Suchergebnisse - "DRUG tolerance"

Incorporation of macrophage immune stresses into an intracellular assay of drug tolerance in Mycobacterium tuberculosis .

Autoren: Kirubakar G Johnston L Nae Rin Lee B et al.

Quelle: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2025 Oct; Vol. 69 (10), pp. e0079525. Date of Electronic Publication: 2025 Sep 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/drug effects , Mycobacterium tuberculosis*/immunology , Mycobacterium tuberculosis*/genetics , Macrophages*/microbiology , Macrophages*/immunology , Macrophages*/drug effects , Antitubercular Agents*/pharmacology , Drug Tolerance*/immunology, Animals ; Mice ; Microbial Sensitivity Tests/methods

Sex differences in acute tolerance to the objective and subjective effects of alcohol.

Autoren: Griffith AK Fillmore MT

Quelle: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2025 Dec; Vol. 257, pp. 174111. Date of Electronic Publication: 2025 Oct 09.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0367050 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5177 (Electronic) Linking ISSN: 00913057 NLM ISO Abbreviation: Pharmacol Biochem Behav Subsets: MEDLINE

MeSH-Schlagworte: Alcoholic Intoxication*/psychology , Ethanol*/pharmacology , Ethanol*/blood , Ethanol*/administration & dosage , Drug Tolerance* , Sex Characteristics*, Humans ; Male ; Female ; Adult ; Young Adult ; Psychomotor Performance/drug effects ; Blood Alcohol Content

Combining IMWG GA and hematopoietic score to optimize the evaluation of dynamic chemotherapy tolerance in multiple myeloma.

Autoren: Chen Y He F He Z et al.

Quelle: Annals of medicine [Ann Med] 2025 Dec; Vol. 57 (1), pp. 2558127. Date of Electronic Publication: 2025 Oct 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8906388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2060 (Electronic) Linking ISSN: 07853890 NLM ISO Abbreviation: Ann Med Subsets: MEDLINE

MeSH-Schlagworte: Multiple Myeloma*/drug therapy , Geriatric Assessment*/methods , Frailty*/diagnosis , Antineoplastic Combined Chemotherapy Protocols*/adverse effects , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Drug Tolerance*, Humans ; Male ; Aged ; Retrospective Studies ; Female ; Middle Aged ; Risk Assessment/methods ; Aged, 80 and over

Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic morphine.

Autoren: Sall I Foxall R Felth L et al.

Quelle: Gut microbes [Gut Microbes] 2025 Dec; Vol. 17 (1), pp. 2446423. Date of Electronic Publication: 2025 Jan 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE

MeSH-Schlagworte: Gastrointestinal Microbiome*/drug effects , Dysbiosis*/microbiology , Dysbiosis*/chemically induced , Morphine*/administration & dosage , Morphine*/pharmacology , Drug Tolerance* , Butyrates*/metabolism , Analgesics, Opioid*/administration & dosage , Analgesics, Opioid*/pharmacology, Animals ; Mice ; Male ; Fecal Microbiota Transplantation ; Mice, Inbred C57BL ; Fatty Acids, Volatile/metabolism ; Disease Models, Animal ; Bacteria/classification ; Bacteria/metabolism ; Bacteria/genetics ; Bacteria/isolation & purification

Adolescent intermittent ethanol exposure produces sex-specific development of functional tolerance to ethanol-induced motor impairment and hypothermia.

Autoren: Trapp S Vore AS Lutzke A et al.

Quelle: Neuropharmacology [Neuropharmacology] 2025 Dec 01; Vol. 280, pp. 110682. Date of Electronic Publication: 2025 Sep 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH-Schlagworte: Ethanol*/administration & dosage , Ethanol*/blood , Ethanol*/toxicity , Hypothermia*/chemically induced , Hypothermia*/metabolism , Drug Tolerance*/physiology , Sex Characteristics* , Central Nervous System Depressants*/blood , Central Nervous System Depressants*/administration & dosage, Animals ; Male ; Female ; Rats ; Brain/drug effects ; Brain/metabolism ; Rats, Sprague-Dawley ; Alcohol Dehydrogenase/metabolism

Transition between cell states of sensitivity reveals molecular vulnerability of drug-tolerant cells.

Autoren: Peyre L Péré M Meyer M et al.

Quelle: Molecular systems biology [Mol Syst Biol] 2025 Dec; Vol. 21 (12), pp. 1702-1730. Date of Electronic Publication: 2025 Oct 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101235389 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-4292 (Electronic) Linking ISSN: 17444292 NLM ISO Abbreviation: Mol Syst Biol Subsets: MEDLINE

MeSH-Schlagworte: Apoptosis*/drug effects , Drug Resistance, Neoplasm* , Antineoplastic Agents*/pharmacology , Neoplasms*/drug therapy , Neoplasms*/metabolism , Neoplasms*/genetics , Drug Tolerance*, Humans ; Caspase 8/metabolism ; Caspase 8/genetics ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/genetics ; Cell Line, Tumor ; Necroptosis/drug effects ; Models, Biological

Drug-tolerant persister cells in cancer: bridging the gaps between bench and bedside.

Autoren: Wang Z Wang M Dong B et al.

Quelle: Nature communications [Nat Commun] 2025 Nov 17; Vol. 16 (1), pp. 10048. Date of Electronic Publication: 2025 Nov 17.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Neoplasms*/drug therapy , Neoplasms*/pathology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use , Drug Resistance, Neoplasm* , Drug Tolerance*, Humans ; Translational Research, Biomedical ; Animals

TIM3 attenuates morphine antinociceptive tolerance and microglial neuroinflammation by suppressing the TRAF6/NF-κB pathway in male mice.

Autoren: Yang H Shen T Qi Z et al.

Quelle: Neuropharmacology [Neuropharmacology] 2025 Nov 15; Vol. 279, pp. 110638. Date of Electronic Publication: 2025 Aug 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH-Schlagworte: Morphine*/pharmacology , Drug Tolerance*/physiology , Microglia*/drug effects , Microglia*/metabolism , TNF Receptor-Associated Factor 6*/metabolism , NF-kappa B*/metabolism , Hepatitis A Virus Cellular Receptor 2*/metabolism , Hepatitis A Virus Cellular Receptor 2*/antagonists & inhibitors , Analgesics, Opioid*/pharmacology , Neuroinflammatory Diseases*/metabolism, Animals ; Male ; Mice ; Signal Transduction/drug effects ; Mice, Inbred C57BL ; Tumor Necrosis Factor alpha-Induced Protein 3/metabolism ; Spinal Cord/metabolism ; Spinal Cord/drug effects ; Hyperalgesia/metabolism ; Hyperalgesia/chemically induced

Impact of antibiotic-induced gut microbiota modulation on morphine analgesia, tolerance, withdrawal, and neurophysiological changes in mice.

Autoren: Jokar Z Shahidani S Reisi P et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 14; Vol. 15 (1), pp. 40018. Date of Electronic Publication: 2025 Nov 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Morphine*/pharmacology , Morphine*/administration & dosage , Gastrointestinal Microbiome*/drug effects , Anti-Bacterial Agents*/pharmacology , Substance Withdrawal Syndrome*/drug therapy , Drug Tolerance* , Analgesics, Opioid*/pharmacology, Animals ; Mice ; Male ; Analgesia ; Behavior, Animal/drug effects

Pharmacological inhibition of NaV1.8 by suzetrigine reveals potent analgesic potential without tolerance development in mice.

Autoren: Ali MY Antunes FTT Huang S et al.

Quelle: Molecular brain [Mol Brain] 2025 Nov 13; Vol. 18 (1), pp. 86. Date of Electronic Publication: 2025 Nov 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101468876 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-6606 (Electronic) Linking ISSN: 17566606 NLM ISO Abbreviation: Mol Brain Subsets: MEDLINE

MeSH-Schlagworte: NAV1.8 Voltage-Gated Sodium Channel*/metabolism , Analgesics*/pharmacology , Analgesics*/therapeutic use , Drug Tolerance*, Animals ; Male ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/pathology ; Hyperalgesia/drug therapy ; Hyperalgesia/complications ; Mice, Inbred C57BL ; Neuralgia/drug therapy ; Neuralgia/complications ; Mice ; Behavior, Animal/drug effects ; Tetrodotoxin/pharmacology ; Sciatic Nerve/drug effects ; Sciatic Nerve/pathology

Single-molecule characterization of opioid receptor heterodimers reveals soluble µ-δ dimer blocker peptide alleviates morphine tolerance.

Autoren: Zhou P Kasai RS Fujita W et al.

Quelle: Nature communications [Nat Commun] 2025 Nov 07; Vol. 16 (1), pp. 9859. Date of Electronic Publication: 2025 Nov 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Morphine*/pharmacology , Receptors, Opioid, mu*/metabolism , Receptors, Opioid, mu*/antagonists & inhibitors , Receptors, Opioid, mu*/chemistry , Receptors, Opioid, mu*/genetics , Receptors, Opioid, delta*/metabolism , Receptors, Opioid, delta*/antagonists & inhibitors , Receptors, Opioid, delta*/chemistry , Receptors, Opioid, delta*/genetics , Drug Tolerance* , Peptides*/pharmacology , Peptides*/chemistry, Animals ; Mice ; Protein Multimerization/drug effects ; Humans ; Single Molecule Imaging ; HEK293 Cells ; Binding Sites ; Male ; Receptors, Opioid, kappa/metabolism ; Receptors, Opioid, kappa/chemistry ; Receptors, Opioid, kappa/antagonists & inhibitors ; Receptors, Opioid, kappa/genetics ; Mice, Inbred C57BL ; Analgesics, Opioid/pharmacology

Chronic Δ ⁹ -tetrahydrocannabinol exposure during adolescence is associated with persistent behavioural tolerance in adult nonhuman primates.

Autoren: Razavi Y Kohut SJ Bergman J et al.

Quelle: British journal of pharmacology [Br J Pharmacol] 2025 Nov; Vol. 182 (21), pp. 5149-5156. Date of Electronic Publication: 2025 Aug 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Dronabinol*/administration & dosage , Dronabinol*/pharmacology , Drug Tolerance* , Behavior, Animal*/drug effects, Animals ; Male ; Female ; Dose-Response Relationship, Drug

Bifidobacterium pseudolongum attenuates morphine tolerance via TLR4 in a male mouse model of bone cancer pain.

Autoren: Cao W Shi Y Xing M et al.

Quelle: Neuropharmacology [Neuropharmacology] 2025 Nov 01; Vol. 278, pp. 110590. Date of Electronic Publication: 2025 Jul 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH-Schlagworte: Toll-Like Receptor 4*/metabolism , Morphine*/pharmacology , Cancer Pain*/drug therapy , Cancer Pain*/metabolism , Cancer Pain*/microbiology , Drug Tolerance*/physiology , Bone Neoplasms*/complications , Bone Neoplasms*/metabolism , Bone Neoplasms*/drug therapy , Analgesics, Opioid*/pharmacology , Bifidobacterium*, Animals ; Male ; Mice ; Disease Models, Animal ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Microbiome/physiology ; Spinal Cord/metabolism ; Spinal Cord/drug effects ; Probiotics

Parylation dependent nuclear export of HMGB1 via exportin 1 contributes to morphine tolerance.

Autoren: Liang YP Zhang DY Le DS et al.

Quelle: Brain, behavior, and immunity [Brain Behav Immun] 2025 Nov; Vol. 130, pp. 106070. Date of Electronic Publication: 2025 Aug 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE

MeSH-Schlagworte: Morphine*/pharmacology , HMGB1 Protein*/metabolism , Karyopherins*/metabolism , Receptors, Cytoplasmic and Nuclear*/metabolism , Drug Tolerance*/physiology, Animals ; Exportin 1 Protein ; Rats ; Male ; Active Transport, Cell Nucleus/drug effects ; Rats, Sprague-Dawley ; Analgesics, Opioid/pharmacology ; Spinal Cord/metabolism ; Phosphorylation/drug effects ; Hyperalgesia/metabolism ; Neurons/metabolism

SIRT1-mediated deacetylation and activation of MEK/ERK pathway decreased IL-6 in spinal dorsal horn to promote oxycodone tolerance.

Autoren: Hu S Zhou F Lin B et al.

Quelle: Neuropharmacology [Neuropharmacology] 2025 Nov 01; Vol. 278, pp. 110585. Date of Electronic Publication: 2025 Jul 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH-Schlagworte: Oxycodone*/pharmacology , Sirtuin 1*/metabolism , Interleukin-6*/metabolism , MAP Kinase Signaling System*/drug effects , MAP Kinase Signaling System*/physiology , Analgesics, Opioid*/pharmacology , Drug Tolerance*/physiology , Spinal Cord Dorsal Horn*/metabolism , Spinal Cord Dorsal Horn*/drug effects, Animals ; Male ; Mice, Inbred ICR ; Mice ; Acetylation/drug effects

Bioenergetic reprogramming of macrophages reduces drug tolerance in Mycobacterium tuberculosis.

Autoren: Yadav V Sahoo S Malhotra N et al.

Quelle: Nature communications [Nat Commun] 2025 Oct 23; Vol. 16 (1), pp. 9370. Date of Electronic Publication: 2025 Oct 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/drug effects , Mycobacterium tuberculosis*/metabolism , Mycobacterium tuberculosis*/genetics , Macrophages*/metabolism , Macrophages*/drug effects , Macrophages*/microbiology , Antitubercular Agents*/pharmacology , Drug Tolerance* , Tuberculosis*/drug therapy , Tuberculosis*/microbiology , Energy Metabolism*/drug effects, Animals ; Mice ; Glycolysis/drug effects ; Oxidative Phosphorylation/drug effects ; NF-E2-Related Factor 2/metabolism ; NF-E2-Related Factor 2/genetics ; Humans ; Mice, Inbred C57BL ; Reactive Oxygen Species/metabolism ; Mitochondria/metabolism ; Mitochondria/drug effects ; Oxidative Stress/drug effects ; Oxidation-Reduction/drug effects ; Female

Promising effects of astaxanthin on pain-related behaviors and morphine tolerance in a mouse model of neuropathic pain: Possible involvement of Nrf2 and the NMDA receptor subunit NR2B.

Autoren: Ciapała K Pawlik K Ciechanowska A et al.

Quelle: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics [Neurotherapeutics] 2025 Oct; Vol. 22 (6), pp. e00765. Date of Electronic Publication: 2025 Oct 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Inc. on behalf of American Society for Experimental NeuroTherapeutics Country of Publication: United States NLM ID: 101290381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7479 (Electronic) Linking ISSN: 18787479 NLM ISO Abbreviation: Neurotherapeutics Subsets: MEDLINE

MeSH-Schlagworte: Morphine*/pharmacology , Morphine*/therapeutic use , Receptors, N-Methyl-D-Aspartate*/metabolism , Neuralgia*/drug therapy , Neuralgia*/metabolism , NF-E2-Related Factor 2*/metabolism , Drug Tolerance*/physiology, Animals ; Xanthophylls/pharmacology ; Xanthophylls/therapeutic use ; Mice ; Male ; Disease Models, Animal ; Female ; Analgesics, Opioid/pharmacology ; Analgesics, Opioid/therapeutic use ; Mice, Inbred C57BL ; Behavior, Animal/drug effects

Gα q signaling in primary sensory neurons shifts opioid analgesia to NMDA receptor-driven tolerance and hyperalgesia.

Autoren: Jin D Chen H Zhou MH et al.

Quelle: Science signaling [Sci Signal] 2025 Sep 02; Vol. 18 (902), pp. eadu8839. Date of Electronic Publication: 2025 Sep 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE

MeSH-Schlagworte: Hyperalgesia*/metabolism , Hyperalgesia*/drug therapy , Analgesics, Opioid*/pharmacology , Signal Transduction*/drug effects , GTP-Binding Protein alpha Subunits, Gq-G11*/metabolism , GTP-Binding Protein alpha Subunits, Gq-G11*/genetics , Sensory Receptor Cells*/metabolism , Sensory Receptor Cells*/drug effects , Receptors, N-Methyl-D-Aspartate*/metabolism , Receptors, N-Methyl-D-Aspartate*/genetics , Drug Tolerance*, Animals ; Mice ; Rats ; Morphine/pharmacology ; Receptor, Metabotropic Glutamate 5/metabolism ; Receptor, Metabotropic Glutamate 5/genetics ; Male ; Rats, Sprague-Dawley ; Receptors, Opioid, mu/metabolism ; Mice, Inbred C57BL ; Ganglia, Spinal/metabolism

Cell cycle dynamics analysis of drug-tolerant persister cells in non-small cell lung cancer.

Autoren: Zhou M Haga Y Nishimura A et al.

Quelle: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Aug 15; Vol. 775, pp. 152107. Date of Electronic Publication: 2025 May 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Non-Small-Cell Lung*/pathology , Carcinoma, Non-Small-Cell Lung*/drug therapy , Lung Neoplasms*/pathology , Lung Neoplasms*/drug therapy , Cell Cycle*/drug effects , Drug Resistance, Neoplasm* , Antineoplastic Agents*/pharmacology , Drug Tolerance*, Humans ; Cell Line, Tumor ; Cell Proliferation/drug effects

Eating a high fat/high carbohydrate diet enhances morphine tolerance, while eating a ketogenic diet mitigates morphine withdrawal in male rats.

Autoren: Beltran NM Sullivan LL Naime GM et al.

Quelle: European journal of pharmacology [Eur J Pharmacol] 2025 Aug 05; Vol. 1000, pp. 177709. Date of Electronic Publication: 2025 May 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Morphine*/adverse effects , Morphine*/pharmacology , Drug Tolerance* , Diet, Ketogenic* , Substance Withdrawal Syndrome*/prevention & control , Diet, High-Fat* , Analgesics, Opioid*/pharmacology , Analgesics, Opioid*/adverse effects , Dietary Carbohydrates*/administration & dosage, Animals ; Male ; Rats, Sprague-Dawley ; Rats ; Naltrexone/pharmacology