Výsledky vyhľadávania - "Diabetes Mellitus"

Hypoglycemic effect of C. butyricum -pMTL007-GLP-1 engineered probiotics on type 2 diabetes mellitus.

Autori: Zhou D Li S Hu G a ďalší

Zdroj: Gut microbes [Gut Microbes] 2025 Dec; Vol. 17 (1), pp. 2447814. Date of Electronic Publication: 2025 Jan 02.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE

Výrazy zo slovníka MeSH: Diabetes Mellitus, Type 2*/metabolism , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/microbiology , Glucagon-Like Peptide 1*/metabolism , Probiotics*/administration & dosage , Probiotics*/pharmacology , Clostridium butyricum*/metabolism , Gastrointestinal Microbiome*/drug effects , Blood Glucose*/metabolism, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Hypoglycemic Agents/pharmacology ; Insulin/metabolism ; Glucagon-Like Peptide-1 Receptor/metabolism ; Glucagon-Like Peptide-1 Receptor/genetics ; Humans ; Signal Transduction/drug effects ; Apoptosis/drug effects ; Glucagon-Like Peptide-1 Receptor Agonists

Early insulin degludec with continuous intravenous insulin infusion in the management of diabetic ketoacidosis: A randomized controlled trial.

Autori: Thammakosol K Jantarapootirat M Traiwanatham S a ďalší

Zdroj: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2025 Dec; Vol. 27 (12), pp. 7020-7029. Date of Electronic Publication: 2025 Sep 03.

Spôsob vydávania: Journal Article; Randomized Controlled Trial

Informácie o časopise: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1463-1326 (Electronic) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE

Výrazy zo slovníka MeSH: Insulin, Long-Acting*/administration & dosage , Insulin, Long-Acting*/adverse effects , Insulin, Long-Acting*/therapeutic use , Diabetic Ketoacidosis*/drug therapy , Diabetic Ketoacidosis*/blood , Hypoglycemic Agents*/administration & dosage , Hypoglycemic Agents*/adverse effects , Hypoglycemic Agents*/therapeutic use , Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/blood, Humans ; Male ; Female ; Middle Aged ; Adult ; Infusions, Intravenous ; Prospective Studies ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Treatment Outcome ; Hypoglycemia/chemically induced ; Hypoglycemia/prevention & control ; Drug Therapy, Combination ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/drug therapy ; Length of Stay

Exploring the effect and mechanism of action of Jinlida granules (JLD) in the treatment of diabetes-associated cognitive impairment based on network pharmacology with experimental validation.

Autori: Gu H Zhang Y Sun J a ďalší

Zdroj: Annals of medicine [Ann Med] 2025 Dec; Vol. 57 (1), pp. 2445181. Date of Electronic Publication: 2024 Dec 26.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8906388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2060 (Electronic) Linking ISSN: 07853890 NLM ISO Abbreviation: Ann Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cognitive Dysfunction*/drug therapy , Cognitive Dysfunction*/etiology , Cognitive Dysfunction*/metabolism , Network Pharmacology* , Molecular Docking Simulation* , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/metabolism , Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/therapeutic use, Animals ; Mice ; Male ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Protein Interaction Maps ; Hippocampus/metabolism ; Hippocampus/drug effects ; Signal Transduction/drug effects ; Disease Models, Animal ; Morris Water Maze Test/drug effects

Efficacy and Mechanisms of Action of Oxytocin in NA/STZ-induced Diabetic Wistar Rats: Roles of Adipocytokines, PI3K/AKT, and AMPK Signaling Pathways.

Autori: Ali TM Yassin NYS El Askary A a ďalší

Zdroj: In vivo (Athens, Greece) [In Vivo] 2025 Nov-Dec; Vol. 39 (6), pp. 3333-3350.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8806809 Publication Model: Print Cited Medium: Internet ISSN: 1791-7549 (Electronic) Linking ISSN: 0258851X NLM ISO Abbreviation: In Vivo Subsets: MEDLINE

Výrazy zo slovníka MeSH: Oxytocin*/pharmacology , Oxytocin*/administration & dosage , Signal Transduction*/drug effects , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Experimental*/metabolism , Diabetes Mellitus, Experimental*/pathology , Diabetes Mellitus, Experimental*/chemically induced , Proto-Oncogene Proteins c-akt*/metabolism , Phosphatidylinositol 3-Kinases*/metabolism , Adipokines*/metabolism , AMP-Activated Protein Kinases*/metabolism, Animals ; Rats ; Rats, Wistar ; Streptozocin ; Male ; Niacinamide ; Insulin/blood ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Disease Models, Animal

Protective effect of fisetin alone and in combination with lactobacillus using experimental model of diabetes associated cognitive impairment in rats.

Autori: Maparu K Singh S

Zdroj: Metabolic brain disease [Metab Brain Dis] 2025 Oct 23; Vol. 40 (8), pp. 295. Date of Electronic Publication: 2025 Oct 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer Country of Publication: United States NLM ID: 8610370 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7365 (Electronic) Linking ISSN: 08857490 NLM ISO Abbreviation: Metab Brain Dis Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cognitive Dysfunction*/drug therapy , Cognitive Dysfunction*/etiology , Cognitive Dysfunction*/metabolism , Cognitive Dysfunction*/prevention & control , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Experimental*/complications , Diabetes Mellitus, Experimental*/metabolism , Lactobacillus* , Flavonoids*/pharmacology , Flavonoids*/therapeutic use, Animals ; Flavonols ; Rats ; Rats, Wistar ; Male ; Diet, High-Fat/adverse effects ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Maze Learning/drug effects ; Blood Glucose/drug effects ; Blood Glucose/metabolism

Poor Collateralization in T2DM: Role of SLC4A10+ MAIT Cells.

Autori: Chen S Huang K Zhang T a ďalší

Zdroj: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2025 Oct; Vol. 45 (10), pp. 1893-1911. Date of Electronic Publication: 2025 Aug 14.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505803 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4636 (Electronic) Linking ISSN: 10795642 NLM ISO Abbreviation: Arterioscler Thromb Vasc Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Diabetes Mellitus, Type 2*/immunology , Diabetes Mellitus, Type 2*/genetics , Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/metabolism , Diabetes Mellitus, Type 2*/blood , Diabetes Mellitus, Type 2*/physiopathology , Mucosal-Associated Invariant T Cells*/immunology , Mucosal-Associated Invariant T Cells*/metabolism , Collateral Circulation* , Neovascularization, Physiologic* , Diabetic Angiopathies*/immunology , Diabetic Angiopathies*/physiopathology , Diabetic Angiopathies*/genetics, Animals ; Humans ; Male ; Middle Aged ; Female ; Mice, Inbred C57BL ; Single-Cell Analysis ; Disease Models, Animal ; Cells, Cultured ; Mice ; Hindlimb/blood supply ; Phenotype ; Macrophages/metabolism ; Macrophages/immunology ; Aged ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/immunology ; Coculture Techniques ; Ischemia/physiopathology ; Ischemia/immunology ; Ischemia/genetics ; Case-Control Studies

Proteomics reveals crosstalk between calcium disturbance and multiple stresses facilitating lethal ventricular arrhythmias-sudden cardiac death under the co-morbidity of acute myocardial ischemia and type II diabetes mellitus.

Autori: Zhang Y Zhang X Liang H a ďalší

Zdroj: Life sciences [Life Sci] 2025 Oct 01; Vol. 378, pp. 123826. Date of Electronic Publication: 2025 Jul 02.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Myocardial Ischemia*/metabolism , Myocardial Ischemia*/complications , Diabetes Mellitus, Type 2*/metabolism , Diabetes Mellitus, Type 2*/complications , Calcium*/metabolism , Arrhythmias, Cardiac*/metabolism , Arrhythmias, Cardiac*/etiology , Death, Sudden, Cardiac*/etiology, Animals ; Proteomics/methods ; Mice ; Rats ; Endoplasmic Reticulum Stress ; Male ; Oxidative Stress ; Mice, Inbred C57BL ; Myocytes, Cardiac/metabolism ; Reactive Oxygen Species/metabolism ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/complications

SerpinE2 deficiency exacerbates glomerular injury in diabetic nephropathy through dysregulated angiogenesis and inflammatory responses.

Autori: Idir L Yu J Bonnin P a ďalší

Zdroj: American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2025 Oct 01; Vol. 329 (4), pp. F548-F556. Date of Electronic Publication: 2025 Sep 02.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901990 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1466 (Electronic) Linking ISSN: 15221466 NLM ISO Abbreviation: Am J Physiol Renal Physiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Serpin E2*/deficiency , Serpin E2*/genetics , Serpin E2*/metabolism , Diabetic Nephropathies*/pathology , Diabetic Nephropathies*/metabolism , Diabetic Nephropathies*/genetics , Diabetic Nephropathies*/physiopathology , Kidney Glomerulus*/pathology , Kidney Glomerulus*/metabolism , Kidney Glomerulus*/blood supply , Diabetes Mellitus, Experimental*/metabolism , Diabetes Mellitus, Experimental*/genetics , Diabetes Mellitus, Experimental*/pathology , Diabetes Mellitus, Experimental*/complications , Neovascularization, Pathologic* , Inflammation*/pathology , Inflammation*/metabolism , Inflammation*/genetics, Animals ; Mice, Knockout ; Male ; Mice, Inbred C57BL ; Mice ; Collagen Type IV/metabolism ; Cell Proliferation ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/metabolism ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/pathology ; Membrane Proteins/metabolism ; Inflammation Mediators/metabolism ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Angiogenesis

Modulating glucose homeostasis via expression of PPAR-γ TF: Pharmacological insights into quinolone-based hydrazones.

Autori: Pravin NJ Kavalapure RS Gharge S a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118168. Date of Electronic Publication: 2025 Sep 12.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: PPAR gamma*/metabolism , PPAR gamma*/genetics , Homeostasis*/drug effects , Quinolones*/chemistry , Quinolones*/pharmacology , Quinolones*/chemical synthesis , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Experimental*/metabolism , Diabetes Mellitus, Experimental*/chemically induced , Hydrazones*/pharmacology , Hydrazones*/chemistry , Hydrazones*/chemical synthesis , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/chemical synthesis , Glucose*/metabolism, Animals ; Humans ; Rats ; Structure-Activity Relationship ; Molecular Structure ; Male ; Molecular Docking Simulation ; Hep G2 Cells ; Dose-Response Relationship, Drug ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism

Tanshinone IIA suppresses endoplasmic reticulum stress-mediated IRE1α/TXNIP/NLRP3 pathway to mitigate pyroptosis in type 2 diabetic osteoporosis.

Autori: Jiang Z Zuo J Luo H a ďalší

Zdroj: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 3), pp. 117356. Date of Electronic Publication: 2025 Sep 19.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , NLR Family, Pyrin Domain-Containing 3 Protein*/antagonists & inhibitors , Abietanes*/pharmacology , Abietanes*/therapeutic use , Protein Serine-Threonine Kinases*/metabolism , Protein Serine-Threonine Kinases*/antagonists & inhibitors , Endoplasmic Reticulum Stress*/drug effects , Endoplasmic Reticulum Stress*/physiology , Endoribonucleases*/metabolism , Endoribonucleases*/antagonists & inhibitors , Pyroptosis*/drug effects , Pyroptosis*/physiology , Diabetes Mellitus, Type 2*/metabolism , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/complications , Osteoporosis*/drug therapy , Osteoporosis*/metabolism , Carrier Proteins*/metabolism , Carrier Proteins*/antagonists & inhibitors, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Signal Transduction/drug effects ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/drug therapy ; Dose-Response Relationship, Drug ; Cell Line ; Thioredoxins

GlucoNet-MM: A multimodal attention-based multi-task learning framework with decision transformer for personalised and explainable blood glucose forecasting.

Autori: Maqsood S Sarwar MA Belousovienė E a ďalší

Zdroj: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2025 Dec; Vol. 27 (12), pp. 7416-7430. Date of Electronic Publication: 2025 Sep 22.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1463-1326 (Electronic) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE

Výrazy zo slovníka MeSH: Blood Glucose*/analysis , Precision Medicine*/methods , Deep Learning* , Diabetes Mellitus*/blood , Diabetes Mellitus, Type 2*/blood, Humans ; Blood Glucose Self-Monitoring ; Forecasting ; Machine Learning ; Attention ; Diabetes Mellitus, Type 1/blood

Sulfated Polysaccharides From Gracilaria gracilis (Red Seaweed) Restores Testicular Glucose Metabolism by Improving FSH and Insulin Signaling in Rats With Type 2 Diabetes.

Autori: Erukainure OL Olasehinde TA Olayeriju OS a ďalší

Zdroj: Molecular nutrition & food research [Mol Nutr Food Res] 2025 Dec; Vol. 69 (23), pp. e70280. Date of Electronic Publication: 2025 Oct 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101231818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-4133 (Electronic) Linking ISSN: 16134125 NLM ISO Abbreviation: Mol Nutr Food Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Polysaccharides*/pharmacology , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/metabolism , Testis*/metabolism , Testis*/drug effects , Testis*/pathology , Insulin*/metabolism , Gracilaria*/chemistry , Follicle Stimulating Hormone*/metabolism , Glucose*/metabolism, Male ; Animals ; Signal Transduction/drug effects ; Rats ; Glutathione/metabolism ; Glucose Transporter Type 4/metabolism ; Insulin Receptor Substrate Proteins/metabolism ; Hypoglycemic Agents/pharmacology ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Rats, Wistar ; Sulfates

Understanding the Increasing Prevalence of Obesity in Patients With Type 1 Diabetes: Strategies for Improving Clinical Care.

Autori: Ruddiman KR Bartfield JK Hirsch IB

Zdroj: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2025 Dec; Vol. 33 (12), pp. 2246-2263. Date of Electronic Publication: 2025 Oct 07.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101264860 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1930-739X (Electronic) Linking ISSN: 19307381 NLM ISO Abbreviation: Obesity (Silver Spring) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Diabetes Mellitus, Type 1*/complications , Diabetes Mellitus, Type 1*/epidemiology , Obesity*/epidemiology , Obesity*/therapy , Obesity*/complications, Humans ; Prevalence ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Bariatric Surgery ; Life Style

SPARC-modified mesenchymal stem cells promote recovery of β-cells and insulin secretion by calcium ion homeostasis.

Autori: Gao J Li B Tian H a ďalší

Zdroj: Stem cell research & therapy [Stem Cell Res Ther] 2025 Nov 03; Vol. 16 (1), pp. 607. Date of Electronic Publication: 2025 Nov 03.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: Mesenchymal Stem Cells*/metabolism , Mesenchymal Stem Cells*/cytology , Osteonectin*/metabolism , Osteonectin*/genetics , Insulin-Secreting Cells*/metabolism , Insulin-Secreting Cells*/cytology , Calcium*/metabolism , Insulin Secretion* , Mesenchymal Stem Cell Transplantation* , Diabetes Mellitus, Type 1*/therapy , Diabetes Mellitus, Type 1*/metabolism , Diabetes Mellitus, Type 1*/pathology , Insulin*/metabolism, Animals ; Mice ; Dogs ; Homeostasis ; Diabetes Mellitus, Experimental/therapy ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Male ; Mice, Inbred C57BL

Global Burden of Diabetic Ketoacidosis.

Autori: Mohan V Lee K

Zdroj: Diabetes technology & therapeutics [Diabetes Technol Ther] 2025 Nov; Vol. 27 (S4), pp. S6-S13.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 100889084 Publication Model: Print Cited Medium: Internet ISSN: 1557-8593 (Electronic) Linking ISSN: 15209156 NLM ISO Abbreviation: Diabetes Technol Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: Diabetic Ketoacidosis*/epidemiology , Diabetic Ketoacidosis*/etiology , Diabetes Mellitus, Type 1*/complications , Diabetes Mellitus, Type 1*/epidemiology , Diabetes Mellitus, Type 1*/drug therapy, Humans ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Global Health ; Pregnancy ; Female ; Incidence ; Child ; Blood Glucose/analysis ; Adolescent ; Adult

Race, ethnicity and ancestry in global diabetes research: grappling with complexity to advance equity and scientific integrity - a narrative review and viewpoint.

Autori: Chaturvedi N Voight BF Wells JC a ďalší

Zdroj: Diabetologia [Diabetologia] 2025 Nov; Vol. 68 (11), pp. 2318-2326. Date of Electronic Publication: 2025 Aug 07.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE

Výrazy zo slovníka MeSH: Diabetes Mellitus*/ethnology , Diabetes Mellitus*/genetics , Diabetes Mellitus*/epidemiology, Female ; Humans ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/ethnology ; Diabetes Mellitus, Type 2/genetics ; Diabetes, Gestational/epidemiology ; Diabetes, Gestational/ethnology ; Diabetes, Gestational/genetics ; Ethnicity/genetics ; Ethnicity/statistics & numerical data ; Racial Groups/genetics ; Racial Groups/statistics & numerical data ; Pregnancy

DYRK1A inhibition restores pancreatic functions and improves glucose metabolism in a preclinical model of type 2 diabetes.

Autori: Bertrand R Tolu S Picot D a ďalší

Zdroj: Molecular metabolism [Mol Metab] 2025 Nov; Vol. 101, pp. 102242. Date of Electronic Publication: 2025 Aug 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE

Výrazy zo slovníka MeSH: Diabetes Mellitus, Type 2*/metabolism , Diabetes Mellitus, Type 2*/drug therapy , Protein Serine-Threonine Kinases*/antagonists & inhibitors , Protein Serine-Threonine Kinases*/metabolism , Protein-Tyrosine Kinases*/antagonists & inhibitors , Protein-Tyrosine Kinases*/metabolism , Glucose*/metabolism , Pancreas*/metabolism , Pancreas*/drug effects, Animals ; Dyrk Kinases ; Rats ; Male ; Insulin-Secreting Cells/metabolism ; Insulin-Secreting Cells/drug effects ; Cell Proliferation/drug effects ; Insulin/metabolism ; Disease Models, Animal ; Insulin Resistance ; Rats, Wistar ; Blood Glucose/metabolism ; Blood Glucose/drug effects ; Insulin Secretion/drug effects ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/drug therapy

Hypoglycemic effect of enzymatically extracted Cichorium pumilum Jacq polysaccharide (CGP) on T2DM mice via PI3K/AKT/mTOR signaling pathway.

Autori: Dong N Lu X Qin D

Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2025 Nov; Vol. 329 (Pt 1), pp. 147711. Date of Electronic Publication: 2025 Sep 18.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Polysaccharides*/pharmacology , Polysaccharides*/chemistry , Polysaccharides*/isolation & purification , TOR Serine-Threonine Kinases*/metabolism , Signal Transduction*/drug effects , Phosphatidylinositol 3-Kinases*/metabolism , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/metabolism , Diabetes Mellitus, Type 2*/pathology , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/therapeutic use , Hypoglycemic Agents*/isolation & purification, Animals ; Proto-Oncogene Proteins c-akt/metabolism ; Mice ; Male ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Liver/metabolism ; Liver/drug effects ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Oxidative Stress/drug effects ; Humans ; Blood Glucose/drug effects

Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues.

Autori: Mellor KM Varma U Koutsifeli P a ďalší

Zdroj: Nature cardiovascular research [Nat Cardiovasc Res] 2025 Nov; Vol. 4 (11), pp. 1487-1500. Date of Electronic Publication: 2025 Sep 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer Nature Country of Publication: England NLM ID: 9918284280206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-0590 (Electronic) Linking ISSN: 27310590 NLM ISO Abbreviation: Nat Cardiovasc Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Diabetic Cardiomyopathies*/genetics , Diabetic Cardiomyopathies*/metabolism , Diabetic Cardiomyopathies*/physiopathology , Diabetic Cardiomyopathies*/therapy , Diabetic Cardiomyopathies*/pathology , Autophagy* , Myocytes, Cardiac*/metabolism , Myocytes, Cardiac*/pathology , Glycogen*/metabolism , Autophagy-Related Protein 8 Family*/genetics , Autophagy-Related Protein 8 Family*/metabolism , Autophagy-Related Protein 8 Family*/deficiency , Tissue Engineering*/methods , Microtubule-Associated Proteins*/genetics , Microtubule-Associated Proteins*/metabolism , Genetic Therapy*/methods , Diabetes Mellitus, Type 2*/genetics , Diabetes Mellitus, Type 2*/metabolism , Diabetes Mellitus, Type 2*/complications, Animals ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Organoids/metabolism ; Organoids/pathology ; Mice ; Mice, Inbred C57BL ; Male ; Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Disease Models, Animal ; Ventricular Function, Left ; Mice, Knockout ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/metabolism

Chitosan oligosaccharide improves diabetic nephropathy by attenuating renal fibrogenesis and strengthening intestinal barriers in type 2 diabetic rats.

Autori: Sutthasupha P Promsan S Pengrattanachot N a ďalší

Zdroj: Chemico-biological interactions [Chem Biol Interact] 2025 Oct 22; Vol. 420, pp. 111680. Date of Electronic Publication: 2025 Jul 28.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

Výrazy zo slovníka MeSH: Chitosan*/therapeutic use , Chitosan*/pharmacology , Chitosan*/chemistry , Oligosaccharides*/therapeutic use , Oligosaccharides*/pharmacology , Oligosaccharides*/chemistry , Diabetic Nephropathies*/drug therapy , Diabetic Nephropathies*/pathology , Diabetic Nephropathies*/metabolism , Kidney*/drug effects , Kidney*/pathology , Kidney*/metabolism , Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/pathology, Animals ; Male ; Rats, Wistar ; Oxidative Stress/drug effects ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/pathology ; Diabetes Mellitus, Experimental/complications ; Rats ; Fibrosis ; Metformin/pharmacology ; Metformin/therapeutic use ; AMP-Activated Protein Kinases/metabolism ; Diet, High-Fat ; Intestines/drug effects