Suchergebnisse - "Dopaminergic Neurons: metabolism"

Distinct µ-opioid ensembles trigger positive and negative fentanyl reinforcement

Autoren: Chaudun, Fabrice Python, Laurena Saori Liu, Yu et al.

Weitere Verfasser: Chaudun, Fabrice Python, Laurena Saori Liu, Yu et al.

Quelle: Nature

Schlagwörter: Male, 0301 basic medicine, 616.8, Substance Withdrawal Syndrome / metabolism, Opioid-Related Disorders / metabolism, Dopamine, Fentanyl / pharmacology, Ventral Tegmental Area / drug effects, Receptors, Opioid, mu, Analgesics, Opioid / pharmacology, Article, Nucleus Accumbens, Ventral Tegmental Area / metabolism, Mice, 03 medical and health sciences, Animals, Nucleus Accumbens / cytology, Opioid-Related Disorders / pathology, Nucleus Accumbens / metabolism, Central Amygdaloid Nucleus / drug effects, 0303 health sciences, Dopaminergic Neurons / metabolism, Dopaminergic Neurons, [SCCO.NEUR] Cognitive science/Neuroscience, Central Amygdaloid Nucleus, Ventral Tegmental Area, Central Amygdaloid Nucleus / cytology, Analgesics, Opioid / administration & dosage, Opioid-Related Disorders, Dopaminergic Neurons / drug effects, Substance Withdrawal Syndrome, Ventral Tegmental Area / cytology, Analgesics, Opioid, Fentanyl, Mice, Inbred C57BL, Optogenetics, Central Amygdaloid Nucleus / metabolism, Receptors, Opioid, mu / metabolism, Female, Nucleus Accumbens / drug effects, Substance Withdrawal Syndrome / pathology, Reinforcement, Psychology, Dopamine / metabolism

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38778097
https://hal.science/hal-04594964v1
https://doi.org/10.1038/s41586-024-07440-x
https://hal.science/hal-04594964v1/document
https://archive-ouverte.unige.ch/unige:184588
https://doi.org/10.1038/s41586-024-07440-x

ErbB inhibition rescues nigral dopamine neuron hyperactivity and repetitive behaviors in a mouse model of fragile X syndrome

Autoren: Sebastian Luca D’Addario Eleonora Rosina Mariangela Massaro Cenere et al.

Weitere Verfasser: Sebastian Luca D’Addario Eleonora Rosina Mariangela Massaro Cenere et al.

Quelle: Mol Psychiatry
Molecular psychiatry, vol. 30, no. 5, pp. 2183-2196

Schlagwörter: Male, Receptor, ErbB-4, Behavior, Animal, Autism Spectrum Disorder, Receptor, ErbB-2, Dopaminergic Neurons, Dopamine, Animals, Fragile X Syndrome/metabolism, Fragile X Syndrome/physiopathology, Disease Models, Animal, Mice, Dopaminergic Neurons/metabolism, Dopaminergic Neurons/drug effects, Substantia Nigra/metabolism, Receptors, Metabotropic Glutamate/metabolism, Receptor, ErbB-4/metabolism, Receptor, ErbB-4/antagonists & inhibitors, Mice, Inbred C57BL, Dopamine/metabolism, ErbB Receptors/metabolism, ErbB Receptors/antagonists & inhibitors, Fragile X Mental Retardation Protein/metabolism, Fragile X Mental Retardation Protein/genetics, Stereotyped Behavior/drug effects, Stereotyped Behavior/physiology, Autism Spectrum Disorder/metabolism, Behavior, Animal/drug effects, Receptors, Metabotropic Glutamate, Article, Substantia Nigra, ErbB Receptors, Fragile X Mental Retardation Protein, Settore BIOS-11/A - Farmacologia, Fragile X Syndrome, Stereotyped Behavior

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39543371
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_CB1DC365CBDC6
https://serval.unil.ch/notice/serval:BIB_CB1DC365CBDC
https://serval.unil.ch/resource/serval:BIB_CB1DC365CBDC.P001/REF.pdf

Modeling early phenotypes of Parkinson’s disease by age-induced midbrain-striatum assembloids

Autoren: Kyriaki Barmpa Claudia Saraiva Diego Lopez-Pigozzi et al.

Quelle: Commun Biol
Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)
Communications Biology

Schlagwörter: 0301 basic medicine, Aging, 0303 health sciences, QH301-705.5, Parkinson Disease/pathology, Dopaminergic Neurons, Parkinson Disease, Mesencephalon/metabolism, SDG 3 – Goede gezondheid en welzijn, Article, Corpus Striatum, Dopaminergic Neurons/metabolism, Substantia Nigra, 03 medical and health sciences, Aging/pathology, Phenotype, SDG 3 - Good Health and Well-being, Corpus Striatum/metabolism, Mesencephalon, Humans, Animals, Biology (General), Substantia Nigra/metabolism

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39580573
https://doaj.org/article/01a3e63dcff24b67a4571fd2ecb5411b

α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease

Autoren: Fanni F. Geibl Martin T. Henrich Zhong Xie et al.

Quelle: Mol Neurodegener
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-19 (2024)

Schlagwörter: Dopaminergic, Dopaminergic Neurons, RC952-954.6, Parkinson Disease, Cholinergic Neurons, Mitochondria, Alpha-synuclein, Substantia Nigra, Pedunculopontine nucleus, Mice, Inbred C57BL, Mice, Geriatrics, Parkinson Disease/metabolism [MeSH], Dopaminergic Neurons/metabolism [MeSH], Mice, Inbred C57BL [MeSH], Mitochondria/metabolism [MeSH], Bioenergetics, Cholinergic Neurons/pathology [MeSH], Lewy pathology, Cholinergic Neurons/metabolism [MeSH], Animals [MeSH], Mitochondria/pathology [MeSH], Mice [MeSH], Dopaminergic Neurons/pathology [MeSH], Transcriptome, Electrophysiology, alpha-Synuclein/metabolism [MeSH], Parkinson Disease/pathology [MeSH], Research Article, Parkinson's disease, alpha-Synuclein, Animals, Neurology. Diseases of the nervous system, RC346-429

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39379975
https://doaj.org/article/265447b0a3f045d6bd80bc0702c9544d
https://repository.publisso.de/resource/frl:6493898

Role of Brain Liver X Receptor in Parkinson’s Disease: Hidden Treasure and Emerging Opportunities

Autoren: Saud A. Alnaaim Hayder M. Al‐kuraishy Athanasios Alexiou et al.

Quelle: Mol Neurobiol

Schlagwörter: Physiology, Dopaminergic, Dopamine, Peroxisome Proliferator-Activated Receptors, Nuclear Receptors, Immunology, Biochemistry, Gene, Article, Inflammasome, Neuroinflammation, lipid, Biochemistry, Genetics and Molecular Biology, Health Sciences, Substantia nigra, Liver X receptor, Dopaminergic Neurons/metabolism [MeSH], Brain/metabolism [MeSH], Liver X Receptors/metabolism [MeSH], Humans [MeSH], Neurodegenerative Diseases/metabolism [MeSH], Neurodegenerative diseases, Cholesterol/metabolism [MeSH], Parkinson Disease/pathology [MeSH], Neuroinflammatory Diseases [MeSH], Parkinson's disease, Humans, Disease, Molecular Biology, Biology, Internal medicine, Neuropathology, Liver X Receptors, Inflammation, Molecular Physiology of Purinergic Signalling, Dopaminergic Neurons, FOS: Clinical medicine, Brain, Life Sciences, Parkinson Disease, Neurodegenerative Diseases, Neuroprotection, 3. Good health, Cholesterol, Cholesterol Metabolism and Atherosclerosis, FOS: Biological sciences, Nuclear receptor, Neuroinflammatory Diseases, Medicine, Surgery, LXR, Transcription factor, Neuroscience, Receptor

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/37606719
https://repository.publisso.de/resource/frl:6498409

Inactivation of hypocretin receptor-2 signaling in dopaminergic neurons induces hyperarousal and enhanced cognition but impaired inhibitory control

Autoren: Mojtaba Bandarabadi Sha Li Lea Aeschlimann et al.

Quelle: Mol Psychiatry
Molecular psychiatry, vol. 29, no. 2, pp. 327-341

Schlagwörter: Male, Mice, Knockout, Orexins, Animals, Mice, Dopaminergic Neurons/physiology, Dopaminergic Neurons/metabolism, Cognition/physiology, Orexin Receptors/metabolism, Orexin Receptors/physiology, Wakefulness/physiology, Electroencephalography/methods, Arousal/physiology, Mice, Inbred C57BL, Orexins/metabolism, Orexins/physiology, Sleep, REM/physiology, Signal Transduction/physiology, Theta Rhythm/physiology, Reward, Dopamine/metabolism, Dopaminergic Neurons, Dopamine, Sleep, REM, Electroencephalography, Article, 3. Good health, Cognition, Orexin Receptors, Hypocretin, orexin, dopamine, HcrtR1, HcrtR2, Wakefulness, Theta Rhythm, Arousal, Signal Transduction

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38123729
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_0015D86488541
https://serval.unil.ch/resource/serval:BIB_0015D8648854.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_0015D8648854

The role of tyrosine hydroxylase as a key player in neuromelanin synthesis and the association of neuromelanin with Parkinson’s disease

Autoren: Toshiharu Nagatsu Akira Nakashima Hirohisa Watanabe et al.

Quelle: J Neural Transm (Vienna)
Journal of neural transmission 130 (2023): 611–625. doi:10.1007/s00702-023-02617-6
info:cnr-pdr/source/autori:Nagatsu T.; Nakashima A.; Watanabe H.; Ito S.; Wakamatsu K.; Zucca F.A.; Zecca L.; Youdim M.; Wulf M.; Riederer P.; Dijkstra J.M./titolo:The role of tyrosine hydroxylase as a key player in neuromelanin synthesis and the association of neuromelanin with Parkinson's disease/doi:10.1007%2Fs00702-023-02617-6/rivista:Journal of neural transmission/anno:2023/pagina_da:611/pagina_a:625/intervallo_pagine:611–625/volume:130

Schlagwörter: Tyrosine 3-Monooxygenase/metabolism, Tyrosine 3-Monooxygenase, Dopamine, Parkinson's disease, Norepinephrine/metabolism, tyrosinase, Neuromelanin, norepinephrine, Dopaminergic Neurons/metabolism, Neurology and Preclinical Neurological Studies - Review Article, Norepinephrine, Catecholamines, Cysteine/metabolism, tyrosine hydroxylase, Melanin, Locus coeruleus, Substantia nigra, Humans, Cysteine, Substantia Nigra/metabolism, Melanins, Catecholamines/metabolism, Melanins/metabolism, locus coeruleus, Dopaminergic Neurons, Parkinson Disease, Parkinson Disease/metabolism, melanin, Substantia Nigra, substantia nigra, Tyrosinase, Tyrosine hydroxylase, dopamine, neuromelanin

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/36939908

The amygdala-ventral pallidum pathway contributes to a hypodopaminergic state in the ventral tegmental area during protracted abstinence from chronic cocaine

Autoren: Salin, Adélie Dugast, Emilie Lardeux, Virginie et al.

Weitere Verfasser: Salin, Adélie Dugast, Emilie Lardeux, Virginie et al.

Quelle: British Journal of Pharmacology. 180:1819-1831

Schlagwörter: 0301 basic medicine, MESH: Rats, Basal Forebrain, MESH: Basal Forebrain* / metabolism, [SDV]Life Sciences [q-bio], Dopamine, cocaine, incubation of craving, MESH: Amygdala / metabolism, ventral pallidum, MESH: Ventral Tegmental Area / metabolism, Rats, Sprague-Dawley, 03 medical and health sciences, Cocaine, MESH: Dopaminergic Neurons / metabolism, Animals, MESH: Animals, dysphoria, relapse, 0303 health sciences, Dopaminergic Neurons, Ventral Tegmental Area, amygdala, Amygdala, MESH: Cocaine* / pharmacology, Rats, [SDV] Life Sciences [q-bio], MESH: Dopamine / metabolism, Sprague-Dawley, dopamine

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/36645812
https://hal.science/hal-03971992v1
https://hal.science/hal-03971992v1/document
https://doi.org/10.1111/bph.16034

Impaired striatal glutathione–ascorbate metabolism induces transient dopamine increase and motor dysfunction

Autoren: Malik, Mohd Yaseen Guo, Fei Asif-Malik, Aman et al.

Quelle: Malik, M Y, Guo, F, Asif-Malik, A, Eftychidis, V, Barkas, N, Eliseever, E, Timm, K N, Wolska, A, Bergin, D, Zonta, B, Ratz-Wirsching, V, von Hörsten, S, Walton, M E, Magill, P J, Nerlov, C & Minichiello, L 2024, 'Impaired striatal glutathione–ascorbate metabolism induces transient dopamine increase and motor dysfunction', Nature Metabolism, vol. 6, pp. 2100-2117. https://doi.org/10.1038/s42255-024-01155-z

Schlagwörter: Animals, Brain-Derived Neurotrophic Factor/metabolism, Corpus Striatum/metabolism, Dopamine/metabolism, Dopaminergic Neurons/metabolism, Glutathione Transferase/metabolism, Glutathione/metabolism, Mice, Receptor, trkB/metabolism

Dateibeschreibung: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/39468205; info:eu-repo/semantics/altIdentifier/eissn/2522-5812

Verfügbarkeit: https://pure.northampton.ac.uk/en/publications/b3cf8c35-e0d0-4ec8-a2d2-76bbf57b7a9b
https://doi.org/10.1038/s42255-024-01155-z
https://pure.northampton.ac.uk/ws/files/77926107/Asif-Malik_A_2024_Impaired_striatal_glutathione_ascorbate_metabolism_induces_transient_dopamine_increase_and_motor_dysfunction.pdf
https://www.scopus.com/pages/publications/85207441397

Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease.

Autoren: MUWANIGWA, Mudiwa Nathasia Modamio-Chamarro, Jennifer ANTONY, Paul et al.

Quelle: Molecular and Cellular Neuroscience, 128, 103919 (2024-03)

Schlagwörter: Astrosenescence, Midbrain organoids, α-Synuclein, alpha-Synuclein, Humans, alpha-Synuclein/genetics, alpha-Synuclein/metabolism, Astrocytes/metabolism, Mesencephalon/metabolism, Mesencephalon/pathology, Dopaminergic Neurons/metabolism, Organoids/metabolism, Organoids/pathology, Substantia Nigra/metabolism, Parkinson Disease/metabolism, Neurodegenerative Diseases/metabolism, Astrocytes, Dopaminergic Neurons, Mesencephalon, Neurodegenerative Diseases, Organoids, Parkinson Disease, Substantia Nigra, Molecular Biology, Cellular and Molecular Neuroscience, Cell Biology, Life sciences, Biochemistry, biophysics & molecular biology, Sciences du vivant

Relation: https://api.elsevier.com/content/article/PII:S1044743124000046?httpAccept=text/xml; urn:issn:1044-7431; urn:issn:1095-9327; https://orbilu.uni.lu/handle/10993/63444; info:hdl:10993/63444; https://orbilu.uni.lu/bitstream/10993/63444/1/2024_Muwanigwa.pdf; info:pmid:38307302; wos:001176288800001

Verfügbarkeit: https://orbilu.uni.lu/handle/10993/63444
https://orbilu.uni.lu/bitstream/10993/63444/1/2024_Muwanigwa.pdf
https://doi.org/10.1016/j.mcn.2024.103919

A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies

Autoren: Maike Hartlage-Rübsamen Alexandra Bluhm Sandra Moceri et al.

Quelle: Acta Neuropathol

Schlagwörter: Lewy Body Disease, 0301 basic medicine, 2. Zero hunger, Original Paper, Synucleinopathies, Cell Survival, Dopaminergic Neurons, Glutamine, Brain, Mice, Transgenic, Parkinson Disease, Aminoacyltransferases, 3. Good health, Kinetics, Mice, 03 medical and health sciences, 0302 clinical medicine, Sambucus nigra, Chromatography, Gel, alpha-Synuclein, Animals, Humans, Kinetics [MeSH], Substantia nigra, Parkinson Disease/metabolism [MeSH], Cell Survival [MeSH], Post-translational modification, α-Synuclein, Animal models, Mice, Transgenic [MeSH], Parkinson Disease/genetics [MeSH], Synucleinopathies/genetics [MeSH], Sambucus nigra/metabolism [MeSH], Sambucus nigra/cytology [MeSH], Parkinson's disease, Lewy Body Disease/metabolism [MeSH], Brain/pathology [MeSH], Dopaminergic Neurons/metabolism [MeSH], Aminoacyltransferases/metabolism [MeSH], Humans [MeSH], Glutamine/metabolism [MeSH], Animals [MeSH], Mice [MeSH], Lewy Body Disease/genetics [MeSH], Glutaminyl cyclase, Protein Processing, Post-Translational [MeSH], alpha-Synuclein/metabolism [MeSH], Dementia with Lewy bodies, Chromatography, Gel [MeSH], ddc:610, Protein Processing, Post-Translational

Dateibeschreibung: application/pdf

Zugangs-URL: https://link.springer.com/content/pdf/10.1007/s00401-021-02349-5.pdf
https://pubmed.ncbi.nlm.nih.gov/34309760
https://europepmc.org/article/MED/34309760
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357657
https://pubmed.ncbi.nlm.nih.gov/34309760/
https://link.springer.com/content/pdf/10.1007/s00401-021-02349-5.pdf
https://www.ncbi.nlm.nih.gov/pubmed/34309760
https://link.springer.com/article/10.1007/s00401-021-02349-5
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/22076
https://repository.publisso.de/resource/frl:6450700

Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors

Autoren: Anna Forsby Andrea Cediel-Ulloa Susanne Hougaard Bennekou et al.

Quelle: Arch Toxicol
Delp, J, Cediel-Ulloa, A, Suciu, I, Kranaster, P, van Vugt-Lussenburg, B M, Munic Kos, V, van der Stel, W, Carta, G, Bennekou, S H, Jennings, P, van de Water, B, Forsby, A & Leist, M 2021, ' Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors ', Archives of Toxicology, vol. 95, pp. 591–615 . https://doi.org/10.1007/s00204-020-02970-5
Delp, J, Cediel-Ulloa, A, Suciu, I, Kranaster, P, van Vugt-Lussenburg, B M, Munic Kos, V, van der Stel, W, Carta, G, Bennekou, S H, Jennings, P, van de Water, B, Forsby, A & Leist, M 2021, ' Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors ', Archives of Toxicology, vol. 95, pp. 591–615 . https://doi.org/10.1007/s00204-020

Schlagwörter: 0301 basic medicine, Drug-Related Side Effects and Adverse Reactions, Pharmacology and Toxicology, 3, Dopaminergic Neurons/metabolism [MeSH], Mitochondria/metabolism [MeSH], Humans [MeSH], Enzyme Inhibitors/toxicity [MeSH], Electron Transport Chain Complex Proteins/antagonists, Electron Transport Complex I/antagonists, Electron Transport Complex III/antagonists, Mitochondria/drug effects [MeSH], Electron Transport Complex II/antagonists, Transcriptome [MeSH], Pesticides/toxicity [MeSH], Biomarkers [MeSH], TempO-Seq, Dopaminergic Neurons/drug effects [MeSH] [Cell Line, Tumor [MeSH], Drug-Related Side Effects and Adverse Reactions [MeSH], Risk Assessment [MeSH], Mechanistic safety assessment, In Vitro Systems, Proteostasis/drug effects [MeSH], Cell Line [MeSH], In vitro neurotoxicity, Electron Transport/drug effects [MeSH], Mitotoxicity, High-content imaging, AOP], Risk Assessment, Cell Line, Electron Transport, Electron Transport Complex III, 03 medical and health sciences, in vitro neurotoxicity, AOP:3, Cell Line, Tumor, Humans, Enzyme Inhibitors, Pesticides, AOP, 0303 health sciences, Electron Transport Complex I, Dopaminergic Neurons, Electron Transport Complex II, Farmakologi och toxikologi, Mitochondria, 3. Good health, Electron Transport Chain Complex Proteins, 13. Climate action, Proteostasis, Transcriptome, Biomarkers

Dateibeschreibung: application/pdf

Zugangs-URL: https://link.springer.com/content/pdf/10.1007/s00204-020-02970-5.pdf
https://pubmed.ncbi.nlm.nih.gov/33512557
https://scholarlypublications.universiteitleiden.nl/access/item%3A3204449/view
https://www.narcis.nl/publication/RecordID/oai%3Aresearch.vu.nl%3Apublications%2Fe2a77ca0-56d1-4217-8605-0713f925d927
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870626
https://europepmc.org/article/PMC/PMC7870626
https://pubmed.ncbi.nlm.nih.gov/33512557/
https://www.ncbi.nlm.nih.gov/pubmed/33512557
https://orbit.dtu.dk/en/publications/ae35a386-b950-4048-afe3-b249274e27d2
https://repository.publisso.de/resource/frl:6451713
https://hdl.handle.net/1887/3204448
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-449992

Neuroprotective effects of osmotin in Parkinson’s disease-associated pathology via the AdipoR1/MAPK/AMPK/mTOR signaling pathways

Autoren: Park, Jun Sung Choe, Kyonghwan Lee, Hyeon Jin et al.

Quelle: J Biomed Sci
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-15 (2023)

Schlagwörter: Osmotin, TOR Serine-Threonine Kinases/genetics metabolism pharmacology, AMP-Activated Protein Kinases/metabolism, AMP-Activated Protein Kinases, Inbred C57BL, Dopaminergic Neurons/metabolism, Mice, Neuroinflammation, Humans, Animals, Substantia Nigra/metabolism, a-Synuclein, α-Synuclein, Dopaminergic neuron, Mammals, Animal, Research, Dopaminergic Neurons, TOR Serine-Threonine Kinases, Parkinson Disease, Parkinson Disease/metabolism, 3. Good health, Substantia Nigra, Mice, Inbred C57BL, Disease Models, Animal, Neuroprotective Agents, alpha-Synuclein/genetics metabolism pharmacology, Disease Models, Parkinson's disease, alpha-Synuclein, Medicine, Neuroprotective Agents/pharmacology, Signal Transduction

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/37568205
https://doaj.org/article/31755345aefe4c119cb5aba25c9e1f77
https://cris.maastrichtuniversity.nl/en/publications/d2faa86c-9487-4ab6-8741-cc7a1457d78b
https://doi.org/10.1186/s12929-023-00961-z

The amygdala-ventral pallidum pathway contributes to a hypodopaminergic state in the ventral tegmental area during protracted abstinence from chronic cocaine

Autoren: Salin, Adélie Dugast, Emilie Lardeux, Virginie et al.

Weitere Verfasser: Salin, Adélie Dugast, Emilie Lardeux, Virginie et al.

Quelle: ISSN: 0007-1188.

Schlagwörter: dopamine, amygdala, cocaine, dysphoria, incubation of craving, relapse, ventral pallidum, MESH: Amygdala / metabolism, MESH: Animals, MESH: Basal Forebrain* / metabolism, MESH: Cocaine* / pharmacology, MESH: Dopamine / metabolism, MESH: Dopaminergic Neurons / metabolism, MESH: Rats, Sprague-Dawley, MESH: Ventral Tegmental Area / metabolism, [SDV]Life Sciences [q-bio]

Relation: info:eu-repo/semantics/altIdentifier/pmid/36645812; PUBMED: 36645812; WOS: 000936339600001

Verfügbarkeit: https://hal.science/hal-03971992
https://hal.science/hal-03971992v1/document
https://hal.science/hal-03971992v1/file/The%20amygdala%20ventral%20pallidum%20pathway%20contributes%20to%20a%20hypodopaminergic%20state.pdf
https://doi.org/10.1111/bph.16034

Omics data integration suggests a potential idiopathic Parkinson's disease signature.

Autoren: ZAGARE, Alise Preciat, German NICKELS, Sarah Louise et al.

Quelle: Communications Biology, 6 (1), 1179 (2023-11-20)

Schlagwörter: NAD, Humans, NAD/metabolism, Mitochondria/metabolism, Dopaminergic Neurons/metabolism, Parkinson Disease/metabolism, Neural Stem Cells/metabolism, Medicine (miscellaneous), Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology, Life sciences, Sciences du vivant

Relation: https://www.nature.com/articles/s42003-023-05548-w.pdf; urn:issn:2399-3642; https://orbilu.uni.lu/handle/10993/59276; info:hdl:10993/59276; https://orbilu.uni.lu/bitstream/10993/59276/1/42003_2023_Article_5548.pdf; info:pmid:37985891

Verfügbarkeit: https://orbilu.uni.lu/handle/10993/59276
https://orbilu.uni.lu/bitstream/10993/59276/1/42003_2023_Article_5548.pdf
https://doi.org/10.1038/s42003-023-05548-w

Mitochondria-Endoplasmic Reticulum Contact Sites Dynamics and Calcium Homeostasis Are Differentially Disrupted in PINK1-PD or PRKN-PD Neurons.

Autoren: Grossmann, Dajana Malburg, Nina Grünewald, Anne et al.

Quelle: Movement disorders 38(10), 1822 - 1836 (2023). doi:10.1002/mds.29525

Schlagwörter: info:eu-repo/classification/ddc/610, Humans, Parkinson Disease: pathology, Calcium: metabolism, Thapsigargin: metabolism, Mitochondria: pathology, Dopaminergic Neurons: metabolism, Protein Kinases: genetics, Ubiquitin-Protein Ligases: genetics, Endoplasmic Reticulum: metabolism, Homeostasis, PINK1, Parkin, Parkinson's disease, calcium, mitochondria-ER contact sites, Thapsigargin, Protein Kinases, Ubiquitin-Protein Ligases

Geographisches Schlagwort: DE

Relation: info:eu-repo/semantics/altIdentifier/pmid/pmid:37449534; info:eu-repo/semantics/altIdentifier/issn/1531-8257; info:eu-repo/semantics/altIdentifier/issn/0885-3185; https://pub.dzne.de/record/265796

Verfügbarkeit: https://pub.dzne.de/record/265796
https://pub.dzne.de/search?p=id:%22DZNE-2023-01040%22

SHANK3 controls maturation of social reward circuits in the VTA.

Autoren: Bariselli, S. Tzanoulinou, S. Glangetas, C. et al.

Schlagwörter: Animals, Autism Spectrum Disorder/metabolism, Behavior, Animal/physiology, Dopamine/metabolism, Dopaminergic Neurons/metabolism, GABAergic Neurons/drug effects, Hippocampus/metabolism, Inhibitory Postsynaptic Potentials/drug effects, Mice, Inbred C57BL, Transgenic, Nerve Tissue Proteins/metabolism, Patch-Clamp Techniques/methods, Reward, Synapses/metabolism, Synaptic Transmission/physiology, Ventral Tegmental Area/metabolism

Dateibeschreibung: application/pdf

Relation: Nature Neuroscience; https://iris.unil.ch/handle/iris/82303; serval:BIB_07C0F4A52247; 000378759600011

Verfügbarkeit: https://iris.unil.ch/handle/iris/82303
https://doi.org/10.1038/nn.4319

Co-Expression of Nogo-A in Dopaminergic Neurons of the Human Substantia Nigra Pars Compacta Is Reduced in Parkinson's Disease.

Autoren: Eyer, G.C. Di Santo, S. Hewer, E. et al.

Schlagwörter: Age Factors, Aged, 80 and over, Aging/metabolism, Cell Count, Dopaminergic Neurons/metabolism, Humans, Male, Nogo Proteins/metabolism, Parkinson Disease/metabolism, Substantia Nigra/metabolism, Tyrosine 3-Monooxygenase/metabolism, Nogo-A, Parkinson’s disease, human, immunofluorescence, substantia nigra pars compacta, tyrosine hydroxylase

Dateibeschreibung: application/pdf

Relation: Cells; https://iris.unil.ch/handle/iris/73708; serval:BIB_3C51E6BA58FF; 000736259600001

Verfügbarkeit: https://iris.unil.ch/handle/iris/73708
https://doi.org/10.3390/cells10123368

ErbB inhibition rescues nigral dopamine neuron hyperactivity and repetitive behaviors in a mouse model of fragile X syndrome.

Autoren: D'Addario, S.L. Rosina, E. Massaro Cenere, M. et al.

Schlagwörter: Animals, Fragile X Syndrome/metabolism, Fragile X Syndrome/physiopathology, Disease Models, Animal, Mice, Dopaminergic Neurons/metabolism, Dopaminergic Neurons/drug effects, Substantia Nigra/metabolism, Male, Receptors, Metabotropic Glutamate/metabolism, Receptor, ErbB-4/metabolism, ErbB-4/antagonists & inhibitors, Inbred C57BL, Dopamine/metabolism, ErbB Receptors/metabolism, ErbB Receptors/antagonists & inhibitors, Fragile X Mental Retardation Protein/metabolism, Fragile X Mental Retardation Protein/genetics, Stereotyped Behavior/drug effects, Stereotyped Behavior/physiology, Autism Spectrum Disorder/metabolism, Behavior, Animal/drug effects, ErbB-2

Dateibeschreibung: application/pdf

Relation: Molecular Psychiatry; https://iris.unil.ch/handle/iris/265722; serval:BIB_CB1DC365CBDC; 001354850200001

Verfügbarkeit: https://iris.unil.ch/handle/iris/265722
https://doi.org/10.1038/s41380-024-02831-y

Quantification of noradrenergic‐, dopaminergic‐, and tectal‐neurons during aging in the short‐lived killifish Nothobranchius furzeri

Autoren: Bagnoli, Sara Fronte, Baldassare Bibbiani, Carlo et al.

Schlagwörter: Parkinson Disease/metabolism [MeSH], Parkinson Disease/metabolism, Dopaminergic Neurons/metabolism [MeSH], Aging/genetics [MeSH], Dopamine/metabolism, Animals [MeSH], Parkinson Disease/genetics [MeSH], Fundulidae/metabolism [MeSH], Dopamine/metabolism [MeSH], Aging/genetics, Parkinson Disease/genetics, Dopaminergic Neurons/metabolism, Norepinephrine/metabolism, Animals, Norepinephrine/metabolism [MeSH], Fundulidae/metabolism

Zugangs-URL: https://onlinelibrary.wiley.com/doi/10.1111/acel.13689#support-information-section