Suchergebnisse - "DNA-Binding Proteins: metabolism"

DNA supercoiling enhances DNA condensation by ParB proteins

Autoren: Alejandro Martin Gonzalez Miloš Tišma Brian T. Analikwu et al.

Quelle: Nucleic Acids Res
Nucleic acids research, vol. 52, no. 21, pp. 13255-13268
Nucleic Acids Research

Schlagwörter: DNA, Bacterial, DNA-Binding Proteins, Bacterial Proteins, DNA, Superhelical, DNA, Superhelical/metabolism, DNA, Superhelical/chemistry, DNA, Bacterial/metabolism, Bacterial Proteins/metabolism, Bacterial Proteins/chemistry, DNA-Binding Proteins/metabolism, Chromosomes, Bacterial/metabolism, Chromosomes, Bacterial/chemistry, Escherichia coli/genetics, Escherichia coli/metabolism, Single Molecule Imaging, Escherichia coli Proteins/metabolism, Chromosome Segregation, Escherichia coli Proteins, Escherichia coli, Molecular and Structural Biology, Chromosomes, Bacterial

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39441069
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_9F0306AB2E806
https://serval.unil.ch/notice/serval:BIB_9F0306AB2E80
https://serval.unil.ch/resource/serval:BIB_9F0306AB2E80.P001/REF.pdf

Epigallocatechin-3-gallate binds tandem RNA recognition motifs of TDP-43 and inhibits its aggregation

Autoren: Morando, Maria Agnese D'Alessandro, Vito Spinello, Angelo et al.

Quelle: Sci Rep
Scientific Reports, Vol 15, Iss 1, Pp 1-14 (2025)
Morando, M A, D'Alessandro, V, Spinello, A, Sollazzo, M, Monaca, E, Sabbatella, R, Volpe, M C, Gervaso, F, Polini, A, Mizielinska, S & Alfano, C 2025, ' Epigallocatechin-3-gallate binds tandem RNA recognition motifs of TDP-43 and inhibits its aggregation ', Scientific Reports, vol. 15, no. 1, 17879, pp. 17879 . https://doi.org/10.1038/s41598-025-02035-6

Schlagwörter: DNA-Binding Proteins/metabolism, TDP-43, Science, Amyotrophic Lateral Sclerosis, Protein Aggregates/drug effects, RNA-binding proteins, Protein-ligand interaction, Article, Catechin, DNA-Binding Proteins, Protein Aggregates, Medicine, Humans, EGCG stability, ALS, Protein aggregation, Amyotrophic Lateral Sclerosis/metabolism, RNA Recognition Motif, Catechin/analogs & derivatives, Protein Binding

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/40404809
https://doaj.org/article/05b2ccb0f93044dbb610b9801e20a0ea
https://kclpure.kcl.ac.uk/ws/files/336965596/s41598-025-02035-6.pdf

The repressor PrtR1 and the global H-NS-like regulators MvaT and MvaV enable the fine-tuning of R-tailocin expression in Pseudomonas protegens

Autoren: Clara Margot Heiman Hammam Antar Florian Fournes et al.

Quelle: BMC Microbiol
BMC Microbiology, Vol 25, Iss 1, Pp 1-16 (2025)
BMC microbiology, vol. 25, no. 1, pp. 286

Schlagwörter: SOS response, H-NS regulators, Research, Mitomycin, Gene Expression Regulation, Bacterial, Microbiology, QR1-502, DNA-Binding Proteins, Repressor Proteins, Tailocin, Pyocin, Bacterial Proteins, Pseudomonas, Pseudomonas/genetics, Pseudomonas/metabolism, Pseudomonas/virology, Bacterial Proteins/genetics, Bacterial Proteins/metabolism, DNA-Binding Proteins/metabolism, DNA-Binding Proteins/genetics, Repressor Proteins/metabolism, Repressor Proteins/genetics, Mitomycin/pharmacology, Regulation

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/40350448
https://doaj.org/article/4bf0f9778db242b384e6e5a8d7e8ab4b
https://serval.unil.ch/resource/serval:BIB_941D5210DB6B.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_941D5210DB6B1
https://serval.unil.ch/notice/serval:BIB_941D5210DB6B

Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3

Autoren: Seehawer, Marco Li, Zheqi Nishida, Jun et al.

Weitere Verfasser: Seehawer, Marco Li, Zheqi Nishida, Jun et al.

Quelle: Nat Cell Biol

Schlagwörter: 0301 basic medicine, KMT2C protein, human, Oncologie, Triple Negative Breast Neoplasms/pathology, Triple Negative Breast Neoplasms, Histone-Lysine N-Methyltransferase/genetics, Sciences de la santé humaine, Article, Epigenesis, Genetic, Mice, 03 medical and health sciences, Neoplasm Proteins/genetics, KMT2D protein, human, Cell Line, Tumor, Matrix Metalloproteinase 3/metabolism, Neoplasm Proteins/metabolism, Animals, Humans, Human health sciences, Histone-Lysine N-Methyltransferase/metabolism, Brain Neoplasms/genetics, Histone Demethylases, Mice, Knockout, 0303 health sciences, DNA-Binding Proteins/metabolism, Brain Neoplasms, KDM6A protein, human, Cell Biology, Histone-Lysine N-Methyltransferase, Kmt2d protein, mouse, MMP3 protein, human, Up-Regulation, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, DNA-Binding Proteins, Oncology, Triple Negative Breast Neoplasms/metabolism, Brain Neoplasms/pathology, Histone Demethylases/genetics, Brain Neoplasms/secondary, Matrix Metalloproteinase 3, Female, Histone Demethylases/metabolism, Triple Negative Breast Neoplasms/genetics, Matrix Metalloproteinase 3/genetics, DNA-Binding Proteins/genetics, Myeloid-Lymphoid Leukemia Protein, Brain Neoplasms/metabolism

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38926506

Vertebrate centromere architecture: from chromatin threads to functional structures: from chromatin threads to functional structures

Autoren: Andrade Ruiz, Lorena Kops, Geert J.P.L. Sacristan, Carlos et al.

Weitere Verfasser: Andrade Ruiz, Lorena Kops, Geert J.P.L. Sacristan, Carlos et al.

Quelle: Chromosoma

Schlagwörter: 0301 basic medicine, Chromosomal Proteins, Non-Histone, Centromere, Cell Cycle Proteins, Review, Chromatin/metabolism, 03 medical and health sciences, Multiprotein Complexes/metabolism, Chromatin organization, Genetics, Animals, Humans, Genetics(clinical), Cohesins, Centromere Protein B/metabolism, Adenosine Triphosphatases, 0303 health sciences, DNA-Binding Proteins/metabolism, Cell Cycle Proteins/metabolism, Centromere Protein A/metabolism, Vertebrates/genetics, Chromatin, Chromosomal Proteins, DNA-Binding Proteins, Kinetochore, Non-Histone/metabolism, Multiprotein Complexes, Vertebrates, Centromere/metabolism, Epigenetics, CENP-A, Centromere Protein B, Centromere Protein A

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38856923
https://pure.knaw.nl/portal/en/publications/09f3b869-e625-4e47-9c4f-1371dc8d01ca
https://doi.org/10.1007/s00412-024-00823-z
https://hdl.handle.net/20.500.11755/09f3b869-e625-4e47-9c4f-1371dc8d01ca
https://dspace.library.uu.nl/handle/1874/454619

The missing link: ARID1B non-truncating variants causing Coffin-Siris syndrome due to protein aggregation: ARID1B non-truncating variants causing Coffin-Siris syndrome due to protein aggregation

Autoren: Bosch, Elisabeth Güse, Esther Kirchner, Philipp et al.

Quelle: Hum Genet

Schlagwörter: Male, 0301 basic medicine, 0303 health sciences, Micrognathism, Face/abnormalities [MeSH], Mutation [MeSH], Protein Aggregates [MeSH], Transcription Factors/genetics [MeSH], Abnormalities, Multiple/genetics [MeSH], Humans [MeSH], Intellectual Disability/genetics [MeSH], Micrognathism/genetics [MeSH], DNA-Binding Proteins/genetics [MeSH], DNA-Binding Proteins/metabolism [MeSH], Original Investigation, Hand Deformities, Congenital/genetics [MeSH], Male [MeSH], Neck/abnormalities [MeSH], Transcription Factors/metabolism [MeSH], 3. Good health, DNA-Binding Proteins, Protein Aggregates, 03 medical and health sciences, Intellectual Disability, Face, Mutation, Humans, Abnormalities, Multiple, Hand Deformities, Congenital, Neck, Transcription Factors

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39028335
https://repository.publisso.de/resource/frl:6519927

BZR1 promotes pluripotency acquisition and callus development through direct regulation of ARF7 and ARF19

Autoren: Thomas Ammitsøe Elise Ebstrup Noel Blanco-Touriñán et al.

Quelle: EMBO Rep
EMBO reports, vol. 26, no. 14, pp. 3554-3573
Ammitsoe, T, Ebstrup, E, Blanco-Tourinan, N, Hansen, J, Hardtke, C S, Petersen, M & Rodriguez, E 2025, ' BZR1 promotes pluripotency acquisition and callus development through direct regulation of ARF7 and ARF19 ', EMBO Reports, vol. 26, no. 14, pp. 3554-3573 . https://doi.org/10.1038/s44319-025-00433-5

Schlagwörter: Callus, Pluripotency, Transcriptional Regulation, Bzr1, Arabidopsis Proteins/genetics, Arabidopsis Proteins/metabolism, Arabidopsis/genetics, Arabidopsis/growth & development, Arabidopsis/metabolism, Gene Expression Regulation, Plant, Transcription Factors/genetics, Transcription Factors/metabolism, DNA-Binding Proteins/metabolism, DNA-Binding Proteins/genetics, Indoleacetic Acids/metabolism, Nuclear Proteins/genetics, Nuclear Proteins/metabolism, Promoter Regions, Genetic, Signal Transduction, Mutation, Protein Binding, ARFs, BZR1, Article

Dateibeschreibung: application/pdf

Zugangs-URL: https://serval.unil.ch/notice/serval:BIB_A4AB9CE03B09
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_A4AB9CE03B092
https://serval.unil.ch/resource/serval:BIB_A4AB9CE03B09.P001/REF.pdf
https://curis.ku.dk/ws/files/461316792/ammits_e-et-al-bzr1-promotes-pluripotency-acquisition-and-callus-development-through-direct-regulation-of-arf7-and-arf19.pdf

TET dioxygenases localize at splicing speckles and promote RNA splicing

Autoren: Florian D. Hastert Jasmin Weber Christina Bauer et al.

Weitere Verfasser: Florian D. Hastert Jasmin Weber Christina Bauer et al.

Quelle: Nucleus
Nucleus, Vol 16, Iss 1 (2025)
Hastert, F D, Weber, J, Bauer, C, Zhadan, A, Singh, D N D, Dix, T C, Arnold, R, Bessonov, S, Soller, M, Leonhardt, H, Cardoso, M C & Arroyo, M 2025, 'TET dioxygenases localize at splicing speckles and promote RNA splicing', Nucleus (Austin), vol. 16, no. 1, pp. 2536902. https://doi.org/10.1080/19491034.2025.2536902

Schlagwörter: DNA-Binding Proteins/metabolism, QH573-671, RNA Splicing, TET dioxygenases, QH426-470, Proto-Oncogene Proteins/metabolism, Mixed Function Oxygenases, Dioxygenases/metabolism, splicing, RNA modifications, splicing speckles, Genetics, Animals, Humans, 5-hydroxymethylcytosine, epitranscriptomics, Cytology, Splicing Factor U2AF/metabolism, HeLa Cells, Research Article

Zugangs-URL: https://doaj.org/article/e544f7f04faf436d8372fba8b48351f4
https://research.manchester.ac.uk/en/publications/d1854b44-7718-4796-9e7d-a1f2fb51f906
https://doi.org/10.1080/19491034.2025.2536902
https://resolver.sub.uni-goettingen.de/purl?gro-2/150434

MSH2, MSH6, MLH1, and PMS2 immunohistochemistry as highly sensitive screening method for DNA mismatch repair deficiency syndromes in pediatric high-grade glioma

Autoren: Friker, Lea L Perwein, Thomas Waha, Andreas et al.

Weitere Verfasser: Friker, Lea L Perwein, Thomas Waha, Andreas et al.

Quelle: Acta Neuropathol

Schlagwörter: Male, Glioma / genetics, Adolescent, Colorectal Neoplasms, Hereditary Nonpolyposis / genetics, DNA-Binding Proteins / genetics, DNA Mismatch Repair, DNA Mismatch Repair / genetics, Neoplastic Syndromes, Hereditary / genetics, MutS Homolog 2 Protein / genetics, Immunohistochemistry / methods, Brain Neoplasms / pathology, MutL Protein Homolog 1 / genetics, Neoplastic Syndromes, Hereditary, Germ-Line Mutation / genetics, Humans, Child, Mismatch Repair Endonuclease PMS2, Brain Neoplasms, Mismatch Repair Endonuclease PMS2 / metabolism, Glioma / metabolism, Infant, Colorectal Neoplasms, Hereditary Nonpolyposis / pathology, DNA-Binding Proteins / metabolism, Glioma, Brain Neoplasms / genetics, Immunohistochemistry, Colorectal Neoplasms, Hereditary Nonpolyposis, Mismatch Repair Endonuclease PMS2 / genetics, DNA-Binding Proteins, Lynch syndrome, MutS Homolog 2 Protein, Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis, Pediatric high-grade glioma, Neoplastic Syndromes, Hereditary / diagnosis, Child, Preschool, Glioma / pathology, Original Article, Female, Colorectal Neoplasms, MutL Protein Homolog 1, Constitutional mismatch repair deficiency, MutS Homolog 2 Protein / metabolism

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39894875
https://archive-ouverte.unige.ch/unige:183068
https://doi.org/10.1007/s00401-025-02846-x
https://resolver.sub.uni-goettingen.de/purl?gro-2/148117

Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice

Autoren: Bibi S. van Thiel Martine de Boer Yanto Ridwan et al.

Quelle: Mol Imaging Biol

Schlagwörter: Heart Failure, 0301 basic medicine, Endonucleases/metabolism [MeSH], Heart failure, Heart Failure/diagnostic imaging [MeSH], Endonucleases/genetics [MeSH], Ercc1, Animals [MeSH], Apoptosis [MeSH], DNA-Binding Proteins/genetics [MeSH], Myocardium/pathology [MeSH], DNA-Binding Proteins/metabolism [MeSH], Molecular imaging, FMT, CT, Aging, Mice [MeSH], Heart Failure/pathology [MeSH], Research Article, DNA repair, X-Ray Microtomography [MeSH], 0303 health sciences, Myocardium, Apoptosis, X-Ray Microtomography, Endonucleases, DNA-Binding Proteins, Mice, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Animals

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38498063
https://pure.eur.nl/en/publications/92649533-fd1f-45c8-b6b7-8b3b34b9bcf2
https://doi.org/10.1007/s11307-024-01902-4
https://repository.publisso.de/resource/frl:6524416

The TET protein family interactor PROSER1 sustains hematopoietic stem cell function

Autoren: Knatko, Elena Fleming, Anna Li, Xiang et al.

Quelle: Knatko, E, Fleming, A, Li, X, Crawley, P, Budriunaite, I & Rasmussen, K 2025, 'The TET protein family interactor PROSER1 sustains hematopoietic stem cell function', Blood Advances, vol. 9, no. 17, pp. 4378-4390. https://doi.org/10.1182/bloodadvances.2024015683

Schlagwörter: Hematopoietic Stem Cells/metabolism, Dioxygenases/metabolism, DNA-Binding Proteins/metabolism, Hematopoiesis/genetics, Proto-Oncogene Proteins/metabolism, Animals, Mice, DNA Methylation, Humans, Knockout, /dk/atira/pure/subjectarea/asjc/2700/2720, name=Hematology

Dateibeschreibung: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/40554416

Verfügbarkeit: https://discovery.dundee.ac.uk/en/publications/02dc07b0-85eb-4bf3-9fdf-dfdc982c3048
https://doi.org/10.1182/bloodadvances.2024015683
https://discovery.dundee.ac.uk/ws/files/156522420/blooda_adv-2024-015683-main.pdf
https://www.scopus.com/pages/publications/105014954004

CST Is Epistatic With Shieldin to Limit DNA Double‐Strand Break End Resection and Promote Repair During Igh Class Switch Recombination

Autoren: Lescale, Chloé Marton, Timea Vaysse, Amaury et al.

Weitere Verfasser: Lescale, Chloé Marton, Timea Vaysse, Amaury et al.

Quelle: ISSN: 0014-2980.

Schlagwörter: CST, Class switch recombination, DSB repair, Shieldin, MESH: Animals, MESH: B-Lymphocytes* / immunology, MESH: Immunoglobulin Class Switching* / genetics, MESH: Immunoglobulin Class Switching* / immunology, MESH: Immunoglobulin Heavy Chains* / genetics, MESH: Immunoglobulin Heavy Chains* / immunology, MESH: Mice, Inbred C57BL, Knockout, MESH: Telomere-Binding Proteins* / genetics, MESH: Telomere-Binding Proteins* / metabolism, MESH: Tumor Suppressor p53-Binding Protein 1, MESH: Cytidine Deaminase / genetics, MESH: Cytidine Deaminase / metabolism, MESH: DNA Breaks, Double-Stranded, MESH: DNA End-Joining Repair, MESH: DNA Repair, MESH: DNA-Binding Proteins* / genetics, MESH: DNA-Binding Proteins* / metabolism, MESH: Epistasis, Genetic, [SDV.IMM]Life Sciences [q-bio]/Immunology, [SDV.GEN]Life Sciences [q-bio]/Genetics

Relation: info:eu-repo/semantics/altIdentifier/pmid/40178294; PUBMED: 40178294; PUBMEDCENTRAL: PMC11967320

Verfügbarkeit: https://u-paris.hal.science/hal-05121552
https://u-paris.hal.science/hal-05121552v1/document
https://u-paris.hal.science/hal-05121552v1/file/Eur%20J%20Immunol%20-%202025%20-%20Lescale%20-%20CST%20Is%20Epistatic%20With%20Shieldin%20to%20Limit%20DNA%20Double%E2%80%90Strand%20Break%20End%20Resection%20and%20Promote.pdf
https://doi.org/10.1002/eji.202451585

SUMO2/3 conjugation of TDP-43 protects against aggregation

Autoren: Verde, Enza Maria Antoniani, Francesco Mediani, Laura et al.

Weitere Verfasser: Verde, Enza Maria Antoniani, Francesco Mediani, Laura et al.

Quelle: ISSN: 2375-2548 ; Science Advances ; https://hal.science/hal-05326520 ; Science Advances , 2025, 11 (8), pp.eadq2475. ⟨10.1126/sciadv.adq2475⟩.

Schlagwörter: MESH: DNA-Binding Proteins* / chemistry, MESH: DNA-Binding Proteins* / genetics, MESH: Protein Inhibitors of Activated STAT / metabolism, MESH: Small Ubiquitin-Related Modifier Proteins* / genetics, MESH: Small Ubiquitin-Related Modifier Proteins* / metabolism, MESH: Stress Granules / metabolism, MESH: Sumoylation, MESH: Ubiquitins* / genetics, MESH: Ubiquitins* / metabolism, MESH: DNA-Binding Proteins* / metabolism, MESH: Humans, MESH: Oxidative Stress, MESH: Poly-ADP-Ribose Binding Proteins, MESH: Protein Aggregates, MESH: Protein Aggregation, Pathological* / metabolism, MESH: Protein Binding, MESH: Protein Inhibitors of Activated STAT / genetics, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology

Relation: info:eu-repo/semantics/altIdentifier/pmid/39982984; info:eu-repo/grantAgreement//725836/EU/The chemistry and physics of RNP granules: how they form, age and cause disease/PhaseAge; PUBMED: 39982984; PUBMEDCENTRAL: PMC11844728

Verfügbarkeit: https://hal.science/hal-05326520
https://hal.science/hal-05326520v1/document
https://hal.science/hal-05326520v1/file/sciadv.adq2475.pdf
https://doi.org/10.1126/sciadv.adq2475

HU promotes higher order chromosome organization and influences DNA replication rates in Streptococcus pneumoniae

Autoren: Mazzuoli, Maria-Vittoria van Raaphorst, Renske Martin, Louise S et al.

Quelle: Mazzuoli, M-V, van Raaphorst, R, Martin, L S, Bock, F P, Thierry, A, Marbouty, M, Waclawiková, B, Stinenbosch, J, Koszul, R & Veening, J-W 2025, 'HU promotes higher order chromosome organization and influences DNA replication rates in Streptococcus pneumoniae', Nucleic Acids Research, vol. 53, no. 8, gkaf312. https://doi.org/10.1093/nar/gkaf312

Schlagwörter: Streptococcus pneumoniae/genetics, DNA Replication, Chromosomes, Bacterial/genetics, Bacterial Proteins/metabolism, DNA-Binding Proteins/metabolism, Replication Origin, DNA

Dateibeschreibung: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/40263708; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/11370/e4ef1235-9941-4a4f-8d31-d635f35696c9; info:eu-repo/semantics/altIdentifier/pissn/0305-1048; info:eu-repo/semantics/altIdentifier/eissn/1362-4962

Verfügbarkeit: https://hdl.handle.net/11370/e4ef1235-9941-4a4f-8d31-d635f35696c9
https://research.rug.nl/en/publications/e4ef1235-9941-4a4f-8d31-d635f35696c9
https://doi.org/10.1093/nar/gkaf312
https://pure.rug.nl/ws/files/1293995482/gkaf312.pdf
https://www.scopus.com/pages/publications/105003560162

Proteomics analysis of the TDP-43 interactome in cellular models of ALS pathogenesis

Autoren: Cheng, Flora Chapman, Tyler Venturato, Juliana et al.

Quelle: Cheng , F , Chapman , T , Venturato , J , Davidson , J M , Polido , S A , Rosa-Fernandes , L , San Gil , R , Suddull , H J , Zhang , S , Macaslam , C Y , Szwaja , P , Chung , R , Walker , A K , Rayner , S L , Morsch , M & Lee , A 2025 , ' Proteomics analysis of the TDP-43 interactome in cellular models of ALS pathogenesis ' , Journal of Neurochemistry , vol. 169 , no. 5 , e70079 , ....

Schlagwörter: Humans, DNA-Binding Proteins/metabolism, Amyotrophic Lateral Sclerosis/metabolism, Proteomics/methods, Animals, Oxidative Stress/physiology, MND, proteomics, interactomics, TDP-43, ALS, APEX

Dateibeschreibung: application/pdf

Verfügbarkeit: https://researchers.mq.edu.au/en/publications/2762f157-9c4d-4df8-9de7-0b65fda3adae
https://doi.org/10.1111/jnc.70079
https://research-management.mq.edu.au/ws/files/428726771/Publisher_version_open_access_.pdf
http://www.scopus.com/inward/record.url?scp=105005232612&partnerID=8YFLogxK

Genome-wide profiling of DNA repair proteins in single cells

Autoren: Kim L. de Luca Pim M. J. Rullens Magdalena A. Karpinska et al.

Weitere Verfasser: Kim L. de Luca Pim M. J. Rullens Magdalena A. Karpinska et al.

Quelle: Nat Commun
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Nature Communications, 15, 1, pp. 1-16
Nature Communications

Schlagwörter: 0301 basic medicine, DNA Repair, Science, General Biochemistry,Genetics and Molecular Biology, General Physics and Astronomy, Article, Genomic Instability, Chromatin/metabolism, Double-Stranded, 03 medical and health sciences, Humans, DNA Breaks, Double-Stranded, Molecular Biology, 0303 health sciences, Genome, DNA-Binding Proteins/metabolism, Genome, Human, Single-Cell Analysis/methods, DNA Breaks, General Chemistry, Chromatin, DNA-Binding Proteins, Single-Cell Analysis, Human, Protein Binding, DNA Damage

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39572529
https://doaj.org/article/4a8adea22a094f2e87579c732274e6d0
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/313536
https://dspace.library.uu.nl/handle/1874/459294
https://repository.ubn.ru.nl//bitstream/handle/2066/313536/313536.pdf
https://hdl.handle.net/2066/313536
https://resolver.sub.uni-goettingen.de/purl?gro-2/146662

Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders

Autoren: Alena Kroupova Valentina A. Spiteri Zoe J. Rutter et al.

Quelle: Nat Commun
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Nature Communications

Schlagwörter: Models, Molecular, Crystallography, DNA-Binding Proteins/metabolism, Signal Transducing/metabolism, Protein Conformation, Science, Ubiquitin-Protein Ligases, Adaptor Proteins, Molecular, Crystallography, X-Ray, Article, Thalidomide, DNA-Binding Proteins, Ubiquitin-Protein Ligases/metabolism, Models, Escherichia coli/metabolism, Proteolysis, X-Ray, Escherichia coli, Humans, Thalidomide/chemistry, Lenalidomide, Adaptor Proteins, Signal Transducing

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39406745
https://doaj.org/article/70479f877d614c148e6f8203f19d4b2d

Neuropathological spectrum of anti-IgLON5 disease and stages of brainstem tau pathology: updated neuropathological research criteria of the disease-related tauopathy: updated neuropathological research criteria of the disease-related tauopathy

Autoren: Ellen Gelpi Raphael Reinecke Carles Gaig et al.

Weitere Verfasser: Ellen Gelpi Raphael Reinecke Carles Gaig et al.

Quelle: Acta Neuropathol
Acta Neuropathologica, 148, 1, pp. 53

Schlagwörter: Male, Adult, Anti-IgLON5 disease, TDP-43, Cell Adhesion Molecules, Neuronal, Clinical Neurology, 4R tau, IgLON5, tau Proteins, 3R, Brain Stem/pathology [MeSH], Tauopathies/immunology [MeSH], Aged, 80 and over [MeSH], Aged [MeSH], Atypical, Tauopathies/pathology [MeSH], Stages, Anti-IgLON5 tauopathy, Autoantibodies/immunology [MeSH], tau Proteins/immunology [MeSH], DNA-Binding Proteins/metabolism [MeSH], Cell Adhesion Molecules, Neuronal/metabolism [MeSH], Male [MeSH], Brain Stem/metabolism [MeSH], Brainstem tauopathy, Dementia, PSP, Female [MeSH], Adult [MeSH], Humans [MeSH], Middle Aged [MeSH], Motor neuron disease, Original Paper, ALS, Cell Adhesion Molecules, Neuronal/immunology [MeSH], Neuropathology, Brain Stem/immunology [MeSH], tau Proteins/metabolism [MeSH], Neurology and psychiatry, Pathology and Forensic Medicine, Cellular and Molecular Neuroscience, Humans, Pathology - Radboud University Medical Center - DCMN, Aged, Autoantibodies, Aged, 80 and over, Neurology - Radboud University Medical Center - DCMN, Neurosciences, Middle Aged, DNA-Binding Proteins, Tauopathies, Female, Brain Stem

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39400557
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/311415
https://pure.eur.nl/en/publications/d53e4c8f-6713-4032-8f63-4ae46fb85bc8
https://doi.org/10.1007/s00401-024-02805-y
https://dspace.library.uu.nl/handle/1874/458412
https://pure.amsterdamumc.nl/en/publications/eb45339b-72a4-4f76-8b56-d15eb963acd0
https://doi.org/10.1007/s00401-024-02805-y
https://repository.ubn.ru.nl//bitstream/handle/2066/311415/311415.pdf
https://hdl.handle.net/2066/311415
http://hdl.handle.net/10138/587267
https://repository.publisso.de/resource/frl:6498525

SENP1 mediates zinc-induced ZnT6 deSUMOylation at Lys-409 involved in the regulation of zinc metabolism in Golgi apparatus

Autoren: Chang-Chun Song Tao Liu Christer Hogstrand et al.

Quelle: Cell Mol Life Sci

Schlagwörter: Liver/metabolism, Male, SUMO-1 Protein, Golgi Apparatus, Inbred C57BL, Transcription Factor MTF-1, Mice, Animals, Humans, Transcription Factors/metabolism, Cysteine Endopeptidases/metabolism, Cation Transport Proteins, Protein Processing, Golgi Apparatus/metabolism, DNA-Binding Proteins/metabolism, Post-Translational, Sumoylation, Cation Transport Proteins/metabolism, Zinc/metabolism, DNA-Binding Proteins, Mice, Inbred C57BL, Cysteine Endopeptidases, Zinc, Liver, SUMO-1 Protein/metabolism, Original Article, Carrier Proteins, Protein Processing, Post-Translational, Transcription Factors

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39367979

Novel in vivo TDP-43 stress reporter models to accelerate drug development in ALS

Autoren: Febe Ferro C. Roland Wolf Christopher Henstridge et al.

Quelle: Open Biol
Open Biology, Vol 14, Iss 10 (2024)

Schlagwörter: TDP-43, QH301-705.5, NF-E2-Related Factor 2, Oxidative Stress/drug effects, Mice, Transgenic, Transgenic, Mice, Drug Development, Genes, Reporter, NF-E2-Related Factor 2/metabolism, name=General Biochemistry,Genetics and Molecular Biology, Animals, Humans, name=Immunology, Biology (General), Amyotrophic Lateral Sclerosis/metabolism, Reporter, DNA-Binding Proteins/metabolism, Animal, Amyotrophic Lateral Sclerosis, name=General Neuroscience, reporters, preclinical models, DNA-Binding Proteins, in vivo, Disease Models, Animal, Oxidative Stress, Genes, Disease Models, Biomarkers, Methods and Techniques, DNA Damage

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39471842
https://doaj.org/article/d1dbb0041ec14212ba7468adda3c1fe0