Search Results - "Dose-Response Relationship"

Bayesian Integrated Learning of Longitudinal Dose-Response Relationships via Decentralized Clinical Trials.

Authors: Zhang J Wang T Qu Y et al.

Source: Statistics in medicine [Stat Med] 2025 Dec; Vol. 44 (28-30), pp. e70338.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 8215016 Publication Model: Print Cited Medium: Internet ISSN: 1097-0258 (Electronic) Linking ISSN: 02776715 NLM ISO Abbreviation: Stat Med Subsets: MEDLINE

MeSH Terms: Dose-Response Relationship, Drug* , Clinical Trials, Phase II as Topic*/methods , Clinical Trials, Phase II as Topic*/statistics & numerical data, Bayes Theorem ; Humans ; Longitudinal Studies ; Computer Simulation ; Models, Statistical ; Bias

The new thiazolidine-2,4-dione-based hybrids with promising antimycobacterial activity: design, synthesis, biological evaluation, and drug interaction analysis.

Authors: Trotsko N Głogowska A Kaproń B et al.

Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2442703. Date of Electronic Publication: 2025 Jan 03.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

MeSH Terms: Microbial Sensitivity Tests* , Mycobacterium tuberculosis*/drug effects , Antitubercular Agents*/pharmacology , Antitubercular Agents*/chemical synthesis , Antitubercular Agents*/chemistry , Drug Design* , Thiazolidinediones*/pharmacology , Thiazolidinediones*/chemistry , Thiazolidinediones*/chemical synthesis , Dose-Response Relationship, Drug*, Structure-Activity Relationship ; Molecular Structure ; Drug Interactions

Discrete Bayesian Dose-response Analysis under Dose Uncertainty.

Authors: Hofer E; 3 Constance Road, Claremont, Cape Town 7708, South Africa.

Source: Health physics [Health Phys] 2025 Nov 01; Vol. 129 (5), pp. 331-338. Date of Electronic Publication: 2025 Feb 26.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985093R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-5159 (Electronic) Linking ISSN: 00179078 NLM ISO Abbreviation: Health Phys Subsets: MEDLINE

MeSH Terms: Dose-Response Relationship, Radiation* , Radiation Dosage*, Bayes Theorem ; Humans ; Uncertainty

Randomized optimal selection design for dose optimization.

Authors: Wang S Yuan Y Liu S

Source: Biometrics [Biometrics] 2025 Oct 08; Vol. 81 (4).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0370625 Publication Model: Print Cited Medium: Internet ISSN: 1541-0420 (Electronic) Linking ISSN: 0006341X NLM ISO Abbreviation: Biometrics Subsets: MEDLINE

MeSH Terms: Dose-Response Relationship, Drug* , Maximum Tolerated Dose* , Randomized Controlled Trials as Topic*/methods , Randomized Controlled Trials as Topic*/statistics & numerical data , Research Design*, Humans ; Sample Size ; Computer Simulation ; United States ; United States Food and Drug Administration ; Biometry/methods

Learning double balancing representation for heterogeneous dose-response curve estimation.

Authors: Zhu M Wu A Li H et al.

Source: Neural networks : the official journal of the International Neural Network Society [Neural Netw] 2025 Sep; Vol. 189, pp. 107600. Date of Electronic Publication: 2025 May 22.

Publication Type: Journal Article

Journal Info: Publisher: Pergamon Press Country of Publication: United States NLM ID: 8805018 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2782 (Electronic) Linking ISSN: 08936080 NLM ISO Abbreviation: Neural Netw Subsets: MEDLINE

MeSH Terms: Dose-Response Relationship, Drug* , Machine Learning* , Neural Networks, Computer*, Humans ; Precision Medicine ; Algorithms

Testing for Similarity of Dose Response in Multiregional Clinical Trials.

Authors: Dette H Koletzko L Bretz F

Source: Statistics in medicine [Stat Med] 2025 Sep; Vol. 44 (20-22), pp. e70255.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 8215016 Publication Model: Print Cited Medium: Internet ISSN: 1097-0258 (Electronic) Linking ISSN: 02776715 NLM ISO Abbreviation: Stat Med Subsets: MEDLINE

MeSH Terms: Dose-Response Relationship, Drug* , Multicenter Studies as Topic*/statistics & numerical data , Multicenter Studies as Topic*/methods , Clinical Trials as Topic*/methods , Clinical Trials as Topic*/statistics & numerical data, Humans ; Computer Simulation ; Models, Statistical

Dose-response characterization: A key to success in drug development.

Authors: Bretz F Bornkamp B Dumortier T

Source: Clinical trials (London, England) [Clin Trials] 2025 Aug; Vol. 22 (4), pp. 384-392. Date of Electronic Publication: 2025 Jul 08.

Publication Type: Journal Article; Review

Journal Info: Publisher: SAGE Publications Country of Publication: England NLM ID: 101197451 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-7753 (Electronic) Linking ISSN: 17407745 NLM ISO Abbreviation: Clin Trials Subsets: MEDLINE

MeSH Terms: Dose-Response Relationship, Drug* , Drug Development*/methods , Research Design* , Clinical Trials as Topic*/methods, Humans

Model robust designs for dose-response models.

Authors: Duarte BPM Atkinson AC Oliveira NMC

Source: Biometrics [Biometrics] 2025 Jul 03; Vol. 81 (3).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0370625 Publication Model: Print Cited Medium: Internet ISSN: 1541-0420 (Electronic) Linking ISSN: 0006341X NLM ISO Abbreviation: Biometrics Subsets: MEDLINE

MeSH Terms: Dose-Response Relationship, Drug* , Models, Statistical* , Research Design* , Biometry*/methods, Computer Simulation ; Humans ; Data Interpretation, Statistical

False and Misleading Claims of Scientific Misconduct in Early Research into Radiation Dose-response: Part 1. Overlooking Key Historical Text.

Authors: Beyea J; Senior Scientist Emeritus, Consulting in the Public Interest.

Source: Health physics [Health Phys] 2025 Jun 01; Vol. 128 (6), pp. 507-523. Date of Electronic Publication: 2024 Dec 10.

Publication Type: Journal Article; Historical Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985093R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-5159 (Electronic) Linking ISSN: 00179078 NLM ISO Abbreviation: Health Phys Subsets: MEDLINE

MeSH Terms: Scientific Misconduct*/history , Dose-Response Relationship, Radiation* , Health Physics*/history, Humans ; History, 20th Century ; Animals

Dose selection criteria to identify the optimal dose based on ranked efficacy-toxicity outcomes without reliance on clinical utilities.

Authors: Porter S Eaton A Murray TA

Source: Statistical methods in medical research [Stat Methods Med Res] 2025 Jun; Vol. 34 (6), pp. 1219-1232. Date of Electronic Publication: 2025 Mar 31.

Publication Type: Journal Article

Journal Info: Publisher: SAGE Publications Country of Publication: England NLM ID: 9212457 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0334 (Electronic) Linking ISSN: 09622802 NLM ISO Abbreviation: Stat Methods Med Res Subsets: MEDLINE

MeSH Terms: Dose-Response Relationship, Drug*, Humans ; Bayes Theorem ; Neoplasms/drug therapy ; Models, Statistical ; Computer Simulation ; Treatment Outcome ; Immunotherapy/adverse effects ; Maximum Tolerated Dose

Benchmark dose modeling for epidemiological dose-response assessment using case-control studies.

Authors: De Pretis F Zhou Y Shao K

Source: Risk analysis : an official publication of the Society for Risk Analysis [Risk Anal] 2025 Jun; Vol. 45 (6), pp. 1386-1398. Date of Electronic Publication: 2024 Nov 03.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Blackwell Publishers Country of Publication: United States NLM ID: 8109978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-6924 (Electronic) Linking ISSN: 02724332 NLM ISO Abbreviation: Risk Anal Subsets: MEDLINE

MeSH Terms: Dose-Response Relationship, Drug*, Humans ; Case-Control Studies ; Risk Assessment/methods ; Benchmarking ; Odds Ratio ; Algorithms

Reviewing methodological approaches to dose-response modelling in complex interventions: insights and perspectives.

Authors: Payne M Stringer D Carter B et al.

Source: BMC medical research methodology [BMC Med Res Methodol] 2025 May 16; Vol. 25 (1), pp. 135. Date of Electronic Publication: 2025 May 16.

Publication Type: Journal Article; Systematic Review

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100968545 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2288 (Electronic) Linking ISSN: 14712288 NLM ISO Abbreviation: BMC Med Res Methodol Subsets: MEDLINE

MeSH Terms: Psychotherapy*/methods , Psychotherapy*/statistics & numerical data , Dose-Response Relationship, Drug* , Models, Statistical*, Humans ; Research Design ; Randomized Controlled Trials as Topic

Design, synthesis, and antitumor activity of NSDs inhibitors targeting lung squamous cell carcinoma.

Authors: Xiu S Jia Z Wang Z et al.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 May 05; Vol. 289, pp. 117388. Date of Electronic Publication: 2025 Feb 12.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH Terms: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism , Drug Design* , Cell Proliferation*/drug effects , Carcinoma, Squamous Cell*/drug therapy , Carcinoma, Squamous Cell*/pathology , Drug Screening Assays, Antitumor* , Dose-Response Relationship, Drug* , Apoptosis*/drug effects, Humans ; Animals ; Mice ; Structure-Activity Relationship ; Molecular Structure ; Histone-Lysine N-Methyltransferase/antagonists & inhibitors ; Histone-Lysine N-Methyltransferase/metabolism ; Cell Line, Tumor ; Mice, Nude

Randomization-Based Inference for MCP-Mod.

Authors: Pin L Sverdlov O Bretz F et al.

Source: Statistics in medicine [Stat Med] 2025 May; Vol. 44 (10-12), pp. e70092.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 8215016 Publication Model: Print Cited Medium: Internet ISSN: 1097-0258 (Electronic) Linking ISSN: 02776715 NLM ISO Abbreviation: Stat Med Subsets: MEDLINE

MeSH Terms: Dose-Response Relationship, Drug* , Randomized Controlled Trials as Topic*/methods , Randomized Controlled Trials as Topic*/statistics & numerical data , Clinical Trials, Phase II as Topic*/methods , Clinical Trials, Phase II as Topic*/statistics & numerical data, Humans ; Likelihood Functions ; Computer Simulation ; Sample Size ; Models, Statistical ; Random Allocation

Analgesic C 20 -diterpenoid alkaloids from the lateral roots of Aconitum carmichaelii Debeaux: Natural inhibitors of NLRP3 activation.

Authors: Yin WF Wang MN Zhang F et al.

Source: Bioorganic chemistry [Bioorg Chem] 2025 May; Vol. 158, pp. 108321. Date of Electronic Publication: 2025 Mar 05.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH Terms: NLR Family, Pyrin Domain-Containing 3 Protein*/antagonists & inhibitors , NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , Aconitum*/chemistry , Analgesics*/pharmacology , Analgesics*/chemistry , Analgesics*/isolation & purification , Plant Roots*/chemistry , Alkaloids*/chemistry , Alkaloids*/pharmacology , Alkaloids*/isolation & purification , Dose-Response Relationship, Drug* , Diterpenes*/pharmacology , Diterpenes*/chemistry , Diterpenes*/isolation & purification, Animals ; Mice ; Molecular Structure ; Structure-Activity Relationship ; Male ; Molecular Docking Simulation ; Humans

Closed MCP-Mod for Pairwise Comparisons of Several Doses With a Control.

Authors: Koenig F Krasnozhon S Bornkamp B et al.

Source: Statistics in medicine [Stat Med] 2025 May; Vol. 44 (10-12), pp. e70124.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 8215016 Publication Model: Print Cited Medium: Internet ISSN: 1097-0258 (Electronic) Linking ISSN: 02776715 NLM ISO Abbreviation: Stat Med Subsets: MEDLINE

MeSH Terms: Dose-Response Relationship, Drug* , Models, Statistical* , Clinical Trials as Topic*/methods , Clinical Trials as Topic*/statistics & numerical data, Humans ; Computer Simulation ; Data Interpretation, Statistical

Diverse anti-inflammatory lindenane sesquiterpenoid hetero- or homo-dimers from Chloranthus holostegius var. shimianensis.

Authors: Wen J Yu M Jiang H et al.

Source: Bioorganic chemistry [Bioorg Chem] 2025 May; Vol. 158, pp. 108327. Date of Electronic Publication: 2025 Mar 01.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH Terms: Sesquiterpenes*/chemistry , Sesquiterpenes*/pharmacology , Sesquiterpenes*/isolation & purification , Dose-Response Relationship, Drug* , Interleukin-1beta*/antagonists & inhibitors , Interleukin-1beta*/metabolism, Humans ; Molecular Structure ; Structure-Activity Relationship ; Magnoliopsida/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/isolation & purification ; Dimerization ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/isolation & purification ; Cell Survival/drug effects

Unraveling the interaction of pyranocoumarins with P-glycoprotein: Implications for overcoming multidrug resistance in cancer therapy.

Authors: Helal MH Alsehli MH Al-Dies AM et al.

Source: Bioorganic chemistry [Bioorg Chem] 2025 May; Vol. 158, pp. 108314. Date of Electronic Publication: 2025 Mar 03.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH Terms: Pyranocoumarins*/chemistry , Pyranocoumarins*/pharmacology , Pyranocoumarins*/chemical synthesis , Drug Resistance, Neoplasm*/drug effects , Drug Resistance, Multiple*/drug effects , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Cell Proliferation*/drug effects , Drug Screening Assays, Antitumor* , ATP Binding Cassette Transporter, Subfamily B, Member 1*/metabolism , ATP Binding Cassette Transporter, Subfamily B, Member 1*/antagonists & inhibitors , Dose-Response Relationship, Drug*, Humans ; Structure-Activity Relationship ; Molecular Structure ; Molecular Docking Simulation ; Doxorubicin/pharmacology ; Doxorubicin/chemistry

Structurally diverse sesquiterpenes with anti-leukemia activity from the rare medicinal plant Liriodendron chinense.

Authors: He YH Xiang H Long ZJ et al.

Source: Bioorganic chemistry [Bioorg Chem] 2025 May; Vol. 158, pp. 108341. Date of Electronic Publication: 2025 Mar 08.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH Terms: Sesquiterpenes*/pharmacology , Sesquiterpenes*/chemistry , Sesquiterpenes*/isolation & purification , Antineoplastic Agents, Phytogenic*/pharmacology , Antineoplastic Agents, Phytogenic*/chemistry , Antineoplastic Agents, Phytogenic*/isolation & purification , Drug Screening Assays, Antitumor* , Apoptosis*/drug effects , Dose-Response Relationship, Drug* , Cell Proliferation*/drug effects , Plants, Medicinal*/chemistry, Humans ; Structure-Activity Relationship ; Molecular Structure ; Cell Line, Tumor ; Leukemia/drug therapy ; Leukemia/pathology ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors

Discovery of 4-(2-(methylamino)thiazol-5-yl)pyrimidin-2-amine derivatives as novel cyclin-dependent kinase 12 (CDK12) inhibitors for the treatment of esophageal squamous cell carcinoma.

Authors: Cao Y Huang S He Y et al.

Source: Bioorganic chemistry [Bioorg Chem] 2025 May; Vol. 158, pp. 108302. Date of Electronic Publication: 2025 Feb 24.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH Terms: Esophageal Squamous Cell Carcinoma*/drug therapy , Esophageal Squamous Cell Carcinoma*/pathology , Esophageal Squamous Cell Carcinoma*/metabolism , Cyclin-Dependent Kinases*/antagonists & inhibitors , Cyclin-Dependent Kinases*/metabolism , Esophageal Neoplasms*/drug therapy , Esophageal Neoplasms*/pathology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/chemical synthesis , Cell Proliferation*/drug effects , Dose-Response Relationship, Drug*, Humans ; Structure-Activity Relationship ; Molecular Structure ; Animals ; Drug Screening Assays, Antitumor ; Drug Discovery ; Mice ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Pyrimidines/chemical synthesis ; Mice, Nude ; Cell Line, Tumor