Výsledky vyhledávání - "DROSOPHILA"

Nonionic signaling rapidly remodels postsynaptic DLG to induce retrograde homeostatic plasticity.

Autoři: Qiu C Perry S Chen C a další

Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Dec 02; Vol. 122 (48), pp. e2502997122. Date of Electronic Publication: 2025 Nov 26.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Výrazy ze slovníku MeSH: Drosophila Proteins*/metabolism , Drosophila Proteins*/genetics , Neuronal Plasticity*/physiology , Neuromuscular Junction*/metabolism , Neuromuscular Junction*/physiology , Homeostasis*/physiology , Signal Transduction* , Synapses*/metabolism , Synapses*/physiology, Animals ; Receptors, Glutamate/metabolism ; Drosophila melanogaster ; Synaptic Transmission/physiology ; Drosophila ; Tumor Suppressor Proteins

Inhibition of scheggia/SLC25A1 citrate transporter alleviates XPD deficits.

Autoři: Cho DG Jung J Hwang JH a další

Zdroj: Scientific reports [Sci Rep] 2025 Dec 01; Vol. 15 (1), pp. 42891. Date of Electronic Publication: 2025 Dec 01.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Výrazy ze slovníku MeSH: Drosophila Proteins*/genetics , Drosophila Proteins*/metabolism , Drosophila Proteins*/antagonists & inhibitors , Xeroderma Pigmentosum Group D Protein*/genetics , Xeroderma Pigmentosum Group D Protein*/metabolism , Mitochondrial Proteins*/genetics , Mitochondrial Proteins*/metabolism , Mitochondrial Proteins*/antagonists & inhibitors, Animals ; Humans ; HeLa Cells ; DNA Damage ; Drosophila/genetics ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; RNA Interference ; Cell Survival/drug effects ; Organic Anion Transporters

Innate immunity pathways activate cell proliferation after penetrating traumatic brain injury in adult Drosophila .

Autoři: Ahern-Djamali S Marischuk K Crocker KL a další

Zdroj: Fly [Fly (Austin)] 2025 Dec; Vol. 19 (1), pp. 2586357. Date of Electronic Publication: 2025 Nov 14.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101470897 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-6942 (Electronic) Linking ISSN: 19336934 NLM ISO Abbreviation: Fly (Austin) Subsets: MEDLINE

Výrazy ze slovníku MeSH: Immunity, Innate* , Cell Proliferation* , Brain Injuries, Traumatic*/immunology , Drosophila melanogaster*/immunology , Drosophila melanogaster*/genetics , Drosophila*/immunology, Animals ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Signal Transduction ; Transcription Factors/genetics ; Transcription Factors/metabolism ; DNA-Binding Proteins

miR-124 acts During Drosophila Development to Determine the Phase of Adult Circadian Behavior.

Autoři: Xia Y Chen C Emery P

Zdroj: Journal of biological rhythms [J Biol Rhythms] 2025 Dec; Vol. 40 (6), pp. 574-593. Date of Electronic Publication: 2025 Aug 29.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Sage Publishers Country of Publication: United States NLM ID: 8700115 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4531 (Electronic) Linking ISSN: 07487304 NLM ISO Abbreviation: J Biol Rhythms Subsets: MEDLINE

Výrazy ze slovníku MeSH: MicroRNAs*/genetics , MicroRNAs*/metabolism , Circadian Rhythm*/genetics , Circadian Rhythm*/physiology , Drosophila melanogaster*/genetics , Drosophila melanogaster*/physiology , Drosophila melanogaster*/growth & development , Drosophila*/genetics , Drosophila*/physiology, Animals ; Photoperiod ; Neurons/physiology ; Neurons/metabolism ; Circadian Clocks/genetics ; Larva/genetics ; Larva/physiology ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Behavior, Animal ; Motor Activity/genetics

What the fruit fly can tell us about autosomal recessive primary microcephaly.

Autoři: Chakraborty S Florez S Schoborg T

Zdroj: Fly [Fly (Austin)] 2025 Dec; Vol. 19 (1), pp. 2572866. Date of Electronic Publication: 2025 Oct 11.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101470897 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-6942 (Electronic) Linking ISSN: 19336934 NLM ISO Abbreviation: Fly (Austin) Subsets: MEDLINE

Výrazy ze slovníku MeSH: Microcephaly*/genetics , Drosophila*/genetics , Drosophila melanogaster*/genetics, Animals ; Humans ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Disease Models, Animal ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism

SCR Disease Name: Autosomal Recessive Primary Microcephaly

Utility of Drosophila for studying hypoxia-inducible factor (HIF) in neurodegenerative diseases: Advantages versus limitations.

Autoři: Serebrovska Z Xi L Khetsuriani M a další

Zdroj: Brain research [Brain Res] 2025 Nov 15; Vol. 1867, pp. 149953. Date of Electronic Publication: 2025 Sep 19.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE

Výrazy ze slovníku MeSH: Neurodegenerative Diseases*/metabolism , Neurodegenerative Diseases*/genetics , Drosophila Proteins*/metabolism , Drosophila Proteins*/genetics , Disease Models, Animal* , Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Hypoxia-Inducible Factor 1, alpha Subunit*/genetics, Animals ; Humans ; Drosophila melanogaster/metabolism ; Oxidative Stress/physiology ; Autophagy/physiology ; alpha-Synuclein/metabolism ; Signal Transduction/physiology ; Drosophila ; DNA-Binding Proteins

TDP-43 Regulates Rab4 Levels to Support Synaptic Vesicle Recycling and Neuromuscular Connectivity in Drosophila and Human ALS Models.

Autoři: Gbadamosi M Romano G Simbula M a další

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 14; Vol. 26 (22). Date of Electronic Publication: 2025 Nov 14.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Amyotrophic Lateral Sclerosis*/metabolism , Amyotrophic Lateral Sclerosis*/genetics , Amyotrophic Lateral Sclerosis*/pathology , Synaptic Vesicles*/metabolism , Neuromuscular Junction*/metabolism , Drosophila Proteins*/metabolism , Drosophila Proteins*/genetics , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics , rab4 GTP-Binding Proteins*/metabolism , rab4 GTP-Binding Proteins*/genetics, Animals ; Humans ; Motor Neurons/metabolism ; Disease Models, Animal ; Microtubule-Associated Proteins/metabolism ; Microtubule-Associated Proteins/genetics ; Drosophila melanogaster/metabolism ; Induced Pluripotent Stem Cells/metabolism ; Drosophila

The ARVC-5-associated protein TMEM43 controls mitochondrial energy metabolism by stabilising ER-mitochondrial contact sites.

Autoři: Jürgens K Menzel L Klinke N a další

Zdroj: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2025 Nov 14; Vol. 82 (1), pp. 400. Date of Electronic Publication: 2025 Nov 14.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Endoplasmic Reticulum*/metabolism , Energy Metabolism* , Drosophila Proteins*/metabolism , Drosophila Proteins*/genetics , Mitochondria*/metabolism , Mitochondria*/ultrastructure , Arrhythmogenic Right Ventricular Dysplasia*/metabolism , Arrhythmogenic Right Ventricular Dysplasia*/genetics , Arrhythmogenic Right Ventricular Dysplasia*/pathology , Membrane Proteins*/metabolism , Membrane Proteins*/genetics, Humans ; Animals ; Membrane Potential, Mitochondrial ; Reactive Oxygen Species/metabolism ; Mutation, Missense ; Drosophila ; Drosophila melanogaster/metabolism ; Mitochondria Associated Membranes

A Single NPFR Neuropeptide F Receptor Neuron That Regulates Thirst Behaviors in Drosophila .

Autoři: Orozco Ramirez D Wang BP Landayan D a další

Zdroj: ENeuro [eNeuro] 2025 Oct 28; Vol. 12 (10). Date of Electronic Publication: 2025 Oct 28 (Print Publication: 2025).

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 101647362 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2373-2822 (Electronic) Linking ISSN: 23732822 NLM ISO Abbreviation: eNeuro Subsets: MEDLINE

Výrazy ze slovníku MeSH: Thirst*/physiology , Drosophila Proteins*/metabolism , Drosophila Proteins*/genetics , Neurons*/metabolism , Neurons*/physiology , Receptors, Neuropeptide*/metabolism , Receptors, Neuropeptide*/genetics , Neuropeptides*/metabolism, Animals ; Male ; Animals, Genetically Modified ; Drosophila ; Drosophila melanogaster ; Dopaminergic Neurons/metabolism ; Behavior, Animal/physiology ; Brain/metabolism

Frazzled/DCC Regulates Gap Junction Formation at a Drosophila Giant Synapse.

Autoři: Lopez J Boerner J Robbins K a další

Zdroj: ENeuro [eNeuro] 2025 Oct 28; Vol. 12 (10). Date of Electronic Publication: 2025 Oct 28 (Print Publication: 2025).

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 101647362 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2373-2822 (Electronic) Linking ISSN: 23732822 NLM ISO Abbreviation: eNeuro Subsets: MEDLINE

Výrazy ze slovníku MeSH: Drosophila Proteins*/genetics , Drosophila Proteins*/metabolism , Gap Junctions*/metabolism , Gap Junctions*/physiology , Synapses*/physiology , Synapses*/metabolism , Electrical Synapses*/metabolism , Electrical Synapses*/physiology , Receptors, Cell Surface*/genetics , Receptors, Cell Surface*/metabolism, Animals ; Female ; Male ; Animals, Genetically Modified ; Drosophila ; Motor Neurons/physiology ; Motor Neurons/metabolism ; Connexins/metabolism ; Drosophila melanogaster

Machine Learning-Driven Prediction of Spatiotemporal Dynamics of Active Nuclei During Drosophila Embryogenesis.

Autoři: Malidarreh PB Borad P Rout B a další

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 23; Vol. 26 (21). Date of Electronic Publication: 2025 Oct 23.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Machine Learning* , Embryonic Development*/genetics , Cell Nucleus*/metabolism , Cell Nucleus*/genetics , Drosophila*/embryology , Drosophila*/genetics , Drosophila melanogaster*/embryology , Drosophila melanogaster*/genetics, Animals ; Gene Expression Regulation, Developmental ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism

The E3 Ligase UBR5/Hyd Ensures Meiotic Fidelity Through Catalysis-Independent Regulation of β2-Tubulin in Drosophila .

Autoři: Zhou L Lin L Zhang Y a další

Zdroj: Genes [Genes (Basel)] 2025 Oct 22; Vol. 16 (11). Date of Electronic Publication: 2025 Oct 22.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE

Výrazy ze slovníku MeSH: Tubulin*/metabolism , Tubulin*/genetics , Ubiquitin-Protein Ligases*/genetics , Ubiquitin-Protein Ligases*/metabolism , Drosophila Proteins*/genetics , Drosophila Proteins*/metabolism , Meiosis*/genetics, Animals ; Male ; Spermatogenesis/genetics ; Drosophila/genetics ; Microtubules/metabolism ; Drosophila melanogaster/genetics ; Testis/metabolism

Synaptic vesicle glycoprotein 2 enables viable aneuploidy following centrosome amplification.

Autoři: Blackmer JE Jezuit EA Chakraborty A a další

Zdroj: Genetics [Genetics] 2025 Oct 08; Vol. 231 (2).

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0374636 Publication Model: Print Cited Medium: Internet ISSN: 1943-2631 (Electronic) Linking ISSN: 00166731 NLM ISO Abbreviation: Genetics Subsets: MEDLINE

Výrazy ze slovníku MeSH: Centrosome*/metabolism , Aneuploidy* , Drosophila Proteins*/genetics , Drosophila Proteins*/metabolism , Nerve Tissue Proteins*/genetics , Nerve Tissue Proteins*/metabolism, Animals ; Chromosome Segregation ; Drosophila melanogaster/genetics ; Humans ; Mitosis ; Drosophila/genetics ; Cell Membrane/metabolism

Ectopic sodium channel expression decreases excitability of Drosophila Kenyon cells.

Autoři: Greenin-Whitehead K Rozenfeld E Moreno-Sanchez A a další

Zdroj: The Journal of physiology [J Physiol] 2025 Oct; Vol. 603 (19), pp. 5565-5612. Date of Electronic Publication: 2025 Aug 25.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Cambridge Univ. Press Country of Publication: England NLM ID: 0266262 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-7793 (Electronic) Linking ISSN: 00223751 NLM ISO Abbreviation: J Physiol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Drosophila Proteins*/genetics , Drosophila Proteins*/metabolism , Sodium Channels*/genetics , Sodium Channels*/metabolism , Neurons*/physiology , Voltage-Gated Sodium Channels*/genetics , Voltage-Gated Sodium Channels*/metabolism, Animals ; Drosophila ; Drosophila melanogaster ; Action Potentials ; Calcium/metabolism ; Homeostasis ; Smell

Transcriptomic profiling of eyeless Drosophila reveals molecular network orchestrating response to blue light.

Autoři: Yang J Yujuan S Kumar R a další

Zdroj: Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2025 Oct; Vol. 271, pp. 113225. Date of Electronic Publication: 2025 Jul 21.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Sequoia Country of Publication: Switzerland NLM ID: 8804966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2682 (Electronic) Linking ISSN: 10111344 NLM ISO Abbreviation: J Photochem Photobiol B Subsets: MEDLINE

Výrazy ze slovníku MeSH: Light* , Gene Expression Profiling* , Transcriptome*/radiation effects , Drosophila*/genetics , Drosophila melanogaster*/genetics , Drosophila melanogaster*/radiation effects , Gene Regulatory Networks*/radiation effects, Animals ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Promoter Regions, Genetic ; Blue Light

Drosophila and mouse intestinal stem cells are spatiotemporally specified by Notch suppression and Wnt activation.

Autoři: Wu Y Yu L Yu Y a další

Zdroj: Science advances [Sci Adv] 2025 Dec 05; Vol. 11 (49), pp. eady7272. Date of Electronic Publication: 2025 Dec 03.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

Výrazy ze slovníku MeSH: Receptors, Notch*/metabolism , Receptors, Notch*/genetics , Stem Cells*/metabolism , Stem Cells*/cytology , Drosophila Proteins*/metabolism , Drosophila Proteins*/genetics , Intestines*/cytology , Wnt Signaling Pathway* , Wnt Proteins*/metabolism, Animals ; Mice ; Drosophila ; Drosophila melanogaster ; Receptors, G-Protein-Coupled/metabolism ; Cell Differentiation ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/cytology

Probing direct interactions between nuclear proteins in cells with nxReLo.

Autoři: Ismail S Kubíková J Maichel M a další

Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Dec 02; Vol. 122 (48), pp. e2518711122. Date of Electronic Publication: 2025 Nov 26.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Výrazy ze slovníku MeSH: Drosophila Proteins*/metabolism , Drosophila Proteins*/genetics , Drosophila Proteins*/chemistry , Nuclear Proteins*/metabolism , Nuclear Proteins*/genetics , Nuclear Proteins*/chemistry , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics, Animals ; Drosophila melanogaster/metabolism ; Drosophila melanogaster/genetics ; RNA, Small Interfering/metabolism ; RNA, Small Interfering/genetics ; Protein Binding ; Argonaute Proteins/metabolism

Targeting and anchoring the mechanosensitive ion channel Piezo to facilitate its inhibition of axon regeneration.

Autoři: Wang Q Miles L Wang S a další

Zdroj: PLoS genetics [PLoS Genet] 2025 Dec 01; Vol. 21 (12), pp. e1011968. Date of Electronic Publication: 2025 Dec 01 (Print Publication: 2025).

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet Subsets: MEDLINE

Výrazy ze slovníku MeSH: Axons*/physiology , Axons*/metabolism , Nerve Regeneration*/genetics , Ion Channels*/genetics , Ion Channels*/metabolism , Drosophila Proteins*/genetics , Drosophila Proteins*/metabolism, Animals ; Mice ; Integrin beta1/genetics ; Integrin beta1/metabolism ; Mechanotransduction, Cellular/genetics ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/metabolism ; Sensory Receptor Cells/metabolism ; Spinal Cord Injuries/genetics ; Spinal Cord Injuries/pathology ; Spinal Cord Injuries/metabolism ; Drosophila ; Drosophila melanogaster/genetics ; Humans

High-resolution single-cell analyses reveal evolutionary constraints and evolvability of sexual circuits in Drosophila .

Autoři: Walsh JT Junker IP Chen YD a další

Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 25; Vol. 122 (47), pp. e2516083122. Date of Electronic Publication: 2025 Nov 17.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Výrazy ze slovníku MeSH: Single-Cell Analysis*/methods , Biological Evolution* , Sexual Behavior, Animal*/physiology , Drosophila*/genetics , Drosophila*/physiology, Animals ; Male ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/physiology ; Female ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Neurons/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Transcriptome ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Evolution, Molecular

EyaHOST, a modular genetic system for investigation of intercellular and tumor-host interactions in Drosophila melanogaster.

Autoři: Teles-Reis J Jain A Liu D a další

Zdroj: Cell reports methods [Cell Rep Methods] 2025 Nov 17; Vol. 5 (11), pp. 101220. Date of Electronic Publication: 2025 Nov 04.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9918227360606676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2667-2375 (Electronic) Linking ISSN: 26672375 NLM ISO Abbreviation: Cell Rep Methods Subsets: MEDLINE

Výrazy ze slovníku MeSH: Drosophila melanogaster*/genetics , Drosophila melanogaster*/metabolism , Neoplasms*/pathology , Neoplasms*/genetics , Cell Communication*, Animals ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Apoptosis ; Autophagy