Search Results - "Disease Models"

Novel standardized method for inducing medication-related osteonecrosis of the jaw in rats and precise quantitative assessment of pathological outcomes.

Authors: Hanada D Mochizuki M Nakahara T et al.

Source: Odontology [Odontology] 2025 Oct; Vol. 113 (4), pp. 1415-1426. Date of Electronic Publication: 2025 Mar 01.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Tokyo Country of Publication: Japan NLM ID: 101134822 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-1255 (Electronic) Linking ISSN: 16181247 NLM ISO Abbreviation: Odontology Subsets: MEDLINE

MeSH Terms: Bisphosphonate-Associated Osteonecrosis of the Jaw*/pathology , Bisphosphonate-Associated Osteonecrosis of the Jaw*/etiology , Bisphosphonate-Associated Osteonecrosis of the Jaw*/diagnostic imaging , Disease Models, Animal*, Animals ; Rats ; X-Ray Microtomography ; Tooth Extraction ; Rats, Sprague-Dawley ; Male ; Molar/surgery

Investigating the effects of melatonin on structural and vascular changes in an experimentally induced ovarian hyperstimulation syndrome model : Effects of melatonin on experimentally induced ovarian hyperstimulation syndrome.

Authors: Yiğit F Ömeroğlu S Yiğman Z et al.

Source: Histochemistry and cell biology [Histochem Cell Biol] 2025 Dec 06; Vol. 163 (1), pp. 116. Date of Electronic Publication: 2025 Dec 06.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 9506663 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-119X (Electronic) Linking ISSN: 09486143 NLM ISO Abbreviation: Histochem Cell Biol Subsets: MEDLINE

MeSH Terms: Melatonin*/pharmacology , Melatonin*/therapeutic use , Melatonin*/administration & dosage , Ovarian Hyperstimulation Syndrome*/drug therapy , Ovarian Hyperstimulation Syndrome*/pathology , Ovarian Hyperstimulation Syndrome*/chemically induced , Ovarian Hyperstimulation Syndrome*/metabolism , Disease Models, Animal*, Animals ; Female ; Rats ; Vascular Endothelial Growth Factor A/metabolism ; Rats, Sprague-Dawley ; Rats, Wistar ; Ovary/drug effects ; Ovary/pathology ; Ovary/blood supply

Determination of appropriate time for establishing a model of postmenopausal osteoporosis induced by bilateral oophorectomy: From bibliometric analysis to animal experiment.

Authors: She Y Yin L Kuang Y et al.

Source: PloS one [PLoS One] 2025 Dec 04; Vol. 20 (12), pp. e0336703. Date of Electronic Publication: 2025 Dec 04 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH Terms: Ovariectomy*/adverse effects , Osteoporosis, Postmenopausal*/etiology , Osteoporosis, Postmenopausal*/pathology , Disease Models, Animal*, Animals ; Female ; Mice ; Bone Density ; Bibliometrics ; Humans ; Mice, Inbred C57BL ; Time Factors

Zebrafish: The Aquatic Pioneers of Brain Research.

Authors: Mishra M Nayak BP

Source: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience [Int J Dev Neurosci] 2025 Dec; Vol. 85 (8), pp. e70061.

Publication Type: Journal Article; Review

Journal Info: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 8401784 Publication Model: Print Cited Medium: Internet ISSN: 1873-474X (Electronic) Linking ISSN: 07365748 NLM ISO Abbreviation: Int J Dev Neurosci Subsets: MEDLINE

MeSH Terms: Zebrafish*/physiology , Brain*/physiology , Disease Models, Animal* , Brain Diseases*/physiopathology, Animals ; Humans

A Survey of Opsin Localization, Glycosylation, and Light/Chromophore Influence on Degeneration in 26 Rhodopsin-Associated RP Models.

Authors: Loewen AD Tam BM Chiu CN et al.

Source: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2025 Dec 01; Vol. 66 (15), pp. 9.

Publication Type: Journal Article

Journal Info: Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE

MeSH Terms: Rhodopsin*/genetics , Rhodopsin*/metabolism , Disease Models, Animal* , Retinal Degeneration*/metabolism , Retinal Degeneration*/genetics , Opsins*/metabolism, Animals ; Glycosylation ; Xenopus laevis ; Humans ; Animals, Genetically Modified ; Mutation ; Light ; Microscopy, Confocal

The Woodchuck Hepatitis Virus Model of Hepatocellular Carcinoma for Interventional Radiology Research.

Authors: Reed SL Chandra VM Pritchard WF et al.

Source: Journal of vascular and interventional radiology : JVIR [J Vasc Interv Radiol] 2025 Dec; Vol. 36 (12), pp. 1888-1893.

Publication Type: Journal Article; Review

Journal Info: Publisher: Society of Cardiovascular and Interventional Radiology Country of Publication: United States NLM ID: 9203369 Publication Model: Print Cited Medium: Internet ISSN: 1535-7732 (Electronic) Linking ISSN: 10510443 NLM ISO Abbreviation: J Vasc Interv Radiol Subsets: MEDLINE

MeSH Terms: Carcinoma, Hepatocellular*/virology , Carcinoma, Hepatocellular*/diagnostic imaging , Carcinoma, Hepatocellular*/therapy , Carcinoma, Hepatocellular*/pathology , Marmota*/virology , Hepatitis B Virus, Woodchuck*/pathogenicity , Liver Neoplasms*/virology , Liver Neoplasms*/therapy , Liver Neoplasms*/pathology , Liver Neoplasms*/diagnostic imaging , Disease Models, Animal* , Radiology, Interventional*/methods , Liver Neoplasms, Experimental*/virology , Liver Neoplasms, Experimental*/pathology , Liver Neoplasms, Experimental*/therapy , Liver Neoplasms, Experimental*/diagnostic imaging , Radiography, Interventional*, Animals ; Humans ; Tumor Microenvironment ; Translational Research, Biomedical

Experimental modeling for tauopathies: An isogenic panel of humanized MAPT knock-in mice.

Authors: Morito T Watamura N

Source: Neuroscience research [Neurosci Res] 2025 Dec; Vol. 221, pp. 104986. Date of Electronic Publication: 2025 Nov 11.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 8500749 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8111 (Electronic) Linking ISSN: 01680102 NLM ISO Abbreviation: Neurosci Res Subsets: MEDLINE

MeSH Terms: Tauopathies*/genetics , Tauopathies*/metabolism , Tauopathies*/pathology , tau Proteins*/genetics , tau Proteins*/metabolism , Disease Models, Animal*, Animals ; Humans ; Gene Knock-In Techniques ; Mice ; Mice, Transgenic ; Brain/metabolism ; Mutation

Advances in non-human primate models for Alzheimer's disease research.

Authors: Joho D Sato K Kumita W et al.

Source: Neuroscience research [Neurosci Res] 2025 Dec; Vol. 221, pp. 104984. Date of Electronic Publication: 2025 Nov 08.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 8500749 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8111 (Electronic) Linking ISSN: 01680102 NLM ISO Abbreviation: Neurosci Res Subsets: MEDLINE

MeSH Terms: Alzheimer Disease*/pathology , Alzheimer Disease*/genetics , Alzheimer Disease*/metabolism , Disease Models, Animal* , Brain*/pathology , Brain*/metabolism, Animals ; Callithrix ; Humans ; Amyloid beta-Peptides/metabolism

Research progress and application prospects of animal models of group B Coxsackievirus infections.

Authors: Weng S Zhu R Wu Y et al.

Source: Emerging microbes & infections [Emerg Microbes Infect] 2025 Dec; Vol. 14 (1), pp. 2441391. Date of Electronic Publication: 2024 Dec 22.

Publication Type: Journal Article; Review

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE

MeSH Terms: Coxsackievirus Infections*/virology , Disease Models, Animal*, Animals ; Humans ; Mice ; Enterovirus B, Human/pathogenicity ; Enterovirus B, Human/physiology ; Hand, Foot and Mouth Disease/virology

A novel X-linked retinitis pigmentosa beagle dog model for ophthalmic research established rapidly by editing the RPGR gene in zygotes.

Authors: Xie D Wang J Huang L et al.

Source: Experimental eye research [Exp Eye Res] 2025 Dec; Vol. 261, pp. 110697. Date of Electronic Publication: 2025 Oct 15.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 0370707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0007 (Electronic) Linking ISSN: 00144835 NLM ISO Abbreviation: Exp Eye Res Subsets: MEDLINE

MeSH Terms: Retinitis Pigmentosa*/genetics , Retinitis Pigmentosa*/metabolism , Retinitis Pigmentosa*/physiopathology , Disease Models, Animal* , Eye Proteins*/genetics , Gene Editing*/methods , Genetic Diseases, X-Linked*/genetics , Zygote*/metabolism, Animals ; Dogs ; Female ; Electroretinography ; CRISPR-Cas Systems ; Male ; Mutation

Assessing the application potential of different species as obstructive sleep apnea models: a comparative analysis based on cranial CT anatomy.

Authors: Feng Y Cai W Ming X et al.

Source: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2025 Dec; Vol. 282 (12), pp. 6477-6487. Date of Electronic Publication: 2025 Sep 23.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: Springer International Country of Publication: Germany NLM ID: 9002937 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1434-4726 (Electronic) Linking ISSN: 09374477 NLM ISO Abbreviation: Eur Arch Otorhinolaryngol Subsets: MEDLINE

MeSH Terms: Sleep Apnea, Obstructive*/diagnostic imaging , Disease Models, Animal* , Tomography, X-Ray Computed* , Skull*/diagnostic imaging , Skull*/anatomy & histology, Animals ; Rabbits ; Rats ; Humans ; Mice ; Species Specificity ; Tupaiidae ; Hyoid Bone/diagnostic imaging ; Imaging, Three-Dimensional ; Palate, Soft/diagnostic imaging ; Tongue/diagnostic imaging ; Mandible/diagnostic imaging

Traumatic brain injury and Alzheimer's disease related neurodegenerative diseases: Insights from animal models.

Authors: Zhao X He Z

Source: Neuroscience research [Neurosci Res] 2025 Dec; Vol. 221, pp. 104979. Date of Electronic Publication: 2025 Nov 01.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 8500749 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8111 (Electronic) Linking ISSN: 01680102 NLM ISO Abbreviation: Neurosci Res Subsets: MEDLINE

MeSH Terms: Brain Injuries, Traumatic*/pathology , Brain Injuries, Traumatic*/metabolism , Brain Injuries, Traumatic*/complications , Brain Injuries, Traumatic*/epidemiology , Alzheimer Disease*/pathology , Alzheimer Disease*/metabolism , Disease Models, Animal* , Neurodegenerative Diseases*/pathology , Neurodegenerative Diseases*/metabolism, Animals ; Humans

Animal Models of Parkinson's Disease.

Authors: Dawson VL Dawson TM

Source: Cold Spring Harbor perspectives in medicine [Cold Spring Harb Perspect Med] 2025 Dec 01; Vol. 15 (12). Date of Electronic Publication: 2025 Dec 01.

Publication Type: Journal Article; Review

Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 101571139 Publication Model: Electronic Cited Medium: Internet ISSN: 2157-1422 (Electronic) Linking ISSN: 21571422 NLM ISO Abbreviation: Cold Spring Harb Perspect Med Subsets: MEDLINE

MeSH Terms: Parkinson Disease*/genetics , Parkinson Disease*/pathology , Disease Models, Animal* , alpha-Synuclein*/genetics , alpha-Synuclein*/metabolism, Animals ; Mice ; Humans ; Mice, Knockout ; Mice, Transgenic

Uterine inflammation and lessons from large animal models of endometritis.

Authors: Nash DM Giles JL

Source: Nature reviews. Immunology [Nat Rev Immunol] 2025 Dec; Vol. 25 (12), pp. 934-946. Date of Electronic Publication: 2025 Jul 22.

Publication Type: Journal Article; Review

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-1741 (Electronic) Linking ISSN: 14741733 NLM ISO Abbreviation: Nat Rev Immunol Subsets: MEDLINE

MeSH Terms: Endometritis*/immunology , Disease Models, Animal* , Uterus*/immunology , Uterus*/pathology, Animals ; Female ; Humans ; Swine ; Cattle ; Immunity, Innate ; Endometrium/immunology ; Inflammation/immunology

Comprehensive characterization of the rat magnetic microbead model using longitudinal monitoring of structural and functional parameters.

Authors: Mickevičius K Paulauskas T Čėsna R et al.

Source: Experimental eye research [Exp Eye Res] 2025 Dec; Vol. 261, pp. 110651. Date of Electronic Publication: 2025 Sep 20.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 0370707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0007 (Electronic) Linking ISSN: 00144835 NLM ISO Abbreviation: Exp Eye Res Subsets: MEDLINE

MeSH Terms: Retinal Ganglion Cells*/pathology , Retinal Ganglion Cells*/physiology , Disease Models, Animal* , Glaucoma*/physiopathology , Glaucoma*/diagnosis , Ocular Hypertension*/physiopathology, Animals ; Tomography, Optical Coherence/methods ; Electroretinography ; Intraocular Pressure/physiology ; Rats ; Visual Acuity/physiology ; Male ; Contrast Sensitivity/physiology ; Optic Nerve/pathology ; Retina/physiopathology

Animal models for enterovirus 71: Mechanisms, immunity, and applications.

Authors: Zou Z Liu J Fu L et al.

Source: Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2025 Dec; Vol. 21 (1), pp. 2523109. Date of Electronic Publication: 2025 Jun 24.

Publication Type: Journal Article; Review

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101572652 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-554X (Electronic) Linking ISSN: 21645515 NLM ISO Abbreviation: Hum Vaccin Immunother Subsets: MEDLINE

MeSH Terms: Enterovirus A, Human*/immunology , Enterovirus A, Human*/pathogenicity , Disease Models, Animal* , Hand, Foot and Mouth Disease*/immunology , Hand, Foot and Mouth Disease*/virology , Hand, Foot and Mouth Disease*/prevention & control , Enterovirus Infections*/immunology , Enterovirus Infections*/virology, Animals ; Humans ; Mice ; Viral Vaccines/immunology ; Viral Vaccines/administration & dosage

Developing a model of temporomandibular disorder in the common marmoset using nerve growth factor.

Authors: Holzscherer EJ Kersten R Bertrand M et al.

Source: Journal of neurophysiology [J Neurophysiol] 2025 Dec 01; Vol. 134 (6), pp. 1927-1938. Date of Electronic Publication: 2025 Nov 04.

Publication Type: Journal Article

Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 0375404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1598 (Electronic) Linking ISSN: 00223077 NLM ISO Abbreviation: J Neurophysiol Subsets: MEDLINE

MeSH Terms: Nerve Growth Factor*/administration & dosage , Nerve Growth Factor*/pharmacology , Disease Models, Animal* , Temporomandibular Joint Disorders*/physiopathology , Temporomandibular Joint Disorders*/chemically induced, Animals ; Callithrix ; Male ; Circadian Rhythm/drug effects ; Behavior, Animal/drug effects ; Female ; Masseter Muscle/drug effects ; Masseter Muscle/physiopathology

The progression of metabolic dysfunction-associated steatotic liver disease toward hepatocellular carcinoma in an efficient rat model.

Authors: Márquez-Quiroga LV Cardoso-Lezama I Alarcón-Sánchez BR et al.

Source: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 3), pp. 117369. Date of Electronic Publication: 2025 Sep 25.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH Terms: Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/etiology , Disease Progression* , Fatty Liver*/metabolism , Fatty Liver*/pathology , Fatty Liver*/complications , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/etiology , Disease Models, Animal* , Liver Neoplasms, Experimental*/metabolism , Liver Neoplasms, Experimental*/pathology, Animals ; Male ; Rats, Inbred F344 ; Rats ; Diethylnitrosamine/toxicity

Drosophila melanogaster as a physiologically relevant invertebrate teaching model system of complex neurological disease.

Authors: Rouse JL Corns LF Seeley A et al.

Source: Advances in physiology education [Adv Physiol Educ] 2025 Dec 01; Vol. 49 (4), pp. 1142-1148. Date of Electronic Publication: 2025 Oct 17.

Publication Type: Journal Article

Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100913944 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1229 (Electronic) Linking ISSN: 10434046 NLM ISO Abbreviation: Adv Physiol Educ Subsets: MEDLINE

MeSH Terms: Drosophila melanogaster*/physiology , Drosophila melanogaster*/genetics , Disease Models, Animal* , Nervous System Diseases*/physiopathology , Nervous System Diseases*/genetics , Physiology*/education, Animals ; Teaching ; Humans

Animal Models of Porphyria with Hepatic Involvement.

Authors: Balogun O Nejak-Bowen K

Source: Seminars in liver disease [Semin Liver Dis] 2025 Dec; Vol. 45 (4), pp. 531-548. Date of Electronic Publication: 2025 Aug 21.

Publication Type: Journal Article; Review

Journal Info: Publisher: Thieme Country of Publication: United States NLM ID: 8110297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-8971 (Electronic) Linking ISSN: 02728087 NLM ISO Abbreviation: Semin Liver Dis Subsets: MEDLINE

MeSH Terms: Disease Models, Animal* , Porphyrias, Hepatic*/metabolism , Liver*/metabolism , Liver*/pathology , Porphyrias*/metabolism, Animals ; Humans ; Heme/biosynthesis ; Heme/metabolism ; Porphyrins/metabolism