Suchergebnisse - "Dna"

Saccharomyces cerevisiae Xrs2 Binds DNA Through Its FHA Domain.

Autoren: Vigneswaran A Canny MD Azatian SB et al.

Quelle: Journal of molecular biology [J Mol Biol] 2025 Dec 01; Vol. 437 (23), pp. 169348. Date of Electronic Publication: 2025 Jul 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

MeSH-Schlagworte: Saccharomyces cerevisiae Proteins*/metabolism , Saccharomyces cerevisiae Proteins*/chemistry , Saccharomyces cerevisiae Proteins*/genetics , Saccharomyces cerevisiae*/metabolism , Saccharomyces cerevisiae*/genetics , Exodeoxyribonucleases*/metabolism , Exodeoxyribonucleases*/chemistry , Exodeoxyribonucleases*/genetics , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/chemistry , DNA-Binding Proteins*/genetics , DNA, Fungal*/metabolism , DNA*/metabolism, Protein Binding ; Binding Sites ; Protein Domains ; Models, Molecular ; DNA Repair ; DNA Breaks, Double-Stranded

Genome integrity relies on rapid recycling of DNA Pol III in bacteria.

Autoren: Rascón Pérez JP d'Acoz OD Soubry N et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 25; Vol. 122 (47), pp. e2511725122. Date of Electronic Publication: 2025 Nov 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: DNA Polymerase III*/metabolism , DNA Polymerase III*/genetics , DNA Replication* , Genomic Instability* , Escherichia coli*/genetics , Escherichia coli*/metabolism , Genome, Bacterial*, DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/genetics ; DNA, Single-Stranded/metabolism ; DNA, Single-Stranded/genetics ; DNA, Bacterial/genetics ; DNA, Bacterial/metabolism ; Escherichia coli Proteins/metabolism ; Escherichia coli Proteins/genetics ; DNA Helicases/metabolism

Glutathionylated DNA adducts accumulate in mitochondrial DNA and are regulated by AP endonuclease 1 and tyrosyl-DNA phosphodiesterase 1.

Autoren: Chen YH Esparza Sanchez M Hung TI et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 25; Vol. 122 (47), pp. e2509312122. Date of Electronic Publication: 2025 Nov 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: DNA, Mitochondrial*/metabolism , DNA, Mitochondrial*/genetics , DNA, Mitochondrial*/chemistry , DNA Adducts*/metabolism , DNA Adducts*/genetics , DNA-(Apurinic or Apyrimidinic Site) Lyase*/metabolism , DNA-(Apurinic or Apyrimidinic Site) Lyase*/genetics , Phosphoric Diester Hydrolases*/metabolism , Phosphoric Diester Hydrolases*/genetics , Glutathione*/metabolism, Humans ; DNA Damage ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/genetics ; DNA Repair ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Mitochondria/metabolism ; Mitochondria/genetics ; Mitochondrial Proteins

A starvation-triggered AAA+ ATPase halts chromosome replication progression by disassembling the bacterial DNA sliding clamp.

Autoren: Surbhi Shau AK Chacko FM et al.

Quelle: Current biology : CB [Curr Biol] 2025 Nov 03; Vol. 35 (21), pp. 5264-5277.e6. Date of Electronic Publication: 2025 Oct 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: England NLM ID: 9107782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0445 (Electronic) Linking ISSN: 09609822 NLM ISO Abbreviation: Curr Biol Subsets: MEDLINE

MeSH-Schlagworte: DNA Replication* , Caulobacter crescentus*/genetics , Caulobacter crescentus*/metabolism , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Chromosomes, Bacterial*/metabolism , Chromosomes, Bacterial*/genetics , DNA, Bacterial*/metabolism , DNA, Bacterial*/genetics , Adenosine Triphosphatases*/metabolism , Adenosine Triphosphatases*/genetics, DNA-Directed DNA Polymerase

Conflicts between the DNA replication and repair machineries promote cell death in Gram-positive bacteria.

Autoren: Gaimster H Stevens D Grimshaw J et al.

Quelle: Microbiology (Reading, England) [Microbiology (Reading)] 2025 Nov; Vol. 171 (11).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Microbiology Society Country of Publication: England NLM ID: 9430468 Publication Model: Print Cited Medium: Internet ISSN: 1465-2080 (Electronic) Linking ISSN: 13500872 NLM ISO Abbreviation: Microbiology (Reading) Subsets: MEDLINE

MeSH-Schlagworte: DNA Replication* , Staphylococcus aureus*/genetics , Staphylococcus aureus*/growth & development , Staphylococcus aureus*/metabolism , Bacillus subtilis*/genetics , Bacillus subtilis*/growth & development , Bacillus subtilis*/metabolism , DNA Repair*, Animals ; Mice ; DNA Damage ; DNA, Bacterial/genetics ; Cell Death ; Bacterial Proteins/metabolism ; Bacterial Proteins/genetics ; Macrophages/microbiology

DNA-PKcs participates in the repair of renal tubular epithelial cell injury.

Autoren: Feng D Hu YJ Sun L et al.

Quelle: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2537811. Date of Electronic Publication: 2025 Jul 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

MeSH-Schlagworte: DNA-Activated Protein Kinase*/metabolism , DNA-Activated Protein Kinase*/antagonists & inhibitors , DNA-Activated Protein Kinase*/genetics , Reperfusion Injury*/pathology , Epithelial Cells*/pathology , Epithelial Cells*/metabolism , Acute Kidney Injury*/pathology , Acute Kidney Injury*/etiology , Acute Kidney Injury*/metabolism , Kidney Tubules, Proximal*/pathology, Animals ; Rats ; Male ; Cell Line ; Disease Models, Animal ; Mice ; Kidney Tubules ; DNA Damage ; Chromones/pharmacology ; Morpholines/pharmacology ; Humans ; DNA-Binding Proteins

Interplay of replication timing, DNA repair, and translesion synthesis in UV mutagenesis in yeast.

Autoren: Sewell A Wyrick JJ

Quelle: Nucleus (Austin, Tex.) [Nucleus] 2025 Dec; Vol. 16 (1), pp. 2476935. Date of Electronic Publication: 2025 Mar 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101518322 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-1042 (Electronic) Linking ISSN: 19491034 NLM ISO Abbreviation: Nucleus Subsets: MEDLINE

MeSH-Schlagworte: DNA Repair*/radiation effects , DNA Repair*/genetics , Ultraviolet Rays* , Saccharomyces cerevisiae*/genetics , Saccharomyces cerevisiae*/radiation effects , Saccharomyces cerevisiae*/metabolism , Mutagenesis*/radiation effects , DNA Replication*/radiation effects , DNA Replication Timing*/radiation effects, DNA Damage ; Pyrimidine Dimers/metabolism ; Mutation ; Translesion DNA Synthesis

Coordinated transfer of DNA between Pol θ and Pol δ resets microhomology choice during double-strand break repair.

Autoren: Li Y Returan M Guerin AT et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 25; Vol. 122 (47), pp. e2513018122. Date of Electronic Publication: 2025 Nov 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: DNA Breaks, Double-Stranded* , DNA-Directed DNA Polymerase*/metabolism , DNA-Directed DNA Polymerase*/genetics , DNA Polymerase III*/metabolism , DNA Polymerase III*/genetics , DNA End-Joining Repair* , DNA Repair* , DNA*/metabolism , DNA*/genetics, Humans ; DNA Polymerase theta ; DNA, Single-Stranded/metabolism

WDFY2 promotes MRN complex formation required for homologous recombination-mediated DNA repair.

Autoren: Lu YF Tang H Di L et al.

Quelle: Cell reports [Cell Rep] 2025 Nov 25; Vol. 44 (11), pp. 116520. Date of Electronic Publication: 2025 Nov 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH-Schlagworte: Recombinational DNA Repair* , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics, Humans ; MRE11 Homologue Protein/metabolism ; MRE11 Homologue Protein/genetics ; DNA Breaks, Double-Stranded ; Cell Cycle Proteins/metabolism ; Cell Cycle Proteins/genetics ; Phosphorylation ; Nuclear Proteins/metabolism ; DNA Repair Enzymes/metabolism ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Acid Anhydride Hydrolases ; Animals ; Checkpoint Kinase 2/metabolism ; HEK293 Cells ; Homologous Recombination ; Mice ; Multiprotein Complexes/metabolism

Specific changes in the levels of circulating cell-free mitochondrial DNA in the serum of patients with diabetic microangiopathy.

Autoren: Dong S Wang H Zhou X et al.

Quelle: Laboratory medicine [Lab Med] 2025 Nov 22; Vol. 56 (6), pp. 722-730.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 0250641 Publication Model: Print Cited Medium: Internet ISSN: 1943-7730 (Electronic) Linking ISSN: 00075027 NLM ISO Abbreviation: Lab Med Subsets: MEDLINE

MeSH-Schlagworte: DNA, Mitochondrial*/blood , DNA, Mitochondrial*/genetics , Cell-Free Nucleic Acids*/blood , Diabetic Angiopathies*/blood , Diabetic Angiopathies*/genetics , Diabetic Angiopathies*/diagnosis, Humans ; Male ; Female ; Middle Aged ; DNA Methylation ; Aged ; Adult ; Biomarkers/blood ; Real-Time Polymerase Chain Reaction ; DNA Copy Number Variations

Molecular mechanism of Eco8-mediated anti-phage defense.

Autoren: Yuan L Xu L Wu B et al.

Quelle: Molecular cell [Mol Cell] 2025 Nov 20; Vol. 85 (22), pp. 4229-4242.e4. Date of Electronic Publication: 2025 Oct 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

MeSH-Schlagworte: Escherichia coli*/genetics , Escherichia coli*/virology , Escherichia coli*/enzymology , DNA, Single-Stranded*/metabolism , DNA, Single-Stranded*/genetics , DNA, Single-Stranded*/chemistry , Bacteriophage T7*/genetics , Bacteriophage T7*/metabolism , Escherichia coli Proteins*/metabolism , Escherichia coli Proteins*/genetics , Escherichia coli Proteins*/chemistry , DNA-Directed RNA Polymerases*/metabolism , DNA-Directed RNA Polymerases*/genetics , DNA-Directed RNA Polymerases*/chemistry, Cryoelectron Microscopy ; Adenosine Triphosphate/metabolism ; DNA, Viral/metabolism ; DNA, Viral/genetics ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/chemistry ; Hydrolysis ; Models, Molecular ; Protein Binding ; Lysogeny

Decitabine-mediated DNA methylation dynamics at pericentromeric satellite 2 repeats.

Autoren: Sordini E Ciurlia E Zanella A et al.

Quelle: BMC cancer [BMC Cancer] 2025 Nov 18; Vol. 25 (1), pp. 1778. Date of Electronic Publication: 2025 Nov 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE

MeSH-Schlagworte: DNA Methylation*/drug effects , Azacitidine*/analogs & derivatives , Azacitidine*/pharmacology , DNA, Satellite*/genetics , Leukemia, Myeloid, Acute*/genetics , Leukemia, Myeloid, Acute*/drug therapy , Antimetabolites, Antineoplastic*/pharmacology , Centromere*/genetics, Humans ; Decitabine ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/drug therapy ; Cell Line, Tumor ; DNA (Cytosine-5-)-Methyltransferases/genetics ; DNA (Cytosine-5-)-Methyltransferases/metabolism

A Rare Molecular Diagnosis in a Patient With Hepatocerebral Syndrome Contributes to the Expansion of the Phenotypic Spectrum of POLG2 -Related Mitochondrial Disorder.

Autoren: Rossi V Brooks D Dai H et al.

Quelle: American journal of medical genetics. Part A [Am J Med Genet A] 2025 Nov; Vol. 197 (11), pp. e64177. Date of Electronic Publication: 2025 Jul 09.

Publikationsart: Case Reports; Journal Article

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101235741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4833 (Electronic) Linking ISSN: 15524825 NLM ISO Abbreviation: Am J Med Genet A Subsets: MEDLINE

MeSH-Schlagworte: DNA-Directed DNA Polymerase*/genetics , Mitochondrial Diseases*/genetics , Mitochondrial Diseases*/diagnosis , Mitochondrial Diseases*/pathology, Humans ; Female ; Phenotype ; Infant ; DNA, Mitochondrial/genetics ; Mutation ; DNA Polymerase gamma/genetics

Mitochondrial DNA Replication and Disease: A Historical Perspective on Molecular Insights and Therapeutic Advances.

Autoren: Somai S Aloh CH King DE et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 22; Vol. 26 (21). Date of Electronic Publication: 2025 Oct 22.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: DNA Replication* , DNA, Mitochondrial*/genetics , DNA, Mitochondrial*/metabolism , Mitochondrial Diseases*/genetics , Mitochondrial Diseases*/therapy , Mitochondrial Diseases*/metabolism, Humans ; Animals ; Mitochondria/genetics ; Mitochondria/metabolism ; DNA Polymerase gamma/genetics ; DNA Polymerase gamma/metabolism ; Mitochondrial Proteins/metabolism ; Mitochondrial Proteins/genetics ; DNA Helicases/genetics ; DNA Helicases/metabolism ; Mutation

Genome-wide profiling of unmodified DNA using methyltransferase-directed tagging and enrichment.

Autoren: Tosti L Mould C Gatehouse I et al.

Quelle: Cell reports methods [Cell Rep Methods] 2025 Oct 20; Vol. 5 (10), pp. 101187. Date of Electronic Publication: 2025 Sep 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9918227360606676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2667-2375 (Electronic) Linking ISSN: 26672375 NLM ISO Abbreviation: Cell Rep Methods Subsets: MEDLINE

MeSH-Schlagworte: DNA*/genetics , DNA*/metabolism , Epigenomics*/methods , Methyltransferases*/metabolism, Humans ; DNA Methylation/genetics ; CpG Islands/genetics ; Sequence Analysis, DNA/methods ; Colorectal Neoplasms/genetics

PARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed.

Autoren: Elsborg JD Munk SHN Adelantado-Rubio A et al.

Quelle: Molecular cell [Mol Cell] 2025 Oct 02; Vol. 85 (19), pp. 3562-3575.e10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

MeSH-Schlagworte: Poly (ADP-Ribose) Polymerase-1*/genetics , Poly (ADP-Ribose) Polymerase-1*/metabolism , DNA Replication* , DNA*/genetics , DNA*/metabolism, Humans ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; DNA Repair ; Flap Endonucleases/metabolism ; Flap Endonucleases/genetics ; DNA Breaks, Double-Stranded ; Synthetic Lethal Mutations

DUF-721 and N-terminal extension of the helicase loader DciA bind ssDNA to promote replicative DnaB helicase loading in Caulobacter crescentus.

Autoren: Watanabe K Sato S Itani N et al.

Quelle: The Journal of biological chemistry [J Biol Chem] 2025 Oct; Vol. 301 (10), pp. 110724. Date of Electronic Publication: 2025 Sep 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

MeSH-Schlagworte: Caulobacter crescentus*/genetics , Caulobacter crescentus*/metabolism , Caulobacter crescentus*/enzymology , DNA, Single-Stranded*/metabolism , DNA, Single-Stranded*/genetics , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Bacterial Proteins*/chemistry , DnaB Helicases*/metabolism , DnaB Helicases*/genetics , DnaB Helicases*/chemistry, DNA Replication ; Protein Binding ; Protein Domains ; Binding Sites ; DNA, Bacterial/metabolism ; DNA, Bacterial/genetics

APE1 active site residue Asn174 stabilizes the AP site and is essential for catalysis.

Autoren: DeHart KM Hoitsma NM Thompson SH et al.

Quelle: The Journal of biological chemistry [J Biol Chem] 2025 Oct; Vol. 301 (10), pp. 110655. Date of Electronic Publication: 2025 Sep 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

MeSH-Schlagworte: DNA-(Apurinic or Apyrimidinic Site) Lyase*/chemistry , DNA-(Apurinic or Apyrimidinic Site) Lyase*/genetics , DNA-(Apurinic or Apyrimidinic Site) Lyase*/metabolism , Asparagine*/chemistry , Asparagine*/metabolism , Asparagine*/genetics, Catalytic Domain ; Humans ; Crystallography, X-Ray ; Hydrogen Bonding ; Molecular Dynamics Simulation ; Catalysis ; DNA/chemistry ; DNA/metabolism ; DNA/genetics ; Kinetics ; DNA Repair ; Amino Acid Substitution

ZNF831-YTHDF1-DNMT1/3a feedback loop regulates lung carcinogenesis and progression through WNT7B-FZD5-β-catenin signalling axis.

Autoren: Chen D Chen H Zeng Y et al.

Quelle: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 16; Vol. 241, pp. 338-352. Date of Electronic Publication: 2025 Sep 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH-Schlagworte: Lung Neoplasms*/pathology , Lung Neoplasms*/genetics , Lung Neoplasms*/metabolism , DNA (Cytosine-5-)-Methyltransferase 1*/genetics , DNA (Cytosine-5-)-Methyltransferase 1*/metabolism , RNA-Binding Proteins*/genetics , RNA-Binding Proteins*/metabolism , Frizzled Receptors*/genetics , Frizzled Receptors*/metabolism , Wnt Proteins*/genetics , Wnt Proteins*/metabolism, Humans ; Animals ; beta Catenin/genetics ; beta Catenin/metabolism ; Mice ; DNA Methyltransferase 3A ; Gene Expression Regulation, Neoplastic ; DNA Methylation ; DNA (Cytosine-5-)-Methyltransferases/genetics ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Carcinogenesis/genetics ; Wnt Signaling Pathway ; Female ; Disease Progression ; Male ; Cell Movement ; Feedback, Physiological ; Mice, Nude ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism

Characterization of the cell-free DNA released by tumor organoids derived from colorectal cancer patients.

Autoren: Mirandola A Cartry J Bedja S et al.

Quelle: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2025 Dec 09; Vol. 231, pp. 116097. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE

MeSH-Schlagworte: Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/blood , Organoids*/metabolism , Organoids*/pathology , Cell-Free Nucleic Acids*/genetics , Biomarkers, Tumor*/genetics , Circulating Tumor DNA*/genetics, Humans ; Female ; Male ; Middle Aged ; Aged ; Mutation ; DNA, Mitochondrial/genetics ; DNA Mutational Analysis ; Aged, 80 and over ; Prospective Studies