Suchergebnisse - "Diterpenes pharmacology"

Antimicrobial susceptibility profiles of Mycoplasma hyosynoviae strains isolated from five European countries between 2018 and 2023

Autoren: Klein, Ulrich Földi, Dorottya Nagy, Eszter Zsófia et al.

Quelle: Sci Rep
Scientific Reports, Vol 15, Iss 1, Pp 1-11 (2025)

Schlagwörter: Mycoplasma Infections Veterinary, Swine, Science, Diterpenes Pharmacology, Microbial Sensitivity Tests, Article, Tylosin Pharmacology, Lincomycin Pharmacology, Belgium, Germany, Animals, Mycoplasma Infections, MIC, Anti-Bacterial Agents Pharmacology, Swine Diseases, Hungary, Tylosin Analogs & Derivatives, Mycoplasma Hyosynoviae Drug Effects, Mycoplasma hyosynoviae, Broth micro-dilution, Anti-Bacterial Agents, Lincomycin, Europe, Mycoplasma Infections Microbiology, Mycoplasma Infections Drug Therapy, Italy, Swine Diseases Microbiology, Doxycycline, Austria, Medicine, Tylosin, Diterpenes, Doxycycline Pharmacology

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39774192
https://doaj.org/article/b3032bf013e04f8487aec7149c763493

Hit-to-Lead Identification and Validation of a Triaromatic Pleuromutilin Antibiotic Candidate

Autoren: Christoffer V. Heidtmann Andreas R. Fejer Kristian Stærk et al.

Quelle: Journal of Medicinal Chemistry. 67:3692-3710

Schlagwörter: 0301 basic medicine, 0303 health sciences, Swine, Polycyclic Compounds/pharmacology, Biological Availability, Staphylococcal Infections/drug therapy, Microbial Sensitivity Tests, Staphylococcal Infections, Anti-Bacterial Agents, 3. Good health, Anti-Bacterial Agents/therapeutic use, Mice, 03 medical and health sciences, Humans, Animals, Pleuromutilins, Polycyclic Compounds, Diterpenes/pharmacology, Caco-2 Cells, Diterpenes

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38385364
https://portal.findresearcher.sdu.dk/da/publications/b12d96d7-5b95-4ce3-978e-29eedaaad1fc
https://doi.org/10.1021/acs.jmedchem.3c02153

Network Pharmacology of Triptolide in Cancer Cells: Implications for Transcription Factor Binding

Autoren: Thomas Efferth Ean-Jeong Seo Martin L. Olsson et al.

Weitere Verfasser: Thomas Efferth Ean-Jeong Seo Martin L. Olsson et al.

Quelle: Invest New Drugs

Schlagwörter: 0301 basic medicine, Molecular Docking Simulation [MeSH], RNA, Messenger [MeSH], Protein Binding/drug effects [MeSH], Cell Line, Tumor [MeSH], NF-kappa B/drug effects [MeSH], Network Pharmacology/methods [MeSH], Humans [MeSH], Cell Survival/drug effects [MeSH], Natural products, Diterpenes/pharmacology [MeSH], Epoxy Compounds/pharmacology [MeSH], Network pharmacology, Precision medicine, Preclinical Studies, Electrophoretic Mobility Shift Assay [MeSH], Microarrays, GATA1 Transcription Factor/drug effects [MeSH], Phytochemicals, Phenanthrenes/pharmacology [MeSH], Transcription Factors/drug effects [MeSH], Cell Survival, 610 Medizin, Electrophoretic Mobility Shift Assay, Network Pharmacology, 570 Life sciences, 03 medical and health sciences, Cell Line, Tumor, 610 Medical sciences, Humans, GATA1 Transcription Factor, RNA, Messenger, ddc:610, 0303 health sciences, NF-kappa B, Phenanthrenes, 3. Good health, Molecular Docking Simulation, Epoxy Compounds, ddc:570, Diterpenes, Protein Binding, Transcription Factors, 570 Biowissenschaften

Zugangs-URL: https://europepmc.org/articles/pmc8541937?pdf=render
https://link.springer.com/content/pdf/10.1007/s10637-021-01137-y.pdf
https://pubmed.ncbi.nlm.nih.gov/34213719
https://www.researchsquare.com/article/rs-443813/v1.pdf?c=1622767545000
https://lup.lub.lu.se/search/publication/927259d1-af66-49e9-a0f1-a195f7476d98
https://pubmed.ncbi.nlm.nih.gov/34213719/
https://www.researchsquare.com/article/rs-443813/v1
https://portal.research.lu.se/portal/en/publications/network-pharmacology-of-triptolide-in-cancer-cells(927259d1-af66-49e9-a0f1-a195f7476d98).html
https://www.ncbi.nlm.nih.gov/pubmed/34213719
https://openscience.ub.uni-mainz.de/handle/20.500.12030/7488
https://doi.org/10.25358/openscience-7474
https://repository.publisso.de/resource/frl:6444961

Potential of platinum-resensitization by Wnt signaling modulators as treatment approach for epithelial ovarian cancer

Autoren: Helene Hildegard Heidegger Valentina Preinfalk Bastian Czogalla et al.

Quelle: J Cancer Res Clin Oncol

Schlagwörter: Indoles, Organoplatinum Compounds, Carcinoma, Ovarian Epithelial, Maleimides, 03 medical and health sciences, 0302 clinical medicine, Antigens, CD, Cell Movement, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, Humans, Wnt Signaling Pathway, Neoplasm Staging, Ovarian Neoplasms, ddc:610, Middle Aged, Phenanthrenes, Cadherins, 3. Good health, Drug Resistance, Neoplasm, Epoxy Compounds, Cell Line, Tumor [MeSH], Carcinoma, Ovarian Epithelial/drug therapy [MeSH], Ovarian Neoplasms/drug therapy [MeSH], Cell Movement/drug effects [MeSH], Snail/ slug, Antigens, CD/biosynthesis [MeSH], Ovarian Neoplasms/metabolism [MeSH], Neoplasm Staging [MeSH], Heterocyclic Compounds, 3-Ring/pharmacology [MeSH], Indoles/pharmacology [MeSH], β-catenin, Phenanthrenes/pharmacology [MeSH], Cadherins/metabolism [MeSH], Platinum-resistance, Drug Resistance, Neoplasm [MeSH], Ovarian Neoplasms/pathology [MeSH], Female [MeSH], beta Catenin/metabolism [MeSH], E-cadherin, Original Article – Cancer Research, Maleimides/pharmacology [MeSH], Ovarian cancer, Humans [MeSH], Diterpenes/pharmacology [MeSH], Epoxy Compounds/pharmacology [MeSH], Middle Aged [MeSH], Organoplatinum Compounds/administration, Carcinoma, Ovarian Epithelial/pathology [MeSH], beta Catenin/biosynthesis [MeSH], Carcinoma, Ovarian Epithelial/metabolism [MeSH], Antineoplastic Combined Chemotherapy Protocols/pharmacology [MeSH], Cadherins/biosynthesis [MeSH], Wnt Signaling Pathway/drug effects [MeSH], Organoplatinum Compounds/pharmacology [MeSH], Wnt, Antigens, CD/metabolism [MeSH], Female, Diterpenes, Heterocyclic Compounds, 3-Ring

Dateibeschreibung: application/pdf

Zugangs-URL: https://link.springer.com/content/pdf/10.1007/s00432-020-03317-4.pdf
https://pubmed.ncbi.nlm.nih.gov/32681294
https://pubmed.ncbi.nlm.nih.gov/32681294/
https://www.ncbi.nlm.nih.gov/pubmed/32681294
https://link.springer.com/content/pdf/10.1007/s00432-020-03317-4.pdf
https://epub.ub.uni-muenchen.de/73190/
http://europepmc.org/article/MED/32681294
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467966
https://opus.bibliothek.uni-augsburg.de/opus4/files/80467/Kaltofen2020_Article_PotentialOfPlatinum-resensitiz.pdf
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/80467
https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-804675
https://doi.org/10.1007/s00432-020-03317-4
https://repository.publisso.de/resource/frl:6469356
https://epub.ub.uni-muenchen.de/73190/

Dynamic binding of Ku80, Ku70 and NF90 to the IL-2 promoter in vivo in activated T-cells

Autoren: Shi, L. Qiu, D. Zhao, G. et al.

Schlagwörter: Animals Antigens, Nuclear/*metabolism Binding Sites Cells, Cultured Chromatin Immunoprecipitation Cyclosporine/pharmacology DNA-Activated Protein Kinase/metabolism DNA-Binding Proteins/*metabolism Diterpenes/pharmacology Epoxy Compounds/pharmacology Humans Immunosuppressive Agents/pharmacology Interleukin-2/*genetics Jurkat Cells Lymphocyte Activation Mice Mice, Inbred C57BL Nuclear Factor 45 Protein/metabolism Nuclear Factor 90 Proteins/*metabolism Phenanthrenes/pharmacology *Promoter Regions (Genetics) Protein Subunits/metabolism Response Elements T-Lymphocytes/*immunology

Dateibeschreibung: application/pdf

Relation: Nucleic Acids Research; https://iris.unil.ch/handle/iris/98679; serval:BIB_4B3FD321B301; 000246294700027

Verfügbarkeit: https://iris.unil.ch/handle/iris/98679
https://doi.org/10.1093/nar/gkm117

METHYLENE BLUE SENSITIVITY 1 (MBS1) is required for acclimation of Arabidopsis to singlet oxygen and acts downstream of β‐cyclocitral

Autoren: Brigitte Ksas Leonard Shumbe Michel Havaux et al.

Weitere Verfasser: Brigitte Ksas Leonard Shumbe Michel Havaux et al.

Quelle: Plant, Cell & Environment. 40:216-226

Schlagwörter: 0301 basic medicine, Photosynthesis/radiation effects, Mutation/genetics, Light, Acclimatization, Green Fluorescent Proteins, Gene Expression Regulation, Plant/drug effects/radiation effects, Arabidopsis, 03 medical and health sciences, Gene Expression Regulation, Plant, Stress, Physiological, high light stress, [SDV.BV] Life Sciences [q-bio]/Vegetal Biology, Arabidopsis/genetics/growth & development/physiology/radiation effects, Diterpenes/pharmacology, signalling, Photosynthesis, Singlet Oxygen/pharmacology, carotenoid oxidation, Green Fluorescent Proteins/metabolism, Arabidopsis Proteins/genetics/metabolism, Plant Leaves/physiology/radiation effects, Aldehydes, 0303 health sciences, Singlet Oxygen, Arabidopsis Proteins, Acclimatization/radiation effects, Life sciences, 3. Good health, Biologie végétale (sciences végétales, sylviculture, mycologie...), Plant Leaves, Stress, Physiological/radiation effects, Phenotype, Aldehydes/pharmacology, Mutation, Sciences du vivant, Diterpenes, Phytobiology (plant sciences, forestry, mycology...)

Dateibeschreibung: application/pdf

Zugangs-URL: https://iris.unito.it/bitstream/2318/1784679/1/2017_METHYLENE%20BLUE%20SENSITIVITY%201%20%28MBS1%29%20is%20required%20for%20acclimation%20of%20Arabidopsis%20to%20singlet%20oxygen%20and%20acts%20downstream%20of%20%ce%b2-cyclocitral.pdf
https://pubmed.ncbi.nlm.nih.gov/27813110
https://onlinelibrary.wiley.com/doi/10.1111/pce.12856/abstract
https://pubmed.ncbi.nlm.nih.gov/27813110/
https://iris.unito.it/handle/2318/1784679
https://hal-amu.archives-ouvertes.fr/hal-03303934
https://europepmc.org/abstract/MED/27813110
https://pure.mpg.de/pubman/faces/ViewItemOverviewPage.jsp?itemId=item_2357757
https://amu.hal.science/hal-01682743v1
https://doi.org/10.1111/pce.12856
https://amu.hal.science/hal-01682743v1/document

TRPM7 triggers Ca2+ sparks and invadosome formation in neuroblastoma cells

Autoren: Visser, D. Langeslag, M. Kedziora, K.M. et al.

Quelle: Visser, D, Langeslag, M, Kedziora, K M, Klarenbeek, J, Kamermans, A, Horgen, F D, Fleig, A, van Leeuwen, F N & Jalink, K 2013, 'TRPM7 triggers Ca2+ sparks and invadosome formation in neuroblastoma cells', Cell Calcium, vol. 54, no. 6, pp. 404-15. https://doi.org/10.1016/j.ceca.2013.09.003
Cell Calcium, 54, 6, pp. 404-15

Schlagwörter: 0301 basic medicine, Calcium/metabolism, TRPM Cation Channels/antagonists & inhibitors, Neuroblastoma/metabolism, Small Interfering/metabolism, TRPM Cation Channels, Actomyosin/metabolism, Cell Movement/drug effects, Acetates, Cell Line, Mice, Neuroblastoma, 03 medical and health sciences, Cell Movement, Cell Line, Tumor, Cell Adhesion, Animals, Cell Adhesion/drug effects, Calcium Signaling, Diterpenes/pharmacology, RNA, Small Interfering, 0303 health sciences, Tumor, Cell Membrane/metabolism, Cell Membrane, Actomyosin, ONCOL 2: Age-related aspects of cancer NCMLS 2: Immune Regulation, Laboratory Medicine - Radboud University Medical Center, Acetates/pharmacology, RNA, Calcium, RNA Interference, NCEBP 14: Cardiovascular diseases, Diterpenes

Zugangs-URL: https://europepmc.org/articles/pmc4912378?pdf=render
https://pubmed.ncbi.nlm.nih.gov/24176224
https://europepmc.org/abstract/MED/24176224
https://research.vumc.nl/en/publications/trpm7-triggers-ca2-sparks-and-invadosome-formation-in-neuroblasto
https://repository.ubn.ru.nl/handle/2066/126299
http://www.ncbi.nlm.nih.gov/pubmed/24176224
https://core.ac.uk/display/85434295
https://www.sciencedirect.com/science/article/pii/S0143416013001383
https://research.vumc.nl/en/publications/8deb4430-5ac9-40eb-a9b6-d914034ecefa
https://hdl.handle.net/2066/126299

Combined treatment with triptolide and rapamycin prolongs graft survival in a mouse model of cardiac transplantation

Autoren: Chen, Y Liu, FQ Lamb, JR et al.

Quelle: Transplant International. 21:483-494

Schlagwörter: Male, 0301 basic medicine, DC-SIGN, T-Lymphocytes, Regulatory, Th1/Th2 cytokines, Mice, 03 medical and health sciences, Animals, Transplantation, Homologous, Rapamycin, Sirolimus, Mice, Inbred BALB C, 0303 health sciences, Triptolide, Chemokine CCL21, Graft Survival, Immunosuppressive Agents - pharmacology, Dendritic Cells, Phenanthrenes, Interleukin-10, 3. Good health, Mice, Inbred C57BL, Toll-Like Receptor 4, CD4+CD25+Foxp3+ T cells, Diterpenes - pharmacology, Cardiac allografts, Chemokine CCL19, Epoxy Compounds, Heart Transplantation, Graft Survival - drug effects, Phenanthrenes - pharmacology, Interleukin-4, Diterpenes, Immunosuppressive Agents

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/18266776
https://www.research.ed.ac.uk/portal/en/publications/combined-treatment-with-triptolide-and-rapamycin-prolongs-graft-survival-in-a-mouse-model-of-cardiac-transplantation(fa8e2953-2250-4ccc-bb61-623a95d07d8d)/export.html
https://hub.hku.hk/handle/10722/84575
https://core.ac.uk/display/37913731
https://www.ncbi.nlm.nih.gov/pubmed/18266776
https://pubmed.ncbi.nlm.nih.gov/18266776/
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1432-2277.2007.00630.x
http://hdl.handle.net/10722/84575

Triptolide impairs dendritic cell migration by inhibiting CCR7 and COX-2 expression through PI3-K/Akt and NF-κB pathways

Autoren: Qiuyan Liu Guoyou Chen Pengcheng Ma et al.

Quelle: Molecular Immunology. 44:2686-2696

Schlagwörter: Lipopolysaccharides, Male, 0301 basic medicine, Phosphatidylinositol 3-Kinases - Antagonists & Inhibitors, Receptors, CCR7, Phenanthrenes - Pharmacology, CC - Metabolism, Inbred C57bl, Receptors, Chemokine - Antagonists & Inhibitors - Metabolism, Dendritic Cells - Drug Effects, Diterpenes - Pharmacology, Dinoprostone, Mice, 03 medical and health sciences, 0302 clinical medicine, Nf-Kappa B - Antagonists & Inhibitors, Cell Movement, Receptors, Dinoprostone - Metabolism, Chemokine - Antagonists & Inhibitors - Metabolism, Animals, Chemokine CCl19, Cyclooxygenase 2 - Metabolism, Proto-Oncogene Proteins C-Akt - Antagonists & Inhibitors, CCr7, Phosphoinositide-3 Kinase Inhibitors, Receptors, CCr7, Chemokines, CC - Metabolism, NF-kappa B, Epoxy Compounds - Pharmacology, Dendritic Cells, Cytokines - Metabolism, Phenanthrenes, 3. Good health, Mice, Inbred C57bl, Mice, Inbred C57BL, Immunosuppressive Agents - Pharmacology, Cyclooxygenase 2, Chemokines, CC, Chemokine CCL19, Cytokines, Epoxy Compounds, Chemokines, Diterpenes, Lipopolysaccharides - Pharmacology, Cell Movement - Drug Effects, Proto-Oncogene Proteins c-akt, Immunosuppressive Agents

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/17223196
http://www.sciencedirect.com/science/article/pii/S0161589006007255
http://hub.hku.hk/handle/10722/148500
https://www.sciencedirect.com/science/article/pii/S0161589006007255
https://core.ac.uk/display/37969647
https://www.ncbi.nlm.nih.gov/pubmed/17223196
https://pubmed.ncbi.nlm.nih.gov/17223196/
http://hdl.handle.net/10722/148500

Induction of Heat Shock Response Protects the Heart Against Atrial Fibrillation

Autoren: Brundel, Bianca J J M Shiroshita-Takeshita, Akiko Qi, Xiaoyan et al.

Quelle: Brundel, B J J M, Shiroshita-Takeshita, A, Qi, X, Yeh, Y-H, Chartier, D, van Gelder, I C, Henning, R H, Kampinga, H H & Nattel, S 2006, 'Induction of heat shock response protects the heart against atrial fibrillation', Circulation Research, vol. 99, no. 12, pp. 1394-402. https://doi.org/10.1161/01.RES.0000252323.83137.fe

Schlagwörter: Pacemaker, Artificial, Patch-Clamp Techniques, heat shock protein, HSP27 Heat-Shock Proteins, PREVENTS, 0302 clinical medicine, Neoplasm Proteins/genetics, Atrial Fibrillation, Heat-Shock Proteins/genetics, Cardiac/cytology, atrial fibrillation, Myocytes, Cardiac, Diterpenes/pharmacology, OXIDATIVE STRESS, Phosphorylation, RNA, Small Interfering, PHOSPHORYLATION, Heat-Shock Proteins, remodeling, SMOOTH-MUSCLE, Neoplasm Proteins, Pacemaker, Heat-Shock Response/drug effects, Artificial, Myocardial Contraction/drug effects, TACHYCARDIA, Diterpenes, EXPRESSION, Cardiotonic Agents, PROTEINS, Cardiotonic Agents/pharmacology, Small Interfering, MYOCYTES, Transfection, Heart Atria/cytology, 03 medical and health sciences, Dogs, Animals, Humans, HSP70 Heat-Shock Proteins, Heart Atria, Atrial Fibrillation/metabolism, Myocytes, HSP70 Heat-Shock Proteins/genetics, Myocardial Contraction, CELLS, RNA, CONTRACTILE DYSFUNCTION, Heat-Shock Response, Molecular Chaperones

Zugangs-URL: https://www.ahajournals.org/doi/pdf/10.1161/01.RES.0000252323.83137.fe
https://pubmed.ncbi.nlm.nih.gov/17110598
https://www.ahajournals.org/doi/10.1161/01.RES.0000252323.83137.fe?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
https://europepmc.org/article/MED/17110598
https://www.ncbi.nlm.nih.gov/pubmed/17110598
https://pubmed.ncbi.nlm.nih.gov/17110598/
https://circres.ahajournals.org/content/99/12/1394.full.pdf
https://www.narcis.nl/publication/RecordID/oai%3Apure.rug.nl%3Apublications%2F5c082dd6-cb14-464a-931f-6c2185144273
https://research.vumc.nl/en/publications/451eb952-e23a-4e9c-8c71-3303f8de6b27

Eriocalyxin B Inhibits Nuclear Factor-κB Activation by Interfering with the Binding of Both p65 and p50 to the Response Element in a Noncompetitive Manner

Autoren: Cheng, YC Leung, CH Grill, SP et al.

Quelle: Molecular Pharmacology. 70:1946-1955

Schlagwörter: 0301 basic medicine, Chromatin Immunoprecipitation, Dna Primers, Nitric Oxide Synthase Type II, Electrophoretic Mobility Shift Assay, Diterpenes - Pharmacology, Cell Line, 03 medical and health sciences, Cell Line, Tumor, Humans, Cyclooxygenase 2 - Metabolism, DNA Primers, 0303 health sciences, Tumor, Base Sequence, Reverse Transcriptase Polymerase Chain Reaction, Tumor Necrosis Factor-alpha, NF-kappa B, 3. Good health, Protein Transport, Cyclooxygenase 2, Nitric Oxide Synthase Type Ii - Metabolism, Tumor Necrosis Factor-Alpha - Pharmacology, Diterpenes, Nf-Kappa B - Antagonists & Inhibitors - Metabolism, Protein Binding

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/16940413
http://www.irgrid.ac.cn/handle/1471x/1000651
https://molpharm.aspetjournals.org/content/70/6/1946
https://molpharm.aspetjournals.org/content/molpharm/early/2006/08/29/mol.106.028480.full.pdf
http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.106.028480
https://www.ncbi.nlm.nih.gov/pubmed/16940413
http://hub.hku.hk/handle/10722/168067
http://hdl.handle.net/10722/168067

Depletion of substrates for protein prenylation increases apoptosis in human periovulatory granulosa cells

Autoren: Rung, Emilia Friberg, P. Anders Bergh, Christina et al.

Quelle: Molecular reproduction and development. 73(10):1277-83

Schlagwörter: Medical and Health Sciences, Medicin och hälsovetenskap, Physiology and Anatomy, Fysiologi och anatomi, *Apoptosis/drug effects, Cells, Cultured, Cholesterol/*biosynthesis, Diterpenes/pharmacology, Estrenes/pharmacology, Farnesol/pharmacology, Farnesyltranstransferase/antagonists & inhibitors, Female, Furans/pharmacology, Granulosa Cells/drug effects/metabolism/*physiology, Hormone Antagonists/pharmacology, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology, Imidazoles/pharmacology, Leucine/analogs & derivatives/pharmacology, Mifepristone/pharmacology, Ovulation, Protein Isoprenylation/*drug effects, Quinolones/pharmacology, Receptors, Progesterone/antagonists & inhibitors

Zugangs-URL: https://gup.ub.gu.se/publication/45356

p53-independent pRB degradation contributes to a drug-induced apoptosis in AGS cells

Autoren: Sung, JJY Jin, Y Leung, WK et al.

Quelle: Cell Research. 15:695-703

Schlagwörter: Electrophoresis, 0301 basic medicine, Enzyme Inhibitors - Pharmacology, Phenanthrenes - Pharmacology, Blotting, Western, Apoptosis, DNA Fragmentation, Cysteine Proteinase Inhibitors, Diterpenes - Pharmacology, Cell Line, Stomach Neoplasms - Drug Therapy - Pathology, Dna Fragmentation, 03 medical and health sciences, Cytosol, Cytosol - Metabolism, Tumor Suppressor Protein P53 - Metabolism - Physiology, Cell Line, Tumor, Mitochondria - Metabolism, Humans, Dominant, Enzyme Inhibitors, Cysteine Endopeptidases - Metabolism, Cysteine Proteinase Inhibitors - Pharmacology, Plasmids - Metabolism, Genes, Dominant, Neoplastic, 0303 health sciences, Tumor, Polyacrylamide Gel, Blotting, Cell Cycle, Proteasome Endopeptidase Complex - Metabolism, Phenanthrenes, Flow Cytometry, Mitochondria, 3. Good health, Gene Expression Regulation, Neoplastic, Cysteine Endopeptidases, Genes, Dna Damage, Gene Expression Regulation, Retinoblastoma Protein - Metabolism - Physiology, Electrophoresis, Polyacrylamide Gel, Comet Assay, Diterpenes, Western, DNA Damage

Zugangs-URL: https://www.nature.com/articles/7290339.pdf
https://pubmed.ncbi.nlm.nih.gov/16212876
https://www.nature.com/articles/7290339
http://www.irgrid.ac.cn/handle/1471x/969966
https://www.ncbi.nlm.nih.gov/pubmed/16212876
https://www.nature.com/articles/7290339.pdf
https://pubmed.ncbi.nlm.nih.gov/16212876/
https://core.ac.uk/display/37983814
http://hdl.handle.net/10722/162906

PG490-88, a derivative of triptolide, attenuates obliterative airway disease in a mouse heterotopic tracheal allograft model

Autoren: Leonard, Colm T Gasche-Soccal, Paola Marina Alessandra Berry, Gerald J et al.

Quelle: The Journal of heart and lung transplantation, Vol. 21, No 12 (2002) pp. 1314-8

Schlagwörter: Graft Rejection, Male, 0301 basic medicine, Transplantation, Heterotopic, Bronchiolitis Obliterans/etiology/prevention & control, Inbred C57BL, Sensitivity and Specificity, Lung Transplantation/adverse effects/methods, Mice, 03 medical and health sciences, 0302 clinical medicine, Reference Values, Animals, Diterpenes/pharmacology, Bronchiolitis Obliterans, ddc:616, Transplantation, Animal, Graft Survival, Immunohistochemistry, 3. Good health, Mice, Inbred C57BL, Trachea, Trachea/pathology/transplantation, Disease Models, Animal, Treatment Outcome, Disease Models, Heterotopic, Diterpenes, Lung Transplantation

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/12490278
https://archive-ouverte.unige.ch/unige:154495
https://www.research.manchester.ac.uk/portal/en/publications/pg49088-a-derivative-of-triptolide-attenuates-obliterative-airway-disease-in-a-mouse-heterotopic-tracheal-allograft-model(a5959729-aac1-4479-b0a2-7d88acb950c3).html
https://www.escholar.manchester.ac.uk/uk-ac-man-scw:1d28496
https://pubmed.ncbi.nlm.nih.gov/12490278/
https://www.sciencedirect.com/science/article/abs/pii/S1053249802004497
https://www.ncbi.nlm.nih.gov/pubmed/12490278
https://archive-ouverte.unige.ch/unige:154495
https://archive-ouverte.unige.ch/unige:154495
https://doi.org/10.1016/s1053-2498(02)00449-7

Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-κB activation in gastric cancer cells

Autoren: Jiang, XH Wong, BCY Lin, MCM et al.

Quelle: Oncogene. 20:8009-8018

Schlagwörter: 0301 basic medicine, Neoplastic - Drug Effects, Cell Division - Drug Effects, Oligonucleotides, Apoptosis, Electrophoretic Mobility Shift Assay, Diterpenes - Pharmacology, Tumor Cells, Cultured, Gene Expression Regulation, Neoplastic - Drug Effects, Cultured, Blotting, Caspase 3, Cell Cycle, Oligonucleotides, Antisense - Genetics, NF-kappa B, Flow Cytometry, Tumor Cells, 3. Good health, Gene Expression Regulation, Neoplastic, Cyclins - Metabolism, Caspases, Drug, Diterpenes, Poly(ADP-ribose) Polymerases, Antisense - Genetics, Western, Cell Division, Cyclin-Dependent Kinase Inhibitor p21, Apoptosis - Drug Effects, Poly(Adp-Ribose) Polymerases - Metabolism, Blotting, Western, Bcl-2-Associated X Protein, Dose-Response Relationship, 03 medical and health sciences, Cell Cycle - Drug Effects, Protein Binding - Drug Effects, Cyclins, Humans, Transcription Factor Ap-1 - Metabolism, Cyclin-Dependent Kinase Inhibitor P21, Dose-Response Relationship, Drug, Stomach Neoplasms - Metabolism - Pathology, Tumor Suppressor Protein P53 - Biosynthesis - Genetics - Metabolism, DNA, Oligonucleotides, Antisense, Phenanthrenes, Caspases - Metabolism, Gene Expression Regulation, Proto-Oncogene Proteins - Metabolism, Epoxy Compounds, Proto-Oncogene Proteins C-Bcl-2, Transcriptional Activation - Drug Effects, Nf-Kappa B - Metabolism, Dna - Genetics - Metabolism

Zugangs-URL: https://www.nature.com/articles/1204981.pdf
https://pubmed.ncbi.nlm.nih.gov/11753684
https://www.nature.com/articles/1204981
https://www.ncbi.nlm.nih.gov/pubmed/11753684
https://core.ac.uk/display/37991288
https://hub.hku.hk/handle/10722/167721
https://pubmed.ncbi.nlm.nih.gov/11753684/
https://www.nature.com/articles/1204981.pdf
http://hdl.handle.net/10722/167721

Labdane type diterpenes down-regulate the expression of c-myc protein, but not of bcl-2, in human leukemia T-cells undergoing apoptosis

Autoren: Dimas, K Demetzos, C Vaos, V et al.

Quelle: Leukemia Research. 25:449-454

Schlagwörter: 0301 basic medicine, 0303 health sciences, Leukemia, Apoptosis, Gene Expression Regulation, Leukemic, T-Lymphocytes, Genes, myc, Down-Regulation, Gene Expression Regulation, Leukemic/*drug effects, Genes, bcl-2, Proto-Oncogene Mas, 3. Good health, T-Lymphocytes/*metabolism, Diterpenes/*pharmacology, 03 medical and health sciences, Leukemia/*metabolism/pathology, Humans, Diterpenes

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/11337016
https://europepmc.org/abstract/MED/11337016
https://www.sciencedirect.com/science/article/abs/pii/S0145212600001508
http://olympias.lib.uoi.gr/jspui/handle/123456789/7558
https://pergamos.lib.uoa.gr/uoa/dl/object/3080326

The effect of sclareol on growth and cell cycle progression of human leukemic cell lines

Autoren: Dimas, K. Kokkinopoulos, D. Demetzos, C. et al.

Quelle: Leukemia Research. 23:217-234

Schlagwörter: 0301 basic medicine, 0303 health sciences, Leukemia, Cell Division/drug effects, DNA/biosynthesis, Cell Cycle, Cell Cycle/drug effects, Leukemia/*drug therapy/pathology, DNA, Antineoplastic Agents, Phytogenic/*pharmacology, Antineoplastic Agents, Phytogenic, Diterpenes/*pharmacology, 03 medical and health sciences, Tumor Cells, Cultured, Humans, Diterpenes, Cell Division, DNA Damage

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/10071073
https://www.sciencedirect.com/science/article/abs/pii/S0145212698001349
https://pubmed.ncbi.nlm.nih.gov/10071073/
https://europepmc.org/article/MED/10071073
http://www.sciencedirect.com/science/article/pii/S0145212698001349
https://www.ncbi.nlm.nih.gov/pubmed/10071073/
http://olympias.lib.uoi.gr/jspui/handle/123456789/24546

Peripheral Afferent Mechanisms Underlying Acupuncture Inhibition of Cocaine Behavioral Effects in Rats

Weitere Verfasser: Seol Ah Kim Bong Hyo Lee Jong Han Bae et al.

Quelle: T201305322.pdf

Schlagwörter: Acupuncture Points, Acupuncture Therapy, Afferent Pathways/drug effects, Afferent Pathways/physiopathology, Animals, Behavior, Animal/drug effects, Capsaicin/pharmacology, Cocaine-Related Disorders/physiopathology, Cocaine-Related Disorders/therapy, Diterpenes/pharmacology, Electric Stimulation, Locomotion/drug effects, Male, Nerve Fibers, Myelinated/drug effects, Unmyelinated/drug effects, Rats, Sprague-Dawley, Sensory System Agents/pharmacology, Ulnar Nerve/drug effects

Relation: PLOS ONE; J02540; https://ir.ymlib.yonsei.ac.kr/handle/22282913/88939; T201305322; PLOS ONE, Vol.8(11) : e81018, 2013; 33690

Verfügbarkeit: https://ir.ymlib.yonsei.ac.kr/handle/22282913/88939
https://doi.org/10.1371/journal.pone.0081018

Studies on Differentiation without Cleavage in Chaetopterus: Effects of Inhibition of DNA Synthesis with Aphidicolin

Autoren: J. Bracket B. De Petrocellis Henri Alexandre

Quelle: Differentiation, 19 (1

Schlagwörter: DNA Replication, 0301 basic medicine, 0303 health sciences, Time Factors, DNA -- biosynthesis, DNA Replication -- drug effects, Cell Differentiation, Polychaeta, DNA, Sciences bio-médicales et agricoles, 03 medical and health sciences, Cell Differentiation -- drug effects, Larva -- drug effects, Aphidicolin, Larva, Polychaeta -- metabolism -- physiology, Animals, Diterpenes, Diterpenes -- pharmacology

Dateibeschreibung: 1 full-text file(s): application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/6799347
https://www.onlinelibrary.wiley.com/doi/10.1111/j.1432-0436.1981.tb01126.x
http://europepmc.org/abstract/MED/6799347
https://core.ac.uk/display/77563859
https://www.sciencedirect.com/science/article/pii/S0301468111613777
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/172947/Details
https://www.ncbi.nlm.nih.gov/pubmed/6799347
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/172947

Secretin-induced changes in rate, contractility and adenylate cyclase activity in rat heart atria

Autoren: Robberecht, Patrick De Neef, Philippe Waelbroeck, Magali et al.

Quelle: Pflügers Archiv, 401 (1

Schlagwörter: Male, 0301 basic medicine, Cardiotonic Agents, Inbred Strains, Chemical, Myocardial Contraction -- drug effects, Isoproterenol -- pharmacology, 03 medical and health sciences, Cardiotonic Agents -- pharmacology, Secretin, Heart Rate, Heart Rate -- drug effects, Heart Atria -- drug effects -- enzymology, Animals, Heart Atria, Diterpenes -- pharmacology, 0303 health sciences, Colforsin, Isoproterenol, Rats, Inbred Strains, Sciences bio-médicales et agricoles, Atrial Function, Myocardial Contraction, Stimulation, Chemical, Rats, Stimulation, Adenylate Cyclase -- metabolism, Diterpenes, Secretin -- pharmacology, Forskolin, Adenylyl Cyclases

Dateibeschreibung: 1 full-text file(s): application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/6540864
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/148240/Details
https://europepmc.org/article/MED/6540864
https://www.ncbi.nlm.nih.gov/pubmed/6540864
https://link.springer.com/article/10.1007/BF00581525
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/148240