Suchergebnisse - "Depsipeptides"

Marine-derived Acremonium strain prioritization using untargeted metabolomics approach for the identification of cytotoxic cyclic depsipeptides.

Autoren: Maharjan S Isaksson J Rämä T et al.

Quelle: BMC biotechnology [BMC Biotechnol] 2025 Nov 24; Vol. 25 (1), pp. 129. Date of Electronic Publication: 2025 Nov 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101088663 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6750 (Electronic) Linking ISSN: 14726750 NLM ISO Abbreviation: BMC Biotechnol Subsets: MEDLINE

MeSH-Schlagworte: Metabolomics*/methods , Depsipeptides*/metabolism , Depsipeptides*/chemistry , Depsipeptides*/pharmacology , Acremonium*/metabolism , Acremonium*/chemistry , Acremonium*/classification , Acremonium*/isolation & purification, Humans ; Arctic Regions ; Cell Line, Tumor

An Integrated Strategy for Rapid Profiling of Depsipeptides by High-Performance Liquid Chromatography Coupled to Quadrupole Time-of-Flight Mass Spectrometry: Bombyx batryticatus as an Example.

Autoren: Sun H Li Y Feng Y et al.

Quelle: Journal of the American Society for Mass Spectrometry [J Am Soc Mass Spectrom] 2025 Nov 05; Vol. 36 (11), pp. 2531-2540. Date of Electronic Publication: 2025 Oct 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: ACS Publications Country of Publication: United States NLM ID: 9010412 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1123 (Electronic) Linking ISSN: 10440305 NLM ISO Abbreviation: J Am Soc Mass Spectrom Subsets: MEDLINE

MeSH-Schlagworte: Depsipeptides*/chemistry , Depsipeptides*/analysis , Tandem Mass Spectrometry*/methods , Bombyx*/chemistry, Chromatography, High Pressure Liquid/methods ; Animals

Protopeptide backbone affects assembly in aqueous solutions.

Autoren: Fisher S Ezerzer Y Edri R et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Oct 07; Vol. 122 (40), pp. e2500503122. Date of Electronic Publication: 2025 Sep 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: Water*/chemistry , Depsipeptides*/chemistry , Depsipeptides*/chemical synthesis , Peptides*/chemistry, Solutions ; Origin of Life ; Amino Acids/chemistry

Nanoromidepsin, a polymer nanoparticle of the HDAC inhibitor, improves safety and efficacy in models of T-cell lymphoma.

Autoren: Pal I Illendula A Joyner A et al.

Quelle: Blood [Blood] 2025 Dec 04; Vol. 146 (23), pp. 2794-2807.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

MeSH-Schlagworte: Depsipeptides*/administration & dosage , Depsipeptides*/pharmacology , Depsipeptides*/chemistry , Depsipeptides*/therapeutic use , Depsipeptides*/adverse effects , Lymphoma, T-Cell*/drug therapy , Lymphoma, T-Cell*/pathology , Nanoparticles*/chemistry , Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/administration & dosage , Histone Deacetylase Inhibitors*/chemistry , Histone Deacetylase Inhibitors*/therapeutic use, Animals ; Humans ; Mice ; Xenograft Model Antitumor Assays ; Cell Line, Tumor ; Female ; Polymers/chemistry

Total Synthesis of WS9326B via a Bioinspired Macrolactonization Strategy.

Autoren: Choi SH Lee SB Hong J et al.

Quelle: Organic letters [Org Lett] 2025 Nov 28; Vol. 27 (47), pp. 13085-13090. Date of Electronic Publication: 2025 Nov 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE

MeSH-Schlagworte: Streptomyces*/chemistry , Depsipeptides*/chemical synthesis , Depsipeptides*/chemistry , Depsipeptides*/pharmacology , Cinnamates*/chemistry, Molecular Structure ; Cyclization ; Esterification

Veraguamide E, a Marine Cyanobacterial Depsipeptide Targeting σ 2 R/TMEM97: Chemical and Neurobiological Characterization.

Autoren: Sotelo-Morales JE Mofidi Tabatabaei S Fofie CK et al.

Quelle: Journal of natural products [J Nat Prod] 2025 Nov 28; Vol. 88 (11), pp. 2736-2749. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE

MeSH-Schlagworte: Cyanobacteria*/chemistry , Depsipeptides*/pharmacology , Depsipeptides*/chemistry , Depsipeptides*/isolation & purification , Receptors, sigma*/metabolism , Receptors, sigma*/antagonists & inhibitors , Membrane Proteins*/metabolism, Animals ; Humans ; Mice ; Molecular Structure ; Calcium/metabolism ; Induced Pluripotent Stem Cells

ClpC1 Modulating Ohmyungsamycin A and Ecumicin Natural Product Analogues are Potent Antimycobacterials.

Autoren: Hawkins PME Bedding MJ Hoi DM et al.

Quelle: ACS infectious diseases [ACS Infect Dis] 2025 Nov 14; Vol. 11 (11), pp. 3298-3309. Date of Electronic Publication: 2025 Oct 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/drug effects , Mycobacterium tuberculosis*/enzymology , Bacterial Proteins*/metabolism , Antitubercular Agents*/pharmacology , Antitubercular Agents*/chemistry , Antitubercular Agents*/chemical synthesis , Peptides, Cyclic*/pharmacology , Peptides, Cyclic*/chemistry , Peptides, Cyclic*/chemical synthesis , Depsipeptides*/pharmacology , Depsipeptides*/chemistry , Depsipeptides*/chemical synthesis , Biological Products*/pharmacology , Biological Products*/chemistry, Animals ; Microbial Sensitivity Tests ; Zebrafish ; Heat-Shock Proteins

Self-resistance mechanism to acyldepsipeptide antibiotics in the Streptomyces producer.

Autoren: Thomy D Reinhardt L Liebhart E et al.

Quelle: MBio [mBio] 2025 Nov 12; Vol. 16 (11), pp. e0165225. Date of Electronic Publication: 2025 Oct 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

MeSH-Schlagworte: Streptomyces*/genetics , Streptomyces*/drug effects , Streptomyces*/metabolism , Streptomyces*/enzymology , Depsipeptides*/pharmacology , Depsipeptides*/biosynthesis , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/biosynthesis , Endopeptidase Clp*/metabolism , Endopeptidase Clp*/genetics , Drug Resistance, Bacterial*, Bacterial Proteins/metabolism ; Bacterial Proteins/genetics

Origin and characterization of cyclodepsipeptides: Comprehensive structural approaches with focus on mass spectrometry analysis of alkali-cationized molecular species.

Autoren: Liuu S Damont A Perret A et al.

Quelle: Mass spectrometry reviews [Mass Spectrom Rev] 2025 Nov-Dec; Vol. 44 (6), pp. 1013-1098. Date of Electronic Publication: 2024 Aug 21.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 8219702 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2787 (Electronic) Linking ISSN: 02777037 NLM ISO Abbreviation: Mass Spectrom Rev Subsets: MEDLINE

MeSH-Schlagworte: Depsipeptides*/chemistry , Depsipeptides*/analysis , Alkalies*/chemistry , Mass Spectrometry*/methods, Tandem Mass Spectrometry/methods ; Spectrometry, Mass, Electrospray Ionization/methods ; Cations/chemistry ; Magnetic Resonance Spectroscopy

Efficacy and safety of ascending doses of emodepside in comparison with ivermectin in adults infected with Strongyloides stercoralis in Laos: a phase 2a, dose-ranging, randomised, parallel-group, placebo-controlled, single-blind clinical trial.

Autoren: Taylor L Many S Jeanguenat H et al.

Quelle: The Lancet. Infectious diseases [Lancet Infect Dis] 2025 Nov; Vol. 25 (11), pp. 1254-1264. Date of Electronic Publication: 2025 Jun 25.

Publikationsart: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Comparative Study

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4457 (Electronic) Linking ISSN: 14733099 NLM ISO Abbreviation: Lancet Infect Dis Subsets: MEDLINE

MeSH-Schlagworte: Ivermectin*/administration & dosage , Ivermectin*/adverse effects , Ivermectin*/therapeutic use , Strongyloidiasis*/drug therapy , Strongyloides stercoralis*/drug effects , Depsipeptides*/administration & dosage , Depsipeptides*/adverse effects , Depsipeptides*/therapeutic use , Anthelmintics*/administration & dosage , Anthelmintics*/adverse effects , Anthelmintics*/therapeutic use, Humans ; Adult ; Male ; Female ; Laos/epidemiology ; Animals ; Single-Blind Method ; Middle Aged ; Young Adult ; Treatment Outcome ; Adolescent ; Dose-Response Relationship, Drug ; Antiparasitic Agents/administration & dosage ; Feces/parasitology

Exploration of the Tertiary Amide Chemical Space of Dolastatin 15 Analogs Reveals New Insights into the Structure-Anticancer Activity Relationship.

Autoren: Alonso D Reguera L Rennert R et al.

Quelle: ChemMedChem [ChemMedChem] 2025 Oct 06; Vol. 20 (19), pp. e202500580. Date of Electronic Publication: 2025 Aug 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

MeSH-Schlagworte: Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Amides*/chemistry , Amides*/pharmacology , Depsipeptides*/chemistry , Depsipeptides*/pharmacology , Depsipeptides*/chemical synthesis, Humans ; Structure-Activity Relationship ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Molecular Structure

Optimizing Jasplakinolide delivery in rhabdomyosarcoma cells using pulsed electric fields (PEFs) for enhanced therapeutic impact.

Autoren: Szewczyk A Rembiałkowska N Migocka-Patrzałek M et al.

Quelle: Bioelectrochemistry (Amsterdam, Netherlands) [Bioelectrochemistry] 2025 Oct; Vol. 165, pp. 108969. Date of Electronic Publication: 2025 Mar 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 100953583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-562X (Electronic) Linking ISSN: 15675394 NLM ISO Abbreviation: Bioelectrochemistry Subsets: MEDLINE

MeSH-Schlagworte: Depsipeptides*/pharmacology , Depsipeptides*/administration & dosage , Depsipeptides*/metabolism , Depsipeptides*/chemistry , Electroporation*/methods , Rhabdomyosarcoma*/pathology , Rhabdomyosarcoma*/drug therapy , Rhabdomyosarcoma*/metabolism , Electricity* , Antineoplastic Agents*/administration & dosage , Antineoplastic Agents*/pharmacology, Animals ; Mice ; Cell Survival/drug effects ; Cell Line, Tumor ; Cricetulus ; CHO Cells ; Cricetinae ; Actins/metabolism ; Molecular Docking Simulation ; Humans

Cyanidin 3-O-glucoside and other anthocyanins affect enniatins production in Fusarium avenaceum.

Autoren: Felici L Atanasova V Ponts N et al.

Quelle: Fungal biology [Fungal Biol] 2025 Oct; Vol. 129 (6), pp. 101640. Date of Electronic Publication: 2025 Aug 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Published by Elsevier, copyright by British Mycological Society Country of Publication: Netherlands NLM ID: 101524465 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-6146 (Print) NLM ISO Abbreviation: Fungal Biol Subsets: MEDLINE

MeSH-Schlagworte: Anthocyanins*/pharmacology , Anthocyanins*/metabolism , Fusarium*/drug effects , Fusarium*/metabolism , Fusarium*/growth & development , Fusarium*/genetics , Depsipeptides*/metabolism , Depsipeptides*/biosynthesis , Glucosides*/pharmacology , Glucosides*/metabolism , Antifungal Agents*/pharmacology, Spores, Fungal/drug effects ; Spores, Fungal/growth & development ; Biomass

Phage Display of Graspeptides via SrtA-Mediated Peptide Ligation and Cyclization.

Autoren: Xue JH Wei HM Wu F et al.

Quelle: Organic letters [Org Lett] 2025 Nov 14; Vol. 27 (45), pp. 12563-12568. Date of Electronic Publication: 2025 Nov 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE

MeSH-Schlagworte: Cysteine Endopeptidases*/metabolism , Cysteine Endopeptidases*/chemistry , Aminoacyltransferases*/chemistry , Aminoacyltransferases*/metabolism , Bacterial Proteins*/chemistry , Bacterial Proteins*/metabolism , Peptide Library* , Peptides, Cyclic*/chemistry , Depsipeptides*/chemistry , Peptides*/chemistry, Cyclization ; Molecular Structure

Experimental assessment of beauvericin toxicity in tadpoles of Dendropsophus minutus (Anura: Hylidae).

Autoren: Chacon de Vicente M Ferreira de Paula LG Pereira de Freitas RM et al.

Quelle: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2025 Nov; Vol. 267, pp. 108600. Date of Electronic Publication: 2025 Sep 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 1307333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3150 (Electronic) Linking ISSN: 00410101 NLM ISO Abbreviation: Toxicon Subsets: MEDLINE

MeSH-Schlagworte: Anura*/growth & development , Depsipeptides*/toxicity, Animals ; Larva/drug effects ; Liver/drug effects ; Liver/pathology ; Oxidative Stress/drug effects ; Micronucleus Tests ; Comet Assay

Beauvericin disrupts G2/M transition and induces meiotic arrest during mouse oocyte maturation.

Autoren: Kim Y Jo YJ Yoon SB et al.

Quelle: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2025 Oct; Vol. 137, pp. 109032. Date of Electronic Publication: 2025 Aug 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon In Cooperation With The Reproductive Toxicology Center Country of Publication: United States NLM ID: 8803591 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1708 (Electronic) Linking ISSN: 08906238 NLM ISO Abbreviation: Reprod Toxicol Subsets: MEDLINE

MeSH-Schlagworte: Oocytes*/drug effects , Oocytes*/metabolism , Depsipeptides*/toxicity , Mycotoxins*/toxicity, Animals ; Meiosis/drug effects ; Female ; Mice ; Cyclic AMP/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 3/metabolism ; In Vitro Oocyte Maturation Techniques ; Phosphatidylinositol 3-Kinases/metabolism ; Maturation-Promoting Factor/metabolism ; cdc25 Phosphatases/metabolism ; Cell Cycle Proteins/metabolism ; Signal Transduction/drug effects ; DNA Damage ; CDC2 Protein Kinase/metabolism ; Phosphatidylinositol 3-Kinase/metabolism

FK228 reshapes tumor microenvironment to enhance anti-PD-L1 efficacy.

Autoren: Gong L Tian L Li H et al.

Quelle: Oncogene [Oncogene] 2025 Oct; Vol. 44 (39), pp. 3665-3678. Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE

MeSH-Schlagworte: Tumor Microenvironment*/drug effects , Tumor Microenvironment*/immunology , Depsipeptides*/pharmacology , B7-H1 Antigen*/antagonists & inhibitors , Immune Checkpoint Inhibitors*/pharmacology , Neoplasms*/drug therapy , Neoplasms*/pathology , Neoplasms*/immunology, Animals ; Mice ; Humans ; Cell Line, Tumor ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; Histone Deacetylase Inhibitors/pharmacology ; Xenograft Model Antitumor Assays ; Endoplasmic Reticulum Stress/drug effects ; Female

Screening FDA-Approved Oncology Drugs with Three-Dimensional Spheroids Identifies Romidepsin as a Therapeutic Candidate for Osteosarcoma.

Autoren: Seiden EE Richardson SM Everitt LA et al.

Quelle: Cancer research communications [Cancer Res Commun] 2025 Oct 01; Vol. 5 (10), pp. 1821-1838.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium: Internet ISSN: 2767-9764 (Electronic) Linking ISSN: 27679764 NLM ISO Abbreviation: Cancer Res Commun Subsets: MEDLINE

MeSH-Schlagworte: Osteosarcoma*/drug therapy , Osteosarcoma*/pathology , Depsipeptides*/pharmacology , Spheroids, Cellular*/drug effects , Bone Neoplasms*/drug therapy , Bone Neoplasms*/pathology , Antineoplastic Agents*/pharmacology, Humans ; Cell Line, Tumor ; Drug Screening Assays, Antitumor/methods ; United States ; Drug Approval ; Lung Neoplasms/secondary ; Lung Neoplasms/drug therapy ; Animals ; United States Food and Drug Administration ; Histone Deacetylase Inhibitors/pharmacology ; Cell Proliferation/drug effects

Antiparasitic agent emodepside exerts cytotoxicity in human corneal stromal cells by blocking the interaction between mini-chromosome maintenance 6 protein (MCM6) and chromatin licensing and DNA replication factor 1 (CDT1).

Autoren: Gao H Yin H

Quelle: Toxicology [Toxicology] 2026 Jan; Vol. 519, pp. 154334. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3185 (Electronic) Linking ISSN: 0300483X NLM ISO Abbreviation: Toxicology Subsets: MEDLINE

MeSH-Schlagworte: Depsipeptides*/toxicity , Depsipeptides*/pharmacology , Minichromosome Maintenance Complex Component 6*/metabolism , Minichromosome Maintenance Complex Component 6*/antagonists & inhibitors , Cell Cycle Proteins*/metabolism , Stromal Cells*/drug effects , Stromal Cells*/metabolism, Humans ; Molecular Docking Simulation ; Cell Survival/drug effects ; DNA Replication/drug effects ; Cells, Cultured ; Chromatin/metabolism ; Chromatin/drug effects

Metabolomic insights into the role of isoleucine in regulating cereulide biosynthesis in emetic Bacillus cereus.

Autoren: Li J Qin K Shang Y et al.

Quelle: Food research international (Ottawa, Ont.) [Food Res Int] 2026 Jan; Vol. 223 (Pt 1), pp. 117793. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science Country of Publication: Canada NLM ID: 9210143 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7145 (Electronic) Linking ISSN: 09639969 NLM ISO Abbreviation: Food Res Int Subsets: MEDLINE

MeSH-Schlagworte: Bacillus cereus*/metabolism , Bacillus cereus*/drug effects , Bacillus cereus*/genetics , Depsipeptides*/biosynthesis , Isoleucine*/pharmacology , Isoleucine*/metabolism , Metabolomics*/methods, Folic Acid/metabolism ; Chromatography, Liquid