Search Results - "Disulfiram"

Repurposing antimicrobials, disulfiram, and metformin for cancer therapy: Bridging mechanistic gaps through RNA sequencing.

Authors: Hassan SN Ahmad F

Source: European journal of pharmacology [Eur J Pharmacol] 2025 Nov 15; Vol. 1007, pp. 178258. Date of Electronic Publication: 2025 Oct 14.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH Terms: Drug Repositioning* , Metformin*/therapeutic use , Metformin*/pharmacology , Neoplasms*/drug therapy , Neoplasms*/genetics , Neoplasms*/pathology , Disulfiram*/therapeutic use , Disulfiram*/pharmacology , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/pharmacology , Sequence Analysis, RNA* , Anti-Infective Agents*/therapeutic use , Anti-Infective Agents*/pharmacology, Humans ; Animals

The hepatic and developmental toxicity of chronic morphine and disulfiram co-treatment for pain relief - a comprehensive in vitro and in vivo assessment.

Authors: Zelazewska Z Lazarczyk M Paszkiewicz J et al.

Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2025 Nov; Vol. 504, pp. 117499. Date of Electronic Publication: 2025 Aug 07.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE

MeSH Terms: Disulfiram*/toxicity , Disulfiram*/administration & dosage , Morphine*/toxicity , Morphine*/administration & dosage , Liver*/drug effects , Liver*/pathology , Analgesics, Opioid*/toxicity , Analgesics, Opioid*/administration & dosage , Chemical and Drug Induced Liver Injury*/etiology , Chemical and Drug Induced Liver Injury*/pathology, Animals ; Zebrafish/embryology ; Humans ; Hep G2 Cells ; Rats ; Male ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Rats, Sprague-Dawley ; Drug Synergism

Liposomal delivery of a disulfiram metabolite drives copper-mediated tumor immunity.

Authors: Heroux D Leung AWY Gilabert-Oriol R et al.

Source: International journal of pharmaceutics [Int J Pharm] 2025 Oct 15; Vol. 683, pp. 126010. Date of Electronic Publication: 2025 Aug 02.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE

MeSH Terms: Copper*/chemistry , Copper*/administration & dosage , Copper*/metabolism , Disulfiram*/administration & dosage , Disulfiram*/metabolism , Disulfiram*/pharmacology , Ditiocarb*/administration & dosage , Ditiocarb*/chemistry , Ditiocarb*/pharmacology , Antineoplastic Agents*/administration & dosage , Antineoplastic Agents*/pharmacology, Animals ; Liposomes ; Female ; Cell Line, Tumor ; Humans ; Mice, Inbred BALB C ; Mice

A dual-targeted liposomal nanosystem for co-delivery of estrogen receptor β antagonist and disulfiram for the non-hormonal treatment of endometriosis.

Authors: Liao Z Li J Xian S et al.

Source: Acta biomaterialia [Acta Biomater] 2025 Dec; Vol. 208, pp. 456-471. Date of Electronic Publication: 2025 Oct 29.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE

MeSH Terms: Disulfiram*/pharmacology , Disulfiram*/chemistry , Disulfiram*/pharmacokinetics , Disulfiram*/therapeutic use , Endometriosis*/drug therapy , Endometriosis*/pathology , Endometriosis*/metabolism , Estrogen Receptor beta*/antagonists & inhibitors , Estrogen Receptor beta*/metabolism , Liposomes*/chemistry , Drug Delivery Systems*, Female ; Animals ; Humans ; Mice ; Pyroptosis/drug effects

A photothermally triggered cascade bioreactor for cuproptosis and ferroptosis-driven cancer immunotherapy.

Authors: Xu J Wang Y Williams GR et al.

Source: Journal of colloid and interface science [J Colloid Interface Sci] 2025 Dec; Vol. 699 (Pt 1), pp. 138100. Date of Electronic Publication: 2025 Jun 06.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0043125 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-7103 (Electronic) Linking ISSN: 00219797 NLM ISO Abbreviation: J Colloid Interface Sci Subsets: MEDLINE

MeSH Terms: Ferroptosis*/drug effects , Copper*/chemistry , Immunotherapy* , Disulfiram*/pharmacology , Disulfiram*/chemistry , Bioreactors* , Neoplasms*/therapy , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry, Humans ; Gold/chemistry ; Particle Size ; Surface Properties ; Cell Survival/drug effects ; Nanoparticles/chemistry ; Cell Line, Tumor ; Silicon Dioxide/chemistry

Lung cancer chemo-interception by sulfasalazine and disulfiram codelivered using a nano self-emulsifying drug delivery system in mice.

Authors: Kassie F Wang K Bang K et al.

Source: Carcinogenesis [Carcinogenesis] 2025 Nov 21; Vol. 46 (4).

Publication Type: Journal Article

Journal Info: Publisher: Irl Press At Oxford University Press Country of Publication: England NLM ID: 8008055 Publication Model: Print Cited Medium: Internet ISSN: 1460-2180 (Electronic) Linking ISSN: 01433334 NLM ISO Abbreviation: Carcinogenesis Subsets: MEDLINE

MeSH Terms: Disulfiram*/administration & dosage , Sulfasalazine*/administration & dosage , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Lung Neoplasms*/chemically induced , Lung Neoplasms*/prevention & control , Drug Delivery Systems*, Animals ; Mice ; Emulsions ; Nitrosamines/toxicity ; Male ; Adenoma/drug therapy ; Adenoma/chemically induced ; Adenoma/pathology

Disulfiram Prevents Blood-Brain Barrier Disruption in Epileptic Mice by Inhibiting Astrocyte Pyroptosis to Improve Seizure Activity.

Authors: Zhang M Zhao L Chen S et al.

Source: Molecular neurobiology [Mol Neurobiol] 2025 Nov 12; Vol. 63 (1), pp. 34. Date of Electronic Publication: 2025 Nov 12.

Publication Type: Journal Article

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH Terms: Blood-Brain Barrier*/drug effects , Blood-Brain Barrier*/pathology , Pyroptosis*/drug effects , Astrocytes*/drug effects , Astrocytes*/pathology , Astrocytes*/metabolism , Disulfiram*/pharmacology , Disulfiram*/therapeutic use , Epilepsy*/drug therapy , Epilepsy*/pathology , Epilepsy*/physiopathology , Seizures*/drug therapy , Seizures*/pathology , Seizures*/physiopathology , Seizures*/complications, Animals ; Male ; Mice, Inbred C57BL ; Mice ; Hippocampus/drug effects ; Hippocampus/pathology ; Kainic Acid ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism

Intranasal delivery of temozolomide and disulfiram in situ gel combined with copper for enhanced glioblastoma therapy.

Authors: Qu Y Zhao J Ma L et al.

Source: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2025 Nov; Vol. 255, pp. 114898. Date of Electronic Publication: 2025 Jun 24.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE

MeSH Terms: Disulfiram*/pharmacology , Disulfiram*/chemistry , Disulfiram*/administration & dosage , Glioblastoma*/drug therapy , Glioblastoma*/pathology , Copper*/chemistry , Copper*/pharmacology , Temozolomide*/pharmacology , Temozolomide*/chemistry , Temozolomide*/administration & dosage , Brain Neoplasms*/drug therapy , Brain Neoplasms*/pathology , Antineoplastic Agents, Alkylating*/pharmacology , Antineoplastic Agents, Alkylating*/administration & dosage , Antineoplastic Agents, Alkylating*/chemistry, Humans ; Administration, Intranasal ; Animals ; Mice ; Apoptosis/drug effects ; Hydrogels/chemistry ; Drug Delivery Systems ; Gels/chemistry ; Cell Proliferation/drug effects ; Drug Liberation ; Cell Line, Tumor ; Tumor Microenvironment/drug effects

Doxorubicin and disulfiram metabolite encapsulated biomimetic liposomal formulation as an effective combination therapy against leukaemia.

Authors: Tariq U Rana NF Anees M et al.

Source: Biomedical materials (Bristol, England) [Biomed Mater] 2025 Oct 03; Vol. 20 (6). Date of Electronic Publication: 2025 Oct 03.

Publication Type: Journal Article

Journal Info: Publisher: Institute of Physics Pub Country of Publication: England NLM ID: 101285195 Publication Model: Electronic Cited Medium: Internet ISSN: 1748-605X (Electronic) Linking ISSN: 17486041 NLM ISO Abbreviation: Biomed Mater Subsets: MEDLINE

MeSH Terms: Doxorubicin*/administration & dosage , Doxorubicin*/chemistry , Liposomes*/chemistry , Disulfiram*/chemistry , Disulfiram*/administration & dosage , Leukemia*/drug therapy , Biomimetic Materials*/chemistry, Animals ; Rats ; Rats, Wistar ; Male ; Ditiocarb/chemistry ; Humans ; Antioxidants/chemistry ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Nanoparticles/chemistry ; Cell Line, Tumor

Repurposing disulfiram: targeting Zeb1 to attenuate paraquat-induced pulmonary fibrosis in rats.

Authors: Karimzadeh F Daraei A Zabihi-Neyshaburi E et al.

Source: Journal of molecular histology [J Mol Histol] 2025 Sep 18; Vol. 56 (5), pp. 318. Date of Electronic Publication: 2025 Sep 18.

Publication Type: Journal Article

Journal Info: Publisher: Springer Netherlands Country of Publication: Netherlands NLM ID: 101193653 Publication Model: Electronic Cited Medium: Internet ISSN: 1567-2387 (Electronic) Linking ISSN: 15672379 NLM ISO Abbreviation: J Mol Histol Subsets: MEDLINE

MeSH Terms: Paraquat*/toxicity , Paraquat*/adverse effects , Pulmonary Fibrosis*/chemically induced , Pulmonary Fibrosis*/drug therapy , Pulmonary Fibrosis*/pathology , Pulmonary Fibrosis*/metabolism , Disulfiram*/pharmacology , Disulfiram*/therapeutic use , Zinc Finger E-box-Binding Homeobox 1*/metabolism , Zinc Finger E-box-Binding Homeobox 1*/genetics , Drug Repositioning*, Animals ; Male ; Rats ; Rats, Wistar ; Lung/pathology ; Lung/drug effects ; Lung/metabolism ; Disease Models, Animal

Disulfiram Protects Against Multiorgan Injuries and Cell Pyroptosis via Inhibiting GSDMD in Severe Acute Pancreatitis Mice.

Authors: Zhao T Zhao S Fang R et al.

Source: Journal of cellular and molecular medicine [J Cell Mol Med] 2025 Aug; Vol. 29 (15), pp. e70707.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101083777 Publication Model: Print Cited Medium: Internet ISSN: 1582-4934 (Electronic) Linking ISSN: 15821838 NLM ISO Abbreviation: J Cell Mol Med Subsets: MEDLINE

MeSH Terms: Disulfiram*/pharmacology , Disulfiram*/therapeutic use , Pyroptosis*/drug effects , Phosphate-Binding Proteins*/metabolism , Phosphate-Binding Proteins*/antagonists & inhibitors , Phosphate-Binding Proteins*/genetics , Pancreatitis*/drug therapy , Pancreatitis*/pathology , Pancreatitis*/metabolism , Pancreatitis*/complications , Multiple Organ Failure*/pathology , Multiple Organ Failure*/prevention & control , Multiple Organ Failure*/drug therapy , Multiple Organ Failure*/etiology , Intracellular Signaling Peptides and Proteins*/metabolism , Intracellular Signaling Peptides and Proteins*/antagonists & inhibitors , Protective Agents*/pharmacology, Animals ; Mice ; Male ; Disease Models, Animal ; Cytokines/metabolism ; Cytokines/genetics ; Mice, Inbred C57BL ; Pancreas/pathology ; Pancreas/drug effects ; Pancreas/metabolism ; Gasdermins

Repurposing disulfiram: An innovative inhibitory approach against a broad spectrum of viruses.

Authors: Zhou Y Feng M Zhang L

Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Sep 30; Vol. 782, pp. 152596. Date of Electronic Publication: 2025 Sep 04.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH Terms: Disulfiram*/pharmacology , Disulfiram*/therapeutic use , Antiviral Agents*/pharmacology , Antiviral Agents*/therapeutic use , Antiviral Agents*/chemistry , Drug Repositioning* , Virus Diseases*/drug therapy , Virus Diseases*/virology , Viruses*/drug effects, Humans ; SARS-CoV-2/drug effects ; Virus Replication/drug effects ; Viral Proteins/metabolism ; Viral Proteins/antagonists & inhibitors ; Viral Proteins/chemistry ; Zinc/metabolism ; COVID-19 Drug Treatment

Characterization of immune cells in the rat intestinal mucosa and liver involved in inflammation caused by LPS and evaluation of the effects of N-acetylcysteine and disulfiram (well-known sulfur drugs) for this inflammation.

Authors: Miller A Lombardo GP Spiccia L et al.

Source: Acta histochemica [Acta Histochem] 2025 Sep; Vol. 127 (3), pp. 152272. Date of Electronic Publication: 2025 Jun 06.

Publication Type: Journal Article

Journal Info: Publisher: Gustav Fischer Verlag Country of Publication: Germany NLM ID: 0370320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0372 (Electronic) Linking ISSN: 00651281 NLM ISO Abbreviation: Acta Histochem Subsets: MEDLINE

MeSH Terms: Disulfiram*/pharmacology , Lipopolysaccharides*/toxicity , Intestinal Mucosa*/immunology , Intestinal Mucosa*/drug effects , Intestinal Mucosa*/pathology , Acetylcysteine*/pharmacology , Inflammation*/drug therapy , Inflammation*/chemically induced , Inflammation*/immunology , Inflammation*/pathology , Liver*/immunology , Liver*/drug effects , Liver*/pathology, Animals ; Rats ; Male ; Rats, Wistar

A novel Zn ²⁺ probe for fluorescent monitoring of drug and E6/E7 protein interaction in living cells.

Authors: Xie Z Yu L Li Z et al.

Source: Analytica chimica acta [Anal Chim Acta] 2025 Aug 15; Vol. 1363, pp. 344202. Date of Electronic Publication: 2025 May 17.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4324 (Electronic) Linking ISSN: 00032670 NLM ISO Abbreviation: Anal Chim Acta Subsets: MEDLINE

MeSH Terms: Zinc*/metabolism , Zinc*/chemistry , Zinc*/analysis , Oncogene Proteins, Viral*/metabolism , Oncogene Proteins, Viral*/chemistry , Fluorescent Dyes*/chemistry , Fluorescent Dyes*/chemical synthesis , Papillomavirus E7 Proteins*/metabolism , Papillomavirus E7 Proteins*/chemistry , Repressor Proteins*/metabolism , Repressor Proteins*/chemistry , Disulfiram*/pharmacology , Disulfiram*/chemistry, Humans ; Cell Line, Tumor

Exploiting mitochondrial dysfunction to overcome BRAF inhibitor resistance in advanced melanoma: the role of disulfiram as a copper ionophore.

Authors: Zhao B Ban F Li Y et al.

Source: Cell death & disease [Cell Death Dis] 2025 Jul 01; Vol. 16 (1), pp. 482. Date of Electronic Publication: 2025 Jul 01.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

MeSH Terms: Disulfiram*/pharmacology , Melanoma*/drug therapy , Melanoma*/pathology , Melanoma*/genetics , Melanoma*/metabolism , Mitochondria*/drug effects , Mitochondria*/metabolism , Mitochondria*/pathology , Drug Resistance, Neoplasm*/drug effects , Copper*/metabolism , Proto-Oncogene Proteins B-raf*/antagonists & inhibitors , Proto-Oncogene Proteins B-raf*/metabolism , Proto-Oncogene Proteins B-raf*/genetics , Protein Kinase Inhibitors*/pharmacology , Ionophores*/pharmacology, Humans ; Animals ; Cell Line, Tumor ; Mice ; Mice, Nude ; Oxidative Stress/drug effects

Disulfiram alleviates epithelial barrier disruption in ozone-induced chronic obstructive pulmonary disease mouse models via inhibiting Gasdermin D-mediated pyroptosis.

Authors: Gao J Han L Zhang Y et al.

Source: International immunopharmacology [Int Immunopharmacol] 2025 Jun 26; Vol. 159, pp. 114887. Date of Electronic Publication: 2025 May 20.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH Terms: Pulmonary Disease, Chronic Obstructive*/drug therapy , Pulmonary Disease, Chronic Obstructive*/chemically induced , Pulmonary Disease, Chronic Obstructive*/pathology , Pulmonary Disease, Chronic Obstructive*/metabolism , Pyroptosis*/drug effects , Disulfiram*/pharmacology , Disulfiram*/therapeutic use , Phosphate-Binding Proteins*/metabolism , Phosphate-Binding Proteins*/genetics , Intracellular Signaling Peptides and Proteins*/metabolism , Epithelial Cells*/drug effects , Epithelial Cells*/metabolism, Animals ; Ozone ; Humans ; Mice ; Disease Models, Animal ; Male ; Mice, Inbred C57BL ; Lung/drug effects ; Lung/pathology ; Female ; Gasdermins

A randomized clinical trial of disulfiram at higher doses for the treatment of cocaine use disorder among methadone-stabilized patients.

Authors: Oliveto AH McGaugh J Chopra MP et al.

Source: Journal of psychiatric research [J Psychiatr Res] 2025 Jun; Vol. 186, pp. 387-395. Date of Electronic Publication: 2025 Apr 26.

Publication Type: Journal Article; Randomized Controlled Trial

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 0376331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1379 (Electronic) Linking ISSN: 00223956 NLM ISO Abbreviation: J Psychiatr Res Subsets: MEDLINE

MeSH Terms: Disulfiram*/administration & dosage , Disulfiram*/therapeutic use , Cocaine-Related Disorders*/drug therapy , Cocaine-Related Disorders*/complications , Cocaine-Related Disorders*/urine , Methadone*/therapeutic use , Opioid-Related Disorders*/drug therapy , Opioid-Related Disorders*/complications , Alcohol Deterrents*/administration & dosage , Alcohol Deterrents*/therapeutic use, Humans ; Male ; Female ; Adult ; Double-Blind Method ; Middle Aged ; Dose-Response Relationship, Drug ; Treatment Outcome ; Opiate Substitution Treatment ; Cocaine/urine ; Narcotics/therapeutic use

Disulfiram activation of prostaglandin E2 synthesis: a novel antifibrotic mechanism in pulmonary fibrosis.

Authors: Pei X Zheng F Li Y et al.

Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2025 Jun; Vol. 392 (6), pp. 103588. Date of Electronic Publication: 2025 Apr 21.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

MeSH Terms: Disulfiram*/pharmacology , Disulfiram*/therapeutic use , Dinoprostone*/biosynthesis , Idiopathic Pulmonary Fibrosis*/drug therapy , Idiopathic Pulmonary Fibrosis*/metabolism , Idiopathic Pulmonary Fibrosis*/pathology , Pulmonary Fibrosis*/drug therapy , Pulmonary Fibrosis*/metabolism , Antifibrotic Agents*/pharmacology , Antifibrotic Agents*/therapeutic use, Animals ; Humans ; Mice ; Cyclooxygenase 2/metabolism ; Mice, Inbred C57BL ; Male ; Epithelial-Mesenchymal Transition/drug effects ; A549 Cells ; Cell Survival/drug effects ; Cell Movement/drug effects ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Lung/drug effects ; Lung/pathology ; Lung/metabolism

Disulfiram-loaded electrospun fibers with antimicrobial and antitumoral properties for glioblastoma treatment.

Authors: Gonzalez-Prada I Barcelos Ribeiro A Dion M et al.

Source: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 May 10; Vol. 381, pp. 113615. Date of Electronic Publication: 2025 Mar 12.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

MeSH Terms: Glioblastoma*/drug therapy , Glioblastoma*/pathology , Disulfiram*/administration & dosage , Disulfiram*/chemistry , Disulfiram*/pharmacology , Disulfiram*/therapeutic use , Nanofibers*/chemistry , Nanofibers*/administration & dosage , Brain Neoplasms*/drug therapy , Brain Neoplasms*/pathology , Antineoplastic Agents*/administration & dosage , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use , Anti-Infective Agents*/administration & dosage , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemistry, Animals ; Humans ; Cell Line, Tumor ; 2-Hydroxypropyl-beta-cyclodextrin/chemistry ; Pseudomonas aeruginosa/drug effects ; Staphylococcus aureus/drug effects ; Drug Liberation ; Copper/chemistry ; Copper/administration & dosage ; Fibroins/chemistry ; Rats

Disulfiram in liver diseases: a double-edged sword.

Authors: Xiong W Tian A Qian Z et al.

Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 May; Vol. 398 (5), pp. 4875-4889. Date of Electronic Publication: 2024 Dec 16.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

MeSH Terms: Disulfiram*/therapeutic use , Disulfiram*/adverse effects , Alcohol Deterrents*/adverse effects , Alcohol Deterrents*/therapeutic use , Liver Diseases*/drug therapy, Humans ; Animals ; Chemical and Drug Induced Liver Injury/etiology ; Liver Diseases, Alcoholic/drug therapy