Suchergebnisse - "DOXORUBICIN"

Enhancing GSDME-induced pyroptosis through low-dose doxorubicin/biflavonoid derivative co-loaded nanodisc in hepatocellular carcinoma.

Autoren: Wang Y Fu Y Wu M et al.

Quelle: Drug delivery [Drug Deliv] 2025 Dec 31; Vol. 32 (1), pp. 2587034. Date of Electronic Publication: 2025 Nov 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9417471 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0464 (Electronic) Linking ISSN: 10717544 NLM ISO Abbreviation: Drug Deliv Subsets: MEDLINE

MeSH-Schlagworte: Pyroptosis*/drug effects , Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Doxorubicin*/administration & dosage , Doxorubicin*/pharmacology , Liver Neoplasms*/drug therapy , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , Biflavonoids*/administration & dosage , Biflavonoids*/pharmacology , Biflavonoids*/chemistry, Humans ; Animals ; Mice ; Cell Line, Tumor ; Mice, Nude ; Mice, Inbred BALB C ; Nanoparticles/chemistry ; Xenograft Model Antitumor Assays ; Autophagy/drug effects ; Drug Synergism ; Male ; Dose-Response Relationship, Drug ; Gasdermins

Advanced internally bridged silica core-shell nanocarriers: Design and applications.

Autoren: Heidari Nia M Heidari Nia S Munguia-Lopez JG et al.

Quelle: Journal of colloid and interface science [J Colloid Interface Sci] 2025 Dec 15; Vol. 700 (Pt 3), pp. 138627. Date of Electronic Publication: 2025 Aug 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 0043125 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-7103 (Electronic) Linking ISSN: 00219797 NLM ISO Abbreviation: J Colloid Interface Sci Subsets: MEDLINE

MeSH-Schlagworte: Silicon Dioxide*/chemistry , Doxorubicin*/pharmacology , Doxorubicin*/chemistry , Drug Carriers*/chemistry , Nanostructures*/chemistry , Antibiotics, Antineoplastic*/pharmacology , Antibiotics, Antineoplastic*/chemistry , Nanoparticles*/chemistry, Humans ; Surface Properties ; Particle Size ; Cell Survival/drug effects ; Drug Liberation

Synergistic anticancer effects of doxorubicin in combination with tilorone in breast cancer.

Autoren: Chhipa AS Gallicchio M Boscaro V et al.

Quelle: European journal of pharmacology [Eur J Pharmacol] 2025 Dec 05; Vol. 1008, pp. 178249. Date of Electronic Publication: 2025 Nov 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Doxorubicin*/pharmacology , Doxorubicin*/therapeutic use , Breast Neoplasms*/pathology , Breast Neoplasms*/drug therapy , Breast Neoplasms*/metabolism , Tilorone*/pharmacology , Tilorone*/therapeutic use , Antineoplastic Combined Chemotherapy Protocols*/pharmacology , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Antineoplastic Agents*/pharmacology, Drug Synergism ; Humans ; Female ; Animals ; Cell Line, Tumor ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Mice ; Cell Survival/drug effects ; Xenograft Model Antitumor Assays

Oligoclonal anti-HER2 nanobody-targeted exosomes as a nano carrier for doxorubicin delivery to HER2-positive breast cancer in vitro and in vivo.

Autoren: Al-Khafaji MK Rahbarizadeh F Ahmadvand D

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Dec; Vol. 333 (Pt 2), pp. 148626. Date of Electronic Publication: 2025 Nov 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Doxorubicin*/pharmacology , Doxorubicin*/chemistry , Doxorubicin*/administration & dosage , Exosomes*/chemistry , Exosomes*/metabolism , Receptor, ErbB-2*/metabolism , Receptor, ErbB-2*/antagonists & inhibitors , Receptor, ErbB-2*/immunology , Breast Neoplasms*/drug therapy , Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology , Single-Domain Antibodies*/chemistry , Drug Carriers*/chemistry, Animals ; Female ; Humans ; Mice ; Cell Line, Tumor ; Mice, Inbred BALB C ; Drug Delivery Systems

Injectable sustained local release doxorubicin depot technology- a promising adjuvant to systemic treatment?

Autoren: Jørgensen AR Hansen AE Henriksen JR et al.

Quelle: Drug delivery and translational research [Drug Deliv Transl Res] 2025 Dec; Vol. 15 (12), pp. 4601-4610. Date of Electronic Publication: 2025 Apr 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE

MeSH-Schlagworte: Doxorubicin*/administration & dosage , Doxorubicin*/pharmacokinetics , Doxorubicin*/chemistry , Doxorubicin*/therapeutic use , Antibiotics, Antineoplastic*/administration & dosage , Antibiotics, Antineoplastic*/pharmacokinetics , Antibiotics, Antineoplastic*/chemistry , Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/pathology, Animals ; Female ; Delayed-Action Preparations/administration & dosage ; Delayed-Action Preparations/pharmacokinetics ; Mice ; Swine ; Injections, Subcutaneous ; Cell Line, Tumor ; Drug Liberation

Fenofibrate attenuates doxorubicin-induced cardiotoxicity in patients with breast cancer: a randomized controlled trial.

Autoren: Dewidar HK Ghannam AA Mostafa TM

Quelle: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 Dec; Vol. 398 (12), pp. 17109-17119. Date of Electronic Publication: 2025 Jun 03.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Doxorubicin*/adverse effects , Doxorubicin*/administration & dosage , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/blood , Fenofibrate*/therapeutic use , Fenofibrate*/adverse effects , Fenofibrate*/administration & dosage , Cardiotoxicity*/prevention & control , Cardiotoxicity*/etiology , Cardiotoxicity*/blood , Cardiotoxicity*/drug therapy , Antibiotics, Antineoplastic*/adverse effects , Antineoplastic Combined Chemotherapy Protocols*/adverse effects , Hypolipidemic Agents*/therapeutic use , Hypolipidemic Agents*/adverse effects, Humans ; Female ; Middle Aged ; Adult ; Cyclophosphamide/administration & dosage ; Cyclophosphamide/adverse effects ; Natriuretic Peptide, Brain/blood ; Peroxidase/blood ; Peptide Fragments/blood ; Ventricular Function, Left/drug effects ; Aspartate Aminotransferases/blood ; Alanine Transaminase/blood ; Aged ; Stroke Volume/drug effects

Evaluation of the protective effect of resveratrol-loaded solid lipid nanoparticles on radiation- or doxorubicin-induced spermatogenic damage in mice.

Autoren: Farhadi Rad M Aghaz F Rashidi K et al.

Quelle: Reproductive biology [Reprod Biol] 2025 Dec; Vol. 25 (4), pp. 101058. Date of Electronic Publication: 2025 Sep 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Urban & Partner Country of Publication: Poland NLM ID: 101160559 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2300-732X (Electronic) Linking ISSN: 1642431X NLM ISO Abbreviation: Reprod Biol Subsets: MEDLINE

MeSH-Schlagworte: Resveratrol*/pharmacology , Doxorubicin*/toxicity , Doxorubicin*/adverse effects , Nanoparticles*/chemistry , Nanoparticles*/administration & dosage , Testis*/drug effects , Testis*/radiation effects , Testis*/pathology , Antioxidants*/pharmacology , Antioxidants*/administration & dosage , Spermatogenesis*/drug effects , Spermatogenesis*/radiation effects, Animals ; Male ; Mice ; Malondialdehyde/metabolism ; Superoxide Dismutase/metabolism ; Lipids/chemistry ; Oxidative Stress/drug effects ; Antibiotics, Antineoplastic/toxicity ; Liposomes

Targeted cross-linking tumor extracellular matrix by genipin and doxorubicin co-loaded nanomedicine to efficiently inhibit tumor metastasis.

Autoren: Cui J Jiang J Feng L et al.

Quelle: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2025 Dec; Vol. 256 (Pt 1), pp. 115016. Date of Electronic Publication: 2025 Aug 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE

MeSH-Schlagworte: Iridoids*/chemistry , Iridoids*/pharmacology , Doxorubicin*/pharmacology , Doxorubicin*/chemistry , Extracellular Matrix*/drug effects , Extracellular Matrix*/metabolism , Extracellular Matrix*/chemistry , Nanomedicine*/methods , Cross-Linking Reagents*/chemistry , Cross-Linking Reagents*/pharmacology , Antibiotics, Antineoplastic*/pharmacology , Antibiotics, Antineoplastic*/chemistry, Animals ; Mice, Inbred BALB C ; Mice ; Female ; Drug Liberation ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Humans ; Particle Size ; Liposomes/chemistry ; Oligopeptides/chemistry

FOXO1-NMNAT3 axis dysregulation promotes doxorubicin cardiotoxicity: NAD ⁺ replenishment as a redox-targeted antioxidant therapy.

Autoren: Cheng F Zhao M Wang Q et al.

Quelle: Redox report : communications in free radical research [Redox Rep] 2025 Dec; Vol. 30 (1), pp. 2565033. Date of Electronic Publication: 2025 Sep 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9511366 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1743-2928 (Electronic) Linking ISSN: 13510002 NLM ISO Abbreviation: Redox Rep Subsets: MEDLINE

MeSH-Schlagworte: Doxorubicin*/adverse effects , Doxorubicin*/toxicity , NAD*/metabolism , Cardiotoxicity*/metabolism , Cardiotoxicity*/drug therapy , Forkhead Box Protein O1*/metabolism , Forkhead Box Protein O1*/genetics , Nicotinamide-Nucleotide Adenylyltransferase*/metabolism , Nicotinamide-Nucleotide Adenylyltransferase*/genetics , Antioxidants*/pharmacology, Animals ; Mice ; Oxidation-Reduction/drug effects ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/drug effects ; Humans ; Mice, Inbred C57BL ; Oxidative Stress/drug effects ; Male

Development and in vitro evaluation of lipodisks optimized for co-delivery of chemotherapeutic drugs and membranolytic anticancer peptides.

Autoren: Silva L Ali S Gedda L et al.

Quelle: Journal of colloid and interface science [J Colloid Interface Sci] 2025 Dec; Vol. 699 (Pt 1), pp. 138173. Date of Electronic Publication: 2025 Jun 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 0043125 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-7103 (Electronic) Linking ISSN: 00219797 NLM ISO Abbreviation: J Colloid Interface Sci Subsets: MEDLINE

MeSH-Schlagworte: Doxorubicin*/pharmacology , Doxorubicin*/chemistry , Doxorubicin*/administration & dosage , Melitten*/chemistry , Melitten*/pharmacology , Melitten*/administration & dosage , Drug Carriers*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/administration & dosage , Lipids*/chemistry , Drug Delivery Systems* , Camptothecin*/analogs & derivatives , Camptothecin*/pharmacology , Camptothecin*/chemistry , Camptothecin*/administration & dosage , Peptides*/chemistry , Peptides*/pharmacology, Humans ; Polyethylene Glycols/chemistry ; Irinotecan ; Cell Survival/drug effects ; Particle Size ; Cell Line, Tumor ; Drug Liberation ; Surface Properties

Computer-aided drug design of SP94 peptide-functionalized human H-chain ferritin for targeted doxorubicin delivery.

Autoren: Zhao W Huang F Uddin S et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Dec; Vol. 332 (Pt 1), pp. 148521. Date of Electronic Publication: 2025 Oct 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Doxorubicin*/chemistry , Doxorubicin*/pharmacology , Drug Design* , Apoferritins*/chemistry , Peptides*/chemistry , Computer-Aided Design* , Drug Delivery Systems*, Humans ; Hep G2 Cells ; Endoplasmic Reticulum Chaperone BiP ; Molecular Dynamics Simulation ; Drug Carriers/chemistry ; Nanoparticles/chemistry

Anticancer effects of doxorubicin-conjugated magnetite MXene/Callicarpa extract on MCF-7 breast cancer cell line.

Autoren: Jabbarzadeh M Zaboli P Chekin F et al.

Quelle: Talanta [Talanta] 2025 Dec 01; Vol. 295, pp. 128380. Date of Electronic Publication: 2025 May 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE

MeSH-Schlagworte: Doxorubicin*/pharmacology , Doxorubicin*/chemistry , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Magnetite Nanoparticles*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry, Humans ; MCF-7 Cells ; Cell Survival/drug effects ; Drug Carriers/chemistry ; Drug Liberation ; Breast Neoplasms/pathology ; Breast Neoplasms/drug therapy ; Female ; Nitrites ; Transition Elements

Enhancing targeted delivery and efficacy of PEGylated liposomal doxorubicin with liposomal minoxidil: comprehensive in silico, in vitro, and in vivo tumor model studies.

Autoren: Mohammadzadeh V Arabi L Hosseinikhah SM et al.

Quelle: Drug delivery [Drug Deliv] 2025 Dec; Vol. 32 (1), pp. 2536802. Date of Electronic Publication: 2025 Aug 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9417471 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0464 (Electronic) Linking ISSN: 10717544 NLM ISO Abbreviation: Drug Deliv Subsets: MEDLINE

MeSH-Schlagworte: Doxorubicin*/analogs & derivatives , Doxorubicin*/administration & dosage , Doxorubicin*/pharmacology , Doxorubicin*/chemistry , Polyethylene Glycols*/chemistry , Polyethylene Glycols*/administration & dosage , Polyethylene Glycols*/pharmacology , Minoxidil*/administration & dosage , Minoxidil*/chemistry , Minoxidil*/pharmacology, Animals ; Mice ; Liposomes/chemistry ; Humans ; Cell Line, Tumor ; Nanoparticles/chemistry ; Drug Delivery Systems/methods ; Particle Size ; Mice, Nude ; Pancreatic Neoplasms/drug therapy ; Mice, Inbred BALB C ; Antibiotics, Antineoplastic/administration & dosage ; Xenograft Model Antitumor Assays ; Colorectal Neoplasms/drug therapy

Modular engineering of the doxorubicin biosynthetic gene cluster based on component functional clustering in Streptomyces.

Autoren: Cui T Jiang C Li J et al.

Quelle: Journal of biotechnology [J Biotechnol] 2025 Dec; Vol. 408, pp. 265-274. Date of Electronic Publication: 2025 Oct 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8411927 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4863 (Electronic) Linking ISSN: 01681656 NLM ISO Abbreviation: J Biotechnol Subsets: MEDLINE

MeSH-Schlagworte: Doxorubicin*/biosynthesis , Doxorubicin*/metabolism , Streptomyces*/genetics , Streptomyces*/metabolism , Multigene Family*/genetics , Metabolic Engineering*/methods, Glycosylation ; Biosynthetic Pathways/genetics ; Antibiotics, Antineoplastic ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism

SCR Organism: Streptomyces albus

Esculetin Attenuates Doxorubicin-Induced Cardiotoxicity via Modulation of Apoptotic and Mitochondrial Gene Expression Networks.

Autoren: Demir Y Ceylan H Karağaç MS et al.

Quelle: Cell biology international [Cell Biol Int] 2025 Dec; Vol. 49 (12), pp. 1705-1715. Date of Electronic Publication: 2025 Sep 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Chichester Country of Publication: England NLM ID: 9307129 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8355 (Electronic) Linking ISSN: 10656995 NLM ISO Abbreviation: Cell Biol Int Subsets: MEDLINE

MeSH-Schlagworte: Umbelliferones*/pharmacology , Doxorubicin*/toxicity , Doxorubicin*/adverse effects , Apoptosis*/drug effects , Apoptosis*/genetics , Cardiotoxicity*/genetics , Cardiotoxicity*/drug therapy , Mitochondria*/drug effects , Mitochondria*/metabolism , Mitochondria*/genetics, Animals ; Rats, Wistar ; Male ; Rats ; Oxidative Stress/drug effects ; Antioxidants/pharmacology ; Gene Regulatory Networks/drug effects ; Cardiotonic Agents/pharmacology

Co-Encapsulation of Doxorubicin HCl and Paclitaxel in Nanovesicles for Enhanced Breast Cancer Therapy.

Autoren: Kafle U Moore E Lushnikov A et al.

Quelle: AAPS PharmSciTech [AAPS PharmSciTech] 2025 Nov 26; Vol. 27 (1), pp. 41. Date of Electronic Publication: 2025 Nov 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: United States NLM ID: 100960111 Publication Model: Electronic Cited Medium: Internet ISSN: 1530-9932 (Electronic) Linking ISSN: 15309932 NLM ISO Abbreviation: AAPS PharmSciTech Subsets: MEDLINE

MeSH-Schlagworte: Doxorubicin*/chemistry , Doxorubicin*/administration & dosage , Paclitaxel*/chemistry , Paclitaxel*/administration & dosage , Breast Neoplasms*/drug therapy , Nanoparticles*/chemistry, Humans ; Female ; Liposomes/chemistry ; Drug Liberation ; Particle Size ; Cell Line, Tumor ; Drug Carriers/chemistry ; Drug Compounding/methods ; Chemistry, Pharmaceutical/methods

The role of nitric oxide and connexin 43 in the cardioprotective effects of apigenin against doxorubicin-induced cardiotoxicity in male rats.

Autoren: Safaei A Fallah M Dehpour AR et al.

Quelle: Molecular biology reports [Mol Biol Rep] 2025 Nov 24; Vol. 53 (1), pp. 113. Date of Electronic Publication: 2025 Nov 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

MeSH-Schlagworte: Connexin 43*/metabolism , Doxorubicin*/adverse effects , Doxorubicin*/toxicity , Doxorubicin*/pharmacology , Apigenin*/pharmacology , Apigenin*/metabolism , Nitric Oxide*/metabolism , Cardiotoxicity*/metabolism , Cardiotoxicity*/drug therapy , Cardiotoxicity*/prevention & control , Cardiotonic Agents*/pharmacology, Animals ; Male ; Rats, Wistar ; Rats ; Oxidative Stress/drug effects ; NG-Nitroarginine Methyl Ester/pharmacology ; Heart/drug effects ; Myocardium/metabolism

Synergistic anticancer effects of carrier-free self-assembled doxorubicin and emodin nanoparticles in non-small cell lung cancer.

Autoren: Tang C Zou Y Meng H et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 17; Vol. 15 (1), pp. 40205. Date of Electronic Publication: 2025 Nov 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Doxorubicin*/pharmacology , Doxorubicin*/chemistry , Doxorubicin*/administration & dosage , Emodin*/pharmacology , Emodin*/chemistry , Emodin*/administration & dosage , Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/pathology , Carcinoma, Non-Small-Cell Lung*/metabolism , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism , Nanoparticles*/chemistry , Antineoplastic Agents*/pharmacology, Humans ; Animals ; A549 Cells ; Drug Synergism ; Mice ; Xenograft Model Antitumor Assays ; Drug Carriers/chemistry ; Cell Line, Tumor ; Mice, Nude

LC-MS/MS based cellular pharmacokinetics to explore the mechanism of palmatine against doxorubicin-induced cardiotoxicity.

Autoren: Jiang C Chen S Huang M et al.

Quelle: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2025 Nov 15; Vol. 265, pp. 117037. Date of Electronic Publication: 2025 Jun 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

MeSH-Schlagworte: Doxorubicin*/pharmacokinetics , Doxorubicin*/toxicity , Doxorubicin*/adverse effects , Berberine Alkaloids*/pharmacology , Berberine Alkaloids*/pharmacokinetics , Cardiotoxicity*/prevention & control , Cardiotoxicity*/drug therapy , Cardiotoxicity*/etiology, Tandem Mass Spectrometry/methods ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Animals ; Rats ; Molecular Docking Simulation ; Cell Line ; Apoptosis/drug effects ; Chromatography, Liquid/methods ; Antibiotics, Antineoplastic/toxicity ; Antibiotics, Antineoplastic/pharmacokinetics ; Antibiotics, Antineoplastic/adverse effects ; Liquid Chromatography-Mass Spectrometry

Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin.

Autoren: Kopsida M Regtop L Lennernäs H et al.

Quelle: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2025 Nov 15; Vol. 265, pp. 117012. Date of Electronic Publication: 2025 Jun 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

MeSH-Schlagworte: Atorvastatin*/pharmacology , Atorvastatin*/administration & dosage , Doxorubicin*/pharmacology , Doxorubicin*/administration & dosage , Liver Neoplasms*/drug therapy , Liver Neoplasms*/metabolism , Metabolome*/drug effects , Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/metabolism , Antineoplastic Combined Chemotherapy Protocols*/pharmacology, Humans ; Cell Line, Tumor ; Drug Synergism ; Oxidative Stress/drug effects ; Lipid Metabolism/drug effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Inhibitory Concentration 50 ; Metabolomics/methods ; Dose-Response Relationship, Drug