Suchergebnisse - "Dopamine Uptake Inhibitors"

Xanomeline treatment attenuates cocaine self-administration in rats and nonhuman primates.

Autoren: Marsh SA Heslep N Paronis CA et al.

Quelle: Neuropharmacology [Neuropharmacology] 2025 Dec 15; Vol. 281, pp. 110686. Date of Electronic Publication: 2025 Sep 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH-Schlagworte: Cocaine*/administration & dosage , Dopamine Uptake Inhibitors*/administration & dosage , Cocaine-Related Disorders*/drug therapy , Muscarinic Agonists*/pharmacology, Animals ; Self Administration ; Male ; Female ; Rats ; Rats, Sprague-Dawley ; Choice Behavior/drug effects ; Macaca mulatta ; Conditioning, Operant/drug effects

Cocaine and Morphine Converge to Disrupt Chloride Homeostasis in Ventral Tegmental Area GABA Neurons.

Autoren: Pearson AC Kimmey BA Taormina MB et al.

Quelle: Addiction biology [Addict Biol] 2025 Dec; Vol. 30 (12), pp. e70104.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 9604935 Publication Model: Print Cited Medium: Internet ISSN: 1369-1600 (Electronic) Linking ISSN: 13556215 NLM ISO Abbreviation: Addict Biol Subsets: MEDLINE

MeSH-Schlagworte: Ventral Tegmental Area*/drug effects , Ventral Tegmental Area*/metabolism , Morphine*/pharmacology , Cocaine*/pharmacology , GABAergic Neurons*/drug effects , GABAergic Neurons*/metabolism , Chlorides*/metabolism , Dopamine Uptake Inhibitors*/pharmacology, Animals ; Homeostasis/drug effects ; Rats ; Male ; K Cl- Cotransporters ; Symporters/drug effects ; Symporters/metabolism ; Self Administration ; Rats, Sprague-Dawley ; Receptors, Dopamine D1/drug effects

Inhibiting the JAK-STAT3 pathway in nucleus accumbens astrocytes alleviates cocaine-induced motor hyperactivity.

Autoren: Arnoux I Capano A Yakoubi R et al.

Quelle: Progress in neurobiology [Prog Neurobiol] 2025 Dec; Vol. 255, pp. 102852. Date of Electronic Publication: 2025 Nov 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 0370121 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5118 (Electronic) Linking ISSN: 03010082 NLM ISO Abbreviation: Prog Neurobiol Subsets: MEDLINE

MeSH-Schlagworte: Astrocytes*/drug effects , Astrocytes*/metabolism , Nucleus Accumbens*/drug effects , Nucleus Accumbens*/metabolism , Cocaine*/pharmacology , STAT3 Transcription Factor*/metabolism , Signal Transduction*/drug effects , Signal Transduction*/physiology , Dopamine Uptake Inhibitors*/pharmacology , Janus Kinases*/metabolism , Hyperkinesis*/chemically induced , Hyperkinesis*/metabolism, Animals ; Male ; Rats, Sprague-Dawley ; Rats ; Cocaine-Related Disorders/metabolism

Progesterone attenuates the effects of cocaine on hypermobility and dopaminergic transmission in the nucleus accumbens.

Autoren: Sánchez WN Pochapski JA Morrow AL et al.

Quelle: Neuropharmacology [Neuropharmacology] 2025 Dec 01; Vol. 280, pp. 110680. Date of Electronic Publication: 2025 Sep 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH-Schlagworte: Nucleus Accumbens*/drug effects , Nucleus Accumbens*/metabolism , Progesterone*/pharmacology , Cocaine*/pharmacology , Cocaine*/antagonists & inhibitors , Dopamine*/metabolism , Dopamine Uptake Inhibitors*/pharmacology , Synaptic Transmission*/drug effects, Animals ; Male ; Female ; Rats, Sprague-Dawley ; Rats ; Vocalization, Animal/drug effects ; Locomotion/drug effects ; Motor Activity/drug effects ; Electric Stimulation

Parsing the hypophagic and anxiogenic effects of cocaine in male and female rats.

Autoren: Schmidt KT Das SS Mengotti Estrada MP et al.

Quelle: Behavioural pharmacology [Behav Pharmacol] 2025 Dec 01; Vol. 36 (8), pp. 606-611. Date of Electronic Publication: 2025 Oct 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Lippincott Williams and Wilkins Country of Publication: England NLM ID: 9013016 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5849 (Electronic) Linking ISSN: 09558810 NLM ISO Abbreviation: Behav Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Cocaine*/pharmacology , Cocaine*/administration & dosage , Anxiety*/chemically induced , Feeding Behavior*/drug effects , Dopamine Uptake Inhibitors*/pharmacology, Animals ; Rats, Long-Evans ; Male ; Female ; Rats ; Conditioning, Operant/drug effects ; Sucrose/administration & dosage ; Reinforcement Schedule ; Exploratory Behavior/drug effects ; Behavior, Animal/drug effects

Cocaine self-administration in adult female and male rhesus monkeys: longitudinal comparison with adolescent behavior and role of early life stress.

Autoren: Allen MI Siebert ER Wakeford AGP et al.

Quelle: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2025 Dec; Vol. 50 (13), pp. 2006-2014. Date of Electronic Publication: 2025 Jul 05.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE

MeSH-Schlagworte: Cocaine*/administration & dosage , Stress, Psychological*/psychology , Cocaine-Related Disorders*/psychology , Dopamine Uptake Inhibitors*/administration & dosage , Sex Characteristics*, Animals ; Macaca mulatta ; Male ; Self Administration ; Female ; Longitudinal Studies ; Reinforcement Schedule ; Dose-Response Relationship, Drug ; Age Factors ; Reinforcement, Psychology

Adolescent isolation disrupts medial amygdala and ventral tegmental area maturation and sex-specifically dysregulates transcriptional responses to cocaine and stress.

Autoren: Andrus MD Vu T Juarez B et al.

Quelle: Neuropharmacology [Neuropharmacology] 2025 Nov 15; Vol. 279, pp. 110629. Date of Electronic Publication: 2025 Aug 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH-Schlagworte: Ventral Tegmental Area*/drug effects , Ventral Tegmental Area*/growth & development , Ventral Tegmental Area*/metabolism , Cocaine*/pharmacology , Sex Characteristics* , Stress, Psychological*/metabolism , Social Isolation*/psychology , Corticomedial Nuclear Complex*/drug effects , Corticomedial Nuclear Complex*/metabolism , Corticomedial Nuclear Complex*/growth & development , Dopamine Uptake Inhibitors*/pharmacology, Animals ; Male ; Female ; Mice, Inbred C57BL ; Mice ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics ; Receptors, Dopamine D2/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism

Temporal and spatial patterns of secondary motor cortex calcium activity in cocaine self-administration: A study using miniScope imaging and machine learning.

Autoren: Korada A Chen Y Bi Z et al.

Quelle: Neuropharmacology [Neuropharmacology] 2025 Nov 01; Vol. 278, pp. 110574. Date of Electronic Publication: 2025 Jun 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH-Schlagworte: Cocaine*/administration & dosage , Machine Learning* , Motor Cortex*/drug effects , Motor Cortex*/metabolism , Motor Cortex*/diagnostic imaging , Calcium*/metabolism , Dopamine Uptake Inhibitors*/administration & dosage, Animals ; Male ; Self Administration ; Mice, Inbred C57BL ; Mice ; Drug-Seeking Behavior/drug effects ; Drug-Seeking Behavior/physiology ; Cocaine-Related Disorders/metabolism

Effects of Long-Term Cocaine Self-Administration on Kappa Opioid Receptors in Socially Housed Cynomolgus Monkeys as Assessed With Positron Emission Tomography Imaging and Neuronally Derived Exosomes.

Autoren: Johnson BN Allen MI Nader SH et al.

Quelle: Biological psychiatry [Biol Psychiatry] 2025 Oct 15; Vol. 98 (8), pp. 624-633. Date of Electronic Publication: 2025 Mar 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2402 (Electronic) Linking ISSN: 00063223 NLM ISO Abbreviation: Biol Psychiatry Subsets: MEDLINE

MeSH-Schlagworte: Cocaine*/administration & dosage , Cocaine*/pharmacology , Receptors, Opioid, kappa*/metabolism , Receptors, Opioid, kappa*/agonists , Brain*/metabolism , Brain*/diagnostic imaging , Brain*/drug effects , Dopamine Uptake Inhibitors*/administration & dosage, Animals ; Positron-Emission Tomography ; Male ; Female ; Self Administration ; Macaca fascicularis ; Neurons/metabolism ; Neurons/drug effects ; Cocaine-Related Disorders/metabolism ; Cocaine-Related Disorders/diagnostic imaging

Synaptic Plasticity of D1 and D2 Types of Neurons in the Central Amygdala After Sucrose and Cocaine Exposure.

Autoren: Bijoch Ł Wiśniewska J Beroun A

Quelle: The European journal of neuroscience [Eur J Neurosci] 2025 Oct; Vol. 62 (8), pp. e70292.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: France NLM ID: 8918110 Publication Model: Print Cited Medium: Internet ISSN: 1460-9568 (Electronic) Linking ISSN: 0953816X NLM ISO Abbreviation: Eur J Neurosci Subsets: MEDLINE

MeSH-Schlagworte: Cocaine*/pharmacology , Receptors, Dopamine D2*/metabolism , Receptors, Dopamine D1*/metabolism , Sucrose*/pharmacology , Central Amygdaloid Nucleus*/drug effects , Central Amygdaloid Nucleus*/physiology , Central Amygdaloid Nucleus*/cytology , Neuronal Plasticity*/drug effects , Neuronal Plasticity*/physiology , Dopamine Uptake Inhibitors*/pharmacology , Neurons*/drug effects , Neurons*/physiology, Animals ; Mice ; Male ; Excitatory Postsynaptic Potentials/drug effects ; Mice, Inbred C57BL ; Reward

Individual differences in frequency modulated 50-kHz ultrasonic vocalizations reflect but do not predict cocaine self-administration in rats.

Autoren: Skórzewska A Kuchniak K Wyszogrodzka E et al.

Quelle: Behavioural brain research [Behav Brain Res] 2026 Feb 26; Vol. 498, pp. 115906. Date of Electronic Publication: 2025 Oct 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8004872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7549 (Electronic) Linking ISSN: 01664328 NLM ISO Abbreviation: Behav Brain Res Subsets: MEDLINE

MeSH-Schlagworte: Vocalization, Animal*/drug effects , Vocalization, Animal*/physiology , Cocaine*/administration & dosage , Cocaine*/pharmacology , Individuality* , Dopamine Uptake Inhibitors*/administration & dosage , Dopamine Uptake Inhibitors*/pharmacology, Animals ; Self Administration ; Male ; Rats ; Amphetamine/pharmacology ; Rats, Sprague-Dawley ; Ultrasonics ; Central Nervous System Stimulants/pharmacology

Cocaine affects astrocyte iNOS expression.

Autoren: Yin W Fandaros M Liu Y et al.

Quelle: Brain research [Brain Res] 2026 Jan 01; Vol. 1870, pp. 150068. Date of Electronic Publication: 2025 Nov 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE

MeSH-Schlagworte: Astrocytes*/drug effects , Astrocytes*/metabolism , Astrocytes*/enzymology , Nitric Oxide Synthase Type II*/metabolism , Cocaine*/pharmacology , Dopamine Uptake Inhibitors*/pharmacology, Animals ; Mice, Inbred C57BL ; Humans ; Male ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/metabolism ; Cells, Cultured ; Mice ; Cerebral Cortex/drug effects ; Cocaine-Related Disorders/metabolism

Mathematical modeling of dopamine rhythms and timing of dopamine reuptake inhibitors.

Autoren: Yao T Kim R

Quelle: PLoS computational biology [PLoS Comput Biol] 2025 Sep 25; Vol. 21 (9), pp. e1013508. Date of Electronic Publication: 2025 Sep 25 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7358 (Electronic) Linking ISSN: 1553734X NLM ISO Abbreviation: PLoS Comput Biol Subsets: MEDLINE

MeSH-Schlagworte: Dopamine*/metabolism , Circadian Rhythm*/physiology , Circadian Rhythm*/drug effects , Dopamine Uptake Inhibitors*/pharmacology , Dopamine Uptake Inhibitors*/administration & dosage , Models, Biological*, Humans ; Computational Biology

Dopamine D 1 receptors in the medial prefrontal cortex and basolateral amygdala cooperatively contribute to social defeat stress-induced augmentation of cocaine reward in mice.

Autoren: Saito A Esaki H Murata H et al.

Quelle: Neuropharmacology [Neuropharmacology] 2025 Sep 15; Vol. 276, pp. 110524. Date of Electronic Publication: 2025 May 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH-Schlagworte: Prefrontal Cortex*/drug effects , Prefrontal Cortex*/metabolism , Receptors, Dopamine D1*/metabolism , Receptors, Dopamine D1*/antagonists & inhibitors , Basolateral Nuclear Complex*/drug effects , Basolateral Nuclear Complex*/metabolism , Reward* , Cocaine*/pharmacology , Cocaine*/administration & dosage , Social Defeat* , Stress, Psychological*/metabolism , Stress, Psychological*/psychology , Dopamine Uptake Inhibitors*/pharmacology , Dopamine Uptake Inhibitors*/administration & dosage, Animals ; Male ; Benzazepines/pharmacology ; Mice ; Dopamine Antagonists/pharmacology ; Mice, Inbred C57BL ; Dopamine/metabolism

Methylphenidate Inhibits the Development of Myopia by Altering Dopamine and Norepinephrine Reuptake.

Autoren: Karouta C Thomson K Morgan I et al.

Quelle: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2025 Sep 02; Vol. 66 (12), pp. 52.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE

MeSH-Schlagworte: Myopia*/metabolism , Myopia*/prevention & control , Myopia*/physiopathology , Myopia*/drug therapy , Dopamine*/metabolism , Methylphenidate*/administration & dosage , Methylphenidate*/pharmacology , Norepinephrine*/metabolism , Dopamine Uptake Inhibitors*/pharmacology , Dopamine Uptake Inhibitors*/administration & dosage, Animals ; Disease Models, Animal ; Refraction, Ocular/drug effects ; Refraction, Ocular/physiology ; Chickens ; Intravitreal Injections ; Retina/metabolism ; Retina/drug effects ; Administration, Oral

Bupropion and Anxiety: A Brief Review.

Autoren: Oldak SE Maristany AJ

Quelle: Human psychopharmacology [Hum Psychopharmacol] 2025 Sep; Vol. 40 (5), pp. e70018.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Wiley & Sons Country of Publication: England NLM ID: 8702539 Publication Model: Print Cited Medium: Internet ISSN: 1099-1077 (Electronic) Linking ISSN: 08856222 NLM ISO Abbreviation: Hum Psychopharmacol Subsets: MEDLINE

MeSH-Schlagworte: Bupropion*/adverse effects , Bupropion*/therapeutic use , Bupropion*/pharmacology , Bupropion*/administration & dosage , Anxiety Disorders*/drug therapy , Anxiety*/drug therapy , Anti-Anxiety Agents*/therapeutic use , Anti-Anxiety Agents*/adverse effects , Anti-Anxiety Agents*/pharmacology , Antidepressive Agents, Second-Generation*/adverse effects , Antidepressive Agents, Second-Generation*/therapeutic use , Antidepressive Agents, Second-Generation*/pharmacology , Dopamine Uptake Inhibitors*/therapeutic use , Dopamine Uptake Inhibitors*/adverse effects, Humans

Peri-adolescent bupropion treatment alters adult operant responding and is associated with reduced ΔFosB and thin spine density in the nucleus accumbens in rats.

Autoren: Smith SN Holahan MR

Quelle: Brain research bulletin [Brain Res Bull] 2025 Sep; Vol. 229, pp. 111442. Date of Electronic Publication: 2025 Jun 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2747 (Electronic) Linking ISSN: 03619230 NLM ISO Abbreviation: Brain Res Bull Subsets: MEDLINE

MeSH-Schlagworte: Bupropion*/pharmacology , Nucleus Accumbens*/drug effects , Nucleus Accumbens*/metabolism , Nucleus Accumbens*/growth & development , Conditioning, Operant*/drug effects , Proto-Oncogene Proteins c-fos*/metabolism , Dendritic Spines*/drug effects , Dendritic Spines*/metabolism , Dopamine Uptake Inhibitors*/pharmacology, Animals ; Male ; Rats, Long-Evans ; Female ; Reward ; Rats ; Extinction, Psychological/drug effects ; Age Factors

Semaglutide suppresses cocaine taking, seeking, and cocaine-evoked dopamine levels in the nucleus accumbens.

Autoren: Aranäs C Caffrey A Edvardsson CE et al.

Quelle: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2025 Sep; Vol. 98, pp. 1-10. Date of Electronic Publication: 2025 Jul 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9111390 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7862 (Electronic) Linking ISSN: 0924977X NLM ISO Abbreviation: Eur Neuropsychopharmacol Subsets: MEDLINE

MeSH-Schlagworte: Nucleus Accumbens*/drug effects , Nucleus Accumbens*/metabolism , Dopamine*/metabolism , Cocaine*/administration & dosage , Drug-Seeking Behavior*/drug effects , Glucagon-Like Peptides*/pharmacology , Cocaine-Related Disorders*/drug therapy , Cocaine-Related Disorders*/metabolism , Dopamine Uptake Inhibitors*/administration & dosage, Animals ; Male ; Self Administration ; Rats ; Mice ; Dose-Response Relationship, Drug ; Glucagon-Like Peptide 1

Sex-dependent role of the dorsolateral septum in shaping contextual cocaine memory strength.

Autoren: Qi S Ritchie JL Soto DA et al.

Quelle: Neuropharmacology [Neuropharmacology] 2025 Aug 01; Vol. 273, pp. 110459. Date of Electronic Publication: 2025 Apr 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH-Schlagworte: Cocaine*/administration & dosage , Sex Characteristics* , Memory*/drug effects , Memory*/physiology , Septal Nuclei*/drug effects , Septal Nuclei*/physiology , Dopamine Uptake Inhibitors*/administration & dosage, Animals ; Male ; Female ; Rats, Sprague-Dawley ; Rats ; Extinction, Psychological/drug effects ; Extinction, Psychological/physiology ; Self Administration ; Baclofen/pharmacology ; Muscimol/pharmacology ; GABA-B Receptor Agonists/pharmacology ; Cocaine-Related Disorders

Repeated cocaine exposure and prolonged withdrawal induce spatial memory impairment and dysregulate the glutamatergic synapse composition in the dorsal hippocampus of male rats.

Autoren: Mottarlini F Miglioranza P Rizzi B et al.

Quelle: Neuropharmacology [Neuropharmacology] 2025 Aug 01; Vol. 273, pp. 110453. Date of Electronic Publication: 2025 Apr 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH-Schlagworte: Cocaine*/adverse effects , Cocaine*/administration & dosage , Hippocampus*/drug effects , Hippocampus*/metabolism , Hippocampus*/pathology , Spatial Memory*/drug effects , Spatial Memory*/physiology , Substance Withdrawal Syndrome*/metabolism , Synapses*/drug effects , Synapses*/metabolism , Memory Disorders*/metabolism , Memory Disorders*/chemically induced , Glutamic Acid*/metabolism , Dopamine Uptake Inhibitors*, Animals ; Male ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/metabolism ; Rats ; Recognition, Psychology/drug effects