Search Results - "DRUG absorption"

Plasma Pharmacokinetics of Topical 0.1% Diclofenac Sodium and 0.5% Ketorolac Tromethamine in Dogs.

Authors: Peraza, Jacqueline Ross, Matthew K. Langston, Vernon C. et al.

Source: Veterinary Ophthalmology. Nov2025, p1. 7p. 2 Illustrations.

Subject Terms: *PHARMACOKINETICS, *DRUG absorption, *NONSTEROIDAL anti-inflammatory agents, *OPHTHALMIC surgery, *LIQUID chromatography-mass spectrometry, *DOGS

Genome edited intestine liver on a chip system for integrated intestinal hepatic drug absorption and metabolism evaluation.

Authors: Negoro, Ryosuke Deguchi, Sayaka Yamazaki, Daiju et al.

Source: Scientific Reports. 11/4/2025, Vol. 15 Issue 1, p1-13. 13p.

Subject Terms: *DRUG absorption, *PHARMACOKINETICS, *INTESTINAL mucosa, *MICROPHYSIOLOGICAL systems, *METABOLITES, *GENOME editing, *MICROFLUIDIC devices, *LIVER enzymes

Predicting Food Effect On Oral Drug Absorption For Solubility-Epithelial Membrane Permeation-Limited Cases With Bile Micelle Solubilization.

Authors: Higashiguchi, Yuji Ishida, Shiori Lee, Samuel et al.

Source: Pharmaceutical Research. Oct2025, Vol. 42 Issue 10, p1837-1855. 19p.

Subject Terms: *DRUG-food interactions, *DRUG absorption, *TREATMENT effectiveness, *SOLUBILITY, *MEMBRANE permeability (Biology), *PHARMACOKINETICS

Metabolic Insights into Drug Absorption: Unveiling Piperine's Transformative Bioenhancing Potential.

Authors: Tripathi, Devika Gupta, Vivek Kumar Pandey, Prashant et al.

Source: Pharmaceutical Research. Oct2025, Vol. 42 Issue 10, p1857-1891. 35p.

Subject Terms: *DRUG absorption, *BIOAVAILABILITY, *CLINICAL trials, *NANOTECHNOLOGY, *PHARMACOKINETICS, *CYTOCHROME P-450

Epinephrine, absorption, and local anaesthetic systemic toxicity: insights from continuous fascial block pharmacokinetic models.

Authors: De Cassai, Alessandro Dost, Burhan Mormando, Giulia et al.

Source: BJA: The British Journal of Anaesthesia. Oct2025, Vol. 135 Issue 4, p857-860. 4p.

Subject Terms: *ERECTOR spinae muscles, *DRUG absorption, *ADRENALINE, *PHARMACOKINETICS, *ANESTHETICS

Enhanced intestinal permeation of novel sulpiride electrospun nanofibers: formulation, optimization, and ex vivo evaluation of drug absorption.

Authors: Khaled, Safaa Mady, Omar Hedaya, Asmaa et al.

Source: Drug Development & Industrial Pharmacy. Apr2025, Vol. 51 Issue 4, p295-308. 14p.

Subject Terms: TRANSCYTOSIS, DRUG absorption, TIGHT junctions, SURFACE area, PERMEABILITY, DRUG solubility

Exploring the potential of vaginal drug delivery: innovations, efficacy, and therapeutic prospects Open Access.

Authors: Armengol, Eva Sanchez Veider, Florina Millotti, Gioconda et al.

Source: Journal of Pharmacy & Pharmacology. Sep2025, Vol. 77 Issue 9, p1149-1165. 17p.

Subject Terms: *DRUG absorption, *BIOAVAILABILITY, *INTRAVAGINAL administration, *MEDICAL innovations, *POLYMERS, *EXCIPIENTS, *ANTI-infective agents

Indirect Modeling of Post-Prandial Intestinal Lymphatic Uptake of Halofantrine Using PBPK Approaches: Limitations and Implications.

Authors: Yousef, Malaz Mosa, Farag E. S. Barakat, Khaled H. et al.

Source: Pharmaceutics. Sep2025, Vol. 17 Issue 9, p1228. 17p.

Subject Terms: *PHARMACOKINETICS, *DRUG absorption, *MOLECULAR dynamics, *HIGH-fat diet, *DRUGS, *INTESTINAL absorption

Exploring Experimental and Statistical Approaches to Control Oversensitivity of In Vitro Permeability to Excipient Effects.

Authors: García, Mauricio A. Aceituno, Alexis Díaz, Nicole B. et al.

Source: Pharmaceutics. Sep2025, Vol. 17 Issue 9, p1110. 19p.

Subject Terms: *PERMEABILITY (Biology), *DRUG absorption, *ANALYSIS of variance, *CELL culture, *PHARMACEUTICAL industry, *STATISTICS

Quasi-3D Mechanistic Model for Predicting Eye Drop Distribution in the Human Tear Film.

Authors: Garimella, Harsha T. Norris, Carly German, Carrie et al.

Source: Bioengineering (Basel). Aug2025, Vol. 12 Issue 8, p825. 19p.

Subject Terms: *TOPICAL drug administration, *DRUG absorption, *MATHEMATICAL optimization, *TEARS (Body fluid), *BLINKING (Physiology), *PHARMACOKINETICS, *INTRAOCULAR drug administration

Human Small Intestinal Tissue Models to Assess Barrier Permeability: Comparative Analysis of Caco-2 Cells, Jejunal and Duodenal Enteroid-Derived Cells, and EpiIntestinal TM Tissues in Membrane-Based Cultures with and Without Flow.

Authors: Moyer, Haley L. Vergara, Leoncio Stephan, Clifford et al.

Source: Bioengineering (Basel). Aug2025, Vol. 12 Issue 8, p809. 22p.

Subject Terms: *DRUG absorption, *INTESTINAL barrier function, *INTESTINAL mucosa, *ENTEROCYTES, *MICROPHYSIOLOGICAL systems, *PERMEABILITY measurement, *PREDICTION models

Pharmacokinetics of Drug Absorption and Metabolism: Mechanisms, Influencing Factors, and Screening Strategies in Drug Development.

Authors: Shams, Wajihus Acharya, Monika Jacob, Rosmin et al.

Source: Journal of Neonatal Surgery. 2025 Supplement, Vol. 14, p574-581. 8p.

Subject Terms: *PHARMACOKINETICS, *DRUG absorption, *METABOLISM, *THERAPEUTICS, *EPITHELIUM

Using cocaine and apomorphine self-administration in rats to measure the pharmacokinetics of competitive dopamine receptor antagonists administered by different routes.

Authors: Song, Heather J. Desai, Jhanvi N. Norman, Mantana K. et al.

Source: Scientific Reports. 7/5/2025, Vol. 15 Issue 1, p1-7. 7p.

Subject Terms: *DOPAMINE receptors, *DRUG absorption, *PHARMACOKINETICS, *BIOLOGICAL assay, *STIMULANTS, *DOPAMINE antagonists, *APOMORPHINE

Lipid Based Drug Delivery System for enhancing oral absorption of Biopharmaceuticals.

Authors: Pal, Nidhi Dubey, Vishal

Source: International Journal of Pharmacy & Life Sciences. Jul2025, Vol. 16 Issue 7, p15-25. 11p.

Subject Terms: *BIOAVAILABILITY, *DRUG absorption, *TREATMENT effectiveness, *DRUG delivery systems, *DRUG solubility, *BIOPHARMACEUTICS, *SOLUBILITY, *INTESTINAL absorption

Using Pharmacokinetic Parameters from in vitro Permeation Test Data for Predicting Multiple-Dose Penetration Profiles.

Authors: Lehman, Paul A.¹ (AUTHOR)

Source: Skin Pharmacology & Physiology. 2025, Vol. 38 Issue 4, p127-137. 11p.

Subject Terms: *PHARMACOKINETICS, *DRUG absorption, *DOSAGE forms of drugs, *SKIN permeability, *TRANSPORT theory, *SKIN absorption

In Vitro Oral Cavity Permeability Assessment to Enable Simulation of Drug Absorption.

Authors: Dwivedi, Pankaj Kalra, Priyata Zhou, Haiying et al.

Source: Pharmaceutics. Jul2025, Vol. 17 Issue 7, p924. 15p.

Subject Terms: *DRUG absorption, *PERMEABILITY measurement, *BIOLOGICAL models, *GENERIC drug manufacturing, *BIOACTIVE compounds, *PREDICTION models, *DRUG approval

The Gut Microbiota's Role in Drug Absorption, Metabolism and Efficacy: Implications for Personalized Medicine.

Authors: Ahmed Saeed, Mohammed Ali Abdulghani, Mahfoudh A. M. Muthanna, Fares M. S. et al.

Source: Yemeni Journal for Medical Sciences. 2025, Vol. 19 Issue 3, p1-27. 27p.

Subject Terms: *DRUG solubility, *DRUG absorption, *GUT microbiota, *DRUG therapy, *DRUG metabolism

Molecular Docking and ADME Analysis of the novel compound [(Z)-1a,5-dimethyl-9-methylene-8-oxo1a,2,3,6,6a,8,9,9a,10,10a-decahydro-11-oxa bicyclo(8.1.0) undeca-1(10),4-dieno(7,8-b) furan-10-yl acetate] isolated from Tanacetum dolicophyllum (Kitam.) Kitam.

Authors: Sharma, Gunjan Sahaya, Shibu B. Srivastava, Hemlata et al.

Source: Journal of Applied & Natural Science. 2025, Vol. 17 Issue 2, p793-801. 9p.

Subject Terms: *MOLECULAR docking, *DRUG absorption, *ACETATES, *DRUG design, *BINDING energy, *LIPOPHILICITY

Prevalence of OATP1B‐Mediated Drug–Drug Interactions in an Academic Medical Center.

Authors: Bories, Mathilde Malnoë, David Le Corre, Pascal

Source: CTS: Clinical & Translational Science. Jun2025, Vol. 18 Issue 6, p1-7. 7p.

Subject Terms: *DRUG interactions, *DRUG absorption, *DRUG utilization, *MEDICAL research, *RETROSPECTIVE studies, *POLYPHARMACY

Solute–Vehicle–Skin Interactions and Their Contribution to Pharmacokinetics of Skin Delivery.

Authors: Tapfumaneyi, Pronalis Phan, Khanh Huang, Yicheng et al.

Source: Pharmaceutics. Jun2025, Vol. 17 Issue 6, p764. 25p.

Subject Terms: *SKIN absorption, *DRUG absorption, *MATHEMATICAL optimization, *PHARMACOKINETICS, *SOLUBILITY