosis*/chemically induced , Sarcoidosis*/blood , Skin Neoplasms*/drug therapy , Skin Neoplasms*/blood , Skin Neoplasms*/pathology , Immune Checkpoint Inhibitors*/adverse effects , Immune Checkpoint Inhibitors*/therapeutic use , Drug Eruptions*/diagnosis , Drug Eruptions*/blood , Drug Eruptions*/etiology, Humans ; Retrospective Studies ; Male ; Female ; Middle Aged ; Algorithms ; Aged ; Adult ; Aged, 80 and over ; Immunotherapy/adverse effects

Pembrolizumab-Exacerbated Widespread Pigmented Purpuric Dermatosis in an Elderly Patient, a Potential Diagnostic Pitfall Mimicking Pigmented Purpuric Dermatosis-Like Mycosis Fungoides.

Autoren: Chang N Hirsch Y Nemeth K et al.

Quelle: Journal of cutaneous pathology [J Cutan Pathol] 2025 Nov; Vol. 52 (11), pp. 676-680. Date of Electronic Publication: 2025 Jul 24.

Publikationsart: Case Reports; Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 0425124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0560 (Electronic) Linking ISSN: 03036987 NLM ISO Abbreviation: J Cutan Pathol Subsets: MEDLINE

MeSH-Schlagworte: Mycosis Fungoides*/diagnosis , Mycosis Fungoides*/pathology , Antibodies, Monoclonal, Humanized*/adverse effects , Purpura*/chemically induced , Purpura*/pathology , Purpura*/diagnosis , Skin Neoplasms*/diagnosis , Skin Neoplasms*/pathology , Drug Eruptions*/pathology , Drug Eruptions*/etiology , Antineoplastic Agents, Immunological*/adverse effects, Humans ; Male ; Aged ; Diagnosis, Differential ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/pathology

Epidermal growth factor receptor inhibitor-related skin toxicities: a review of management and possible preventive and therapeutic approaches for Asian patients by the Japanese Pharmacist-led Oncodermatology Study Team.

Autoren: Iimura Y Iihara H Saito Y et al.

Quelle: International journal of clinical oncology [Int J Clin Oncol] 2025 Nov; Vol. 30 (11), pp. 2192-2207. Date of Electronic Publication: 2025 Sep 01.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Springer-Verlag Tokyo Country of Publication: Japan NLM ID: 9616295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1437-7772 (Electronic) Linking ISSN: 13419625 NLM ISO Abbreviation: Int J Clin Oncol Subsets: MEDLINE

MeSH-Schlagworte: ErbB Receptors*/antagonists & inhibitors , Protein Kinase Inhibitors*/adverse effects , Drug Eruptions*/prevention & control , Drug Eruptions*/etiology , Neoplasms*/drug therapy , Skin Diseases*/chemically induced , Antineoplastic Agents*/adverse effects, Humans ; Asian People ; Japan ; Pharmacists ; East Asian People

The Use of Etanercept in the Palliative Treatment of a Patient With Generalised Bullous Fixed Drug Eruption.

Autoren: Pawlik O Cowan T Miller A

Quelle: The Australasian journal of dermatology [Australas J Dermatol] 2025 Nov; Vol. 66 (7), pp. e471-e473. Date of Electronic Publication: 2025 Sep 02.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: Australia NLM ID: 0135232 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-0960 (Electronic) Linking ISSN: 00048380 NLM ISO Abbreviation: Australas J Dermatol Subsets: MEDLINE

MeSH-Schlagworte: Etanercept*/therapeutic use , Drug Eruptions*/drug therapy , Drug Eruptions*/pathology , Palliative Care*/methods , Skin Diseases, Vesiculobullous*/drug therapy , Skin Diseases, Vesiculobullous*/chemically induced, Humans ; Female ; Aged

Predictive factors for eczematous eruptions and candidiasis during anti-interleukin-17 treatment in patients with psoriasis: a multicentre real-life experience in Lazio region, Italy.

Autoren: Caldarola G De Luca E Amato S et al.

Quelle: Clinical and experimental dermatology [Clin Exp Dermatol] 2025 Oct 27; Vol. 50 (11), pp. 2185-2191.

Publikationsart: Journal Article; Multicenter Study; Observational Study

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 7606847 Publication Model: Print Cited Medium: Internet ISSN: 1365-2230 (Electronic) Linking ISSN: 03076938 NLM ISO Abbreviation: Clin Exp Dermatol Subsets: MEDLINE

MeSH-Schlagworte: Psoriasis*/drug therapy , Interleukin-17*/antagonists & inhibitors , Eczema*/chemically induced , Eczema*/epidemiology , Dermatologic Agents*/adverse effects , Drug Eruptions*/etiology , Drug Eruptions*/epidemiology , Candidiasis*/epidemiology , Candidiasis*/chemically induced, Humans ; Male ; Female ; Retrospective Studies ; Italy/epidemiology ; Middle Aged ; Antibodies, Monoclonal, Humanized/adverse effects ; Adult ; Risk Factors ; Aged

Dermatological adverse events during hematological and oncological therapies (Bruton's tyrosine kinase inhibitors and mogamulizumab): an Italian retrospective multicenter study.

Autoren: Starace M Cedirian S Rapparini L et al.

Körperschaften: Starace M Cedirian S Rapparini L et al.

Quelle: Italian journal of dermatology and venereology [Ital J Dermatol Venerol] 2025 Oct; Vol. 160 (5), pp. 418-422.

Publikationsart: Journal Article; Multicenter Study

Info zur Zeitschrift: Publisher: Edizioni Minerva Medica Country of Publication: Italy NLM ID: 101778002 Publication Model: Print Cited Medium: Internet ISSN: 2784-8450 (Electronic) Linking ISSN: 27848671 NLM ISO Abbreviation: Ital J Dermatol Venerol Subsets: MEDLINE

MeSH-Schlagworte: Antibodies, Monoclonal, Humanized*/adverse effects , Protein Kinase Inhibitors*/adverse effects , Drug Eruptions*/etiology , Drug Eruptions*/epidemiology , Hematologic Neoplasms*/drug therapy , Agammaglobulinaemia Tyrosine Kinase*/antagonists & inhibitors, Humans ; Retrospective Studies ; Male ; Female ; Middle Aged ; Italy/epidemiology ; Aged ; Adult ; Aged, 80 and over ; Incidence ; Tyrosine Kinase Inhibitors

Simultaneous Presentation of Cutaneous Waldenström Macroglobulinemia and Acalabrutinib-Related Toxicity.

Autoren: Platero-Portillo T Mercado-Evans V Ramani N et al.

Quelle: The American Journal of dermatopathology [Am J Dermatopathol] 2025 Oct 01; Vol. 47 (10), pp. 786-789. Date of Electronic Publication: 2025 Jul 24.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7911005 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-0311 (Electronic) Linking ISSN: 01931091 NLM ISO Abbreviation: Am J Dermatopathol Subsets: MEDLINE

MeSH-Schlagworte: Waldenstrom Macroglobulinemia*/pathology , Waldenstrom Macroglobulinemia*/drug therapy , Benzamides*/adverse effects , Pyrazines*/adverse effects , Protein Kinase Inhibitors*/adverse effects , Drug Eruptions*/etiology , Drug Eruptions*/pathology , Antineoplastic Agents*/adverse effects, Humans ; Male ; Aged ; Agammaglobulinaemia Tyrosine Kinase/antagonists & inhibitors

Enfortumab Vedotin-Related Skin Toxicities: Insights From Clinical and Histopathological Analysis.

Autoren: Kuma Y Kido-Nakahara M Kuba-Fuyuno Y et al.

Quelle: The Journal of dermatology [J Dermatol] 2025 Oct; Vol. 52 (10), pp. 1584-1588. Date of Electronic Publication: 2025 Aug 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7600545 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1346-8138 (Electronic) Linking ISSN: 03852407 NLM ISO Abbreviation: J Dermatol Subsets: MEDLINE

MeSH-Schlagworte: Antibodies, Monoclonal*/adverse effects , Antibodies, Monoclonal*/administration & dosage , Immune Checkpoint Inhibitors*/adverse effects , Drug Eruptions*/etiology , Drug Eruptions*/pathology , Drug Eruptions*/immunology , Urinary Bladder Neoplasms*/drug therapy , Urinary Bladder Neoplasms*/immunology , Urinary Bladder Neoplasms*/pathology, Humans ; Skin/pathology ; Skin/drug effects ; Skin/immunology ; Skin/cytology ; Male ; Female ; Keratinocytes/drug effects ; Keratinocytes/pathology ; Keratinocytes/immunology ; Aged ; Middle Aged ; Cell Adhesion Molecules/antagonists & inhibitors ; Cell Adhesion Molecules/immunology